Aliases for TRIM67 Gene

Aliases for TRIM67 Gene

  • Tripartite Motif Containing 67 2 3 5
  • Tripartite Motif-Containing Protein 67 3 4
  • TNL 3 4
  • Tripartite Motif-Containing 67 2
  • TRIM9-Like Protein TNL 3
  • TRIM9-Like Protein 4

External Ids for TRIM67 Gene

Previous GeneCards Identifiers for TRIM67 Gene

  • GC01P227606
  • GC01P229365
  • GC01P231298
  • GC01P201782

Summaries for TRIM67 Gene

GeneCards Summary for TRIM67 Gene

TRIM67 (Tripartite Motif Containing 67) is a Protein Coding gene. Diseases associated with TRIM67 include Preterm Premature Rupture Of The Membranes. An important paralog of this gene is TRIM9.

Additional gene information for TRIM67 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRIM67 Gene

Genomics for TRIM67 Gene

GeneHancer (GH) Regulatory Elements for TRIM67 Gene

Promoters and enhancers for TRIM67 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J231162 Promoter 1.4 EPDnew Ensembl 750.6 -0.1 -111 2 ZBTB40 L3MBTL2 MNT ELF3 ZFX MAFK SP7 NCOA6 ZNF560 KLF14 TRIM67 COG2 HSALNG0011427
GH01J230976 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 10.7 -183.3 -183311 4 SIN3A ZNF24 SP1 ZBTB40 CTCF SIX5 RBPJ SMARCE1 POLR2A ATF1 TTC13 ARV1 C1orf131 SPRTN TRIM67 COG2 EXOC8 FAM89A ENSG00000223393 HSALNG0011415
GH01J231138 Enhancer 0.9 Ensembl ENCODE 12.7 -22.4 -22367 2.7 TCF7L2 NFIB ZKSCAN8 ZFX ZNF639 REST TARDBP CTBP1 ZNF24 MNT TRIM67 HSALNG0011427
GH01J231210 Enhancer 1.3 FANTOM5 Ensembl ENCODE 0.2 +49.8 49824 2 SP1 ZBTB40 CTCF MIXL1 CC2D1A ETV6 L3MBTL2 RAD21 MNT ELF3 C1orf131 COG2 GNPAT FAM89A ENSG00000227934 MIR1182 C1orf198 ENSG00000223393 SPRTN lnc-EXOC8-4
GH01J231200 Enhancer 1.1 Ensembl ENCODE 0.3 +38.5 38508 1 ZBTB40 SMARCE1 CC2D1A L3MBTL2 DACH1 TEAD4 ZKSCAN8 GTF2F1 ZFX BACH1 C1orf131 FAM89A ENSG00000227934 MIR1182 LOC149373 lnc-EXOC8-4 TRIM67
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRIM67 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRIM67 gene promoter:
  • AhR
  • GATA-2
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • NRSF form 1
  • NRSF form 2

Genomic Locations for TRIM67 Gene

Genomic Locations for TRIM67 Gene
59,457 bases
Plus strand
59,457 bases
Plus strand

Genomic View for TRIM67 Gene

Genes around TRIM67 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM67 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM67 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM67 Gene

Proteins for TRIM67 Gene

  • Protein details for TRIM67 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tripartite motif-containing protein 67
    Protein Accession:
    Secondary Accessions:
    • Q5TER7
    • Q5TER8
    • Q7Z4K7

    Protein attributes for TRIM67 Gene

    783 amino acids
    Molecular mass:
    83823 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC86689.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRIM67 Gene


neXtProt entry for TRIM67 Gene

Post-translational modifications for TRIM67 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM67 Gene

No data available for DME Specific Peptides for TRIM67 Gene

Domains & Families for TRIM67 Gene

Gene Families for TRIM67 Gene

Suggested Antigen Peptide Sequences for TRIM67 Gene

GenScript: Design optimal peptide antigens:
  • TRIM9-like protein (TRI67_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRIM/RBCC family.
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM67: view

Function for TRIM67 Gene

Phenotypes From GWAS Catalog for TRIM67 Gene

Gene Ontology (GO) - Molecular Function for TRIM67 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM67: view
genes like me logo Genes that share phenotypes with TRIM67: view

Animal Models for TRIM67 Gene

MGI Knock Outs for TRIM67:

Animal Model Products

CRISPR Products

miRNA for TRIM67 Gene

miRTarBase miRNAs that target TRIM67

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIM67 Gene

Localization for TRIM67 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM67 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Note=Microtubule-associated. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM67 gene
Compartment Confidence
cytoskeleton 3
nucleus 3
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TRIM67 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with TRIM67: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TRIM67 Gene

Pathways & Interactions for TRIM67 Gene

PathCards logo

SuperPathways for TRIM67 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM67 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010976 positive regulation of neuron projection development IEA --
GO:0046580 negative regulation of Ras protein signal transduction IEA --
GO:1903827 regulation of cellular protein localization ISS --
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process IEA --
genes like me logo Genes that share ontologies with TRIM67: view

No data available for Pathways by source and SIGNOR curated interactions for TRIM67 Gene

Drugs & Compounds for TRIM67 Gene

No Compound Related Data Available

Transcripts for TRIM67 Gene

mRNA/cDNA for TRIM67 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(29) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM67 Gene

No ASD Table

Relevant External Links for TRIM67 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM67 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM67 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM67 Gene

This gene is overexpressed in Brain - Cerebellum (x15.3) and Brain - Cerebellar Hemisphere (x14.7).

