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The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this protein has not been identified. This gene lies within the major histocompatibility complex class I region on chromosome 6. Alternate splicing results in ... See more...
Aliases for TRIM39 Gene
Aliases for TRIM39 Gene
External Ids for TRIM39 Gene
- HGNC: 10065
- Entrez Gene: 56658
- Ensembl: ENSG00000204599
- OMIM: 605700
- UniProtKB: Q9HCM9
Previous HGNC Symbols for TRIM39 Gene
- RNF23
Previous GeneCards Identifiers for TRIM39 Gene
- GC06P030352
- GC06P030065
- GC06P030401
- GC06P030403
- GC06P030294
- GC06P030092
- GC06P030331
- GC06P030441
- GC06P032270
- GC06P032443
- GC06P032572
- GC06P033230
- GC06P030456
- GC06P030523
- GC06P030729
- GC06P030887
- GC06P031044
- GC06P031195
- GC06P031398
- GC06P032040
Summaries for TRIM39 Gene
-
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this protein has not been identified. This gene lies within the major histocompatibility complex class I region on chromosome 6. Alternate splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for TRIM39 Gene
TRIM39 (Tripartite Motif Containing 39) is a Protein Coding gene. Diseases associated with TRIM39 include Multiple Personality Disorder and Behcet Syndrome. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include identical protein binding and ligase activity. An important paralog of this gene is TRIM39-RPP21.
UniProtKB/Swiss-Prot Summary for TRIM39 Gene
-
[Isoform 1]: E3 ubiquitin-protein ligase (PubMed:22529100). May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 (PubMed:19100260, PubMed:22529100). Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (PubMed:23213251). Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (PubMed:23213251).
-
[Isoform 2]: Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (PubMed:23213251). Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (PubMed:23213251). Negatively regulates the canonical NF-kappa-B signaling pathway via stabilization of CACTIN in an ubiquitination-independent manner (PubMed:26363554).
Additional gene information for TRIM39 Gene
- HGNC(10065)
- Entrez Gene(56658)
- Ensembl(ENSG00000204599)
- OMIM(605700)
- UniProtKB(Q9HCM9)
- Open Targets Platform(ENSG00000204599)
- Monarch Initiative
- Search for TRIM39 at DataMed
- Search for TRIM39 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRIM39 Gene
Genomics for TRIM39 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TRIM39 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TRIM39 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRIM39
- Top Transcription factor binding sites by QIAGEN in the TRIM39 gene promoter:
-
- AML1a
- MRF-2
- Nkx2-2
- Nkx2-5
- NRF-2
Genomic Locations for TRIM39 Gene
Genomic Locations for TRIM39 Gene
- chr6:30,326,469-30,343,729
- (GRCh38/hg38)
- Size:
- 17,261 bases
- Orientation:
- Plus strand
- chr6:30,294,256-30,311,506
- (GRCh37/hg19)
- Size:
- 17,251 bases
- Orientation:
- Plus strand
Genomic View for TRIM39 Gene
Genes around TRIM39 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.1 by HGNC
- 6p22.1 by Entrez Gene
- 6p22.1 by Ensembl
TRIM39 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TRIM39 Gene
Proteins for TRIM39 Gene
-
Protein details for TRIM39 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9HCM9-TRI39_HUMAN
- Recommended name:
- E3 ubiquitin-protein ligase TRIM39
- Protein Accession:
- Q9HCM9
- Q5STG3
- Q5STG4
- Q76BL3
- Q8IYT9
- Q96IB6
Protein attributes for TRIM39 Gene
- Size:
- 518 amino acids
- Molecular mass:
- 59690 Da
- Quaternary structure:
-
- Isoform 1 interacts with MOAP1 (PubMed:19100260). Isoform 1 and isoform 2 interact with CDKN1A (PubMed:23213251). Isoform 2 interacts (via domain B box-type) with CACTIN (PubMed:26363554).
Protein Expression for TRIM39 Gene
Post-translational modifications for TRIM39 Gene
- Autoubiquitinated.
