This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, namely a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008] See more...

Aliases for TRIM44 Gene

Aliases for TRIM44 Gene

  • Tripartite Motif Containing 44 2 3 5
  • DIPB 2 3 4
  • Tripartite Motif-Containing Protein 44 3 4
  • MC7 2 3
  • Tripartite Motif-Containing 44 2
  • Protein DIPB 4
  • HSA249128 3
  • TRIM44 5
  • AN3 3

External Ids for TRIM44 Gene

Previous GeneCards Identifiers for TRIM44 Gene

  • GC11P036362
  • GC11P035723
  • GC11P035648
  • GC11P035640
  • GC11P035382

Summaries for TRIM44 Gene

Entrez Gene Summary for TRIM44 Gene

  • This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, namely a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM44 Gene

TRIM44 (Tripartite Motif Containing 44) is a Protein Coding gene. Diseases associated with TRIM44 include Aniridia 3 and Isolated Aniridia. An important paralog of this gene is TRIM33.

UniProtKB/Swiss-Prot Summary for TRIM44 Gene

  • May play a role in the process of differentiation and maturation of neuronal cells (By similarity). May regulate the activity of TRIM17. Is a negative regulator of PAX6 expression (PubMed:26394807).

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRIM44 Gene

Genomics for TRIM44 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TRIM44 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J035661 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.8 809 4.2 RNF2 ARHGAP35 CREB1 GATAD2A TEAD4 PRDM10 REST TFE3 ZNF512 LEF1 TRIM44 TRAF6 ENSG00000251194 CD44-AS1 piR-38351-070 LDLRAD3
GH11J035617 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.9 -41.6 -41648 7.3 HNRNPL PRDM10 ZNF629 REST ZNF692 FOXA1 PRDM1 ZIC2 POLR2A PATZ1 TRAF6 TRIM44 FJX1 PAMR1 ENSG00000254686
GH11J035785 Enhancer 1.4 VISTA Ensembl ENCODE CraniofacialAtlas 10.6 +123.3 123309 7.2 LEF1 IKZF1 JUND PKNOX1 POLR2A MTA1 ZNF24 ZNF740 BRD9 HDAC1 TRIM44 piR-61240-047 piR-59928-028 ENSG00000254919 LDLRAD3
GH11J035629 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.4 -32.7 -32691 2.4 PRDM10 ZNF629 ZNF692 ZNF501 ZNF600 SCRT2 ZBTB44 SP1 ZNF639 JUND TRIM44 FJX1 ENSG00000254686
GH11J035579 Enhancer 1.2 Ensembl ENCODE dbSUPER 10 -80.0 -79992 6.6 GATAD2A LEF1 IKZF1 JUND POLR2A ZNF24 DPF2 HDAC1 ETV6 SOX6 PAMR1 TRAF6 TRIM44 ENSG00000254669 HSALNG0083625 FJX1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRIM44 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRIM44

Top Transcription factor binding sites by QIAGEN in the TRIM44 gene promoter:
  • AML1a
  • AP-1
  • COMP1
  • CREB
  • deltaCREB
  • FOXL1
  • PPAR-gamma1
  • PPAR-gamma2
  • S8

Genomic Locations for TRIM44 Gene

Genomic Locations for TRIM44 Gene
chr11:35,662,692-35,818,007
(GRCh38/hg38)
Size:
155,316 bases
Orientation:
Plus strand
chr11:35,684,353-35,830,930
(GRCh37/hg19)
Size:
146,578 bases
Orientation:
Plus strand

Genomic View for TRIM44 Gene

Genes around TRIM44 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM44 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM44 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM44 Gene

Proteins for TRIM44 Gene

  • Protein details for TRIM44 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DX7-TRI44_HUMAN
    Recommended name:
    Tripartite motif-containing protein 44
    Protein Accession:
    Q96DX7
    Secondary Accessions:
    • D3DR14
    • Q96QY2
    • Q9UGK0

    Protein attributes for TRIM44 Gene

    Size:
    344 amino acids
    Molecular mass:
    38472 Da
    Quaternary structure:
    • Interacts (via coiled coil) with TRIM17 (via coiled coil).

neXtProt entry for TRIM44 Gene

Post-translational modifications for TRIM44 Gene

  • Ubiquitination at Lys225, Lys231, Lys256, Lys268, and Lys314
  • Modification sites at PhosphoSitePlus

Other Protein References for TRIM44 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM44 Gene

Domains & Families for TRIM44 Gene

Gene Families for TRIM44 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for TRIM44 Gene

InterPro:
Blocks:
  • B-box zinc finger signature
ProtoNet:

Suggested Antigen Peptide Sequences for TRIM44 Gene

GenScript: Design optimal peptide antigens:
  • Protein DIPB (TRI44_HUMAN)
genes like me logo Genes that share domains with TRIM44: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TRIM44 Gene

Function for TRIM44 Gene

Molecular function for TRIM44 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the process of differentiation and maturation of neuronal cells (By similarity). May regulate the activity of TRIM17. Is a negative regulator of PAX6 expression (PubMed:26394807).

