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Aliases for TRIM65 Gene
Aliases for TRIM65 Gene
External Ids for TRIM65 Gene
- HGNC: 27316
- NCBI Entrez Gene: 201292
- Ensembl: ENSG00000141569
- UniProtKB/Swiss-Prot: Q6PJ69
Previous GeneCards Identifiers for TRIM65 Gene
- GC17M071397
- GC17M073885
- GC17M069310
Summaries for TRIM65 Gene
GeneCards Summary for TRIM65 Gene
TRIM65 (Tripartite Motif Containing 65) is a Protein Coding gene. An important paralog of this gene is TRIM21.
Additional gene information for TRIM65 Gene
- HGNC (27316)
- NCBI Entrez Gene (201292)
- Ensembl (ENSG00000141569)
- UniProtKB/Swiss-Prot (Q6PJ69)
- Open Targets Platform(ENSG00000141569)
- Monarch Initiative
- Search for TRIM65 at DataMed
- Search for TRIM65 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRIM65 Gene
Genomics for TRIM65 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TRIM65 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TRIM65 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRIM65
- Top Transcription factor binding sites by QIAGEN in the TRIM65 gene promoter:
-
- AhR
- AML1a
- Egr-2
- Egr-4
- ER-alpha
- GATA-2
- HOXA5
- ITF-2
- PPAR-alpha
- Tal-1beta
Genomic Locations for TRIM65 Gene
Latest Assembly
- chr17:75,880,335-75,897,008
- (GRCh38/hg38)
- Size:
- 16,674 bases
- Orientation:
- Minus strand
Previous Assembly
- chr17:73,885,044-73,893,032
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 7,989 bases
- Orientation:
- Minus strand
- chr17:73,876,416-73,893,084
- (GRCh37/hg19 by Ensembl)
- Size:
- 16,669 bases
- Orientation:
- Minus strand
Genomic View for TRIM65 Gene
Genes around TRIM65 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.1 by HGNC
- 17q25.1 by Entrez Gene
- 17q25.1 by Ensembl
TRIM65 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TRIM65 Gene
Proteins for TRIM65 Gene
-
Protein details for TRIM65 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6PJ69-TRI65_HUMAN
- Recommended name:
- Tripartite motif-containing protein 65
- Protein Accession:
- Q6PJ69
- Q4G0F0
- Q6DKJ6
- Q9BRP6
Protein attributes for TRIM65 Gene
- Size:
- 517 amino acids
- Molecular mass:
- 57353 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAH73831.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Protein Expression for TRIM65 Gene
Post-translational modifications for TRIM65 Gene
Other Protein References for TRIM65 Gene
Antibodies for research
- Novus Biologicals Antibodies for TRIM65
-
Abcam antibodies for TRIM65
- Invitrogen Antibodies for TRIM65 (AFLGC-TRIM65)
- antibodies-online: Show 12 available TRIM65 Antibodies ranked by validation data
-
Custom Antibody ServicesProSci Antibodies for TRIM65
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for TRIM65
- Origene Custom Protein Services for TRIM65
-
Abcam proteins for TRIM65
Assay products for research
No data available for DME Specific Peptides for TRIM65 Gene
Domains & Families for TRIM65 Gene
Gene Families for TRIM65 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for TRIM65 Gene
- InterPro:
- Blocks:
-
- Zn-finger, RING
- B-box zinc finger signature
- ProtoNet:
Suggested Antigen Peptide Sequences for TRIM65 Gene
- GenScript: Design optimal peptide antigens:
-
- TRIM65 protein (Q96DX1_HUMAN)
- Tripartite motif-containing protein 65 (TRI65_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q6PJ69- Family:
-
- Belongs to the TRIM/RBCC family.