-
Ubiquitination at Lys92
- NX_Q9HCM9 (NX_Q9HCM9-1)
- Modification sites at PhosphoSitePlus
Other Protein References for TRIM39 Gene
Antibody Products
- Creative Diagnostics Anti-TRIM39 monoclonal antibody, clone 3B7
- Creative Biolabs Mouse Anti-TRIM39 Recombinant Antibody (2A6)
- Novus Biologicals Antibodies for TRIM39
- Invitrogen Antibodies for TRIM39 (AFLGC-TRIM39)
-
Biorbyt antibodies for TRIM39
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for TRIM39
- Origene Custom Protein Services for TRIM39
- antibodies-online: Show 5 available TRIM39 Proteins ranked by validation data
- Compare Top TRIM39 Proteins
-
Quality Products:
-
Signalway Proteins for TRIM39
-
Abcam proteins for TRIM39
No data available for DME Specific Peptides for TRIM39 Gene
Domains & Families for TRIM39 Gene
Gene Families for TRIM39 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for TRIM39 Gene
- InterPro:
- Blocks:
-
- Zn-finger, RING
- Butyrophylin C-terminal DUF signature
- SPRY-associated domain
- B-box zinc finger signature
- ProtoNet:
Suggested Antigen Peptide Sequences for TRIM39 Gene
- GenScript: Design optimal peptide antigens:
-
- Tripartite motif-containing 39 (A2AAZ7_HUMAN)
- cDNA FLJ76683, highly similar to Homo sapiens tripartite motif-containing 39 (TRIM39), transcript variant 1, mRNA (Q5STG3_HUMAN)
- Testis-abundant finger protein (TRI39_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9HCM9- Family:
-
- Belongs to the TRIM/RBCC family.
Function for TRIM39 Gene
Molecular function for TRIM39 Gene
- UniProtKB/Swiss-Prot Function:
- [Isoform 1]: E3 ubiquitin-protein ligase (PubMed:22529100). May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 (PubMed:19100260, PubMed:22529100). Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (PubMed:23213251). Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (PubMed:23213251).
- UniProtKB/Swiss-Prot Function:
- [Isoform 2]: Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (PubMed:23213251). Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (PubMed:23213251). Negatively regulates the canonical NF-kappa-B signaling pathway via stabilization of CACTIN in an ubiquitination-independent manner (PubMed:26363554).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27;.
Enzyme Numbers (IUBMB) for TRIM39 Gene
Phenotypes From GWAS Catalog for TRIM39 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0008270 | zinc ion binding | IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0042802 | identical protein binding | IPI | 16189514 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for TRIM39 Gene
- MGI mutant phenotypes for TRIM39:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for TRIM39:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Increased cell death HMECs cells
- Decreased vaccinia virus (VACV) infection
- Synthetic lethal with Ras
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- shRNA abundance <= 25%
- Increased Nanog expression
- Increased ionizing radiation sensitivity
- Increased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis
- Decreased viability with SS1P at EC30
Animal Models for TRIM39 Gene
- MGI Knock Outs for TRIM39:
-
- Trim39 Trim39<tm1b(EUCOMM)Hmgu>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TRIM39 - Select products 50% OFF >
- * TRIM39 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TRIM39
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TRIM39
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRIM39
miRNA for TRIM39 Gene
- miRTarBase miRNAs that target TRIM39
-
- hsa-miR-218-5p (MIRT439391)
- hsa-miR-6866-5p (MIRT496701)
- hsa-miR-1827 (MIRT496702)
- hsa-miR-4742-5p (MIRT496703)
- hsa-miR-940 (MIRT496704)
- hsa-miR-6893-5p (MIRT496705)
- hsa-miR-6808-5p (MIRT496706)
- mmu-miR-129-5p (MIRT585531)
- mmu-miR-1896 (MIRT585532)
- mmu-miR-3087-3p (MIRT585533)
- mmu-miR-3470a (MIRT585534)
- mmu-miR-5125 (MIRT602963)
- mmu-miR-3110-5p (MIRT602964)
- hsa-miR-6515-3p (MIRT652194)
- hsa-miR-4469 (MIRT652195)
- hsa-miR-877-3p (MIRT652196)
- hsa-miR-5193 (MIRT652197)
- hsa-miR-4667-3p (MIRT652198)
- hsa-miR-1470 (MIRT652199)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TRIM39
- Browse OriGene Inhibitory RNA Products For TRIM39
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM39
Clone Products
- Applied Biological Materials (abm): Clones for TRIM39 - Select products 50% OFF >
- * TRIM39 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG207964
