Aliases for TRIM52 Gene

Aliases for TRIM52 Gene

  • Tripartite Motif Containing 52 2 3 5
  • Tripartite Motif-Containing Protein 52 3 4
  • RING Finger Protein 102 3 4
  • RNF102 3 4
  • Tripartite Motif-Containing 52 2

External Ids for TRIM52 Gene

Previous GeneCards Identifiers for TRIM52 Gene

  • GC05P181677
  • GC05M180745
  • GC05M180793
  • GC05M180615
  • GC05M180682
  • GC05M175410
  • GC05M180687
  • GC05M180702

Summaries for TRIM52 Gene

GeneCards Summary for TRIM52 Gene

TRIM52 (Tripartite Motif Containing 52) is a Protein Coding gene. An important paralog of this gene is TRIM41.

Additional gene information for TRIM52 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRIM52 Gene

Genomics for TRIM52 Gene

GeneHancer (GH) Regulatory Elements for TRIM52 Gene

Promoters and enhancers for TRIM52 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J181258 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 761.3 +0.5 459 4.6 SIN3A ZNF24 ZBTB40 CTCF SIX5 LCORL ZBTB6 MLX RBPJ POLR2A TRIM52-AS1 TRIM52 CNOT6 RACK1 ENSG00000233937 ZFP62 MGAT1 SNORD96A piR-50444-384 RF00017-5182
GH05J181221 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 93.9 +38.0 38047 4.6 GTF3C2 ZNF785 SIN3A ZNF24 SP1 ZBTB40 CTCF SIX5 ZBTB6 RBPJ MIR4638 TRIM41 TRK-CTT2-3 TRV-CAC1-5 piR-39017-005 piR-33161-005 piR-33164-014 piR-39608 piR-40458 ENSG00000233937
GH05J181187 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 66.6 +71.0 71030 6.7 GTF3C2 ZNF785 SIN3A ZNF24 ZBTB40 CTCF SREBF1 ZBTB6 MLX SMARCE1 ENSG00000250222 LOC105377769 TRP-TGG3-1 TRT-TGT6-1 TRV-AAC2-1 piR-33519 lnc-OR2V2-3 piR-44992-003 ENSG00000233937 TRIM52
GH05J181202 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 62.9 +55.5 55450 5.6 GTF3C2 SIN3A ZNF24 ZBTB40 ZBTB6 RBPJ SMARCE1 POLR2A USF2 NR2F6 TRIM7 ENSG00000248514 TRA-TGC3-1 lnc-RACK1-3 piR-36225-003 piR-49039-002 ENSG00000233937 TRIM52 ZFP62 CNOT6
GH05J180798 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 35.4 +452.1 452089 21.1 E2F8 SP1 ZBTB40 CTCF RBPJ SMARCE1 POLR2A USF2 NR2F1 NR2F6 MGAT1 ENSG00000280161 lnc-BTNL8-6 ENSG00000233937 CNOT6 ENSG00000245317 MRNIP TRIM52 ZFP62 RN7SKP150
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRIM52 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRIM52 gene promoter:
  • Brachyury
  • Chx10
  • Max1
  • STAT3
  • TBP
  • USF-1
  • USF1
  • XBP-1

Genomic Locations for TRIM52 Gene

Genomic Locations for TRIM52 Gene
chr5:181,254,417-181,261,160
(GRCh38/hg38)
Size:
6,744 bases
Orientation:
Minus strand
chr5:180,681,417-180,688,119
(GRCh37/hg19)
Size:
6,703 bases
Orientation:
Minus strand

Genomic View for TRIM52 Gene

Genes around TRIM52 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM52 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM52 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM52 Gene

Proteins for TRIM52 Gene

  • Protein details for TRIM52 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A61-TRI52_HUMAN
    Recommended name:
    Tripartite motif-containing protein 52
    Protein Accession:
    Q96A61

    Protein attributes for TRIM52 Gene

    Size:
    297 amino acids
    Molecular mass:
    34653 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRIM52 Gene

Post-translational modifications for TRIM52 Gene

Other Protein References for TRIM52 Gene

No data available for DME Specific Peptides for TRIM52 Gene

Domains & Families for TRIM52 Gene

Gene Families for TRIM52 Gene

Protein Domains for TRIM52 Gene

Suggested Antigen Peptide Sequences for TRIM52 Gene

GenScript: Design optimal peptide antigens:
  • RING finger protein 102 (TRI52_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96A61

UniProtKB/Swiss-Prot:

