Aliases for TRIM61 Gene

Aliases for TRIM61 Gene

  • Tripartite Motif Containing 61 2 3 5
  • Putative Tripartite Motif-Containing Protein 61 3 4
  • Ring Finger Protein 35 2 3
  • RNF35 3 4
  • Tripartite Motif-Containing 61 2
  • RING Finger Protein 35 4
  • TRIM61 5

External Ids for TRIM61 Gene

Previous HGNC Symbols for TRIM61 Gene

  • RNF35

Previous GeneCards Identifiers for TRIM61 Gene

  • GC04M166247
  • GC04M166095
  • GC04M165875
  • GC04M161629

Summaries for TRIM61 Gene

GeneCards Summary for TRIM61 Gene

TRIM61 (Tripartite Motif Containing 61) is a Protein Coding gene. Diseases associated with TRIM61 include Gyrate Atrophy Of Choroid And Retina and Leber Plus Disease. An important paralog of this gene is TRIM60.

Additional gene information for TRIM61 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRIM61 Gene

Genomics for TRIM61 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TRIM61 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J164977 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.2 243 2 GABPA SMAD5 RCOR1 POLR2A NRF1 ELK1 CTCF RUNX3 ZBTB40 CBFB TRIM61 piR-34593-034 TRIM60P14 lnc-FAM218A-5 lnc-FAM218A-3 APELA
GH04J165001 Enhancer 0.3 Ensembl 27.6 -24.6 -24633 1 CTCF piR-30963-026 piR-38904-034 TRIM61 ENSG00000250430 ENSG00000248645 MG598805-007 TRIM60
GH04J164936 Enhancer 0.7 Ensembl 11.4 +40.5 40467 1.6 IKZF2 TRIM22 YY1 CTCF ARID3A GATAD2B NFE2 ZNF592 SMC3 MAFG TRIM60P14 TRIM61 RNU6-668P ENSG00000248645 LOC391710 lnc-TRIM61-2 APELA
GH04J164798 Enhancer 0.6 Ensembl ENCODE 10.8 +177.8 177767 2.6 CTCF TEAD4 ZNF24 NANOG SP1 POU5F1 RF00017-4446 TRIM61 SMIM31 lnc-APELA-2 lnc-APELA-1 APELA
GH04J164949 Enhancer 0.4 Ensembl 12 +27.8 27767 0.2 CTCF ZNF143 HDGF RAD21 ENSG00000236941 LOC391711 lnc-FAM218A-3 TRIM61 FAM218A APELA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRIM61 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRIM61

Top Transcription factor binding sites by QIAGEN in the TRIM61 gene promoter:
  • GATA-1
  • GR-alpha
  • GR-beta
  • LUN-1
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • STAT3

Genomic Locations for TRIM61 Gene

Genomic Locations for TRIM61 Gene
chr4:164,954,446-164,977,668
(GRCh38/hg38)
Size:
23,223 bases
Orientation:
Minus strand
chr4:165,875,598-165,898,820
(GRCh37/hg19)
Size:
23,223 bases
Orientation:
Minus strand

Genomic View for TRIM61 Gene

Genes around TRIM61 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM61 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM61 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM61 Gene

Proteins for TRIM61 Gene

  • Protein details for TRIM61 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5EBN2-TRI61_HUMAN
    Recommended name:
    Putative tripartite motif-containing protein 61
    Protein Accession:
    Q5EBN2

    Protein attributes for TRIM61 Gene

    Size:
    209 amino acids
    Molecular mass:
    24047 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRIM61 Gene

Post-translational modifications for TRIM61 Gene

No Post-translational modifications

Other Protein References for TRIM61 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM61 Gene

Domains & Families for TRIM61 Gene

Gene Families for TRIM61 Gene

Protein Domains for TRIM61 Gene

InterPro:
Blocks:
  • B-box zinc finger signature
ProtoNet:

Suggested Antigen Peptide Sequences for TRIM61 Gene

GenScript: Design optimal peptide antigens:
  • RING finger protein 35 (TRI61_HUMAN)
genes like me logo Genes that share domains with TRIM61: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TRIM61 Gene

