Aliases for TRIM65 Gene

Aliases for TRIM65 Gene

  • Tripartite Motif Containing 65 2 3 5
  • Tripartite Motif-Containing Protein 65 3 4
  • Tripartite Motif-Containing 65 2
  • 4732463G12Rik 3

External Ids for TRIM65 Gene

Previous GeneCards Identifiers for TRIM65 Gene

  • GC17M071397
  • GC17M073885
  • GC17M069310

Summaries for TRIM65 Gene

GeneCards Summary for TRIM65 Gene

TRIM65 (Tripartite Motif Containing 65) is a Protein Coding gene. An important paralog of this gene is TRIM47.

Additional gene information for TRIM65 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRIM65 Gene

Genomics for TRIM65 Gene

GeneHancer (GH) Regulatory Elements for TRIM65 Gene

Promoters and enhancers for TRIM65 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J075894 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 761.9 +0.5 478 3.3 ZBTB40 CTCF ZBTB6 MLX RBPJ SMARCE1 POLR2A HCFC1 MYC L3MBTL2 TRIM65 ENSG00000267342 lnc-MRPL38-1 FBF1 SNHG16 MIF4GD ENSG00000267078 SPHK1 ST6GALNAC2 RF00017-2553
GH17J076734 Promoter/Enhancer 2.6 UCNEbase EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 107.1 -840.3 -840256 7.8 E2F8 ZNF785 SIN3A ZNF24 SP1 ZBTB40 SREBF1 SIX5 ZBTB6 SMARCE1 SRSF2 MFSD11 MIR636 NONHSAG022835.2 lnc-JMJD6-1 UNK ENSG00000267342 TRIM65 SEPTIN9 ENSG00000266980
GH17J075776 Promoter/Enhancer 2.8 UCNEbase EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 98.8 +115.1 115113 11.6 PPP1R10 E2F8 SIN3A SP1 CTCF SREBF1 SIX5 LCORL MLX SMARCE1 UNK H3-3B NUP85 SRSF2 NT5C ENSG00000267342 TRIM65 ENSG00000266980 GGA3 METTL23
GH17J076258 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 75.6 -371.0 -370972 19.6 FOXK2 SIN3A ZNF24 SP1 ZBTB40 ZBTB6 MLX RBPJ SMARCE1 POLR2A UBALD2 UNK ENSG00000267342 SRSF2 TRIM65 ENSG00000266980 ENSG00000267546 EXOC7 MFSD11 TSEN54
GH17J075031 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 52.2 +862.4 862382 5.8 GTF3C2 ZNF785 SIN3A ZNF24 ZBTB40 ZBTB6 LCORL MLX SMARCE1 RBPJ KCTD2 AJ535831-003 AJ535831-004 TRR-CCT1-1 TRR-CCT2-1 TRR-TCG3-1 piR-30855-001 NUP85 UNK ENSG00000266980
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRIM65 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRIM65 gene promoter:
  • AhR
  • AML1a
  • Egr-2
  • Egr-4
  • ER-alpha
  • GATA-2
  • HOXA5
  • ITF-2
  • PPAR-alpha
  • Tal-1beta

Genomic Locations for TRIM65 Gene

Genomic Locations for TRIM65 Gene
chr17:75,880,335-75,897,003
(GRCh38/hg38)
Size:
16,669 bases
Orientation:
Minus strand
chr17:73,876,416-73,893,084
(GRCh37/hg19)
Size:
16,669 bases
Orientation:
Minus strand

Genomic View for TRIM65 Gene

Genes around TRIM65 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM65 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM65 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM65 Gene

Proteins for TRIM65 Gene

  • Protein details for TRIM65 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PJ69-TRI65_HUMAN
    Recommended name:
    Tripartite motif-containing protein 65
    Protein Accession:
    Q6PJ69
    Secondary Accessions:
    • Q4G0F0
    • Q6DKJ6
    • Q9BRP6

    Protein attributes for TRIM65 Gene

    Size:
    517 amino acids
    Molecular mass:
    57353 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH73831.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for TRIM65 Gene

Post-translational modifications for TRIM65 Gene

  • Ubiquitination at Lys206
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TRIM65 Gene

Domains & Families for TRIM65 Gene

Gene Families for TRIM65 Gene

Suggested Antigen Peptide Sequences for TRIM65 Gene

GenScript: Design optimal peptide antigens:
  • TRIM65 protein (Q96DX1_HUMAN)
  • Tripartite motif-containing protein 65 (TRI65_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6PJ69

UniProtKB/Swiss-Prot:

TRI65_HUMAN :
  • Belongs to the TRIM/RBCC family.
Family:
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM65: view