Function for TRIM65 Gene
Phenotypes From GWAS Catalog for TRIM65 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IEA | -- |
| GO:0008270 | zinc ion binding | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for TRIM65 Gene
- MGI mutant phenotypes for TRIM65:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for TRIM65:
-
- Increased gamma-H2AX phosphorylation
- Increased vaccinia virus (VACV) infection
- Decreased hepcidin::fluc mRNA expression
- Decreased viability
- Decreased viability ratio
- Dynamic nuclei (hole, folded or small irregular)
- Decreased epidermal growth factor (EGF) endocytosis, increased transferrin (TF) endocytosis
Animal Models for TRIM65 Gene
- MGI Knock Outs for TRIM65:
-
- Trim65 Trim65<tm1b(KOMP)Wtsi>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for TRIM65 - Starting at $85 >
- * TRIM65 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for TRIM65
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TRIM65
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRIM65
miRNA for TRIM65 Gene
- miRTarBase miRNAs that target TRIM65
-
- hsa-miR-124-3p (MIRT022681)
- hsa-miR-122-5p (MIRT023281)
- hsa-miR-26b-5p (MIRT029564)
- hsa-miR-484 (MIRT042378)
- hsa-miR-324-3p (MIRT042948)
- hsa-miR-331-3p (MIRT043464)
- hsa-miR-93-5p (MIRT048856)
- hsa-miR-218-5p (MIRT439389)
- mmu-miR-382-5p (MIRT596895)
- mmu-miR-345-5p (MIRT596896)
- mmu-miR-574-5p (MIRT603186)
- mmu-miR-466l-5p (MIRT603187)
- mmu-miR-466i-5p (MIRT603188)
- mmu-miR-466k (MIRT603189)
- mmu-miR-466d-5p (MIRT603190)
- mmu-miR-466n-5p (MIRT603191)
- mmu-miR-466h-5p (MIRT603192)
- mmu-miR-466j (MIRT603193)
- mmu-miR-669m-5p (MIRT603194)
- mmu-miR-466m-5p (MIRT603195)
- mmu-miR-210-3p (MIRT603196)
- hsa-miR-665 (MIRT626700)
- hsa-miR-8055 (MIRT626701)
- hsa-miR-6780a-5p (MIRT626702)
- hsa-miR-6779-5p (MIRT626703)
- hsa-miR-3689c (MIRT626704)
- hsa-miR-3689b-3p (MIRT626705)
- hsa-miR-3689a-3p (MIRT626706)
- hsa-miR-30b-3p (MIRT626707)
- hsa-miR-1273h-5p (MIRT626708)
- hsa-miR-4443 (MIRT626709)
- hsa-miR-516b-5p (MIRT626710)
- hsa-miR-6778-5p (MIRT626711)
- hsa-miR-1233-5p (MIRT626712)
- hsa-miR-6799-5p (MIRT626713)
- hsa-miR-6883-5p (MIRT626714)
- hsa-miR-6785-5p (MIRT626715)
- hsa-miR-4728-5p (MIRT626716)
- hsa-miR-149-3p (MIRT626717)
- hsa-miR-7106-5p (MIRT626718)
- hsa-miR-650 (MIRT626719)
- hsa-miR-3612 (MIRT626720)
- hsa-miR-6894-5p (MIRT626721)
- hsa-miR-6134 (MIRT626722)
- hsa-miR-7854-3p (MIRT626723)
- hsa-miR-6884-5p (MIRT626724)
- hsa-miR-485-5p (MIRT626725)
- hsa-miR-3670 (MIRT626726)
- hsa-miR-518c-5p (MIRT626727)
- hsa-miR-3121-5p (MIRT626728)
- hsa-miR-501-5p (MIRT626729)
- hsa-miR-4661-3p (MIRT626730)
- hsa-miR-514a-5p (MIRT626731)
- hsa-miR-498 (MIRT649239)
- hsa-miR-6783-3p (MIRT649240)
- hsa-miR-1343-3p (MIRT649241)
- hsa-miR-23b-5p (MIRT649242)
- hsa-miR-23a-5p (MIRT649243)
- hsa-miR-4772-3p (MIRT649244)
- hsa-miR-6787-3p (MIRT649245)
- hsa-miR-1304-3p (MIRT649246)
- hsa-miR-6742-3p (MIRT649247)
- hsa-miR-6852-5p (MIRT649248)
- hsa-miR-660-3p (MIRT649249)
- hsa-miR-6736-3p (MIRT649250)
- hsa-miR-6890-3p (MIRT649251)
- hsa-miR-1306-5p (MIRT649252)
- hsa-miR-216a-5p (MIRT649254)
- hsa-miR-7160-5p (MIRT664655)
- hsa-miR-610 (MIRT664656)
- hsa-miR-7162-3p (MIRT664657)
- hsa-miR-4478 (MIRT664658)
- hsa-miR-4419b (MIRT664659)
- hsa-miR-3929 (MIRT664660)
- hsa-miR-3664-5p (MIRT664661)
- hsa-miR-4714-5p (MIRT664662)
- hsa-miR-8070 (MIRT677569)
- hsa-miR-6848-3p (MIRT677570)
- hsa-miR-6843-3p (MIRT677571)
- hsa-miR-3187-3p (MIRT677572)
- hsa-miR-4435 (MIRT677573)
- hsa-miR-588 (MIRT677574)
- hsa-miR-4701-5p (MIRT677575)
- hsa-miR-548s (MIRT677576)
- hsa-miR-378a-5p (MIRT677577)
- hsa-miR-6131 (MIRT677578)
- hsa-miR-4763-5p (MIRT677579)
- hsa-miR-4755-3p (MIRT677580)
- hsa-miR-4454 (MIRT677581)
- hsa-miR-6759-3p (MIRT677582)
- hsa-miR-3653-5p (MIRT677583)
- hsa-miR-3663-5p (MIRT677584)
- hsa-miR-6747-3p (MIRT677585)
- hsa-miR-4485-5p (MIRT677586)
- hsa-miR-106a-5p (MIRT761128)
- hsa-miR-106b-5p (MIRT761136)
- hsa-miR-1273g-3p (MIRT761998)
- hsa-miR-150-5p (MIRT762879)
- hsa-miR-17-5p (MIRT762958)
- hsa-miR-186-3p (MIRT763199)
- hsa-miR-20a-5p (MIRT763765)
- hsa-miR-20b-5p (MIRT763777)
- hsa-miR-302a-3p (MIRT764447)
- hsa-miR-302b-3p (MIRT764468)
- hsa-miR-302c-3p (MIRT764485)
- hsa-miR-302d-3p (MIRT764500)
- hsa-miR-302e (MIRT764516)
- hsa-miR-372-3p (MIRT767245)
- hsa-miR-373-3p (MIRT767288)
- hsa-miR-4252 (MIRT768062)
- hsa-miR-4731-5p (MIRT771787)
- hsa-miR-5089-5p (MIRT773249)
