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Aliases for TRIM66 Gene

Aliases for TRIM66 Gene

  • Tripartite Motif Containing 66 2 3 5
  • C11orf29 3 4
  • Transcriptional Intermediary Factor 1 Delta 3
  • Tripartite Motif-Containing Protein 66 3
  • Chromosome 11 Open Reading Frame 29 2
  • Tripartite Motif-Containing 66 2
  • KIAA0298 4
  • TIF1D 3

External Ids for TRIM66 Gene

Previous HGNC Symbols for TRIM66 Gene

  • C11orf29

Previous GeneCards Identifiers for TRIM66 Gene

  • GC11M008301

Summaries for TRIM66 Gene

GeneCards Summary for TRIM66 Gene

TRIM66 (Tripartite Motif Containing 66) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and chromatin binding. An important paralog of this gene is TRIM24.

UniProtKB/Swiss-Prot for TRIM66 Gene

  • May function as transcription repressor; The repressive effects are mediated, at least in part, by recruitment of deacetylase activity. May play a role as negative regulator of postmeiotic genes acting through CBX3 complex formation and centromere association (By similarity).

Additional gene information for TRIM66 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM66 Gene

Genomics for TRIM66 Gene

GeneHancer (GH) Regulatory Elements for TRIM66 Gene

Promoters and enhancers for TRIM66 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I008659 Promoter 0.9 EPDnew 550.3 +23.8 23797 0.1 MXI1 PKNOX1 ATF1 RFX1 CEBPG ZNF645 ZIC2 ATF2 GLIS1 CREB1 TRIM66 RPL27A SNORA3A SNORA3B ENSG00000254665 GC11M008675 GC11M008618 PIR37396
GH11I008658 Promoter 0.8 EPDnew 557.3 +24.1 24136 0.1 ATF4 MXI1 ATF1 POLR2A CEBPB TRIM24 CEBPG TRIM66 RPL27A SNORA3A SNORA3B ENSG00000254665 GC11M008675 GC11M008618 PIR37396
GH11I008681 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 59.1 -3.2 -3152 8.7 MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC SNORA3B RPL27A GC11P008722 GC11P008723 GC11P008725 GC11P008726 GC11P008728 GC11P008729 PIR32700 PIR61800
GH11I008697 Enhancer 1.3 Ensembl ENCODE dbSUPER 45.2 -17.1 -17090 4.1 HDAC1 ELF3 PKNOX1 ATF1 RAD21 THRB ZSCAN9 RARA HSF1 CREM TRIM66 STK33 TMEM9B ENSG00000254665 RPL27A PIR56836 ST5
GH11I009564 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 19 -889.5 -889545 15.2 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 WEE1 SNORA3B SWAP70 ZNF143 TRIM66 RPL21P97 AKIP1 TMEM41B DENND5A ENSG00000238387
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRIM66 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRIM66 gene promoter:

Genomic Locations for TRIM66 Gene

Genomic Locations for TRIM66 Gene
70,667 bases
Minus strand

Genomic View for TRIM66 Gene

Genes around TRIM66 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM66 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM66 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM66 Gene

Proteins for TRIM66 Gene

  • Protein details for TRIM66 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tripartite motif-containing protein 66
    Protein Accession:
    Secondary Accessions:
    • Q9BQQ4

    Protein attributes for TRIM66 Gene

    1216 amino acids
    Molecular mass:
    134663 Da
    Quaternary structure:
    • Can form homodimers and heterodimers. Interacts with CBX5, CBX1 and CBX3 via PxVxL motif (By similarity).
    • Sequence=BAA20758.2; Type=Frameshift; Positions=797; Evidence={ECO:0000305};

    Alternative splice isoforms for TRIM66 Gene


neXtProt entry for TRIM66 Gene

Post-translational modifications for TRIM66 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TRIM66 Gene

Domains & Families for TRIM66 Gene

Gene Families for TRIM66 Gene

Suggested Antigen Peptide Sequences for TRIM66 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRIM66: view

No data available for UniProtKB/Swiss-Prot for TRIM66 Gene

Function for TRIM66 Gene

Molecular function for TRIM66 Gene

UniProtKB/Swiss-Prot Function:
May function as transcription repressor; The repressive effects are mediated, at least in part, by recruitment of deacetylase activity. May play a role as negative regulator of postmeiotic genes acting through CBX3 complex formation and centromere association (By similarity).

