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Aliases for TRIM6-TRIM34 Gene

Aliases for TRIM6-TRIM34 Gene

  • TRIM6-TRIM34 Readthrough 2 3 5
  • Tripartite Motif-Containing 6 And Tripartite Motif-Containing 34 3
  • Interferon-Responsive Finger Protein 1 Long Form 3
  • TRIM6-TRIM34 Readthrough Transcript 12
  • TRIM34 3
  • RNF21 3
  • IFP1 3

External Ids for TRIM6-TRIM34 Gene

Previous GeneCards Identifiers for TRIM6-TRIM34 Gene

  • GC11U900629
  • GC11P005578
  • GC11P005277

Summaries for TRIM6-TRIM34 Gene

Entrez Gene Summary for TRIM6-TRIM34 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This gene represents a readthrough transcript from genes TRIM6 and TRIM34, and it was described as a splice variant of TRIM34. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. [provided by RefSeq, Nov 2009]

GeneCards Summary for TRIM6-TRIM34 Gene

TRIM6-TRIM34 (TRIM6-TRIM34 Readthrough) is a Protein Coding gene. An important paralog of this gene is TRIM34.

Additional gene information for TRIM6-TRIM34 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM6-TRIM34 Gene

Genomics for TRIM6-TRIM34 Gene

GeneHancer (GH) Regulatory Elements for TRIM6-TRIM34 Gene

Promoters and enhancers for TRIM6-TRIM34 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J005595 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 650.7 +0.5 451 3.2 PKNOX1 SMAD1 ATF1 ARNT SIN3A TCF12 GLIS2 GATA2 ATF7 NCOA1 TRIM6 TRIM6-TRIM34 OR52H1 PIR57907 GC11P005579 ENSG00000239920 TRIM5
GH11J005599 Enhancer 1.2 Ensembl ENCODE dbSUPER 0.7 +3.9 3933 1.4 HDAC1 ATF1 ZBTB40 RAD21 NCOA2 YY1 ZNF143 ATF7 BCLAF1 RUNX3 TRIM6 FAM160A2 TRIM6-TRIM34 PIR57907 GC11P005579 ENSG00000239920 TRIM5
GH11J005623 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 0.3 +28.8 28801 3.2 HDAC1 PKNOX1 SMAD1 SREBF2 ZBTB40 IRF4 RAD21 RFX5 YY1 ZFP91 TRIM34 TRIM5 TRIM22 OR51B2 OR56B4 OR56A1 OR56A3 OR52N4 OR51Q1 OR52E6
GH11J005618 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 0.3 +23.7 23714 3.8 TFAP4 FOXA2 TEAD4 TAL1 SIN3A RARA ZNF7 ZNF205 TCF12 CTBP1 TRIM34 TRIM5 UBQLNL ENSG00000239920 HBG2 TRIM6 TRIM22 TRIM6-TRIM34 GC11P005579
GH11J005603 Promoter/Enhancer 1.2 EPDnew ENCODE dbSUPER 0.4 +8.1 8076 3 ZNF335 CTCF SMC3 RAD21 TRIM6 TRIM5 PIR57907 TRIM6-TRIM34 GC11P005579 ENSG00000239920
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRIM6-TRIM34 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRIM6-TRIM34 gene promoter:
  • AP-1
  • Sp1
  • MyoD
  • C/EBPalpha
  • LCR-F1
  • Meis-1
  • Meis-1a
  • Meis-1b
  • NF-AT
  • NF-AT1

Genomic Locations for TRIM6-TRIM34 Gene

Genomic Locations for TRIM6-TRIM34 Gene
47,764 bases
Plus strand
47,764 bases
Plus strand

Genomic View for TRIM6-TRIM34 Gene

Genes around TRIM6-TRIM34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM6-TRIM34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM6-TRIM34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM6-TRIM34 Gene

Proteins for TRIM6-TRIM34 Gene

  • Protein details for TRIM6-TRIM34 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    TRIM6-TRIM34 readthrough
    Protein Accession:

    Protein attributes for TRIM6-TRIM34 Gene

    842 amino acids
    Molecular mass:
    97729 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRIM6-TRIM34 Gene

Post-translational modifications for TRIM6-TRIM34 Gene

No Post-translational modifications

Other Protein References for TRIM6-TRIM34 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM6-TRIM34 Gene

Domains & Families for TRIM6-TRIM34 Gene

Gene Families for TRIM6-TRIM34 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TRIM6-TRIM34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRIM6-TRIM34: view

No data available for UniProtKB/Swiss-Prot for TRIM6-TRIM34 Gene

Function for TRIM6-TRIM34 Gene

Phenotypes From GWAS Catalog for TRIM6-TRIM34 Gene

Gene Ontology (GO) - Molecular Function for TRIM6-TRIM34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM6-TRIM34: view
genes like me logo Genes that share phenotypes with TRIM6-TRIM34: view