- hsa-miR-512-3p (MIRT773357)
- hsa-miR-519d-3p (MIRT773726)
- hsa-miR-520a-3p (MIRT773759)
- hsa-miR-520b (MIRT773779)
- hsa-miR-520c-3p (MIRT773792)
- hsa-miR-520d-3p (MIRT773808)
- hsa-miR-520e (MIRT773824)
- hsa-miR-520g-3p (MIRT773852)
- hsa-miR-520h (MIRT773879)
- hsa-miR-526b-3p (MIRT773922)
- hsa-miR-5589-5p (MIRT774818)
- hsa-miR-619-5p (MIRT776062)
- hsa-miR-6506-5p (MIRT776611)
- hsa-miR-668-5p (MIRT777662)
- hsa-miR-6720-3p (MIRT777718)
- hsa-miR-6807-5p (MIRT779624)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TRIM65
- Browse OriGene Inhibitory RNA Products For TRIM65
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM65
Clone products for research
- Applied Biological Materials (abm): Clones for TRIM65 - Starting at $45 >
- * TRIM65 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for TRIM65
- Addgene plasmids for TRIM65
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TRIM65
Cell Lines for research
-
Horizon Cell Lines for TRIM65
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIM65 Gene
Localization for TRIM65 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
- Nucleoplasm (4)
- Cytosol (3)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005829 | cytosol | IDA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM65 Gene
Pathways & Interactions for TRIM65 Gene
Interacting Proteins for TRIM65 Gene
Selected Interacting proteins:
Q6PJ69-TRI65_HUMAN
ENSP00000269383
for TRIM65 Gene via
MINT
STRING
IID
GPS-Prot Interaction Network for TRIM65
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0010508 | positive regulation of autophagy | IMP | 26347139 |
No data available for Pathways by source and SIGNOR curated interactions for TRIM65 Gene
Transcripts for TRIM65 Gene
mRNA/cDNA for TRIM65 Gene
- 2 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000269383 3384 nts (view in UCSC)
- ENST00000540128 886 nts (view in UCSC)
- ENST00000540812 385 nts (view in UCSC)
- ENST00000543309 865 nts (view in UCSC)
- ENST00000591668 644 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for TRIM65 - Starting at $85 >
- * TRIM65 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for TRIM65
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TRIM65
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRIM65
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TRIM65
- Browse OriGene Inhibitory RNA Products For TRIM65
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM65
Clone products for research
- Applied Biological Materials (abm): Clones for TRIM65 - Starting at $45 >
- * TRIM65 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for TRIM65
- Addgene plasmids for TRIM65
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TRIM65
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||
| SP3: | |||||||||||||||||||||||
| SP4: |
Relevant External Links for TRIM65 Gene
- GeneLoc Exon Structure for
- TRIM65
Expression for TRIM65 Gene
This gene is overexpressed in Serum (37.8) and Peripheral blood mononuclear cells (8.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRIM65 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRIM65
SOURCE GeneReport for Unigene cluster for TRIM65 Gene:
Hs.189823Evidence on tissue expression from TISSUES for TRIM65 Gene
- Nervous system(4.4)
- Liver(4.1)
Primer products for research
-
OriGene qPCR primer pairs for TRIM65
-
OriGene qPCR primer pairs and template standards for TRIM65
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM65 Gene
Orthologs for TRIM65 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TRIM65 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | TRIM65 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | TRIM65 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Trim65 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Trim65 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | TRIM65 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | TRIM65 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | TRIM65 30 |
|
||
| -- 31 |
|
ManyToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | TRIM65 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | trim65 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | LOC100149099 30 |
|
||
| trim65 31 |
|
OneToOne |
- Species where no ortholog for TRIM65 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for TRIM65 Gene
- ENSEMBL:
- Gene Tree for TRIM65 (if available)
- TreeFam:
