Aliases for TRIM66 Gene

Aliases for TRIM66 Gene

  • Tripartite Motif Containing 66 2 3 5
  • Tripartite Motif-Containing Protein 66 3 4
  • C11orf29 3 4
  • KIAA0298 2 4
  • TIF1D 2 3
  • Transcriptional Intermediary Factor 1 Delta 3
  • Chromosome 11 Open Reading Frame 29 2
  • Tripartite Motif-Containing 66 2
  • TIF1DELTA 3
  • TRIM66 5

External Ids for TRIM66 Gene

Previous HGNC Symbols for TRIM66 Gene

  • C11orf29

Previous GeneCards Identifiers for TRIM66 Gene

  • GC11M008595
  • GC11M008301

Summaries for TRIM66 Gene

GeneCards Summary for TRIM66 Gene

TRIM66 (Tripartite Motif Containing 66) is a Protein Coding gene. Diseases associated with TRIM66 include Non-Invasive Bladder Urothelial Carcinoma and Cystathioninuria. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and chromatin binding. An important paralog of this gene is TRIM33.

UniProtKB/Swiss-Prot Summary for TRIM66 Gene

  • May function as transcription repressor; The repressive effects are mediated, at least in part, by recruitment of deacetylase activity. May play a role as negative regulator of postmeiotic genes acting through CBX3 complex formation and centromere association (By similarity).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRIM66 Gene

Genomics for TRIM66 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TRIM66 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRIM66 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRIM66

Top Transcription factor binding sites by QIAGEN in the TRIM66 gene promoter:
  • AP-4
  • E2F
  • E2F-1
  • FOXL1
  • GATA-1
  • Hlf
  • LUN-1
  • Msx-1
  • MZF-1
  • STAT5A

Genomic Locations for TRIM66 Gene

Genomic Locations for TRIM66 Gene
chr11:8,612,037-8,683,217
(GRCh38/hg38)
Size:
71,181 bases
Orientation:
Minus strand
chr11:8,633,584-8,693,413
(GRCh37/hg19)
Size:
59,830 bases
Orientation:
Minus strand

Genomic View for TRIM66 Gene

Genes around TRIM66 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM66 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM66 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM66 Gene

Proteins for TRIM66 Gene

  • Protein details for TRIM66 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15016-TRI66_HUMAN
    Recommended name:
    Tripartite motif-containing protein 66
    Protein Accession:
    O15016
    Secondary Accessions:
    • Q9BQQ4

    Protein attributes for TRIM66 Gene

    Size:
    1216 amino acids
    Molecular mass:
    134663 Da
    Quaternary structure:
    • Can form homodimers and heterodimers. Interacts with CBX5, CBX1 and CBX3 via PxVxL motif (By similarity).
    SequenceCaution:
    • Sequence=BAA20758.2; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRIM66 Gene

    Alternative splice isoforms for TRIM66 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM66 Gene

Post-translational modifications for TRIM66 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TRIM66 Gene

Domains & Families for TRIM66 Gene

Gene Families for TRIM66 Gene

Protein Domains for TRIM66 Gene

InterPro:
Blocks:
  • Zn-finger-like, PHD finger
  • Bromodomain signature
  • B-box zinc finger signature
  • B-box, C-terminal
ProtoNet:

Suggested Antigen Peptide Sequences for TRIM66 Gene

GenScript: Design optimal peptide antigens:
  • Tripartite motif-containing protein 66 (TRI66_HUMAN)
genes like me logo Genes that share domains with TRIM66: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TRIM66 Gene

Function for TRIM66 Gene

Molecular function for TRIM66 Gene

UniProtKB/Swiss-Prot Function:
May function as transcription repressor; The repressive effects are mediated, at least in part, by recruitment of deacetylase activity. May play a role as negative regulator of postmeiotic genes acting through CBX3 complex formation and centromere association (By similarity).