Function for TRIM61 Gene

Phenotypes From GWAS Catalog for TRIM61 Gene

Gene Ontology (GO) - Molecular Function for TRIM61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IBA 21873635
genes like me logo Genes that share ontologies with TRIM61: view
genes like me logo Genes that share phenotypes with TRIM61: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM61

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRIM61 Gene

Localization for TRIM61 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM61 gene
Compartment Confidence
nucleus 3
cytosol 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRIM61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with TRIM61: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM61 Gene

Pathways & Interactions for TRIM61 Gene

PathCards logo

SuperPathways for TRIM61 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010468 regulation of gene expression IBA 21873635
GO:0016567 protein ubiquitination IBA 21873635
GO:0045087 innate immune response IBA 21873635
genes like me logo Genes that share ontologies with TRIM61: view

No data available for Pathways by source and SIGNOR curated interactions for TRIM61 Gene

Drugs & Compounds for TRIM61 Gene

No Compound Related Data Available

Transcripts for TRIM61 Gene

mRNA/cDNA for TRIM61 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM61

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM61 Gene

No ASD Table

Relevant External Links for TRIM61 Gene

GeneLoc Exon Structure for
TRIM61

Expression for TRIM61 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRIM61 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM61 Gene

This gene is overexpressed in Testis (x7.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRIM61

SOURCE GeneReport for Unigene cluster for TRIM61 Gene:

Hs.654633
genes like me logo Genes that share expression patterns with TRIM61: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM61 Gene

Orthologs for TRIM61 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM61 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 99 (a)
OneToMany
-- 31
  • 99 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 15 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 31 (a)
ManyToMany
-- 31
  • 23 (a)
ManyToMany
-- 31
  • 22 (a)
ManyToMany
-- 31
  • 16 (a)
ManyToMany
-- 31
  • 15 (a)
ManyToMany
-- 31
  • 12 (a)
ManyToMany
-- 31
  • 12 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii trim109 31
  • 8 (a)
ManyToMany
Species where no ortholog for TRIM61 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TRIM61 Gene

ENSEMBL:
Gene Tree for TRIM61 (if available)
TreeFam:
Gene Tree for TRIM61 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRIM61: view image

Paralogs for TRIM61 Gene

(17) SIMAP similar genes for TRIM61 Gene using alignment to 1 proteins:

  • TRI61_HUMAN
genes like me logo Genes that share paralogs with TRIM61: view

Variants for TRIM61 Gene

Additional dbSNP identifiers (rs#s) for TRIM61 Gene

Structural Variations from Database of Genomic Variants (DGV) for TRIM61 Gene

Variant ID Type Subtype PubMed ID
esv21636 CNV gain 19812545
esv2421831 CNV duplication 20811451
esv2759299 CNV gain 17122850
esv2760876 CNV gain 21179565
esv3603011 CNV gain 21293372
nsv1019150 CNV gain 25217958
nsv10607 CNV gain 18304495
nsv517554 CNV loss 19592680
nsv528686 CNV gain 19592680
nsv830140 CNV loss 17160897
nsv967808 CNV duplication 23825009

Variation tolerance for TRIM61 Gene

Residual Variation Intolerance Score: 64.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.64; 45.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM61 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM61

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRIM61 Gene

Disorders for TRIM61 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TRIM61 Gene - From: DISEASES

Disorder Aliases PubMed IDs
gyrate atrophy of choroid and retina
  • gacr
leber plus disease
  • lca
fundus dystrophy
  • retinal dystrophy
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TRIM61

genes like me logo Genes that share disorders with TRIM61: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM61 Gene

Publications for TRIM61 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. Negative transcriptional modulation and silencing of the bi-exonic Rnf35 gene in the preimplantation embryo. Binding of the CCAAT-displacement protein/Cux to the untranslated exon 1 sequence. (PMID: 15994318) Huang CJ … Choo KB (The Journal of biological chemistry 2005) 3
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R … Stanton LW (Nature biotechnology 2004) 3

Products for TRIM61 Gene

Sources for TRIM61 Gene