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Aliases for TRIM49C Gene

Aliases for TRIM49C Gene

  • Tripartite Motif Containing 49C 2 3 5
  • Tripartite Motif-Containing Protein 49-Like Protein 2 3 4
  • Tripartite Motif Containing 49-Like 2 2 3
  • TRIM49L2 3 4
  • Tripartite Motif-Containing Protein LOC642612 3
  • Tripartite Motif-Containing Protein 49C 3

External Ids for TRIM49C Gene

Previous HGNC Symbols for TRIM49C Gene

  • TRIM49L2

Previous GeneCards Identifiers for TRIM49C Gene

  • GC11P089768

Summaries for TRIM49C Gene

GeneCards Summary for TRIM49C Gene

TRIM49C (Tripartite Motif Containing 49C) is a Protein Coding gene. An important paralog of this gene is TRIM49.

Additional gene information for TRIM49C Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM49C Gene

Genomics for TRIM49C Gene

GeneHancer (GH) Regulatory Elements for TRIM49C Gene

Promoters and enhancers for TRIM49C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I090133 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 5.4 +104.6 104593 2.1 FOXA2 THRB ZNF48 ZNF335 GLIS2 RCOR1 SP3 SP5 ZBTB11 ELF1 NAALAD2 TRIM49C GC11P090149
GH11I090251 Enhancer 0.7 ENCODE 5 +221.0 220999 0.2 DRAP1 ELF3 SAP130 ARID4B DMAP1 ELF1 MNT GABPA KAT8 GATAD1 DISC1FP1 CHORDC1 TRIM49C
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRIM49C on UCSC Golden Path with GeneCards custom track

Genomic Locations for TRIM49C Gene

Genomic Locations for TRIM49C Gene
chr11:90,030,149-90,042,029
(GRCh38/hg38)
Size:
11,881 bases
Orientation:
Plus strand
chr11:89,764,274-89,806,558
(GRCh37/hg19)

Genomic View for TRIM49C Gene

Genes around TRIM49C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM49C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM49C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM49C Gene

Proteins for TRIM49C Gene

  • Protein details for TRIM49C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CI26-TR49C_HUMAN
    Recommended name:
    Tripartite motif-containing protein 49C
    Protein Accession:
    P0CI26
    Secondary Accessions:
    • A0AVR7
    • A0AVR9
    • Q6DJV1
    • Q9NS80

    Protein attributes for TRIM49C Gene

    Size:
    452 amino acids
    Molecular mass:
    52933 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRIM49C Gene

Post-translational modifications for TRIM49C Gene

No Post-translational modifications

Other Protein References for TRIM49C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM49C Gene

Domains & Families for TRIM49C Gene

Gene Families for TRIM49C Gene

Suggested Antigen Peptide Sequences for TRIM49C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRIM49C: view

No data available for UniProtKB/Swiss-Prot for TRIM49C Gene

Function for TRIM49C Gene

Gene Ontology (GO) - Molecular Function for TRIM49C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM49C: view

Phenotypes for TRIM49C Gene

genes like me logo Genes that share phenotypes with TRIM49C: view

Animal Model Products

miRNA for TRIM49C Gene

miRTarBase miRNAs that target TRIM49C

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM49C Gene

Localization for TRIM49C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM49C gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TRIM49C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with TRIM49C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for TRIM49C Gene

Pathways & Interactions for TRIM49C Gene

SuperPathways for TRIM49C Gene

No Data Available

Interacting Proteins for TRIM49C Gene

Gene Ontology (GO) - Biological Process for TRIM49C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRIM49C Gene

Drugs & Compounds for TRIM49C Gene

No Compound Related Data Available

Transcripts for TRIM49C Gene

mRNA/cDNA for TRIM49C Gene

(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM49C Gene

No ASD Table

Relevant External Links for TRIM49C Gene

GeneLoc Exon Structure for
TRIM49C
ECgene alternative splicing isoforms for
TRIM49C

Expression for TRIM49C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM49C Gene

mRNA differential expression in normal tissues according to GTEx for TRIM49C Gene

This gene is overexpressed in Testis (x39.9) and Brain - Substantia nigra (x7.2).

NURSA nuclear receptor signaling pathways regulating expression of TRIM49C Gene:

TRIM49C

SOURCE GeneReport for Unigene cluster for TRIM49C Gene:

Hs.740080
genes like me logo Genes that share expression patterns with TRIM49C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM49C Gene

Orthologs for TRIM49C Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM49C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM48 33
  • 98.97 (n)
-- 34
  • 98 (a)
ManyToMany
-- 34
  • 98 (a)
ManyToMany
-- 34
  • 97 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia LOC485140 33
  • 64.07 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 33 (a)
ManyToMany
-- 34
  • 30 (a)
ManyToMany
-- 34
  • 29 (a)
ManyToMany
-- 34
  • 29 (a)
ManyToMany
-- 34
  • 29 (a)
ManyToMany
-- 34
  • 29 (a)
ManyToMany
-- 34
  • 29 (a)
ManyToMany
-- 34
  • 28 (a)
ManyToMany
-- 34
  • 28 (a)
ManyToMany
-- 34
  • 28 (a)
ManyToMany
-- 34
  • 28 (a)
ManyToMany
-- 34
  • 26 (a)
ManyToMany
-- 34
  • 24 (a)
ManyToMany
-- 34
  • 21 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 17 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 29 (a)
ManyToMany
-- 34
  • 28 (a)
ManyToMany
-- 34
  • 27 (a)
ManyToMany
-- 34
  • 24 (a)
ManyToMany
-- 34
  • 23 (a)
ManyToMany
-- 34
  • 21 (a)
ManyToMany
-- 34
  • 19 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii trim109 34
  • 20 (a)
ManyToMany
Species where no ortholog for TRIM49C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM49C Gene

ENSEMBL:
Gene Tree for TRIM49C (if available)
TreeFam:
Gene Tree for TRIM49C (if available)

Paralogs for TRIM49C Gene

genes like me logo Genes that share paralogs with TRIM49C: view

Variants for TRIM49C Gene

Sequence variations from dbSNP and Humsavar for TRIM49C Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000376202 -- 90,041,605(+) A/T 3_prime_UTR_variant
rs1003214064 -- 90,032,378(+) G/A genic_upstream_transcript_variant, intron_variant
rs1003595672 -- 90,032,941(+) T/C genic_upstream_transcript_variant, intron_variant
rs1004054679 -- 90,039,204(+) C/T intron_variant
rs1004427635 -- 90,040,812(+) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM49C Gene

Variant ID Type Subtype PubMed ID
nsv983051 CNV duplication 23825009
nsv951055 CNV deletion 24416366
nsv832225 CNV gain 17160897
nsv7222 OTHER inversion 18451855
nsv508647 CNV deletion 20534489
nsv1070475 CNV deletion 25765185
nsv1036092 CNV loss 25217958
esv3892056 CNV gain+loss 25118596
esv3579993 CNV gain 25503493
esv2759849 CNV gain+loss 17122850
dgv407e212 CNV loss 25503493

Variation tolerance for TRIM49C Gene

Gene Damage Index Score: 1.62; 31.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM49C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM49C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM49C Gene

Disorders for TRIM49C Gene

Additional Disease Information for TRIM49C

No disorders were found for TRIM49C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM49C Gene

Publications for TRIM49C Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Identification of a genomic reservoir for new TRIM genes in primate genomes. (PMID: 22144910) Han K … Sawyer SL (PLoS genetics 2011) 3 58
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for TRIM49C Gene

Sources for TRIM49C Gene

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