Phenotypes From GWAS Catalog for TRIM66 Gene

Gene Ontology (GO) - Molecular Function for TRIM66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IBA 21873635
GO:0005515 protein binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM66: view
genes like me logo Genes that share phenotypes with TRIM66: view

Animal Models for TRIM66 Gene

MGI Knock Outs for TRIM66:
  • Trim66 Trim66<tm1a(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

miRNA for TRIM66 Gene

miRTarBase miRNAs that target TRIM66

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM66

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIM66 Gene

Localization for TRIM66 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM66 Gene

Nucleus. Note=Forms discrete foci within the centromeric chromocenter and surrounding nucleoplasm. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM66 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TRIM66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm IDA --
GO:0016235 aggresome IDA --
genes like me logo Genes that share ontologies with TRIM66: view

Pathways & Interactions for TRIM66 Gene

PathCards logo

SuperPathways for TRIM66 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045892 negative regulation of transcription, DNA-templated IBA 21873635
genes like me logo Genes that share ontologies with TRIM66: view

No data available for Pathways by source and SIGNOR curated interactions for TRIM66 Gene

Drugs & Compounds for TRIM66 Gene

No Compound Related Data Available

Transcripts for TRIM66 Gene

mRNA/cDNA for TRIM66 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM66

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM66 Gene

No ASD Table

Relevant External Links for TRIM66 Gene

GeneLoc Exon Structure for
TRIM66

Expression for TRIM66 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRIM66 Gene

Protein differential expression in normal tissues from HIPED for TRIM66 Gene

This gene is overexpressed in Adipocyte (61.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRIM66 Gene



Protein tissue co-expression partners for TRIM66 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRIM66

SOURCE GeneReport for Unigene cluster for TRIM66 Gene:

Hs.130836

Evidence on tissue expression from TISSUES for TRIM66 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TRIM66: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM66 Gene

Orthologs for TRIM66 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIM66 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TRIM66 30
  • 99.49 (n)
Cow
(Bos Taurus)
Mammalia TRIM66 30 31
  • 89.27 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TRIM66 30 31
  • 89.13 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Trim66 30 17 31
  • 86.44 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Trim66 30
  • 85.73 (n)
Oppossum
(Monodelphis domestica)
Mammalia TRIM66 31
  • 63 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TRIM66 31
  • 51 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TRIM66 30 31
  • 63.07 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TRIM66 31
  • 52 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia trim66 30
  • 58.99 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24102 30
Zebrafish
(Danio rerio)
Actinopterygii trim66 31
  • 30 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta mei-P26 31
  • 12 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea nhl-2 31
  • 11 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.9380 31
  • 14 (a)
OneToMany
Species where no ortholog for TRIM66 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TRIM66 Gene

ENSEMBL:
Gene Tree for TRIM66 (if available)
TreeFam:
Gene Tree for TRIM66 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRIM66: view image

Paralogs for TRIM66 Gene

(2) SIMAP similar genes for TRIM66 Gene using alignment to 3 proteins:

  • TRI66_HUMAN
  • B5MCJ9_HUMAN
  • H0YF52_HUMAN
genes like me logo Genes that share paralogs with TRIM66: view

Variants for TRIM66 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRIM66 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
711377 Likely Benign: not provided 8,620,456(-) T/C MISSENSE_VARIANT
776583 Benign: not provided 8,624,990(-) C/T MISSENSE_VARIANT
776584 Benign: not provided 8,625,058(-) G/A SYNONYMOUS_VARIANT
785340 Benign: not provided 8,647,963(-) G/A INTRON_VARIANT
787903 Benign: not provided 8,646,469(-) T/G MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for TRIM66 Gene

Structural Variations from Database of Genomic Variants (DGV) for TRIM66 Gene

Variant ID Type Subtype PubMed ID
esv2751035 CNV loss 17911159
nsv499766 OTHER inversion 21111241
nsv7215 OTHER inversion 18451855

Variation tolerance for TRIM66 Gene

Gene Damage Index Score: 14.12; 96.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM66 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM66

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM66 Gene

Disorders for TRIM66 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TRIM66 Gene - From: DISEASES

Disorder Aliases PubMed IDs
non-invasive bladder urothelial carcinoma
  • stage 0 bladder urothelial carcinoma
cystathioninuria
  • cystathionase deficiency
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TRIM66

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TRIM66: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM66 Gene

Publications for TRIM66 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4
  2. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PMID: 21102462) Elks CE … Murray A (Nature genetics 2010) 3 41
  3. TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids. (PMID: 15322135) Khetchoumian K … Losson R (The Journal of biological chemistry 2004) 3 23
  4. Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7. (PMID: 11528127) Amid C … Schmidt ER (Cytogenetics and cell genetics 2001) 3 4
  5. TRIM66 confers tumorigenicity of hepatocellular carcinoma cells by regulating GSK-3β-dependent Wnt/β-catenin signaling. (PMID: 30710548) Fan W … Liu X (European journal of pharmacology 2019) 3

Products for TRIM66 Gene

Sources for TRIM66 Gene