Aliases for TRIM4 Gene
External Ids for TRIM4 Gene
Previous GeneCards Identifiers for TRIM4 Gene
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Alternatively spliced transcript variants that encode different isoforms have been described.[provided by RefSeq, Jul 2010]
GeneCards Summary for TRIM4 Gene
TRIM4 (Tripartite Motif Containing 4) is a Protein Coding gene. Diseases associated with TRIM4 include Tinea Pedis and Dermatophytosis. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is TRIM39.
UniProtKB/Swiss-Prot Summary for TRIM4 Gene
E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination of the innate immune receptor DDX58, this linkage doesn't lead to proteasomal degradation but seems to enhance IFN induction.