Phenotypes From GWAS Catalog for TRIM44 Gene

Gene Ontology (GO) - Molecular Function for TRIM44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17577209
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IBA 21873635
genes like me logo Genes that share ontologies with TRIM44: view
genes like me logo Genes that share phenotypes with TRIM44: view

Human Phenotype Ontology for TRIM44 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for TRIM44 Gene

miRTarBase miRNAs that target TRIM44

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM44

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM44 Gene

Localization for TRIM44 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM44 gene
Compartment Confidence
nucleus 4
plasma membrane 2
extracellular 2
cytosol 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRIM44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with TRIM44: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM44 Gene

Pathways & Interactions for TRIM44 Gene

PathCards logo

SuperPathways for TRIM44 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001961 positive regulation of cytokine-mediated signaling pathway IDA 23460740
GO:0002230 positive regulation of defense response to virus by host IDA 23460740
GO:0010468 regulation of gene expression IMP 26394807
GO:0016567 protein ubiquitination IBA 21873635
GO:0045893 positive regulation of transcription, DNA-templated IDA 23460740
genes like me logo Genes that share ontologies with TRIM44: view

No data available for Pathways by source and SIGNOR curated interactions for TRIM44 Gene

Drugs & Compounds for TRIM44 Gene

No Compound Related Data Available

Transcripts for TRIM44 Gene

mRNA/cDNA for TRIM44 Gene

1 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM44

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM44 Gene

No ASD Table

Relevant External Links for TRIM44 Gene

GeneLoc Exon Structure for
TRIM44

Expression for TRIM44 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRIM44 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRIM44 Gene

This gene is overexpressed in Stomach (33.8) and Adrenal (27.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRIM44 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRIM44

SOURCE GeneReport for Unigene cluster for TRIM44 Gene:

Hs.192103

mRNA Expression by UniProt/SwissProt for TRIM44 Gene:

Q96DX7-TRI44_HUMAN
Tissue specificity: Highly expressed in testis.

Evidence on tissue expression from TISSUES for TRIM44 Gene

  • Nervous system(4.8)
  • Muscle(4.5)
  • Skin(4.4)
  • Kidney(2.8)
  • Lung(2.7)
  • Spleen(2.6)
  • Intestine(2.6)
  • Heart(2.6)
  • Liver(2.6)
  • Lymph node(2.4)
genes like me logo Genes that share expression patterns with TRIM44: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM44 Gene

Orthologs for TRIM44 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM44 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TRIM44 30 31
  • 99.52 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TRIM44 30 31
  • 89.22 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Trim44 30 17 31
  • 86.39 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TRIM44 30 31
  • 82.78 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Trim44 30
  • 81.78 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia TRIM44 31
  • 51 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TRIM44 31
  • 50 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TRIM44 31
  • 43 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia trim44 30
  • 59.51 (n)
Zebrafish
(Danio rerio)
Actinopterygii trim44 30 31
  • 53.7 (n)
OneToOne
Species where no ortholog for TRIM44 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TRIM44 Gene

ENSEMBL:
Gene Tree for TRIM44 (if available)
TreeFam:
Gene Tree for TRIM44 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRIM44: view image

Paralogs for TRIM44 Gene

genes like me logo Genes that share paralogs with TRIM44: view

Variants for TRIM44 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRIM44 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
709789 Benign: not provided 35,726,117(+) A/G MISSENSE_VARIANT
786919 Benign: not provided 35,663,663(+) T/C SYNONYMOUS_VARIANT
786920 Benign: not provided 35,663,690(+) T/C SYNONYMOUS_VARIANT
793004 Likely Benign: not provided 35,663,648(+) T/C SYNONYMOUS_VARIANT
rs886039241 Pathogenic: Aniridia 3. Aniridia 3 (AN3) [MIM:617142] 35,663,574(+) G/Ap.Gly155Arg MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for TRIM44 Gene

Structural Variations from Database of Genomic Variants (DGV) for TRIM44 Gene

Variant ID Type Subtype PubMed ID
esv3625936 CNV loss 21293372
esv3625937 CNV loss 21293372
esv3625939 CNV gain 21293372
nsv1042014 CNV loss 25217958
nsv832121 CNV gain 17160897

Variation tolerance for TRIM44 Gene

Residual Variation Intolerance Score: 23.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM44 Gene

Human Gene Mutation Database (HGMD)
TRIM44
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM44

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM44 Gene

Disorders for TRIM44 Gene

MalaCards: The human disease database

(9) MalaCards diseases for TRIM44 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

TRI44_HUMAN
  • Aniridia 3 (AN3) [MIM:617142]: A form of aniridia, a congenital, bilateral, panocular disorder characterized by complete absence of the iris or extreme iris hypoplasia. Aniridia is not just an isolated defect in iris development but it is associated with macular and optic nerve hypoplasia, cataract, corneal changes, nystagmus. Visual acuity is generally low but is unrelated to the degree of iris hypoplasia. Glaucoma is a secondary problem causing additional visual loss over time. {ECO:0000269 PubMed:26394807}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for TRIM44

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TRIM44: view

No data available for Genatlas for TRIM44 Gene

Publications for TRIM44 Gene

  1. TRIM44 interacts with and stabilizes terf, a TRIM ubiquitin E3 ligase. (PMID: 19358823) Urano T … Inoue S (Biochemical and biophysical research communications 2009) 2 3 4
  2. Variants in TRIM44 Cause Aniridia by Impairing PAX6 Expression. (PMID: 26394807) Zhang X … Yu L (Human mutation 2015) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  4. Genomewide association study of movement-related adverse antipsychotic effects. (PMID: 19875103) Aberg K … van den Oord EJ (Biological psychiatry 2010) 3 41
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 3 4

Products for TRIM44 Gene

Sources for TRIM44 Gene