Protein differential expression in normal tissues from HIPED for TRIM67 Gene

This gene is overexpressed in Fetal Brain (62.0) and Retina (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRIM67 Gene

Protein tissue co-expression partners for TRIM67 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRIM67 Gene:


SOURCE GeneReport for Unigene cluster for TRIM67 Gene:


Evidence on tissue expression from TISSUES for TRIM67 Gene

  • Nervous system(4.6)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with TRIM67: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM67 Gene

Orthologs for TRIM67 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIM67 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRIM67 33 32
  • 99.19 (n)
(Bos Taurus)
Mammalia TRIM67 33 32
  • 90.49 (n)
(Canis familiaris)
Mammalia TRIM67 33 32
  • 90.21 (n)
(Monodelphis domestica)
Mammalia TRIM67 33
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia TRIM67 33
  • 89 (a)
(Rattus norvegicus)
Mammalia Trim67 32
  • 86.54 (n)
(Mus musculus)
Mammalia Trim67 17 33 32
  • 86.41 (n)
(Gallus gallus)
Aves TRIM67 33 32
  • 79.22 (n)
(Anolis carolinensis)
Reptilia TRIM67 33
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia trim67 32
  • 72 (n)
(Danio rerio)
Actinopterygii TRIM67 33
  • 75 (a)
LOC100332164 32
  • 73.61 (n)
fruit fly
(Drosophila melanogaster)
Insecta Trim9 33
  • 43 (a)
(Caenorhabditis elegans)
Secernentea trim-9 33
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 44 (a)
Species where no ortholog for TRIM67 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRIM67 Gene

Gene Tree for TRIM67 (if available)
Gene Tree for TRIM67 (if available)
Evolutionary constrained regions (ECRs) for TRIM67: view image

Paralogs for TRIM67 Gene

(5) SIMAP similar genes for TRIM67 Gene using alignment to 4 proteins:

  • F8W8C1_HUMAN
  • L8E9I3_HUMAN
genes like me logo Genes that share paralogs with TRIM67: view

Variants for TRIM67 Gene

Sequence variations from dbSNP and Humsavar for TRIM67 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000004184 -- 231,179,577(+) A/C intron_variant
rs1000004698 -- 231,212,471(+) T/C intron_variant
rs1000014726 -- 231,215,393(+) T/C coding_sequence_variant, genic_downstream_transcript_variant, synonymous_variant
rs1000026850 -- 231,174,504(+) T/A intron_variant
rs1000063461 -- 231,204,854(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM67 Gene

Variant ID Type Subtype PubMed ID
dgv18n17 CNV loss 16327808
esv1972788 CNV deletion 18987734
esv2182022 CNV deletion 18987734
esv2494270 CNV deletion 19546169
esv2555185 CNV insertion 19546169
esv2669296 CNV deletion 23128226
esv2678520 CNV deletion 23128226
esv2724839 CNV deletion 23290073
esv2724850 CNV deletion 23290073
esv27426 CNV loss 19812545
esv2764227 CNV loss 21179565
esv3310546 CNV novel sequence insertion 20981092
esv3334334 CNV duplication 20981092
esv3548288 CNV deletion 23714750
esv3548299 CNV deletion 23714750
esv3589093 CNV gain 21293372
esv3589106 CNV gain 21293372
esv3589108 CNV loss 21293372
esv7591 CNV loss 19470904
nsv1000488 CNV gain 25217958
nsv1011066 CNV gain 25217958
nsv1122456 CNV deletion 24896259
nsv1129140 CNV insertion 24896259
nsv1133948 CNV deletion 24896259
nsv1142079 CNV tandem duplication 24896259
nsv1144442 CNV deletion 24896259
nsv1148387 CNV insertion 26484159
nsv517116 CNV loss 19592680
nsv818833 CNV loss 17921354

Variation tolerance for TRIM67 Gene

Residual Variation Intolerance Score: 34.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.34; 41.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM67 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM67 Gene

Disorders for TRIM67 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRIM67 Gene - From: DISEASES

Disorder Aliases PubMed IDs
preterm premature rupture of the membranes
  • pprom
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TRIM67

genes like me logo Genes that share disorders with TRIM67: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM67 Gene

Publications for TRIM67 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 56
  2. Subclassification of the RBCC/TRIM superfamily reveals a novel motif necessary for microtubule binding. (PMID: 16434393) Short KM … Cox TC (The Journal of biological chemistry 2006) 3 4 56
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  4. Mammalian TRIM67 Functions in Brain Development and Behavior. (PMID: 29911180) Boyer NP … Gupton SL (eNeuro 2018) 3 56
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 56

Products for TRIM67 Gene

Sources for TRIM67 Gene