Phenotypes From GWAS Catalog for TRIM66 Gene

Gene Ontology (GO) - Molecular Function for TRIM66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM66: view
genes like me logo Genes that share phenotypes with TRIM66: view

Animal Models for TRIM66 Gene

MGI Knock Outs for TRIM66:

Animal Model Products

miRNA for TRIM66 Gene

miRTarBase miRNAs that target TRIM66

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIM66 Gene

Localization for TRIM66 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM66 Gene

Nucleus. Note=Forms discrete foci within the centromeric chromocenter and surrounding nucleoplasm. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM66 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TRIM66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0016235 aggresome IDA --
genes like me logo Genes that share ontologies with TRIM66: view

Pathways & Interactions for TRIM66 Gene

SuperPathways for TRIM66 Gene

No Data Available

Interacting Proteins for TRIM66 Gene

Gene Ontology (GO) - Biological Process for TRIM66 Gene


No data available for Pathways by source and SIGNOR curated interactions for TRIM66 Gene

Drugs & Compounds for TRIM66 Gene

No Compound Related Data Available

Transcripts for TRIM66 Gene

Unigene Clusters for TRIM66 Gene

Tripartite motif containing 66:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM66 Gene

No ASD Table

Relevant External Links for TRIM66 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM66 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM66 Gene

Protein differential expression in normal tissues from HIPED for TRIM66 Gene

This gene is overexpressed in Adipocyte (61.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIM66 Gene

Protein tissue co-expression partners for TRIM66 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRIM66 Gene:


SOURCE GeneReport for Unigene cluster for TRIM66 Gene:


Evidence on tissue expression from TISSUES for TRIM66 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with TRIM66: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM66 Gene

Orthologs for TRIM66 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIM66 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRIM66 33
  • 99.49 (n)
(Bos Taurus)
Mammalia TRIM66 33 34
  • 89.27 (n)
(Canis familiaris)
Mammalia TRIM66 33 34
  • 89.13 (n)
(Mus musculus)
Mammalia Trim66 33 16 34
  • 86.44 (n)
(Rattus norvegicus)
Mammalia Trim66 33
  • 85.73 (n)
(Monodelphis domestica)
Mammalia TRIM66 34
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia TRIM66 34
  • 51 (a)
(Gallus gallus)
Aves TRIM66 33 34
  • 63.07 (n)
(Anolis carolinensis)
Reptilia TRIM66 34
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia trim66 33
  • 58.99 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24102 33
(Danio rerio)
Actinopterygii trim66 34
  • 30 (a)
fruit fly
(Drosophila melanogaster)
Insecta mei-P26 34
  • 12 (a)
(Caenorhabditis elegans)
Secernentea nhl-2 34
  • 11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9380 34
  • 14 (a)
Species where no ortholog for TRIM66 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRIM66 Gene

Gene Tree for TRIM66 (if available)
Gene Tree for TRIM66 (if available)

Paralogs for TRIM66 Gene

Paralogs for TRIM66 Gene

(2) SIMAP similar genes for TRIM66 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TRIM66: view

Variants for TRIM66 Gene

Sequence variations from dbSNP and Humsavar for TRIM66 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000019518 -- 8,673,725(-) T/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000020113 -- 8,636,166(-) CAC/C intron_variant
rs1000036465 -- 8,681,402(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000090916 -- 8,642,665(-) A/G coding_sequence_variant, intron_variant, synonymous_variant
rs1000152110 -- 8,670,414(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM66 Gene

Variant ID Type Subtype PubMed ID
esv2751035 CNV loss 17911159
nsv499766 OTHER inversion 21111241
nsv7215 OTHER inversion 18451855

Variation tolerance for TRIM66 Gene

Gene Damage Index Score: 14.12; 96.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM66 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM66 Gene

Disorders for TRIM66 Gene

Additional Disease Information for TRIM66

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TRIM66 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM66 Gene

Publications for TRIM66 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4 58
  2. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PMID: 21102462) Elks CE … Murray A (Nature genetics 2010) 3 44 58
  3. TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids. (PMID: 15322135) Khetchoumian K … Losson R (The Journal of biological chemistry 2004) 3 22 58
  4. Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7. (PMID: 11528127) Amid C … Schmidt ER (Cytogenetics and cell genetics 2001) 3 4 58
  5. TRIM66 overexpresssion contributes to osteosarcoma carcinogenesis and indicates poor survival outcome. (PMID: 26247633) Chen Y … Chen D (Oncotarget 2015) 3 58

Products for TRIM66 Gene

Sources for TRIM66 Gene

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