Aliases for TRIM43 Gene

Aliases for TRIM43 Gene

  • Tripartite Motif Containing 43 2 3 5
  • Tripartite Motif-Containing Protein 43 3 4
  • TRIM43A 2 3
  • Tripartite Motif-Containing 43 2
  • TRIM43 5

External Ids for TRIM43 Gene

Previous GeneCards Identifiers for TRIM43 Gene

  • GC02P094711
  • GC02P095725
  • GC02P095742
  • GC02P095683
  • GC02P095621
  • GC02P096257
  • GC02P090252

Summaries for TRIM43 Gene

GeneCards Summary for TRIM43 Gene

TRIM43 (Tripartite Motif Containing 43) is a Protein Coding gene. Diseases associated with TRIM43 include Facioscapulohumeral Muscular Dystrophy 1 and Facioscapulohumeral Muscular Dystrophy 2. An important paralog of this gene is TRIM43B.

Additional gene information for TRIM43 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRIM43 Gene

Genomics for TRIM43 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TRIM43 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J095591 Promoter 0.3 EPDnew 600.7 0.0 -19 0.1 ENSG00000230083 TRIM43 lnc-TRIM43B-4 TRIM43B
GH02J095296 Enhancer 0.7 FANTOM5 CraniofacialAtlas dbSUPER 2.9 -295.8 -295764 0.4 RFX1 KCNIP3 TRIM43 HSALNG0016947 PROM2
GH02J095525 Promoter/Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas 0.2 -65.1 -65100 3.4 REST POLR2A BACH1 LARP7 ZNF143 RFX1 IKZF2 CTCF GTF2F1 ZFX ENSG00000229689 ENSG00000272913 LOC100419920 lnc-TRIM43-1 ENSG00000235584 ENSG00000236431 lnc-TRIM43B-2 TRIM43B TRIM43
GH02J095681 Promoter/Enhancer 1.3 ENCODE CraniofacialAtlas 0.2 +90.8 90830 1.6 PRDM10 ZNF512 IKZF1 ZNF692 PRDM1 ZSCAN4 PATZ1 SP1 ZNF341 SCRT2 KANSL3 SNRNP200 ZNF514 LOC101926959 HSALNG0016957 TRIM43 ANKRD36C
GH02J095530 Enhancer 0.8 Ensembl ENCODE 0.2 -60.9 -60936 1.5 BACH1 ZSCAN4 IKZF2 POLR2A EED RELB JUND FOS CREB1 TARDBP ENSG00000235584 ENSG00000272913 ENSG00000236431 ENSG00000229689 lnc-TRIM43-1 lnc-TRIM43B-2 TRIM43B TRIM43
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRIM43 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRIM43

Top Transcription factor binding sites by QIAGEN in the TRIM43 gene promoter:
  • NCX

Genomic Locations for TRIM43 Gene

Genomic Locations for TRIM43 Gene
chr2:95,592,001-95,599,778
(GRCh38/hg38)
Size:
7,778 bases
Orientation:
Plus strand
chr2:96,257,766-96,265,526
(GRCh37/hg19)
Size:
7,761 bases
Orientation:
Plus strand

Genomic View for TRIM43 Gene

Genes around TRIM43 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM43 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM43 Gene

Proteins for TRIM43 Gene

  • Protein details for TRIM43 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BQ3-TRI43_HUMAN
    Recommended name:
    Tripartite motif-containing protein 43
    Protein Accession:
    Q96BQ3
    Secondary Accessions:
    • Q53TJ7

    Protein attributes for TRIM43 Gene

    Size:
    446 amino acids
    Molecular mass:
    52265 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRIM43 Gene

Post-translational modifications for TRIM43 Gene

No Post-translational modifications

Other Protein References for TRIM43 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM43 Gene

Domains & Families for TRIM43 Gene

Gene Families for TRIM43 Gene

Protein Domains for TRIM43 Gene

InterPro:
Blocks:
  • Zn-finger, RING
  • B-box zinc finger signature
ProtoNet:

Suggested Antigen Peptide Sequences for TRIM43 Gene

GenScript: Design optimal peptide antigens:
  • Tripartite motif-containing protein 43 (TRI43_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96BQ3

UniProtKB/Swiss-Prot:

TRI43_HUMAN :
  • Belongs to the TRIM/RBCC family.
Family:
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM43: view

