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Aliases for TRIM59 Gene

Aliases for TRIM59 Gene

  • Tripartite Motif Containing 59 2 3 5
  • Tripartite Motif-Containing 57 2 3
  • Tumor Suppressor TSBF-1 3 4
  • RING Finger Protein 104 3 4
  • TRIM57 3 4
  • RNF104 3 4
  • TSBF1 3 4
  • Tripartite Motif-Containing Protein 59 3
  • Tripartite Motif-Containing 59 2
  • Tumor Suppressor TSBF1 3
  • IFT80L 3
  • MRF1 3

External Ids for TRIM59 Gene

Previous HGNC Symbols for TRIM59 Gene

  • TRIM57

Previous GeneCards Identifiers for TRIM59 Gene

  • GC03M161637
  • GC03M161427
  • GC03M160153
  • GC03M157551

Summaries for TRIM59 Gene

GeneCards Summary for TRIM59 Gene

TRIM59 (Tripartite Motif Containing 59) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is TRIM13.

UniProtKB/Swiss-Prot for TRIM59 Gene

  • May serve as a multifunctional regulator for innate immune signaling pathways.

Additional gene information for TRIM59 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM59 Gene

Genomics for TRIM59 Gene

GeneHancer (GH) Regulatory Elements for TRIM59 Gene

Promoters and enhancers for TRIM59 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I160446 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 562.4 +36.3 36333 5.3 CLOCK SMAD1 ARNT ARID4B SIN3A ZNF2 YY1 POLR2B ZNF766 CBX5 TRIM59 ENSG00000248710 RPL23AP42 B3GAT3P1 SCARNA7 SMC4 GC03P160415
GH03I160485 Promoter 0.8 Ensembl 550.8 -0.1 -128 1 CTCF REST ZBTB33 RAD21 TRIM59 GC03M160515 SCARNA7
GH03I160486 Enhancer 0.5 Ensembl 550.8 -0.9 -927 0.2 CTCF ZNF654 SMC3 CEBPB REST RAD21 RFX5 TRIM59 GC03M160515 SCARNA7
GH03I160457 Enhancer 0.6 dbSUPER 12.5 +27.4 27404 1.9 PKNOX1 TEAD4 TAL1 CBFA2T3 DPF2 TCF12 SMARCA4 FOXK2 TRIM59 SCARNA7 B3GAT3P1 IFT80 GC03P160454 GC03P160455 PIR52189 GC03M160475
GH03I160452 Enhancer 0.5 dbSUPER 12.4 +32.6 32621 1.9 NR4A1 ZMYM3 ZBTB33 MGA ZNF395 NR2C2 B3GAT3P1 GC03P160454 GC03P160455 PIR52189 TRIM59 SCARNA7 IFT80 GC03M160475
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRIM59 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRIM59 gene promoter:

Genomic Locations for TRIM59 Gene

Genomic Locations for TRIM59 Gene
53,329 bases
Minus strand

Genomic View for TRIM59 Gene

Genes around TRIM59 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM59 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM59 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM59 Gene

Proteins for TRIM59 Gene

  • Protein details for TRIM59 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tripartite motif-containing protein 59
    Protein Accession:
    Secondary Accessions:
    • A8K5G9
    • D3DNL9

    Protein attributes for TRIM59 Gene

    403 amino acids
    Molecular mass:
    47114 Da
    Quaternary structure:
    • Interacts with ECSIT.

    Alternative splice isoforms for TRIM59 Gene


neXtProt entry for TRIM59 Gene

Post-translational modifications for TRIM59 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TRIM59 Gene

Domains & Families for TRIM59 Gene

Gene Families for TRIM59 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for TRIM59 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRIM/RBCC family.
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM59: view

Function for TRIM59 Gene

Molecular function for TRIM59 Gene

UniProtKB/Swiss-Prot Function:
May serve as a multifunctional regulator for innate immune signaling pathways.

