This gene encodes a member of the tripartite motif family. The encoded protein may function as a transcriptional repressor of the mitogen-activated protein kinase pathway. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009] See more...

Aliases for TRIM45 Gene

Aliases for TRIM45 Gene

  • Tripartite Motif Containing 45 2 3 5
  • RNF99 2 3 4
  • Tripartite Motif-Containing Protein 45 3 4
  • Tripartite Motif-Containing 45 2
  • Ring Finger Protein 99 3
  • RING Finger Protein 99 4
  • FLJ13181 2
  • TRIM45 5

External Ids for TRIM45 Gene

Previous GeneCards Identifiers for TRIM45 Gene

  • GC01M116493
  • GC01M116801
  • GC01M117001
  • GC01M117365
  • GC01M117654
  • GC01M115511

Summaries for TRIM45 Gene

Entrez Gene Summary for TRIM45 Gene

  • This gene encodes a member of the tripartite motif family. The encoded protein may function as a transcriptional repressor of the mitogen-activated protein kinase pathway. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]

GeneCards Summary for TRIM45 Gene

TRIM45 (Tripartite Motif Containing 45) is a Protein Coding gene. Diseases associated with TRIM45 include Erythematosquamous Dermatosis. Among its related pathways are Innate Immune System and Interferon gamma signaling. An important paralog of this gene is TRIM36.

UniProtKB/Swiss-Prot Summary for TRIM45 Gene

  • May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway.

Gene Wiki entry for TRIM45 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRIM45 Gene

Genomics for TRIM45 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TRIM45 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRIM45 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRIM45

Top Transcription factor binding sites by QIAGEN in the TRIM45 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • HNF-4alpha1
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • Sox9
  • SRF (504 AA)

Genomic Locations for TRIM45 Gene

Latest Assembly
chr1:117,107,711-117,122,587
(GRCh38/hg38)
Size:
14,877 bases
Orientation:
Minus strand

Previous Assembly
chr1:117,653,682-117,664,371
(GRCh37/hg19 by Entrez Gene)
Size:
10,690 bases
Orientation:
Minus strand

chr1:117,653,682-117,665,209
(GRCh37/hg19 by Ensembl)
Size:
11,528 bases
Orientation:
Minus strand

Genomic View for TRIM45 Gene

Genes around TRIM45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM45 Gene

Proteins for TRIM45 Gene

  • Protein details for TRIM45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8W5-TRI45_HUMAN
    Recommended name:
    Tripartite motif-containing protein 45
    Protein Accession:
    Q9H8W5
    Secondary Accessions:
    • Q53GN0
    • Q5T2K4
    • Q5T2K5
    • Q8IYV6

    Protein attributes for TRIM45 Gene

    Size:
    580 amino acids
    Molecular mass:
    64359 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TRIM45 Gene

    Alternative splice isoforms for TRIM45 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM45 Gene

Post-translational modifications for TRIM45 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM45 Gene

No data available for DME Specific Peptides for TRIM45 Gene

Domains & Families for TRIM45 Gene

Gene Families for TRIM45 Gene

Protein Domains for TRIM45 Gene

InterPro:
Blocks:
  • Zn-finger, RING
  • B-box zinc finger signature
ProtoNet:

Suggested Antigen Peptide Sequences for TRIM45 Gene

GenScript: Design optimal peptide antigens:
  • RING finger protein 99 (TRI45_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H8W5

UniProtKB/Swiss-Prot:

TRI45_HUMAN :
  • Belongs to the TRIM/RBCC family.
Family:
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM45: view

Function for TRIM45 Gene

Molecular function for TRIM45 Gene

UniProtKB/Swiss-Prot Function:
May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway.

Gene Ontology (GO) - Molecular Function for TRIM45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IBA 21873635
GO:0005515 protein binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM45: view
genes like me logo Genes that share phenotypes with TRIM45: view

Animal Models for TRIM45 Gene

MGI Knock Outs for TRIM45:
  • Trim45 Trim45<tm1a(KOMP)Wtsi>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM45

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIM45 Gene

Localization for TRIM45 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM45 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM45 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 4
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (3)
  • Cytosol (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRIM45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IBA 21873635
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IBA,IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with TRIM45: view

Pathways & Interactions for TRIM45 Gene

genes like me logo Genes that share pathways with TRIM45: view

Pathways by source for TRIM45 Gene

Gene Ontology (GO) - Biological Process for TRIM45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0045893 positive regulation of transcription, DNA-templated IBA 21873635
GO:0060348 bone development IEA --
genes like me logo Genes that share ontologies with TRIM45: view

No data available for SIGNOR curated interactions for TRIM45 Gene

Drugs & Compounds for TRIM45 Gene

No Compound Related Data Available

Transcripts for TRIM45 Gene

mRNA/cDNA for TRIM45 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM45

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM45 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1: -
SP2:
SP3: - - - - - - -
SP4: -
SP5: -

Relevant External Links for TRIM45 Gene

GeneLoc Exon Structure for
TRIM45

Expression for TRIM45 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRIM45 Gene

Protein differential expression in normal tissues from HIPED for TRIM45 Gene

This gene is overexpressed in Platelet (19.4), Liver, secretome (17.9), and Urine (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRIM45 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRIM45

SOURCE GeneReport for Unigene cluster for TRIM45 Gene:

Hs.301526

mRNA Expression by UniProt/SwissProt for TRIM45 Gene:

Q9H8W5-TRI45_HUMAN
Tissue specificity: Expressed in skeletal muscle, brain, heart and pancreas.

Evidence on tissue expression from TISSUES for TRIM45 Gene

  • Kidney(4.2)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with TRIM45: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM45 Gene

Orthologs for TRIM45 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIM45 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TRIM45 30 31
  • 99.08 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TRIM45 30 31
  • 89.02 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TRIM45 30 31
  • 87.53 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Trim45 30 17 31
  • 84.6 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Trim45 30
  • 84.28 (n)
Oppossum
(Monodelphis domestica)
Mammalia TRIM45 31
  • 58 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TRIM45 30 31
  • 69.86 (n)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14978 30
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.9574 30
Zebrafish
(Danio rerio)
Actinopterygii trim45 30 31
  • 57.01 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG8419 30 31
  • 45.07 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 10 (a)
OneToMany
Species where no ortholog for TRIM45 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TRIM45 Gene

ENSEMBL:
Gene Tree for TRIM45 (if available)
TreeFam:
Gene Tree for TRIM45 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRIM45: view image

Paralogs for TRIM45 Gene

genes like me logo Genes that share paralogs with TRIM45: view

Variants for TRIM45 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRIM45 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs1289658 - p.Met496Thr
rs34863850 - p.Arg353Gln
rs3738413 - p.Arg413Gln
rs749902 - p.Cys375Tyr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TRIM45 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TRIM45 Gene

Variant ID Type Subtype PubMed ID
nsv1009706 CNV gain 25217958

Variation tolerance for TRIM45 Gene

Residual Variation Intolerance Score: 89.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.92; 93.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM45 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM45

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM45 Gene

Disorders for TRIM45 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRIM45 Gene - From: COP

Disorder Aliases PubMed IDs
erythematosquamous dermatosis
  • other erythematosquamous dermatosis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TRIM45

genes like me logo Genes that share disorders with TRIM45: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM45 Gene

Publications for TRIM45 Gene

  1. TRIM45, a novel human RBCC/TRIM protein, inhibits transcriptional activities of ElK-1 and AP-1. (PMID: 15351693) Wang Y … Liu M (Biochemical and biophysical research communications 2004) 2 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for TRIM45 Gene

Sources for TRIM45 Gene