Aliases for TRIM43B Gene

Aliases for TRIM43B Gene

  • Tripartite Motif Containing 43B 2 3 5
  • Tripartite Motif-Containing Protein 43B 3 4
  • Tripartite Motif-Containing Protein 43-Like Protein 1 3
  • Tripartite Motif-Containing 43B 2
  • TRIM43B 5

External Ids for TRIM43B Gene

Previous GeneCards Identifiers for TRIM43B Gene

  • GC02M095508
  • GC02M096143
  • GC02M090143
  • GC02M095517
  • GC02M095553
  • GC02M095655
  • GC02M095672
  • GC02M095685
  • GC02M095716
  • GC02M095571
  • GC02M095579
  • GC02M095585
  • GC02M095596
  • GC02M095605
  • GC02M095614
  • GC02M095629
  • GC02M095643

Summaries for TRIM43B Gene

GeneCards Summary for TRIM43B Gene

TRIM43B (Tripartite Motif Containing 43B) is a Protein Coding gene. Diseases associated with TRIM43B include Malignant Glioma. An important paralog of this gene is TRIM43.

Additional gene information for TRIM43B Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRIM43B Gene

Genomics for TRIM43B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TRIM43B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRIM43B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRIM43B

Genomic Locations for TRIM43B Gene

Genomic Locations for TRIM43B Gene
chr2:95,476,967-95,484,731
(GRCh38/hg38)
Size:
7,765 bases
Orientation:
Minus strand
chr2:96,142,715-96,150,479
(GRCh37/hg19)
Size:
7,765 bases
Orientation:
Minus strand

Genomic View for TRIM43B Gene

Genes around TRIM43B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM43B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM43B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM43B Gene

Proteins for TRIM43B Gene

  • Protein details for TRIM43B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NCK2-TR43B_HUMAN
    Recommended name:
    Tripartite motif-containing protein 43B
    Protein Accession:
    A6NCK2

    Protein attributes for TRIM43B Gene

    Size:
    446 amino acids
    Molecular mass:
    52310 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRIM43B Gene

Post-translational modifications for TRIM43B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM43B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM43B Gene

Domains & Families for TRIM43B Gene

Gene Families for TRIM43B Gene

Suggested Antigen Peptide Sequences for TRIM43B Gene

GenScript: Design optimal peptide antigens:
  • Tripartite motif-containing protein 43B (TR43B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NCK2

UniProtKB/Swiss-Prot:

TR43B_HUMAN :
  • Belongs to the TRIM/RBCC family.
Family:
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM43B: view

Function for TRIM43B Gene

Gene Ontology (GO) - Molecular Function for TRIM43B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IBA 21873635
genes like me logo Genes that share ontologies with TRIM43B: view
genes like me logo Genes that share phenotypes with TRIM43B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM43B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM43B Gene

Localization for TRIM43B Gene

Gene Ontology (GO) - Cellular Components for TRIM43B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with TRIM43B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for TRIM43B Gene

Pathways & Interactions for TRIM43B Gene

PathCards logo

SuperPathways for TRIM43B Gene

No Data Available

Interacting Proteins for TRIM43B Gene

Gene Ontology (GO) - Biological Process for TRIM43B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010468 regulation of gene expression IBA 21873635
GO:0016567 protein ubiquitination IBA 21873635
GO:0045087 innate immune response IBA 21873635
genes like me logo Genes that share ontologies with TRIM43B: view

No data available for Pathways by source and SIGNOR curated interactions for TRIM43B Gene

Drugs & Compounds for TRIM43B Gene

No Compound Related Data Available

Transcripts for TRIM43B Gene

mRNA/cDNA for TRIM43B Gene

1 REFSEQ mRNAs :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM43B

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM43B Gene

No ASD Table

Relevant External Links for TRIM43B Gene

GeneLoc Exon Structure for
TRIM43B

Expression for TRIM43B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRIM43B Gene

mRNA differential expression in normal tissues according to GTEx for TRIM43B Gene

This gene is overexpressed in Testis (x19.3), Brain - Cerebellum (x10.7), and Brain - Cerebellar Hemisphere (x7.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRIM43B

SOURCE GeneReport for Unigene cluster for TRIM43B Gene:

Hs.723811
genes like me logo Genes that share expression patterns with TRIM43B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM43B Gene

Orthologs for TRIM43B Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRIM43B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC739911 30
  • 98.8 (n)
Cow
(Bos Taurus)
Mammalia LOC528629 30
  • 69.41 (n)
Rat
(Rattus norvegicus)
Mammalia Trim43a 30
  • 64.86 (n)
Species where no ortholog for TRIM43B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TRIM43B Gene

ENSEMBL:
Gene Tree for TRIM43B (if available)
TreeFam:
Gene Tree for TRIM43B (if available)

Paralogs for TRIM43B Gene

(22) SIMAP similar genes for TRIM43B Gene using alignment to 1 proteins:

  • TR43B_HUMAN
genes like me logo Genes that share paralogs with TRIM43B: view

Variants for TRIM43B Gene

Additional dbSNP identifiers (rs#s) for TRIM43B Gene

Structural Variations from Database of Genomic Variants (DGV) for TRIM43B Gene

Variant ID Type Subtype PubMed ID
esv2759076 CNV loss 17122850
esv3575267 CNV gain 25503493
esv3583925 CNV loss 25503493
esv3591652 OTHER inversion 21293372
nsv222 OTHER inversion 15895083
nsv7320 OTHER inversion 18451855
nsv834300 CNV gain 17160897
nsv961450 CNV duplication 23825009
nsv998014 CNV gain 25217958

Additional Variant Information for TRIM43B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM43B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for TRIM43B Gene

Disorders for TRIM43B Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRIM43B Gene - From: LncRNADisease

Disorder Aliases PubMed IDs
malignant glioma
  • glial cell tumor
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with TRIM43B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM43B Gene

Publications for TRIM43B Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4
  2. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for TRIM43B Gene

Sources for TRIM43B Gene