- MG216912
- MG218360
- MR207964
- MR207964L3
- MR207964L4
- MR216912
- MR216912L3
- MR216912L4
- MR218360
- MR218360L3
- MR218360L4
- RC205987
- RC205987L3
- RC205987L4
- RC213350
- RC213350L1
- RC213350L2
- RC213350L3
- RC213350L4
- RG205987
- RG213350
- RR202579
- RR202579L3
- RR202579L4
- MR207964L3V
- MR207964L4V
- MR216912L3V
- MR216912L4V
- MR218360L3V
- MR218360L4V
- RC205987L3V
- RC205987L4V
- RC213350L1V
- RC213350L2V
- RC213350L3V
- RC213350L4V
- RR202579L3V
- RR202579L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TRIM39
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TRIM39
Cell Line Products
-
Horizon Cell Lines for TRIM39
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIM39 Gene
Localization for TRIM39 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TRIM39 Gene
- [Isoform 1]: Cytoplasm, cytosol. Mitochondrion. Nucleus. Note=Found predominantly in the cytosol. Partial shift from the cytosol to the mitochondria when colocalized with MOAP1. Colocalizes with CDKN1A in the nucleus. {ECO:0000269 PubMed:19100260, ECO:0000269 PubMed:23213251}.
- [Isoform 2]: Nucleus. Note=Colocalizes with CDKN1A in the nucleus. {ECO:0000269 PubMed:23213251}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| mitochondrion | 4 |
| cytosol | 4 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
- Cytosol (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 23213251 |
| GO:0005737 | cytoplasm | IEA,IBA | 21873635 |
| GO:0005739 | mitochondrion | IDA | 19100260 |
| GO:0005829 | cytosol | IEA,IDA | 19100260 |
Pathways & Interactions for TRIM39 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Innate Immune System |
.61
|
|
Pathways by source for TRIM39 Gene
4 Reactome pathways for TRIM39 Gene
UniProtKB/Swiss-Prot Q9HCM9-TRI39_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for TRIM39 Gene
Selected Interacting proteins:
Q9HCM9-TRI39_HUMAN
ENSP00000365844
for TRIM39 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for TRIM39
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0007049 | cell cycle | IEA | -- |
| GO:0007095 | mitotic G2 DNA damage checkpoint | IMP | 23213251 |
| GO:0010468 | regulation of gene expression | IBA | 21873635 |
| GO:0016567 | protein ubiquitination | IEA | -- |
No data available for SIGNOR curated interactions for TRIM39 Gene
Transcripts for TRIM39 Gene
mRNA/cDNA for TRIM39 Gene
- 5 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000376656 3338 nts (view in UCSC)
- ENST00000376659 3535 nts (view in UCSC)
- ENST00000396547 3187 nts (view in UCSC)
- ENST00000396548 3198 nts (view in UCSC)
- ENST00000396551 3249 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TRIM39 - Select products 50% OFF >
- * TRIM39 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TRIM39
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TRIM39
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRIM39
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TRIM39
- Browse OriGene Inhibitory RNA Products For TRIM39
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM39
Clone Products
- Applied Biological Materials (abm): Clones for TRIM39 - Select products 50% OFF >
- * TRIM39 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG207964
- MG216912
- MG218360
- MR207964
- MR207964L3
- MR207964L4
- MR216912
- MR216912L3
- MR216912L4
- MR218360
- MR218360L3
- MR218360L4
- RC205987
- RC205987L3
- RC205987L4
- RC213350
- RC213350L1
- RC213350L2
- RC213350L3
- RC213350L4
- RG205987
- RG213350
- RR202579
- RR202579L3
- RR202579L4
- MR207964L3V
- MR207964L4V
- MR216912L3V
- MR216912L4V
- MR218360L3V
- MR218360L4V
- RC205987L3V
- RC205987L4V
- RC213350L1V
- RC213350L2V
- RC213350L3V
- RC213350L4V
- RR202579L3V
- RR202579L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TRIM39
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TRIM39
Relevant External Links for TRIM39 Gene
- GeneLoc Exon Structure for
- TRIM39
Expression for TRIM39 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
This gene is overexpressed in Heart (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRIM39 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRIM39
SOURCE GeneReport for Unigene cluster for TRIM39 Gene:
Hs.413493mRNA Expression by UniProt/SwissProt for TRIM39 Gene:
Q9HCM9-TRI39_HUMAN
Tissue specificity:
Ubiquitous; highly expressed in brain, heart, kidney, liver, skeletal muscle, spleen and testis.
