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Aliases for TRIM60 Gene

Aliases for TRIM60 Gene

  • Tripartite Motif Containing 60 2 3 5
  • Ring Finger Protein 129 2 3
  • RNF129 3 4
  • RNF33 3 4
  • Tripartite Motif-Containing Protein 60 3
  • Tripartite Motif-Containing 60 2
  • RING Finger Protein 129 4
  • Ring Finger Protein 33 3
  • RING Finger Protein 33 4

External Ids for TRIM60 Gene

Previous HGNC Symbols for TRIM60 Gene

  • RNF129
  • RNF33

Previous GeneCards Identifiers for TRIM60 Gene

  • GC04P166311
  • GC04P166172
  • GC04P165953
  • GC04P161706

Summaries for TRIM60 Gene

Entrez Gene Summary for TRIM60 Gene

  • The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Pseudogenes of this gene are located on more than six chromosomes including chromosome 4. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013]

GeneCards Summary for TRIM60 Gene

TRIM60 (Tripartite Motif Containing 60) is a Protein Coding gene. An important paralog of this gene is TRIM75P.

Additional gene information for TRIM60 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM60 Gene

Genomics for TRIM60 Gene

GeneHancer (GH) Regulatory Elements for TRIM60 Gene

Promoters and enhancers for TRIM60 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I165031 Promoter 0.7 EPDnew 550.4 +6.2 6247 0.1 GABPB1 NRF1 TRIM60 LOC391713 LOC100420385 ENSG00000249617
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRIM60 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRIM60 gene promoter:

Genomic Locations for TRIM60 Gene

Genomic Locations for TRIM60 Gene
16,057 bases
Plus strand

Genomic View for TRIM60 Gene

Genes around TRIM60 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM60 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM60 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM60 Gene

Proteins for TRIM60 Gene

  • Protein details for TRIM60 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tripartite motif-containing protein 60
    Protein Accession:
    Secondary Accessions:
    • Q8NA35

    Protein attributes for TRIM60 Gene

    471 amino acids
    Molecular mass:
    55114 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRIM60 Gene

Post-translational modifications for TRIM60 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM60 Gene

No data available for DME Specific Peptides for TRIM60 Gene

Domains & Families for TRIM60 Gene

Gene Families for TRIM60 Gene

Suggested Antigen Peptide Sequences for TRIM60 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRIM/RBCC family.
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM60: view

Function for TRIM60 Gene

Gene Ontology (GO) - Molecular Function for TRIM60 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM60: view
genes like me logo Genes that share phenotypes with TRIM60: view

miRNA for TRIM60 Gene

miRTarBase miRNAs that target TRIM60

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM60 Gene

Localization for TRIM60 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM60 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for TRIM60 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with TRIM60: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for TRIM60 Gene

Pathways & Interactions for TRIM60 Gene

SuperPathways for TRIM60 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM60 Gene


No data available for Pathways by source and SIGNOR curated interactions for TRIM60 Gene

Drugs & Compounds for TRIM60 Gene

No Compound Related Data Available

Transcripts for TRIM60 Gene

mRNA/cDNA for TRIM60 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRIM60 Gene

Tripartite motif containing 60:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM60 Gene

No ASD Table

Relevant External Links for TRIM60 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM60 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM60 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM60 Gene

This gene is overexpressed in Testis (x51.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIM60 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRIM60 Gene:


SOURCE GeneReport for Unigene cluster for TRIM60 Gene:

genes like me logo Genes that share expression patterns with TRIM60: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM60 Gene

Orthologs for TRIM60 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM60 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRIM60 33 34
  • 98.73 (n)
(Canis familiaris)
Mammalia TRIM61 33
  • 79.02 (n)
(Mus musculus)
Mammalia Trim60 33 16 34
  • 67.84 (n)
(Ornithorhynchus anatinus)
Mammalia TRIM60 34
  • 49 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 23 (a)
(Gallus gallus)
Aves TRIM7.2 34
  • 28 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 29 (a)
Species where no ortholog for TRIM60 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM60 Gene

Gene Tree for TRIM60 (if available)
Gene Tree for TRIM60 (if available)

Paralogs for TRIM60 Gene

genes like me logo Genes that share paralogs with TRIM60: view

Variants for TRIM60 Gene

Sequence variations from dbSNP and Humsavar for TRIM60 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs10000216 -- 165,033,713(+) T/C intron_variant
rs1000027239 -- 165,031,517(+) G/A/C upstream_transcript_variant
rs1000042211 -- 165,031,441(+) T/C upstream_transcript_variant
rs1000133098 -- 165,032,025(+) G/A 5_prime_UTR_variant
rs1000782303 -- 165,035,972(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM60 Gene

Variant ID Type Subtype PubMed ID
esv2728685 CNV deletion 23290073
esv2759299 CNV gain 17122850
nsv830140 CNV loss 17160897

Variation tolerance for TRIM60 Gene

Residual Variation Intolerance Score: 48.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.77; 33.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM60 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM60 Gene

Disorders for TRIM60 Gene

Additional Disease Information for TRIM60

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TRIM60 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM60 Gene

Publications for TRIM60 Gene

  1. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  5. Does this have a familiar RING? (PMID: 8744354) Saurin AJ … Freemont PS (Trends in biochemical sciences 1996) 3 58

Products for TRIM60 Gene

Sources for TRIM60 Gene

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