Aliases for TRIM59 Gene

Aliases for TRIM59 Gene

  • Tripartite Motif Containing 59 2 3 5
  • RNF104 2 3 4
  • TSBF1 2 3 4
  • Tripartite Motif-Containing Protein 59 3 4
  • Tripartite Motif-Containing 57 2 3
  • RING Finger Protein 104 3 4
  • Tumor Suppressor TSBF-1 3 4
  • TRIM57 3 4
  • Tripartite Motif-Containing 59 2
  • Tumor Suppressor TSBF1 3
  • IFT80L 3
  • TRIM59 5
  • MRF1 3
  • Mrf1 2

External Ids for TRIM59 Gene

Previous HGNC Symbols for TRIM59 Gene

  • TRIM57

Previous GeneCards Identifiers for TRIM59 Gene

  • GC03M161637
  • GC03M161427
  • GC03M160153
  • GC03M157551

Summaries for TRIM59 Gene

GeneCards Summary for TRIM59 Gene

TRIM59 (Tripartite Motif Containing 59) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is ENSG00000248710.

UniProtKB/Swiss-Prot Summary for TRIM59 Gene

  • May serve as a multifunctional regulator for innate immune signaling pathways.

Additional gene information for TRIM59 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRIM59 Gene

Genomics for TRIM59 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TRIM59 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J160446 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 612.4 +36.3 36334 5.3 SP1 ZBTB33 HNRNPL TEAD4 PRDM10 IKZF1 KDM1A ZNF692 POLR2A RCOR2 TRIM59 ENSG00000248710 lnc-SMC4-3 B3GAT3P1 SCARNA7 RPL23AP42 SMC4 TRIM59-IFT80 RF00254 IFT80
GH03J160436 Promoter 0.8 EPDnew 600.3 +49.3 49273 0.1 PRDM10 ZBTB44 KLF9 POLR2A KLF7 OSR2 WT1 KLF17 ZNF18 ZNF366 TRIM59 B3GAT3P1 ENSG00000248710 RF00254 IFT80 TRIM59-IFT80
GH03J160485 Promoter 0.7 Ensembl 600.7 -0.1 -128 1.4 CTCF REST RAD21 CEBPB SMC3 RFX5 ZNF654 ZNF660 ZBTB33 TRIM59 TRIM59-IFT80 lnc-TRIM59-1 KPNA4
GH03J160457 Enhancer 0.7 Ensembl dbSUPER 12.5 +26.9 26872 1.4 PKNOX1 DPF2 FOXK2 ZNF623 ZNF610 TAL1 TCF12 TEAD4 CBFA2T3 ARID1B TRIM59 SCARNA7 SMC4 ENSG00000248710 RF00017-4156 piR-58190-002 TRIM59-IFT80
GH03J160452 Promoter/Enhancer 0.7 Ensembl dbSUPER 12.4 +33.3 33272 0.2 NR2C2 ZNF395 ZBTB33 B3GAT3P1 lnc-SMC4-3 piR-58190-002 TRIM59 SCARNA7 IFT80 ENSG00000248710 TRIM59-IFT80
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRIM59 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRIM59

Top Transcription factor binding sites by QIAGEN in the TRIM59 gene promoter:
  • E47
  • Gfi-1
  • GR
  • GR-alpha
  • Max1
  • NRSF form 1
  • NRSF form 2
  • POU2F1
  • POU2F1a
  • Tal-1beta

Genomic Locations for TRIM59 Gene

Genomic Locations for TRIM59 Gene
53,329 bases
Minus strand
53,329 bases
Minus strand

Genomic View for TRIM59 Gene

Genes around TRIM59 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM59 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM59 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM59 Gene

Proteins for TRIM59 Gene

  • Protein details for TRIM59 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tripartite motif-containing protein 59
    Protein Accession:
    Secondary Accessions:
    • A8K5G9
    • D3DNL9

    Protein attributes for TRIM59 Gene

    403 amino acids
    Molecular mass:
    47114 Da
    Quaternary structure:
    • Interacts with ECSIT.

    Alternative splice isoforms for TRIM59 Gene


neXtProt entry for TRIM59 Gene

Post-translational modifications for TRIM59 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TRIM59 Gene

Domains & Families for TRIM59 Gene

Gene Families for TRIM59 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TRIM59 Gene

  • Zn-finger, RING
  • B-box zinc finger signature

Suggested Antigen Peptide Sequences for TRIM59 Gene

GenScript: Design optimal peptide antigens:
  • Tumor suppressor TSBF-1 (TRI59_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRIM/RBCC family.
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM59: view

Function for TRIM59 Gene

Molecular function for TRIM59 Gene

UniProtKB/Swiss-Prot Function:
May serve as a multifunctional regulator for innate immune signaling pathways.