Evidence on tissue expression from TISSUES for TRIM39 Gene
- Blood(4.3)
- Intestine(4.2)
Primer Products
-
OriGene qPCR primer pairs for TRIM39
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM39 Gene
Orthologs for TRIM39 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TRIM39 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | TRIM39 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | TRIM39 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Trim39 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| Rat (Rattus norvegicus) |
Mammalia | Trim39 30 |
|
||
| Chicken (Gallus gallus) |
Aves | TRIM39 30 |
|
||
| TRIM27.1 31 |
|
ManyToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Zebrafish (Danio rerio) |
Actinopterygii | LOC101883816 30 |
|
- Species where no ortholog for TRIM39 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for TRIM39 Gene
- ENSEMBL:
- Gene Tree for TRIM39 (if available)
- TreeFam:
- Gene Tree for TRIM39 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TRIM39: view image
Paralogs for TRIM39 Gene
Paralogs for TRIM39 Gene
- TRIM39-RPP21 5
- TRIM21 5
- TRIM58 5
- TRIM75P 5
- MEFV 5
- TRIM7 5
- TRIM69 5
- TRIM6-TRIM34 5
- TRIM27 5
- TRIM62 5
- TRIM38 5
- TRIM41 5
- TRIM11 5
- TRIM68 5
- TRIM34 5
- TRIM6 5
- TRIM10 5
- TRIML1 5
- TRIM72 5
- TRIM26 5
- TRIM22 5
- TRIM60 5
- TRIM50 5
- TRIM17 5
- TRIM4 5
- TRIM5 5
- TRIM15 5
- TRIM25 5
- TRIM16 5
- TRIM71 5
- TRIM3 5
- TRIM47 5
- TRIM2 5
- TRIM32 5
- TRIM9 5
- MID1 5
- TRIM67 5
- TRIM35 5
- TRIM64B 5
- TRIM56 5
- TRIM64C 5
- MID2 5
- TRIM14 5
- TRIML2 5
- TRIM64 5
- TRIM33 5
- TRIM51 5
- TRIM24 5
- RNF39 5
- TRIM65 5
- TRIM77 5
- TRIM49 5
- TRIM49C 5
- TRIM42 5
- TRIM51GP 5
- TRIM49B 5
- TRIM43B 5
- TRIM43 5
- TRIM31 5
- TRIM66 5
- TRIM29 5
- TRIM49D1 5
- TRIM49D2 5
- TRIM28 5
- TRIM16L 5
- TRIM40 5
- TRIM46 5
- TRIM36 5
- TRIM55 5
- TRIM8 5
- TRIM37 5
- TRIM54 5
- TRIM13 5
- TRIM45 5
- TRIM61 5
- TRIM63 5
- TRIM52 5
- PML 5
- TRIM73 5
- TRIM74 5
- TRIM48 5
- BSPRY 5
- TRIM44 5
- ENSG00000239920 5
(88) SIMAP similar genes for TRIM39 Gene using alignment to 8 proteins:
- TRI39_HUMAN
- A2AAZ2_HUMAN
- A2AAZ3_HUMAN
- A2AAZ4_HUMAN
- A2AAZ5_HUMAN
- A2AAZ6_HUMAN
- F5H297_HUMAN
- H0Y735_HUMAN
- TRIM39R
- TRIM60
- ERMAP
- TRIM61
- FLJ00123
- TRIM41
- RNF112
- TRIM5
- BT3.3
- RNF168
- TRIM75
- TRIM73
- TRIM17
- TRIM26
- TRIM22
- TRIM46
- RNF151
- PCGF3
- TRIM11
- TRIM31
- TRIM35
- LONRF1
- BFAR
- TRIM27
- TRIM21
- MID1
- TRIM68
- RAD18
- MEFV
- MID2
- RNFT1
- RNF187
- LONRF3
- LNX1
- HLTF
- DKFZp666N1710
- TRIM50
- TRIM58
- RNF39
- RFWD2
- PCGF2
- RFPL3
- TRIML1
- TRIM69
- RNF170
- TRIM6
- TRIM64B
- TRIM7
- TRIM10
- CHFR
- BTNL9
- TRIM49
- TRIM64
- TRIM51
- TRIM2
- LONRF2
- COMMD3-BMI1
- TRIM65
- TRIM49C
- TRIM25
- TRIM38
- TRIM64C
- TRIM56
- RFPL4A
- TRIM8
- DKFZp686F23130
- TRIM3
- RNF5
- RNF166
- RFPL1
- RFPL4AL1
- BMI1
- TRIM48
- ZNFB7
- DKFZp781D1977
- TRIM15
- TRIM72
- PEX10
- NEURL3
- BRAP
- BRCA1
- TRIM62
- TRIM4
- TRIM43
- TRIM34
- RNF181
- CBL
- RFPL4B
Pseudogenes.org Pseudogenes for TRIM39 Gene
Variants for TRIM39 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3411275 | CNV | duplication | 20981092 |
| nsv1074389 | CNV | deletion | 25765185 |
| nsv1122126 | CNV | deletion | 24896259 |
| nsv1144137 | CNV | deletion | 24896259 |
| nsv5241 | CNV | insertion | 18451855 |
| nsv601264 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
16.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.25;
40.44% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TRIM39 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TRIM39
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRIM39 Gene
Disorders for TRIM39 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| multiple personality disorder |
|
|
| behcet syndrome |
|
|
Search TRIM39 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TRIM39
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM39 Gene
Publications for TRIM39 Gene
- Molecular cloning of testis-abundant finger Protein/Ring finger protein 23 (RNF23), a novel RING-B box-coiled coil-B30.2 protein on the class I region of the human MHC. (PMID: 11006080) Orimo A … Muramatsu M (Biochemical and biophysical research communications 2000) 2 3 4 23
- TRIM39 negatively regulates the NFκB-mediated signaling pathway through stabilization of Cactin. (PMID: 26363554) Suzuki M … Hatakeyama S (Cellular and molecular life sciences : CMLS 2016) 3 4
- The Trim39 ubiquitin ligase inhibits APC/CCdh1-mediated degradation of the Bax activator MOAP-1. (PMID: 22529100) Huang NJ … Kornbluth S (The Journal of cell biology 2012) 3 4
- TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21. (PMID: 23213251) Zhang L … You H (Proceedings of the National Academy of Sciences of the United States of America 2012) 3 4
- TRIM39 is a MOAP-1-binding protein that stabilizes MOAP-1 through inhibition of its poly-ubiquitination process. (PMID: 19100260) Lee SS … Yu VC (Experimental cell research 2009) 3 4
ExternalLinks
Products for TRIM39 Gene
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- antibodies-online: Show 15 available TRIM39 Antibodies ranked by validation data
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- antibodies-online: Show 5 available TRIM39 Proteins ranked by validation data
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- Quality Products:
- Horizon Cell Lines for TRIM39
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TRIM39
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM39
- Biorbyt antibodies for TRIM39
- Signalway Proteins for TRIM39
Sources for TRIM39 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB