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Aliases for TRIM49 Gene

Aliases for TRIM49 Gene

  • Tripartite Motif Containing 49 2 3 5
  • Ring Finger Protein 18 2 3
  • RNF18 3 4
  • Tripartite Motif-Containing Protein 49 3
  • Testis-Specific RING Finger Protein 3
  • Testis-Specific Ring-Finger Protein 3
  • Testis-Specific RING-Finger Protein 4
  • Tripartite Motif-Containing 49 2
  • RING Finger Protein 18 4
  • TRIM49L2 3
  • TRIM49A 3

External Ids for TRIM49 Gene

Previous HGNC Symbols for TRIM49 Gene

  • RNF18

Previous GeneCards Identifiers for TRIM49 Gene

  • GC11M089171
  • GC11M089530
  • GC11M085755

Summaries for TRIM49 Gene

Entrez Gene Summary for TRIM49 Gene

  • The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This gene has been found to be preferentially expressed in testis. Related pseudogenes and gene duplicates have also been identified on chromosome 11. [provided by RefSeq, Aug 2010]

GeneCards Summary for TRIM49 Gene

TRIM49 (Tripartite Motif Containing 49) is a Protein Coding gene. An important paralog of this gene is TRIM49C.

Additional gene information for TRIM49 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM49 Gene

Genomics for TRIM49 Gene

GeneHancer (GH) Regulatory Elements for TRIM49 Gene

Top Transcription factor binding sites by QIAGEN in the TRIM49 gene promoter:

Genomic Locations for TRIM49 Gene

Genomic Locations for TRIM49 Gene
10,921 bases
Minus strand

Genomic View for TRIM49 Gene

Genes around TRIM49 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM49 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM49 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM49 Gene

Proteins for TRIM49 Gene

  • Protein details for TRIM49 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tripartite motif-containing protein 49
    Protein Accession:
    Secondary Accessions:
    • A0AVR7
    • A0AVR9
    • Q6DJV1
    • Q9NS80

    Protein attributes for TRIM49 Gene

    452 amino acids
    Molecular mass:
    52888 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRIM49 Gene

Post-translational modifications for TRIM49 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM49 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM49 Gene

Domains & Families for TRIM49 Gene

Gene Families for TRIM49 Gene

Suggested Antigen Peptide Sequences for TRIM49 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRIM/RBCC family.
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM49: view

Function for TRIM49 Gene

Phenotypes From GWAS Catalog for TRIM49 Gene

Gene Ontology (GO) - Molecular Function for TRIM49 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25127057
GO:0008270 zinc ion binding IEA --
GO:0019901 protein kinase binding IPI 25127057
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM49: view
genes like me logo Genes that share phenotypes with TRIM49: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRIM49 Gene

Localization for TRIM49 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM49 gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TRIM49 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with TRIM49: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for TRIM49 Gene

Pathways & Interactions for TRIM49 Gene

SuperPathways for TRIM49 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM49 Gene


No data available for Pathways by source and SIGNOR curated interactions for TRIM49 Gene

Drugs & Compounds for TRIM49 Gene

No Compound Related Data Available

Transcripts for TRIM49 Gene

mRNA/cDNA for TRIM49 Gene

(2) REFSEQ mRNAs :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM49 Gene

No ASD Table

Relevant External Links for TRIM49 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM49 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM49 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM49 Gene

This gene is overexpressed in Testis (x27.1) and Brain - Substantia nigra (x6.9).

NURSA nuclear receptor signaling pathways regulating expression of TRIM49 Gene:


SOURCE GeneReport for Unigene cluster for TRIM49 Gene:


mRNA Expression by UniProt/SwissProt for TRIM49 Gene:

Tissue specificity: Preferentially expressed in testis.
genes like me logo Genes that share expression patterns with TRIM49: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM49 Gene

Orthologs for TRIM49 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM49 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRIM48 33
  • 98.89 (n)
-- 34
  • 98 (a)
-- 34
  • 97 (a)
-- 34
  • 97 (a)
(Canis familiaris)
Mammalia LOC485140 33
  • 63.84 (n)
-- 34
  • 49 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 33 (a)
-- 34
  • 29 (a)
-- 34
  • 29 (a)
-- 34
  • 29 (a)
-- 34
  • 29 (a)
-- 34
  • 29 (a)
-- 34
  • 28 (a)
-- 34
  • 28 (a)
-- 34
  • 28 (a)
-- 34
  • 28 (a)
-- 34
  • 28 (a)
-- 34
  • 26 (a)
-- 34
  • 24 (a)
-- 34
  • 21 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 17 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 29 (a)
-- 34
  • 28 (a)
-- 34
  • 27 (a)
-- 34
  • 24 (a)
-- 34
  • 23 (a)
-- 34
  • 21 (a)
-- 34
  • 19 (a)
(Danio rerio)
Actinopterygii FP015862.1 34
  • 17 (a)
Species where no ortholog for TRIM49 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM49 Gene

Gene Tree for TRIM49 (if available)
Gene Tree for TRIM49 (if available)

Paralogs for TRIM49 Gene

Variants for TRIM49 Gene

Sequence variations from dbSNP and Humsavar for TRIM49 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000008425 -- 89,800,360(-) C/T intron_variant
rs1000466574 -- 89,799,042(-) A/C intron_variant
rs1001069233 -- 89,802,858(-) G/A intron_variant
rs1001119570 -- 89,800,977(-) G/A coding_sequence_variant, synonymous_variant
rs1001183457 -- 89,800,592(-) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM49 Gene

Variant ID Type Subtype PubMed ID
dgv2068n54 CNV gain 21841781
dgv2069n54 CNV loss 21841781
dgv2070n54 CNV loss 21841781
dgv233n67 CNV gain 20364138
dgv405e212 CNV loss 25503493
dgv406e212 CNV loss 25503493
esv2759849 CNV gain+loss 17122850
esv2760355 CNV loss 21179565
esv2762931 CNV gain 21179565
esv3579829 CNV loss 25503493
esv3579993 CNV gain 25503493
esv3580004 CNV gain 25503493
esv3892056 CNV gain+loss 25118596
nsv1043643 CNV gain 25217958
nsv1076379 CNV duplication 25765185
nsv1139553 CNV duplication 24896259
nsv1141198 CNV duplication 24896259
nsv426 CNV insertion 18451855
nsv508644 CNV deletion 20534489
nsv826025 CNV gain 20364138
nsv832225 CNV gain 17160897
nsv951052 CNV duplication 24416366
nsv972058 CNV duplication 23825009

Variation tolerance for TRIM49 Gene

Residual Variation Intolerance Score: 88.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.74; 66.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM49 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM49 Gene

Disorders for TRIM49 Gene

Additional Disease Information for TRIM49

No disorders were found for TRIM49 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM49 Gene

Publications for TRIM49 Gene

  1. Isolation of a cDNA for a novel human RING finger protein gene, RNF18, by the virtual transcribed sequence (VTS) approach(1). (PMID: 11018261) Yoshikawa T … Saito T (Biochimica et biophysica acta 2000) 2 3 4 58
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for TRIM49 Gene

Sources for TRIM49 Gene

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