Phenotypes From GWAS Catalog for TRIM59 Gene

Gene Ontology (GO) - Molecular Function for TRIM59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IBA 21873635
genes like me logo Genes that share ontologies with TRIM59: view
genes like me logo Genes that share phenotypes with TRIM59: view

Animal Models for TRIM59 Gene

MGI Knock Outs for TRIM59:

Animal Model Products

  • Taconic Biosciences Mouse Models for TRIM59

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM59

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIM59 Gene

Localization for TRIM59 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM59 Gene

Endoplasmic reticulum membrane. Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM59 gene
Compartment Confidence
endoplasmic reticulum 4
nucleus 3
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TRIM59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum ISS --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030992 NOT intraciliary transport particle B IBA 21873635
genes like me logo Genes that share ontologies with TRIM59: view

Pathways & Interactions for TRIM59 Gene

PathCards logo

SuperPathways for TRIM59 Gene

No Data Available

SIGNOR curated interactions for TRIM59 Gene


Gene Ontology (GO) - Biological Process for TRIM59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IMP 22588174
GO:0045087 innate immune response IBA 21873635
genes like me logo Genes that share ontologies with TRIM59: view

No data available for Pathways by source for TRIM59 Gene

Drugs & Compounds for TRIM59 Gene

No Compound Related Data Available

Transcripts for TRIM59 Gene

mRNA/cDNA for TRIM59 Gene

6 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM59

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM59 Gene

No ASD Table

Relevant External Links for TRIM59 Gene

GeneLoc Exon Structure for

Expression for TRIM59 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRIM59 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM59 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.2) and Brain - Substantia nigra (x5.4).

Protein differential expression in normal tissues from HIPED for TRIM59 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRIM59 Gene

Protein tissue co-expression partners for TRIM59 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRIM59

SOURCE GeneReport for Unigene cluster for TRIM59 Gene:

genes like me logo Genes that share expression patterns with TRIM59: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM59 Gene

Orthologs for TRIM59 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM59 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRIM59 30
  • 99.09 (n)
(Bos Taurus)
Mammalia TRIM59 30
  • 90.95 (n)
MGC137058 31
  • 90 (a)
(Canis familiaris)
Mammalia TRIM59 30 31
  • 90.94 (n)
(Rattus norvegicus)
Mammalia Trim59 30
  • 87.06 (n)
(Mus musculus)
Mammalia Trim59 30 17 31
  • 85.74 (n)
(Monodelphis domestica)
Mammalia -- 31
  • 65 (a)
-- 31
  • 62 (a)
-- 31
  • 59 (a)
-- 31
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia TRIM59 31
  • 62 (a)
(Gallus gallus)
Aves TRIM59 30 31
  • 65.42 (n)
(Anolis carolinensis)
Reptilia TRIM59 31
  • 57 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia trim59 30
  • 55.18 (n)
(Danio rerio)
Actinopterygii LOC100006971 30
  • 51.12 (n)
TRIM59 31
  • 38 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 23 (a)
Species where no ortholog for TRIM59 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TRIM59 Gene

Gene Tree for TRIM59 (if available)
Gene Tree for TRIM59 (if available)
Evolutionary constrained regions (ECRs) for TRIM59: view image

Paralogs for TRIM59 Gene

Paralogs for TRIM59 Gene

(15) SIMAP similar genes for TRIM59 Gene using alignment to 8 proteins:

  • C9IY67_HUMAN
  • C9J614_HUMAN
  • C9J9F0_HUMAN
  • C9JE08_HUMAN
genes like me logo Genes that share paralogs with TRIM59: view

Variants for TRIM59 Gene

Additional dbSNP identifiers (rs#s) for TRIM59 Gene

Structural Variations from Database of Genomic Variants (DGV) for TRIM59 Gene

Variant ID Type Subtype PubMed ID
esv3598384 CNV loss 21293372
nsv822306 CNV gain 20364138

Variation tolerance for TRIM59 Gene

Residual Variation Intolerance Score: 88.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.43; 42.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM59 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRIM59 Gene

Disorders for TRIM59 Gene

No disorders were found for TRIM59 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM59 Gene

Publications for TRIM59 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. Molecular cloning, mapping and characterization of a novel mouse RING finger gene, Mrf1. (PMID: 12095697) Chang R … Li MD (Gene 2002) 2 3
  3. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. (PMID: 32353859) Gordon DE … Krogan NJ (Nature 2020) 3
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. [Expression of TRIM59 in Non-small Cell Lung Cancer and Its Correlation with Prognosis]. (PMID: 31948534) Tian H … Han Y (Zhongguo fei ai za zhi = Chinese journal of lung cancer 2020) 3

Products for TRIM59 Gene

Sources for TRIM59 Gene