Aliases for TRIM56 Gene
External Ids for TRIM56 Gene
Previous GeneCards Identifiers for TRIM56 Gene
GeneCards Summary for TRIM56 Gene
TRIM56 (Tripartite Motif Containing 56) is a Protein Coding gene. Diseases associated with TRIM56 include Aicardi-Goutieres Syndrome. Among its related pathways are Cytosolic sensors of pathogen-associated DNA and Innate Immune System. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is TRIM14.
UniProtKB/Swiss-Prot Summary for TRIM56 Gene
E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity (PubMed:21289118). In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets STING1 to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity). Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES. Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160).