Aliases for TRIM51 Gene

Aliases for TRIM51 Gene

  • Tripartite Motif-Containing 51 2 3 5
  • Tripartite Motif-Containing Protein 51 3 4
  • SPRY Domain-Containing Protein 5 3 4
  • SPRY Domain Containing 5 2 3
  • SPRYD5 3 4
  • TRIM51A 3

External Ids for TRIM51 Gene

Previous HGNC Symbols for TRIM51 Gene

  • SPRYD5

Previous GeneCards Identifiers for TRIM51 Gene

  • GC11P057166
  • GC11P055904
  • GC11P055428
  • GC11P055410
  • GC11P055651

Summaries for TRIM51 Gene

GeneCards Summary for TRIM51 Gene

TRIM51 (Tripartite Motif-Containing 51) is a Protein Coding gene. An important paralog of this gene is TRIM51GP.

Additional gene information for TRIM51 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRIM51 Gene

Genomics for TRIM51 Gene

GeneHancer (GH) Regulatory Elements for TRIM51 Gene

Promoters and enhancers for TRIM51 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J055885 Promoter 0.3 EPDnew 500.7 +2.6 2577 0.1 TRIM51 piR-38562-013
GH11J055430 Enhancer 0.2 FANTOM5 1.3 -453.0 -452966 0 OR4A10P piR-31432-087 piR-40154-027 lnc-OR4A15-1 lnc-OR4A15-2 piR-52261-044 piR-49423-041 OR5D14 OR5D18 OR4C15
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRIM51 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRIM51

Genomic Locations for TRIM51 Gene

Genomic Locations for TRIM51 Gene
chr11:55,883,297-55,891,810
(GRCh38/hg38)
Size:
8,514 bases
Orientation:
Plus strand
chr11:55,650,773-55,659,286
(GRCh37/hg19)
Size:
8,514 bases
Orientation:
Plus strand

Genomic View for TRIM51 Gene

Genes around TRIM51 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM51 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM51 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM51 Gene

Proteins for TRIM51 Gene

  • Protein details for TRIM51 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSJ1-TRI51_HUMAN
    Recommended name:
    Tripartite motif-containing protein 51
    Protein Accession:
    Q9BSJ1
    Secondary Accessions:
    • A6NMG2

    Protein attributes for TRIM51 Gene

    Size:
    452 amino acids
    Molecular mass:
    52285 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH05014.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRIM51 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM51 Gene

Post-translational modifications for TRIM51 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM51 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM51 Gene

Domains & Families for TRIM51 Gene

Gene Families for TRIM51 Gene

Protein Domains for TRIM51 Gene

Blocks:
  • Butyrophylin C-terminal DUF signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TRIM51 Gene

GenScript: Design optimal peptide antigens:
  • Tripartite motif-containing protein 51 (SPRY5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BSJ1

UniProtKB/Swiss-Prot:

TRI51_HUMAN :
  • Belongs to the TRIM/RBCC family.
Family:
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM51: view

Function for TRIM51 Gene

Phenotypes From GWAS Catalog for TRIM51 Gene

Gene Ontology (GO) - Molecular Function for TRIM51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM51: view
genes like me logo Genes that share phenotypes with TRIM51: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRIM51 Gene

Localization for TRIM51 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM51 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1
plasma membrane 0
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRIM51 Gene

Pathways & Interactions for TRIM51 Gene

PathCards logo

SuperPathways for TRIM51 Gene

No Data Available

Interacting Proteins for TRIM51 Gene

;

Gene Ontology (GO) - Biological Process for TRIM51 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRIM51 Gene

Drugs & Compounds for TRIM51 Gene

No Compound Related Data Available

Transcripts for TRIM51 Gene

mRNA/cDNA for TRIM51 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM51 Gene

No ASD Table

Relevant External Links for TRIM51 Gene

GeneLoc Exon Structure for
TRIM51

Expression for TRIM51 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRIM51 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM51 Gene

This gene is overexpressed in Testis (x29.1), Brain - Anterior cingulate cortex (BA24) (x5.3), Brain - Frontal Cortex (BA9) (x5.2), and Brain - Cortex (x5.1).

Protein differential expression in normal tissues from HIPED for TRIM51 Gene

This gene is overexpressed in Bone marrow stromal cell (60.0) and Heart (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRIM51 Gene



Protein tissue co-expression partners for TRIM51 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRIM51

SOURCE GeneReport for Unigene cluster for TRIM51 Gene:

Hs.326734
genes like me logo Genes that share expression patterns with TRIM51: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM51 Gene

Orthologs for TRIM51 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM51 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM51 31
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 33 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
-- 31
  • 28 (a)
ManyToMany
-- 31
  • 28 (a)
ManyToMany
-- 31
  • 28 (a)
ManyToMany
-- 31
  • 28 (a)
ManyToMany
-- 31
  • 28 (a)
ManyToMany
-- 31
  • 26 (a)
ManyToMany
-- 31
  • 25 (a)
ManyToMany
-- 31
  • 19 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 16 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 31 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
-- 31
  • 26 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
-- 31
  • 23 (a)
ManyToMany
-- 31
  • 21 (a)
ManyToMany
-- 31
  • 20 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii trim109 31
  • 20 (a)
ManyToMany
Species where no ortholog for TRIM51 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM51 Gene

ENSEMBL:
Gene Tree for TRIM51 (if available)
TreeFam:
Gene Tree for TRIM51 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRIM51: view image

Paralogs for TRIM51 Gene

(23) SIMAP similar genes for TRIM51 Gene using alignment to 1 proteins:

  • TRI51_HUMAN
genes like me logo Genes that share paralogs with TRIM51: view

Variants for TRIM51 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRIM51 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
768449 Benign: not provided 55,885,495(+) C/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for TRIM51 Gene

Structural Variations from Database of Genomic Variants (DGV) for TRIM51 Gene

Variant ID Type Subtype PubMed ID
dgv1205n100 CNV gain 25217958
dgv1905n54 CNV gain 21841781
esv2751030 CNV gain 17911159
esv3579771 CNV gain 25503493
esv3579782 CNV gain 25503493
esv3626458 CNV gain 21293372
esv3892013 CNV gain 25118596
nsv1044174 CNV loss 25217958
nsv555077 CNV loss 21841781
nsv821668 CNV loss 15273396
nsv832158 CNV gain 17160897
nsv972028 CNV duplication 23825009

Variation tolerance for TRIM51 Gene

Gene Damage Index Score: 5.25; 70.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM51 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM51

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM51 Gene

Disorders for TRIM51 Gene

Additional Disease Information for TRIM51

No disorders were found for TRIM51 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM51 Gene

Publications for TRIM51 Gene

  1. Identification of a genomic reservoir for new TRIM genes in primate genomes. (PMID: 22144910) Han K … Sawyer SL (PLoS genetics 2011) 3 54
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 54
  3. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual JF … Vidal M (Nature 2005) 3 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 54

Products for TRIM51 Gene

Sources for TRIM51 Gene