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Aliases for TRIM63 Gene

Aliases for TRIM63 Gene

  • Tripartite Motif Containing 63 2 3 5
  • Striated Muscle RING Zinc Finger Protein 2 3 4
  • Muscle-Specific RING Finger Protein 1 2 3 4
  • Tripartite Motif Containing 63, E3 Ubiquitin Protein Ligase 2 3
  • RING-Type E3 Ubiquitin Transferase TRIM63 3 4
  • Tripartite Motif-Containing Protein 63 3 4
  • E3 Ubiquitin-Protein Ligase TRIM63 3 4
  • Iris Ring Finger Protein 2 3
  • Ring Finger Protein 28 2 3
  • RNF28 3 4
  • MURF1 3 4
  • SMRZ 3 4
  • IRF 3 4
  • Muscle Specific Ring Finger Protein 2 3
  • Iris RING Finger Protein 4
  • RING Finger Protein 28 4
  • EC 2.3.2.27 4
  • MuRF-1 4
  • MURF2 3
  • MuRF1 4

External Ids for TRIM63 Gene

Previous HGNC Symbols for TRIM63 Gene

  • RNF28

Previous GeneCards Identifiers for TRIM63 Gene

  • GC01M026250
  • GC01M026377
  • GC01M024631

Summaries for TRIM63 Gene

Entrez Gene Summary for TRIM63 Gene

  • This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase. [provided by RefSeq, Feb 2012]

GeneCards Summary for TRIM63 Gene

TRIM63 (Tripartite Motif Containing 63) is a Protein Coding gene. Diseases associated with TRIM63 include Hypertrophic Cardiomyopathy and Muscle Tissue Disease. Among its related pathways are Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include ligase activity and obsolete signal transducer activity. An important paralog of this gene is TRIM55.

UniProtKB/Swiss-Prot for TRIM63 Gene

  • E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.

Gene Wiki entry for TRIM63 Gene

Additional gene information for TRIM63 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM63 Gene

Genomics for TRIM63 Gene

GeneHancer (GH) Regulatory Elements for TRIM63 Gene

Promoters and enhancers for TRIM63 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRIM63 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRIM63 gene promoter:
  • c-Myc
  • CP2
  • IRF-7A
  • Max1
  • Sp1
  • STAT1
  • USF-1
  • USF1
  • ZIC2

Genomic Locations for TRIM63 Gene

Genomic Locations for TRIM63 Gene
chr1:26,051,304-26,068,436
(GRCh38/hg38)
Size:
17,133 bases
Orientation:
Minus strand
chr1:26,377,795-26,394,927
(GRCh37/hg19)
Size:
17,133 bases
Orientation:
Minus strand

Genomic View for TRIM63 Gene

Genes around TRIM63 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM63 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM63 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM63 Gene

Proteins for TRIM63 Gene

  • Protein details for TRIM63 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969Q1-TRI63_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM63
    Protein Accession:
    Q969Q1
    Secondary Accessions:
    • B4DN95
    • Q5T2I1
    • Q96BD3
    • Q96KD9
    • Q9BYV4

    Protein attributes for TRIM63 Gene

    Size:
    353 amino acids
    Molecular mass:
    40248 Da
    Quaternary structure:
    • Homodimer. Homooligomer and heterooligomer. Interacts with SUMO2, titin/TTN and GMEB1. Interacts with TRIM54 and probably with TRIM55 and TNNI3. Forms a ternary complex with RACK1 and PRKCE (By similarity). Interacts with CKM.
    SequenceCaution:
    • Sequence=AAK52497.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAK52497.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305}; Sequence=CAC33173.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRIM63 Gene

    Alternative splice isoforms for TRIM63 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM63 Gene

Post-translational modifications for TRIM63 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM63 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM63 Gene

Domains & Families for TRIM63 Gene

Gene Families for TRIM63 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TRIM63 Gene

GenScript: Design optimal peptide antigens:
  • Tripartite motif-containing protein 63 (TRI63_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q969Q1

UniProtKB/Swiss-Prot:

TRI63_HUMAN :
  • The RING-type zinc finger mediates interaction with SUMO2 and localization to the nucleus. Also required for the E3 ubiquitin ligase activity (By similarity).
Domain:
  • The RING-type zinc finger mediates interaction with SUMO2 and localization to the nucleus. Also required for the E3 ubiquitin ligase activity (By similarity).
  • The B box-type zinc finger mediates homodimerization.
genes like me logo Genes that share domains with TRIM63: view

Function for TRIM63 Gene

Molecular function for TRIM63 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27;.

Enzyme Numbers (IUBMB) for TRIM63 Gene

Phenotypes From GWAS Catalog for TRIM63 Gene

Gene Ontology (GO) - Molecular Function for TRIM63 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IEA --
GO:0005515 protein binding IPI 18157088
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0031432 titin binding IDA 11927605
genes like me logo Genes that share ontologies with TRIM63: view
genes like me logo Genes that share phenotypes with TRIM63: view

Animal Models for TRIM63 Gene

MGI Knock Outs for TRIM63:

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for TRIM63 - Now 50% OFF >
  • * TRIM63 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TRIM63 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIM63 Gene

Localization for TRIM63 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM63 Gene

Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere, M line. Cytoplasm, myofibril, sarcomere, Z line. Note=Colocalizes with TNNI3 in myocytes (By similarity). Localizes to the M- and Z-lines in skeletal muscle. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM63 gene
Compartment Confidence
cytoskeleton 5
nucleus 4
mitochondrion 2
cytosol 2
lysosome 2
extracellular 1
endoplasmic reticulum 1
plasma membrane 0
peroxisome 0
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for TRIM63 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm NAS 11243782
GO:0005874 microtubule NAS 11243782
GO:0030018 Z disc IEA --
GO:0031430 M band IEA --
genes like me logo Genes that share ontologies with TRIM63: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TRIM63 Gene