Function for TRIM43 Gene

Phenotypes From GWAS Catalog for TRIM43 Gene

Gene Ontology (GO) - Molecular Function for TRIM43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IBA 21873635
genes like me logo Genes that share ontologies with TRIM43: view
genes like me logo Genes that share phenotypes with TRIM43: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM43

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRIM43 Gene

Localization for TRIM43 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM43 gene
Compartment Confidence
nucleus 3
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for TRIM43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with TRIM43: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for TRIM43 Gene

Pathways & Interactions for TRIM43 Gene

PathCards logo

SuperPathways for TRIM43 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010468 regulation of gene expression IBA 21873635
GO:0016567 protein ubiquitination IBA 21873635
GO:0045087 innate immune response IBA 21873635
genes like me logo Genes that share ontologies with TRIM43: view

No data available for Pathways by source and SIGNOR curated interactions for TRIM43 Gene

Drugs & Compounds for TRIM43 Gene

No Compound Related Data Available

Transcripts for TRIM43 Gene

mRNA/cDNA for TRIM43 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM43

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM43 Gene

No ASD Table

Relevant External Links for TRIM43 Gene

GeneLoc Exon Structure for
TRIM43

Expression for TRIM43 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRIM43 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM43 Gene

This gene is overexpressed in Testis (x17.3), Brain - Cerebellar Hemisphere (x7.2), Brain - Cerebellum (x6.2), Brain - Nucleus accumbens (basal ganglia) (x5.0), and Brain - Amygdala (x4.1).

Protein differential expression in normal tissues from HIPED for TRIM43 Gene

This gene is overexpressed in Monocytes (45.2), Fetal Brain (14.4), and Fetal heart (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRIM43 Gene



Protein tissue co-expression partners for TRIM43 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRIM43

SOURCE GeneReport for Unigene cluster for TRIM43 Gene:

Hs.232026
genes like me logo Genes that share expression patterns with TRIM43: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM43 Gene

Orthologs for TRIM43 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM43 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC739911 30
  • 98.88 (n)
TRIM43 31
  • 98 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC528629 30
  • 69.56 (n)
TRIM43 31
  • 49 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Trim43a 30
  • 65.01 (n)
Mouse
(Mus musculus)
Mammalia Trim43c 31
  • 42 (a)
OneToMany
Trim43a 31
  • 41 (a)
OneToMany
Trim43b 31
  • 41 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 36 (a)
ManyToMany
-- 31
  • 32 (a)
ManyToMany
-- 31
  • 32 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
-- 31
  • 27 (a)
ManyToMany
-- 31
  • 27 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
-- 31
  • 22 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 19 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 31 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
-- 31
  • 28 (a)
ManyToMany
-- 31
  • 26 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
-- 31
  • 22 (a)
ManyToMany
-- 31
  • 19 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii trim109 31
  • 20 (a)
ManyToMany
Species where no ortholog for TRIM43 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TRIM43 Gene

ENSEMBL:
Gene Tree for TRIM43 (if available)
TreeFam:
Gene Tree for TRIM43 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRIM43: view image

Paralogs for TRIM43 Gene

(25) SIMAP similar genes for TRIM43 Gene using alignment to 1 proteins:

  • TRI43_HUMAN
genes like me logo Genes that share paralogs with TRIM43: view

Variants for TRIM43 Gene

Additional dbSNP identifiers (rs#s) for TRIM43 Gene

Structural Variations from Database of Genomic Variants (DGV) for TRIM43 Gene

Variant ID Type Subtype PubMed ID
dgv4008n100 CNV gain 25217958
esv3575267 CNV gain 25503493
esv3591652 OTHER inversion 21293372
nsv1008461 CNV gain 25217958
nsv222 OTHER inversion 15895083
nsv516044 CNV gain+loss 19592680
nsv7320 OTHER inversion 18451855
nsv834300 CNV gain 17160897
nsv961830 CNV duplication 23825009
nsv998014 CNV gain 25217958
nsv998587 CNV gain 25217958

Variation tolerance for TRIM43 Gene

Gene Damage Index Score: 0.76; 16.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM43 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM43

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRIM43 Gene

Disorders for TRIM43 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TRIM43 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with TRIM43: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM43 Gene

Publications for TRIM43 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. Centrosomal protein TRIM43 restricts herpesvirus infection by regulating nuclear lamina integrity. (PMID: 30420784) Full F … Gack MU (Nature microbiology 2019) 3
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3

Products for TRIM43 Gene

Sources for TRIM43 Gene