Animal Model Products

miRNA for TRIM6-TRIM34 Gene

miRTarBase miRNAs that target TRIM6-TRIM34

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM6-TRIM34 Gene

Localization for TRIM6-TRIM34 Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRIM6-TRIM34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with TRIM6-TRIM34: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for TRIM6-TRIM34 Gene

Pathways & Interactions for TRIM6-TRIM34 Gene

SuperPathways for TRIM6-TRIM34 Gene

No Data Available

Interacting Proteins for TRIM6-TRIM34 Gene

Gene Ontology (GO) - Biological Process for TRIM6-TRIM34 Gene


No data available for Pathways by source and SIGNOR curated interactions for TRIM6-TRIM34 Gene

Drugs & Compounds for TRIM6-TRIM34 Gene

No Compound Related Data Available

Transcripts for TRIM6-TRIM34 Gene

mRNA/cDNA for TRIM6-TRIM34 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM6-TRIM34 Gene

No ASD Table

Relevant External Links for TRIM6-TRIM34 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM6-TRIM34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM6-TRIM34 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from MaxQB and MOPED for TRIM6-TRIM34 Gene

genes like me logo Genes that share expression patterns with TRIM6-TRIM34: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM6-TRIM34 Gene

Orthologs for TRIM6-TRIM34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM6-TRIM34 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TRIM34 33
  • 82.3 (n)
-- 34
  • 73 (a)
(Canis familiaris)
Mammalia TRIM34 33
  • 81.66 (n)
(Rattus norvegicus)
Mammalia Trim34 33
  • 77.25 (n)
(Mus musculus)
Mammalia Trim34b 16 33
  • 76.77 (n)
(Gallus gallus)
Aves -- 34
  • 32 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 32 (a)
Species where no ortholog for TRIM6-TRIM34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM6-TRIM34 Gene

Gene Tree for TRIM6-TRIM34 (if available)
Gene Tree for TRIM6-TRIM34 (if available)

Paralogs for TRIM6-TRIM34 Gene

(19) SIMAP similar genes for TRIM6-TRIM34 Gene using alignment to 2 proteins:

  • L8E6Z1_HUMAN
genes like me logo Genes that share paralogs with TRIM6-TRIM34: view

Variants for TRIM6-TRIM34 Gene

Sequence variations from dbSNP and Humsavar for TRIM6-TRIM34 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs193920907 uncertain-significance, Malignant tumor of prostate 5,632,327(+) G/A coding_sequence_variant, missense_variant
rs1000011327 -- 5,630,522(+) G/T intron_variant
rs1000043628 -- 5,630,215(+) A/T intron_variant
rs1000045375 -- 5,613,101(+) C/T intron_variant
rs1000137673 -- 5,598,084(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM6-TRIM34 Gene

Variant ID Type Subtype PubMed ID
dgv1604n54 CNV loss 21841781
dgv1605n54 CNV loss 21841781
dgv1606n54 CNV loss 21841781
dgv188e199 CNV deletion 23128226
esv25239 CNV loss 19812545
esv2549687 CNV deletion 19546169
esv2658921 CNV deletion 23128226
esv2671670 CNV deletion 23128226
esv2744063 CNV deletion 23290073
esv2760210 CNV gain 21179565
esv3547256 CNV deletion 23714750
esv3547257 CNV deletion 23714750
esv3625236 CNV loss 21293372
esv3625237 CNV loss 21293372
esv3625238 CNV loss 21293372
esv3625239 CNV loss 21293372
esv3625240 CNV loss 21293372
esv3625241 CNV loss 21293372
esv3891920 CNV loss 25118596
nsv1041568 CNV loss 25217958
nsv1046068 CNV gain 25217958
nsv1048455 CNV gain 25217958
nsv1048608 CNV gain 25217958
nsv1053414 CNV gain 25217958
nsv1054035 CNV gain 25217958
nsv1070431 CNV deletion 25765185
nsv1122581 CNV deletion 24896259
nsv1126284 CNV deletion 24896259
nsv471746 CNV loss 16327809
nsv553241 CNV gain 21841781
nsv553260 CNV loss 21841781
nsv553272 CNV loss 21841781
nsv553273 CNV gain 21841781
nsv819802 CNV loss 19587683
nsv825739 CNV loss 20364138
nsv825740 CNV loss 20364138

Variation tolerance for TRIM6-TRIM34 Gene

Residual Variation Intolerance Score: 46.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.51; 71.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM6-TRIM34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM6-TRIM34 Gene

Disorders for TRIM6-TRIM34 Gene

Additional Disease Information for TRIM6-TRIM34

No disorders were found for TRIM6-TRIM34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM6-TRIM34 Gene

Publications for TRIM6-TRIM34 Gene

  1. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PMID: 23382691) Lauc G … Rudan I (PLoS genetics 2013) 3 58
  2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 58
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  4. Functional replacement of the RING, B-box 2, and coiled-coil domains of tripartite motif 5alpha (TRIM5alpha) by heterologous TRIM domains. (PMID: 16775307) Li X … Sodroski J (Journal of virology 2006) 3 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for TRIM6-TRIM34 Gene

Sources for TRIM6-TRIM34 Gene

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