Pathways & Interactions for TRIM63 Gene

genes like me logo Genes that share pathways with TRIM63: view

UniProtKB/Swiss-Prot Q969Q1-TRI63_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for TRIM63 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TRIM63 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction IEA --
GO:0007165 signal transduction NAS 11243782
GO:0010614 negative regulation of cardiac muscle hypertrophy IEA --
GO:0014732 skeletal muscle atrophy IEA --
GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation ISS,IEA --
genes like me logo Genes that share ontologies with TRIM63: view

Drugs & Compounds for TRIM63 Gene

(9) Drugs for TRIM63 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(5) Additional Compounds for TRIM63 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8
genes like me logo Genes that share compounds with TRIM63: view

Transcripts for TRIM63 Gene

mRNA/cDNA for TRIM63 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(30) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for TRIM63 Gene

Tripartite motif containing 63, E3 ubiquitin protein ligase:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for TRIM63 - Now 50% OFF >
  • * TRIM63 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TRIM63 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM63 Gene

No ASD Table

Relevant External Links for TRIM63 Gene

GeneLoc Exon Structure for
TRIM63
ECgene alternative splicing isoforms for
TRIM63

Expression for TRIM63 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM63 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM63 Gene

This gene is overexpressed in Muscle - Skeletal (x42.8) and Heart - Left Ventricle (x6.0).

Protein differential expression in normal tissues from HIPED for TRIM63 Gene

This gene is overexpressed in Fetal heart (54.2) and Heart (14.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRIM63 Gene



Protein tissue co-expression partners for TRIM63 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRIM63 Gene:

TRIM63

SOURCE GeneReport for Unigene cluster for TRIM63 Gene:

Hs.279709

mRNA Expression by UniProt/SwissProt for TRIM63 Gene:

Q969Q1-TRI63_HUMAN
Tissue specificity: Muscle specific. Selectively expressed in heart and skeletal muscle. Also expressed in the iris.

Evidence on tissue expression from TISSUES for TRIM63 Gene

  • Muscle(4.8)
  • Heart(4.6)
  • Eye(4.1)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with TRIM63: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM63 Gene

Orthologs for TRIM63 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM63 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM63 35 34
  • 99.62 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TRIM63 35 34
  • 91.54 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM63 35 34
  • 90.72 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Trim63 17 35 34
  • 88.18 (n)
rat
(Rattus norvegicus)
Mammalia Trim63 34
  • 87.16 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM63 35
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRIM63 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIM63 35 34
  • 77.51 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIM63 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trim63 34
  • 67.81 (n)
zebrafish
(Danio rerio)
Actinopterygii trim54 35
  • 43 (a)
ManyToMany
zgc56376 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6549 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 47 (a)
OneToMany
Species where no ortholog for TRIM63 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM63 Gene

ENSEMBL:
Gene Tree for TRIM63 (if available)
TreeFam:
Gene Tree for TRIM63 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRIM63: view image

Paralogs for TRIM63 Gene

(2) SIMAP similar genes for TRIM63 Gene using alignment to 1 proteins:

  • TRI63_HUMAN
genes like me logo Genes that share paralogs with TRIM63: view

Variants for TRIM63 Gene

Sequence variations from dbSNP and Humsavar for TRIM63 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs140523053 likely-benign, Primary familial hypertrophic cardiomyopathy 26,067,352(-) G/A coding_sequence_variant, missense_variant
rs148395034 uncertain-significance, likely-pathogenic, Primary familial hypertrophic cardiomyopathy, Inborn genetic diseases 26,058,482(-) G/A/C coding_sequence_variant, missense_variant, stop_gained
rs200811483 uncertain-significance, Primary familial hypertrophic cardiomyopathy 26,066,376(-) C/T coding_sequence_variant, missense_variant
rs730880235 uncertain-significance, Primary familial hypertrophic cardiomyopathy 26,058,571(-) T/C coding_sequence_variant, missense_variant
rs770729739 likely-benign, not specified 26,066,275(-) A/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM63 Gene

Variant ID Type Subtype PubMed ID
nsv508678 CNV deletion 20534489
nsv834513 CNV gain 17160897

Variation tolerance for TRIM63 Gene

Residual Variation Intolerance Score: 64.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.36; 81.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM63 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM63
Human Gene Mutation Database (HGMD)
TRIM63

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM63 Gene

Disorders for TRIM63 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TRIM63 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hypertrophic cardiomyopathy
  • cardiomyopathy, hypertrophic, familial
muscle tissue disease
muscular disease
  • muscular diseases
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TRIM63

genes like me logo Genes that share disorders with TRIM63: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM63 Gene

Publications for TRIM63 Gene

  1. MuRF1-dependent regulation of systemic carbohydrate metabolism as revealed from transgenic mouse studies. (PMID: 18468620) Hirner S … Labeit D (Journal of molecular biology 2008) 3 4 23 58
  2. Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1. (PMID: 11927605) McElhinny AS … Gregorio CC (The Journal of cell biology 2002) 3 4 23 58
  3. Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain. (PMID: 11243782) Centner T … Labeit S (Journal of molecular biology 2001) 2 3 4 58
  4. A novel human striated muscle RING zinc finger protein, SMRZ, interacts with SMT3b via its RING domain. (PMID: 11283016) Dai KS … Liew CC (The Journal of biological chemistry 2001) 2 3 4 58
  5. Rare variants in genes encoding MuRF1 and MuRF2 are modifiers of hypertrophic cardiomyopathy. (PMID: 24865491) Su M … Song L (International journal of molecular sciences 2014) 3 4 58

Products for TRIM63 Gene

Sources for TRIM63 Gene

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