Aliases for TRIM38 Gene
External Ids for TRIM38 Gene
Previous HGNC Symbols for TRIM38 Gene
Previous GeneCards Identifiers for TRIM38 Gene
This gene encodes a member of the tripartite motif (TRIM) family. The encoded protein contains a RING-type zinc finger, B box-type zinc finger and SPRY domain. The function of this protein has not been identified. A pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Jul 2012]
GeneCards Summary for TRIM38 Gene
TRIM38 (Tripartite Motif Containing 38) is a Protein Coding gene. Diseases associated with TRIM38 include Fanconi Renotubular Syndrome 2. Among its related pathways are Innate Immune System and Interferon gamma signaling. Gene Ontology (GO) annotations related to this gene include ligase activity and obsolete signal transducer activity. An important paralog of this gene is TRIM21.
UniProtKB/Swiss-Prot Summary for TRIM38 Gene
E3 ubiquitin-protein ligase. Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling.