Aliases for TRIM46 Gene

Aliases for TRIM46 Gene

  • Tripartite Motif Containing 46 2 3 5
  • Tripartite, Fibronectin Type-III And C-Terminal SPRY Motif Protein 3 4
  • Tripartite Motif-Containing Protein 46 3 4
  • Gene Y Protein 3 4
  • TRIFIC 3 4
  • Tripartite Motif-Containing 46 2
  • GENEY 3
  • GeneY 4

External Ids for TRIM46 Gene

Previous GeneCards Identifiers for TRIM46 Gene

  • GC01P150886
  • GC01P151921
  • GC01P152363
  • GC01P151959
  • GC01P153412
  • GC01P155146
  • GC01P126508

Summaries for TRIM46 Gene

GeneCards Summary for TRIM46 Gene

TRIM46 (Tripartite Motif Containing 46) is a Protein Coding gene. Among its related pathways are Innate Immune System and Interferon gamma signaling. An important paralog of this gene is TRIM36.

UniProtKB/Swiss-Prot Summary for TRIM46 Gene

  • Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. Thereby also required for proper axon specification, the establishment of neuronal polarity and proper neuronal migration.

Additional gene information for TRIM46 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRIM46 Gene

Genomics for TRIM46 Gene

GeneHancer (GH) Regulatory Elements for TRIM46 Gene

Promoters and enhancers for TRIM46 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRIM46 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRIM46

Top Transcription factor binding sites by QIAGEN in the TRIM46 gene promoter:
  • AP-1
  • ATF-2
  • HTF

Genomic Locations for TRIM46 Gene

Genomic Locations for TRIM46 Gene
chr1:155,173,787-155,184,971
(GRCh38/hg38)
Size:
11,185 bases
Orientation:
Plus strand
chr1:155,145,873-155,157,447
(GRCh37/hg19)
Size:
11,575 bases
Orientation:
Plus strand

Genomic View for TRIM46 Gene

Genes around TRIM46 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM46 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM46 Gene

Proteins for TRIM46 Gene

  • Protein details for TRIM46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4K8-TRI46_HUMAN
    Recommended name:
    Tripartite motif-containing protein 46
    Protein Accession:
    Q7Z4K8
    Secondary Accessions:
    • A0AVI6
    • B1AVQ4
    • Q5VT60
    • Q5VT62
    • Q6NT17
    • Q6NT41
    • Q6ZRL7
    • Q9H5P2

    Protein attributes for TRIM46 Gene

    Size:
    759 amino acids
    Molecular mass:
    83424 Da
    Quaternary structure:
    • Interacts with TUBB3 and TUBA4A.

    Alternative splice isoforms for TRIM46 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM46 Gene

Post-translational modifications for TRIM46 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TRIM46 Gene

Domains & Families for TRIM46 Gene

Gene Families for TRIM46 Gene

Protein Domains for TRIM46 Gene

Blocks:
  • Zn-finger, RING
  • B-box zinc finger signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TRIM46 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ55765, highly similar to Tripartite motif-containing protein 46 (B7Z975_HUMAN)
  • Tripartite, fibronectin type-III and C-terminal SPRY motif protein (TRI46_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7Z4K8

UniProtKB/Swiss-Prot:

TRI46_HUMAN :
  • Belongs to the TRIM/RBCC family.
Family:
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM46: view

Function for TRIM46 Gene

Molecular function for TRIM46 Gene

UniProtKB/Swiss-Prot Function:
Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. Thereby also required for proper axon specification, the establishment of neuronal polarity and proper neuronal migration.

Phenotypes From GWAS Catalog for TRIM46 Gene

Gene Ontology (GO) - Molecular Function for TRIM46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM46: view
genes like me logo Genes that share phenotypes with TRIM46: view

Animal Model Products

miRNA for TRIM46 Gene

miRTarBase miRNAs that target TRIM46

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM46 Gene

Localization for TRIM46 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM46 Gene

Cell projection, axon. Cytoplasm, cytoskeleton. Note=Microtubule-associated. Localizes to the proximal part of the axon. {ECO:0000250 UniProtKB:Q7TNM2}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM46 gene
Compartment Confidence
cytoskeleton 4
nucleus 3
cytosol 3
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TRIM46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0030424 axon IEA --
GO:0042995 cell projection IEA --
GO:0043194 axon initial segment IEA --
genes like me logo Genes that share ontologies with TRIM46: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TRIM46 Gene