- Gene Tree for TRIM65 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TRIM65: view image
Paralogs for TRIM65 Gene
Paralogs for TRIM65 Gene
- TRIM21 5
- TRIM7 5
- TRIM11 5
- TRIM4 5
- TRIM41 5
- TRIM25 5
- TRIM17 5
- TRIM27 5
- TRIM39 5
- TRIM6 5
- TRIM6-TRIM34 5
- TRIM34 5
- TRIM38 5
- TRIM10 5
- TRIM68 5
- TRIM35 5
- TRIM50 5
- TRIM5 5
- TRIM22 5
- TRIM69 5
- TRIM72 5
- TRIM62 5
- TRIML1 5
- TRIM58 5
- TRIM15 5
- TRIM26 5
- TRIM39-RPP21 5
- TRIM60 5
- TRIM75P 5
- MID1 5
- MEFV 5
- TRIM46 5
- TRIM3 5
- TRIM71 5
- TRIM14 5
- MID2 5
- TRIM49B 5
- TRIM51 5
- TRIM2 5
- ENSG00000288637 5
- TRIM49D1 5
- TRIM49D2 5
- TRIM66 5
- TRIM32 5
- TRIM9 5
- TRIM16 5
- TRIM51GP 5
- TRIM64C 5
- TRIM8 5
- TRIM77 5
- TRIM49 5
- TRIM64B 5
- TRIM64 5
- TRIM49C 5
- TRIML2 5
- TRIM29 5
- TRIM67 5
- TRIM13 5
- BSPRY 5
- TRIM36 5
- TRIM43B 5
- TRIM43 5
- TRIM56 5
- TRIM24 5
- TRIM42 5
- TRIM31 5
- TRIM33 5
- TRIM47 5
- PML 5
- TRIM44 5
- TRIM55 5
- TRIM73 5
- TRIM63 5
- TRIM61 5
- TRIM28 5
- TRIM37 5
- TRIM45 5
- RNF39 5
- TRIM40 5
- TRIM54 5
- TRIM74 5
- TRIM52 5
- TRIM48 5
- ENSG00000239920 5
(6) SIMAP similar genes for TRIM65 Gene using alignment to 7 proteins:
- TRI65_HUMAN
- H0YG27_HUMAN
- H0YGS7_HUMAN
- K7EJ59_HUMAN
- K7EM44_HUMAN
- L8E9Q5_HUMAN
- Q96DX1_HUMAN
Variants for TRIM65 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRIM65 Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs551753319 | Likely Benign: not provided | 75,892,142(-) |
G/T NM_173547.4(TRIM65):c.788C>A (p.Thr263Asn) |
MISSENSE | |
| rs34593741 | - |
p.Gly364Arg |
|||
| rs3760128 | - |
p.Leu509Pro |
|||
| rs7222757 | - |
p.Val222Gly |
|||
| rs9892938 | - |
p.Gly366Ser |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Gene Damage Index Score:
8.02;
84.22% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TRIM65 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TRIM65
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM65 Gene
Disorders for TRIM65 Gene
Additional Disease Information for TRIM65
- Genetic Association Database
- (GAD)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No disorders were found for TRIM65 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM65 Gene
Publications for TRIM65 Gene
- TRIM65 negatively regulates p53 through ubiquitination. (PMID: 27012201) Li Y … Yu Z (Biochemical and biophysical research communications 2016) 2 3
- TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S … Dorf ME (Proceedings of the National Academy of Sciences of the United States of America 2014) 2 3
- Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium. (PMID: 21681796) Fornage M … Launer LJ (Annals of neurology 2011) 3 41
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- TRIM65 E3 ligase targets VCAM-1 degradation to limit LPS-induced lung inflammation. (PMID: 31310649) Li Y … Fu M (Journal of molecular cell biology 2020) 3
ExternalLinks
Products for TRIM65 Gene
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Sources for TRIM65 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
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- (15) ProtoNet
- (16) Blocks
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- (24) PharmGKB
- (25) DrugBank
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- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
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- (36) Pseudogene
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- (44) Atlas
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- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
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- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
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- (115) NCBI Bookshelf
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- (117) Gene Damage Index
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- (120) VISTA
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- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
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- (135) abm
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- (140) HumanCyc
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- (146) GeneCopoeia
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- (148) RNAcentral
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- (154) Biorbyt
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- (170) snOPY
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- (177) MirGeneDB