The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Alternatively spliced transcript variants that encode different isoforms have been described... See more...

Aliases for TRIM4 Gene

Aliases for TRIM4 Gene

  • Tripartite Motif Containing 4 2 3 5
  • RING-Type E3 Ubiquitin Transferase TRIM4 3 4
  • E3 Ubiquitin-Protein Ligase TRIM4 3 4
  • Tripartite Motif Protein 4 2 3
  • RING Finger Protein 87 3 4
  • RNF87 3 4
  • Tripartite Motif-Containing Protein 4 4
  • Tripartite Motif Protein TRIM4 2
  • Tripartite Motif-Containing 4 2
  • EC 2.3.2.27 4

External Ids for TRIM4 Gene

Previous GeneCards Identifiers for TRIM4 Gene

  • GC07M098022
  • GC07M099085
  • GC07M099099
  • GC07M099133
  • GC07M099134
  • GC07M099325
  • GC07M099474
  • GC07M094123

Summaries for TRIM4 Gene

Entrez Gene Summary for TRIM4 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Alternatively spliced transcript variants that encode different isoforms have been described.[provided by RefSeq, Jul 2010]

GeneCards Summary for TRIM4 Gene

TRIM4 (Tripartite Motif Containing 4) is a Protein Coding gene. Diseases associated with TRIM4 include Tinea Pedis and Dermatophytosis. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is TRIM39.

UniProtKB/Swiss-Prot Summary for TRIM4 Gene

  • E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination of the innate immune receptor DDX58, this linkage doesn't lead to proteasomal degradation but seems to enhance IFN induction.

Additional gene information for TRIM4 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRIM4 Gene

Genomics for TRIM4 Gene

GeneHancer (GH) Regulatory Elements for TRIM4 Gene

Promoters and enhancers for TRIM4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J099917 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 562.5 +0.3 300 3.4 ZBTB40 ZNF217 CTCF TCF12 NRF1 POLR2G SP1 GTF2E2 PHF8 ZFX TRIM4 LOC101927610 lnc-CYP3A43-1 NYAP1 FAM200A piR-36393-492 RF00017-6474
GH07J100427 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 95.8 -513.4 -513393 11.2 FOXK2 HNRNPK ZBTB40 ZNF217 EP300 SIN3A NRF1 TCF12 POLR2G USF1 PPP1R35 MEPCE ZCWPW1 piR-33055 SRRT ZSCAN25 GIGYF1 TRIM4 ZNF3 ZNF655
GH07J100672 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 66.8 -757.4 -757392 8.6 FOXK2 HNRNPK ZNF217 EP300 NRF1 MYC POLR2G USF1 SP1 BCLAF1 GNB2 GIGYF1 TRIM4 ZNF3 SRRT PPP1R35 STAG3L5P PCOLCE AP4M1 ZAN
GH07J100098 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 66.7 -181.3 -181329 5.8 FOXK2 ZBTB40 ZNF217 EP300 SIN3A NRF1 TCF12 MYC POLR2G USF1 AP4M1 MCM7 lnc-TAF6-2 TRIM4 ZSCAN25 ZNF3 ZNF655 SRRT PTCD1 GIGYF1
GH07J100886 Promoter/Enhancer 2.1 Ensembl ENCODE CraniofacialAtlas dbSUPER 70.2 -969.7 -969728 5.2 HNRNPK ZBTB40 ZNF217 SIN3A NRF1 MYC POLR2G USF1 SP1 BCLAF1 KJ425573 UFSP1 TRIM4 ZNF3 GIGYF1 SRRT STAG3L5P PCOLCE PPP1R35 PILRB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRIM4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRIM4

Top Transcription factor binding sites by QIAGEN in the TRIM4 gene promoter:
  • CP2
  • FOXI1
  • FOXJ2
  • FOXJ2 (long isoform)
  • GATA-1
  • HFH-3
  • Max1
  • Spz1
  • SRF
  • SRF (504 AA)

Genomic Locations for TRIM4 Gene

Genomic Locations for TRIM4 Gene
chr7:99,876,958-99,919,600
(GRCh38/hg38)
Size:
42,643 bases
Orientation:
Minus strand
chr7:99,474,581-99,517,223
(GRCh37/hg19)
Size:
42,643 bases
Orientation:
Minus strand

Genomic View for TRIM4 Gene

Genes around TRIM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM4 Gene

Proteins for TRIM4 Gene

  • Protein details for TRIM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C037-TRIM4_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM4
    Protein Accession:
    Q9C037
    Secondary Accessions:
    • A4D298
    • Q75MK1
    • Q96F06
    • Q9C036

    Protein attributes for TRIM4 Gene

    Size:
    500 amino acids
    Molecular mass:
    57461 Da
    Quaternary structure:
    • Homotrimer.