Phenotypes From GWAS Catalog for TRIM59 Gene

Gene Ontology (GO) - Molecular Function for TRIM59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IEA --
genes like me logo Genes that share ontologies with TRIM59: view
genes like me logo Genes that share phenotypes with TRIM59: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM59 Gene

Localization for TRIM59 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM59 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM59 gene
Compartment Confidence
endoplasmic reticulum 4
cytoskeleton 3
nucleus 3
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TRIM59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005783 endoplasmic reticulum ISS --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005813 centrosome IBA --
GO:0005929 cilium IBA --
genes like me logo Genes that share ontologies with TRIM59: view

Pathways & Interactions for TRIM59 Gene

SuperPathways for TRIM59 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IMP,IEA 22588174
GO:0045087 innate immune response IEA --
GO:0046597 negative regulation of viral entry into host cell IEA --
GO:0060271 cilium assembly IBA --
genes like me logo Genes that share ontologies with TRIM59: view

No data available for Pathways by source and SIGNOR curated interactions for TRIM59 Gene

Drugs & Compounds for TRIM59 Gene

No Compound Related Data Available

Transcripts for TRIM59 Gene

Unigene Clusters for TRIM59 Gene

Tripartite motif containing 59:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM59 Gene

No ASD Table

Relevant External Links for TRIM59 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM59 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM59 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM59 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.2) and Brain - Substantia nigra (x5.4).

Protein differential expression in normal tissues from HIPED for TRIM59 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRIM59 Gene

Protein tissue co-expression partners for TRIM59 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRIM59 Gene:


SOURCE GeneReport for Unigene cluster for TRIM59 Gene:

genes like me logo Genes that share expression patterns with TRIM59: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM59 Gene

Orthologs for TRIM59 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM59 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRIM59 33
  • 99.09 (n)
(Bos Taurus)
Mammalia TRIM59 33
  • 90.95 (n)
MGC137058 34
  • 90 (a)
(Canis familiaris)
Mammalia TRIM59 33 34
  • 90.94 (n)
(Rattus norvegicus)
Mammalia Trim59 33
  • 87.06 (n)
(Mus musculus)
Mammalia Trim59 33 16 34
  • 85.74 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 65 (a)
-- 34
  • 62 (a)
-- 34
  • 59 (a)
-- 34
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia TRIM59 34
  • 62 (a)
(Gallus gallus)
Aves TRIM59 33 34
  • 65.42 (n)
(Anolis carolinensis)
Reptilia TRIM59 34
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia trim59 33
  • 55.18 (n)
(Danio rerio)
Actinopterygii LOC100006971 33
  • 51.12 (n)
TRIM59 34
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 23 (a)
Species where no ortholog for TRIM59 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM59 Gene

Gene Tree for TRIM59 (if available)
Gene Tree for TRIM59 (if available)

Paralogs for TRIM59 Gene

Paralogs for TRIM59 Gene

genes like me logo Genes that share paralogs with TRIM59: view

Variants for TRIM59 Gene

Sequence variations from dbSNP and Humsavar for TRIM59 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000184579 -- 160,438,498(-) C/G/T coding_sequence_variant, missense_variant
rs1000240277 -- 160,441,072(-) C/T intron_variant
rs1000532756 -- 160,441,613(-) G/T intron_variant
rs1000847757 -- 160,435,849(-) C/G 3_prime_UTR_variant
rs1000947453 -- 160,449,828(-) C/T 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM59 Gene

Variant ID Type Subtype PubMed ID
esv3598384 CNV loss 21293372
nsv822306 CNV gain 20364138

Variation tolerance for TRIM59 Gene

Residual Variation Intolerance Score: 88.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.43; 42.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM59 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM59 Gene

Disorders for TRIM59 Gene

Additional Disease Information for TRIM59

No disorders were found for TRIM59 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM59 Gene

Publications for TRIM59 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Molecular cloning, mapping and characterization of a novel mouse RING finger gene, Mrf1. (PMID: 12095697) Chang R … Li MD (Gene 2002) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Identification of a synonymous variant in TRIM59 gene for gastric cancer risk in a Chinese population. (PMID: 28009992) Luo D … Yang L (Oncotarget 2017) 3 58
  5. Knockdown of Tripartite-59 (TRIM59) Inhibits Cellular Proliferation and Migration in Human Cervical Cancer Cells. (PMID: 27662486) Aierken G … Kuerban G (Oncology research 2017) 3 58

Products for TRIM59 Gene

Sources for TRIM59 Gene

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