TRI52_HUMAN :
  • Belongs to the TRIM/RBCC family.
Family:
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM52: view

Function for TRIM52 Gene

Phenotypes From GWAS Catalog for TRIM52 Gene

Gene Ontology (GO) - Molecular Function for TRIM52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM52: view
genes like me logo Genes that share phenotypes with TRIM52: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRIM52 Gene

Localization for TRIM52 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM52 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (3)
  • Nucleoli (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRIM52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016604 nuclear body IBA 21873635
genes like me logo Genes that share ontologies with TRIM52: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM52 Gene

Pathways & Interactions for TRIM52 Gene

PathCards logo

SuperPathways for TRIM52 Gene

No Data Available

Interacting Proteins for TRIM52 Gene

Gene Ontology (GO) - Biological Process for TRIM52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051092 positive regulation of NF-kappaB transcription factor activity IDA 23077300
genes like me logo Genes that share ontologies with TRIM52: view

No data available for Pathways by source and SIGNOR curated interactions for TRIM52 Gene

Drugs & Compounds for TRIM52 Gene

No Compound Related Data Available

Transcripts for TRIM52 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM52 Gene

No ASD Table

Relevant External Links for TRIM52 Gene

GeneLoc Exon Structure for
TRIM52
ECgene alternative splicing isoforms for
TRIM52

Expression for TRIM52 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM52 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRIM52 Gene:

TRIM52

SOURCE GeneReport for Unigene cluster for TRIM52 Gene:

Hs.458412

Evidence on tissue expression from TISSUES for TRIM52 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with TRIM52: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM52 Gene

Orthologs for TRIM52 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM52 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC101059672 32
  • 96.24 (n)
TRIM52 33
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM52 33 32
  • 85.39 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TRIM52 33 32
  • 80.64 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 62 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Trim52 33
  • 48 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRIM52 33
  • 28 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIM41 33
  • 21 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 21 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii TRIM52 33
  • 9 (a)
OneToMany
Species where no ortholog for TRIM52 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM52 Gene

ENSEMBL:
Gene Tree for TRIM52 (if available)
TreeFam:
Gene Tree for TRIM52 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRIM52: view image

Paralogs for TRIM52 Gene

(3) SIMAP similar genes for TRIM52 Gene using alignment to 3 proteins:

  • TRI52_HUMAN
  • L0CQ38_HUMAN
  • L0R6S5_HUMAN
genes like me logo Genes that share paralogs with TRIM52: view

Variants for TRIM52 Gene

Sequence variations from dbSNP and Humsavar for TRIM52 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000112663 -- 181,261,439(-) T/C upstream_transcript_variant
rs1000258615 -- 181,250,261(-) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000279735 -- 181,251,216(-) C/G 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000312441 -- 181,262,176(-) T/C upstream_transcript_variant
rs1000538403 -- 181,257,476(-) T/A/C coding_sequence_variant, intron_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM52 Gene

Variant ID Type Subtype PubMed ID
dgv1155e214 CNV gain 21293372
dgv1156e214 CNV loss 21293372
esv3607831 CNV loss 21293372
nsv1019099 CNV loss 25217958
nsv1028730 CNV gain 25217958
nsv428133 CNV gain 18775914
nsv462591 CNV loss 19166990
nsv517697 CNV loss 19592680
nsv600731 CNV loss 21841781

Variation tolerance for TRIM52 Gene

Residual Variation Intolerance Score: 45.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.74; 96.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM52 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM52

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM52 Gene

Disorders for TRIM52 Gene

Additional Disease Information for TRIM52

No disorders were found for TRIM52 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM52 Gene

Publications for TRIM52 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  3. TRIM52 regulates the proliferation and invasiveness of lung cancer cells via the Wnt/β‑catenin pathway. (PMID: 31002351) Mu X … Xu W (Oncology reports 2019) 3 56
  4. TRIM52 up-regulation in hepatocellular carcinoma cells promotes proliferation, migration and invasion through the ubiquitination of PPM1A. (PMID: 29898761) Zhang Y … Zang GQ (Journal of experimental & clinical cancer research : CR 2018) 3 56
  5. Tripartite Motif Containing 52 (TRIM52) Promotes Cell Proliferation in Hepatitis B Virus-Associated Hepatocellular Carcinoma. (PMID: 29089476) Zhang Y … Zang GQ (Medical science monitor : international medical journal of experimental and clinical research 2017) 3 56

Products for TRIM52 Gene

Sources for TRIM52 Gene