Pathways & Interactions for TRIM46 Gene

genes like me logo Genes that share pathways with TRIM46: view

Pathways by source for TRIM46 Gene

Gene Ontology (GO) - Biological Process for TRIM46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001578 microtubule bundle formation IEA --
GO:0001764 neuron migration IEA --
GO:0007409 axonogenesis IEA --
GO:0030517 negative regulation of axon extension ISS --
GO:0048490 anterograde synaptic vesicle transport IEA --
genes like me logo Genes that share ontologies with TRIM46: view

No data available for SIGNOR curated interactions for TRIM46 Gene

Drugs & Compounds for TRIM46 Gene

No Compound Related Data Available

Transcripts for TRIM46 Gene

mRNA/cDNA for TRIM46 Gene

6 REFSEQ mRNAs :
22 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM46 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1:
SP2: - -
SP3:
SP4: - - -
SP5: - -
SP6:

Relevant External Links for TRIM46 Gene

GeneLoc Exon Structure for
TRIM46

Expression for TRIM46 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRIM46 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM46 Gene

This gene is overexpressed in Brain - Cerebellum (x6.1) and Brain - Cerebellar Hemisphere (x5.5).

Protein differential expression in normal tissues from HIPED for TRIM46 Gene

This gene is overexpressed in Fetal Brain (34.9), Platelet (26.2), and Frontal cortex (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRIM46 Gene



Protein tissue co-expression partners for TRIM46 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRIM46

SOURCE GeneReport for Unigene cluster for TRIM46 Gene:

Hs.287735

Evidence on tissue expression from TISSUES for TRIM46 Gene

  • Nervous system(4.6)
  • Kidney(4.1)
genes like me logo Genes that share expression patterns with TRIM46: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM46 Gene

Orthologs for TRIM46 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIM46 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM46 31 30
  • 99.74 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TRIM46 31 30
  • 92.89 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM46 31 30
  • 92.89 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Trim46 17 31 30
  • 90.65 (n)
oppossum
(Monodelphis domestica)
Mammalia TRIM46 31
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim46 30
  • 86.91 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM46 31
  • 65 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii trim46b 31 30
  • 63.77 (n)
OneToMany
TRIM46 (1 of 2) 31
  • 58 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Trim9 31
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea trim-9 31
  • 19 (a)
OneToMany
Species where no ortholog for TRIM46 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TRIM46 Gene

ENSEMBL:
Gene Tree for TRIM46 (if available)
TreeFam:
Gene Tree for TRIM46 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRIM46: view image

Paralogs for TRIM46 Gene

(3) SIMAP similar genes for TRIM46 Gene using alignment to 4 proteins:

  • TRI46_HUMAN
  • B7Z975_HUMAN
  • F5GYK0_HUMAN
  • Q5VT61_HUMAN
genes like me logo Genes that share paralogs with TRIM46: view

Variants for TRIM46 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRIM46 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
773639 Benign: not provided 155,179,729(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for TRIM46 Gene

Structural Variations from Database of Genomic Variants (DGV) for TRIM46 Gene

Variant ID Type Subtype PubMed ID
dgv3n68 CNV loss 17160897
esv2758971 CNV gain 17122850
esv3587615 CNV gain 21293372
nsv1010146 CNV gain 25217958
nsv2988 CNV insertion 18451855
nsv464084 CNV loss 19166990
nsv470741 CNV loss 18288195
nsv527682 CNV gain 19592680
nsv547961 CNV loss 21841781
nsv8447 CNV gain 18304495

Variation tolerance for TRIM46 Gene

Residual Variation Intolerance Score: 7.04% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.50; 43.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM46 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM46

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM46 Gene

Disorders for TRIM46 Gene

Additional Disease Information for TRIM46

No disorders were found for TRIM46 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM46 Gene

Publications for TRIM46 Gene

  1. Subclassification of the RBCC/TRIM superfamily reveals a novel motif necessary for microtubule binding. (PMID: 16434393) Short KM … Cox TC (The Journal of biological chemistry 2006) 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity. (PMID: 29643511) Pao KC … Virdee S (Nature 2018) 3 54
  5. Regulation of the Mdm2-p53 pathway by the ubiquitin E3 ligase MARCH7. (PMID: 29295817) Zhao K … Mei Y (EMBO reports 2018) 3 54

Products for TRIM46 Gene

Sources for TRIM46 Gene