    Alternative splice isoforms for TRIM4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM4 Gene

Post-translational modifications for TRIM4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM4 Gene

No data available for DME Specific Peptides for TRIM4 Gene

Domains & Families for TRIM4 Gene

Gene Families for TRIM4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for TRIM4 Gene

Blocks:
  • Zn-finger, RING
  • B-box zinc finger signature
  • Butyrophylin C-terminal DUF signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TRIM4 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ60086, highly similar to Tripartite motif-containing protein 4 (B4DEC5_HUMAN)
  • RING finger protein 87 (TRIM4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9C037

UniProtKB/Swiss-Prot:

TRIM4_HUMAN :
  • Belongs to the TRIM/RBCC family.
Family:
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM4: view

Function for TRIM4 Gene

Molecular function for TRIM4 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination of the innate immune receptor DDX58, this linkage doesn't lead to proteasomal degradation but seems to enhance IFN induction.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27;.

Enzyme Numbers (IUBMB) for TRIM4 Gene

Phenotypes From GWAS Catalog for TRIM4 Gene

Gene Ontology (GO) - Molecular Function for TRIM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM4: view
genes like me logo Genes that share phenotypes with TRIM4: view

Animal Model Products

CRISPR Products

miRNA for TRIM4 Gene

miRTarBase miRNAs that target TRIM4

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM4 Gene

Localization for TRIM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM4 gene
Compartment Confidence
plasma membrane 4
nucleus 4
cytosol 4
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRIM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 17156811
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
GO:0016604 nuclear body IBA 21873635
genes like me logo Genes that share ontologies with TRIM4: view

Pathways & Interactions for TRIM4 Gene

genes like me logo Genes that share pathways with TRIM4: view

UniProtKB/Swiss-Prot Q9C037-TRIM4_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for TRIM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0045087 innate immune response IEA --
GO:0070206 protein trimerization IDA 17156811
genes like me logo Genes that share ontologies with TRIM4: view

No data available for SIGNOR curated interactions for TRIM4 Gene

Drugs & Compounds for TRIM4 Gene

No Compound Related Data Available

Transcripts for TRIM4 Gene

mRNA/cDNA for TRIM4 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM4 Gene

No ASD Table

Relevant External Links for TRIM4 Gene

GeneLoc Exon Structure for
TRIM4

Expression for TRIM4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRIM4 Gene

Protein differential expression in normal tissues from HIPED for TRIM4 Gene

This gene is overexpressed in Breast (40.5) and Skin (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRIM4 Gene



Protein tissue co-expression partners for TRIM4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRIM4

SOURCE GeneReport for Unigene cluster for TRIM4 Gene:

Hs.50749
genes like me logo Genes that share expression patterns with TRIM4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM4 Gene

Orthologs for TRIM4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRIM4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM4 30
  • 99.51 (n)
dog
(Canis familiaris)
Mammalia TRIM4 31 30
  • 85.3 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 36 (a)
ManyToMany
-- 31
  • 34 (a)
ManyToMany
-- 31
  • 34 (a)
ManyToMany
-- 31
  • 32 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
Species where no ortholog for TRIM4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM4 Gene

ENSEMBL:
Gene Tree for TRIM4 (if available)
TreeFam:
Gene Tree for TRIM4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRIM4: view image

Paralogs for TRIM4 Gene

(7) SIMAP similar genes for TRIM4 Gene using alignment to 2 proteins:

  • TRIM4_HUMAN
  • H7C0Q6_HUMAN
genes like me logo Genes that share paralogs with TRIM4: view

Variants for TRIM4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRIM4 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs1254691563 Not Provided: not provided 99,892,215(-) CA/C FRAMESHIFT_VARIANT
rs33998596 - p.Ser474Cys
rs35432946 - p.Pro367Ser

Additional dbSNP identifiers (rs#s) for TRIM4 Gene

Variation tolerance for TRIM4 Gene

Residual Variation Intolerance Score: 49.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.94; 74.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TRIM4 Gene

Disorders for TRIM4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TRIM4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
tinea pedis
  • athlete's foot
dermatophytosis
  • tinea
- elite association - COSMIC cancer census association via MalaCards
Search TRIM4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TRIM4

genes like me logo Genes that share disorders with TRIM4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM4 Gene

Publications for TRIM4 Gene

  1. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A … Ballabio A (The EMBO journal 2001) 2 3 4 54
  2. TRIM4 modulates type I interferon induction and cellular antiviral response by targeting RIG-I for K63-linked ubiquitination. (PMID: 24755855) Yan J … Shu HB (Journal of molecular cell biology 2014) 3 4 54
  3. Human metabolic individuality in biomedical and pharmaceutical research. (PMID: 21886157) Suhre K … Gieger C (Nature 2011) 3 41 54
  4. Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms. (PMID: 21533175) Zhai G … Wallaschofski H (PLoS genetics 2011) 3 41 54
  5. Unique features of TRIM5alpha among closely related human TRIM family members. (PMID: 17156811) Li X … Sodroski J (Virology 2007) 3 4 54

Products for TRIM4 Gene