Function for TRIM65 Gene

Phenotypes From GWAS Catalog for TRIM65 Gene

Gene Ontology (GO) - Molecular Function for TRIM65 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM65: view
genes like me logo Genes that share phenotypes with TRIM65: view

Animal Models for TRIM65 Gene

MGI Knock Outs for TRIM65:
  • Trim65 Trim65<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for TRIM65 Gene

miRTarBase miRNAs that target TRIM65

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIM65 Gene

Localization for TRIM65 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM65 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRIM65 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with TRIM65: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM65 Gene

Pathways & Interactions for TRIM65 Gene

PathCards logo

SuperPathways for TRIM65 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM65 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010508 positive regulation of autophagy IBA,IMP 26347139
genes like me logo Genes that share ontologies with TRIM65: view

No data available for Pathways by source and SIGNOR curated interactions for TRIM65 Gene

Drugs & Compounds for TRIM65 Gene

No Compound Related Data Available

Transcripts for TRIM65 Gene

mRNA/cDNA for TRIM65 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM65 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2: - -
SP3:
SP4:

Relevant External Links for TRIM65 Gene

GeneLoc Exon Structure for
TRIM65
ECgene alternative splicing isoforms for
TRIM65

Expression for TRIM65 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM65 Gene

Protein differential expression in normal tissues from HIPED for TRIM65 Gene

This gene is overexpressed in Serum (37.8) and Peripheral blood mononuclear cells (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRIM65 Gene



Protein tissue co-expression partners for TRIM65 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRIM65 Gene:

TRIM65

SOURCE GeneReport for Unigene cluster for TRIM65 Gene:

Hs.189823

Evidence on tissue expression from TISSUES for TRIM65 Gene

  • Nervous system(4.3)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with TRIM65: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM65 Gene

Orthologs for TRIM65 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM65 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM65 33 32
  • 99.18 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TRIM65 33 32
  • 83.3 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM65 33 32
  • 81.45 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Trim65 17 33 32
  • 75.02 (n)
rat
(Rattus norvegicus)
Mammalia Trim65 32
  • 73.57 (n)
oppossum
(Monodelphis domestica)
Mammalia TRIM65 33
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM65 33
  • 23 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIM65 32
  • 55.1 (n)
-- 33
  • 21 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia TRIM65 33
  • 22 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trim65 32
  • 45.26 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100149099 32
  • 46.2 (n)
trim65 33
  • 29 (a)
OneToOne
Species where no ortholog for TRIM65 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM65 Gene

ENSEMBL:
Gene Tree for TRIM65 (if available)
TreeFam:
Gene Tree for TRIM65 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRIM65: view image

Paralogs for TRIM65 Gene

(6) SIMAP similar genes for TRIM65 Gene using alignment to 7 proteins:

  • TRI65_HUMAN
  • H0YG27_HUMAN
  • H0YGS7_HUMAN
  • K7EJ59_HUMAN
  • K7EM44_HUMAN
  • L8E9Q5_HUMAN
  • Q96DX1_HUMAN
genes like me logo Genes that share paralogs with TRIM65: view

Variants for TRIM65 Gene

Sequence variations from dbSNP and Humsavar for TRIM65 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000162227 -- 75,898,241(-) C/T upstream_transcript_variant
rs1000178036 -- 75,894,148(-) C/A intron_variant
rs1000236073 -- 75,898,003(-) T/C upstream_transcript_variant
rs1000545846 -- 75,880,014(-) AAA/AAAAAA downstream_transcript_variant
rs1000574119 -- 75,896,818(-) C/T coding_sequence_variant, non_coding_transcript_variant, stop_gained

Structural Variations from Database of Genomic Variants (DGV) for TRIM65 Gene

Variant ID Type Subtype PubMed ID
esv3641269 CNV loss 21293372
nsv510728 CNV deletion 20534489
nsv833545 CNV gain 17160897

Variation tolerance for TRIM65 Gene

Gene Damage Index Score: 8.02; 84.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM65 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM65

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM65 Gene

Disorders for TRIM65 Gene

Additional Disease Information for TRIM65

No disorders were found for TRIM65 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM65 Gene

Publications for TRIM65 Gene

  1. TRIM65 negatively regulates p53 through ubiquitination. (PMID: 27012201) Li Y … Yu Z (Biochemical and biophysical research communications 2016) 2 3 56
  2. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S … Dorf ME (Proceedings of the National Academy of Sciences of the United States of America 2014) 2 3 56
  3. Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium. (PMID: 21681796) Fornage M … Launer LJ (Annals of neurology 2011) 3 43 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  5. Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity. (PMID: 29643511) Pao KC … Virdee S (Nature 2018) 3 56

Products for TRIM65 Gene

Sources for TRIM65 Gene