This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or prot... See more...

Aliases for TRIM37 Gene

Aliases for TRIM37 Gene

  • Tripartite Motif Containing 37 2 3 5
  • RING-Type E3 Ubiquitin Transferase TRIM37 3 4
  • E3 Ubiquitin-Protein Ligase TRIM37 3 4
  • RING-B-Box-Coiled-Coil Protein 2 3
  • Mulibrey Nanism Protein 3 4
  • POB1 3 4
  • MUL 3 4
  • Tripartite Motif-Containing Protein 37 4
  • Tripartite Motif-Containing 37 2
  • EC 2.3.2.27 4
  • KIAA0898 4
  • TEF3 3

External Ids for TRIM37 Gene

Previous HGNC Symbols for TRIM37 Gene

  • MUL

Previous GeneCards Identifiers for TRIM37 Gene

  • GC17M056903
  • GC17M059637
  • GC17M057401
  • GC17M057549
  • GC17M054430
  • GC17M054414
  • GC17M057059
  • GC17M052420

Summaries for TRIM37 Gene

Entrez Gene Summary for TRIM37 Gene

  • This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. [provided by RefSeq, Mar 2016]

GeneCards Summary for TRIM37 Gene

TRIM37 (Tripartite Motif Containing 37) is a Protein Coding gene. Diseases associated with TRIM37 include Mulibrey Nanism and Acid-Labile Subunit Deficiency. Among its related pathways are Ubiquitin mediated proteolysis and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and ligase activity. An important paralog of this gene is TRIM66.

UniProtKB/Swiss-Prot Summary for TRIM37 Gene

  • E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Has anti-HIV activity (PubMed:24317724).

Gene Wiki entry for TRIM37 Gene

Additional gene information for TRIM37 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRIM37 Gene

Genomics for TRIM37 Gene

GeneHancer (GH) Regulatory Elements for TRIM37 Gene

Promoters and enhancers for TRIM37 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRIM37 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRIM37 gene promoter:
  • ATF6
  • Cart-1
  • CUTL1
  • E47
  • p53
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • Tal-1

Genomic Locations for TRIM37 Gene

Genomic Locations for TRIM37 Gene
chr17:58,982,638-59,106,921
(GRCh38/hg38)
Size:
124,284 bases
Orientation:
Minus strand
chr17:57,059,999-57,184,282
(GRCh37/hg19)
Size:
124,284 bases
Orientation:
Minus strand

Genomic View for TRIM37 Gene

Genes around TRIM37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM37 Gene

Proteins for TRIM37 Gene

  • Protein details for TRIM37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94972-TRI37_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM37
    Protein Accession:
    O94972
    Secondary Accessions:
    • A8K0V9
    • A8K8U4
    • A8MZ79
    • B4DGZ3
    • F8WEE6
    • Q7Z3E6
    • Q8IYF7
    • Q8WYF7

    Protein attributes for TRIM37 Gene

    Size:
    964 amino acids
    Molecular mass:
    107906 Da
    Quaternary structure:
    • Associates with the PRC2/EED-EZH2 complex.
    Miscellaneous:
    • Acts as a proto-oncogene via its ability to monoubiquinate 'Lys-119' of histone H2A (H2AK119Ub): overexpressed in a number of breast cancers and promotes transformation of cells by mediating silencing of tumor suppressor genes (PubMed:25470042).
    SequenceCaution:
    • Sequence=BAA74921.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRIM37 Gene

    Alternative splice isoforms for TRIM37 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM37 Gene

Post-translational modifications for TRIM37 Gene

No data available for DME Specific Peptides for TRIM37 Gene

Domains & Families for TRIM37 Gene

Gene Families for TRIM37 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TRIM37 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ75453, highly similar to Homo sapiens tripartite motif-containing 37 (TRIM37), transcript variant 2, mRNA (A8K0V9_HUMAN)
  • Tripartite motif-containing protein 37 (TRI37_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O94972

UniProtKB/Swiss-Prot:

TRI37_HUMAN :
  • Belongs to the TRIM/RBCC family.
Family:
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM37: view

Function for TRIM37 Gene

Molecular function for TRIM37 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Has anti-HIV activity (PubMed:24317724).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=. ;.
UniProtKB/Swiss-Prot Induction:
Overexpressed in a number of breast cancer cell lines.

Enzyme Numbers (IUBMB) for TRIM37 Gene

Phenotypes From GWAS Catalog for TRIM37 Gene

Gene Ontology (GO) - Molecular Function for TRIM37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0004842 ubiquitin-protein transferase activity IDA 15885686
GO:0005164 tumor necrosis factor receptor binding IPI 11279055
GO:0005515 protein binding IEA,IPI 11279055
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with TRIM37: view
genes like me logo Genes that share phenotypes with TRIM37: view

Human Phenotype Ontology for TRIM37 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for TRIM37 Gene

miRTarBase miRNAs that target TRIM37

Clone Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM37 Gene

Localization for TRIM37 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM37 Gene

Cytoplasm, perinuclear region. Peroxisome. Note=Found in vesicles of the peroxisome. Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteasomal degradation. {ECO:0000269 PubMed:15885686}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM37 gene
Compartment Confidence
peroxisome 5
cytosol 5
nucleus 3
extracellular 1

Gene Ontology (GO) - Cellular Components for TRIM37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IDA,IEA 23769972
GO:0005777 peroxisome IEA,IDA 11938494
GO:0005829 cytosol IDA 11279055
GO:0016235 aggresome IDA 15885686
genes like me logo Genes that share ontologies with TRIM37: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TRIM37 Gene

Pathways & Interactions for TRIM37 Gene

genes like me logo Genes that share pathways with TRIM37: view

Pathways by source for TRIM37 Gene

UniProtKB/Swiss-Prot O94972-TRI37_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for TRIM37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 25470042
GO:0016567 protein ubiquitination IEA --
GO:0032088 negative regulation of NF-kappaB transcription factor activity IDA 11279055
GO:0035518 histone H2A monoubiquitination IDA 25470042
GO:0036353 histone H2A-K119 monoubiquitination IDA 25470042
genes like me logo Genes that share ontologies with TRIM37: view

No data available for SIGNOR curated interactions for TRIM37 Gene

Drugs & Compounds for TRIM37 Gene

No Compound Related Data Available

Transcripts for TRIM37 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM37 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a ·
SP1: - - - -
SP2: - - -
SP3: - - - -
SP4:
SP5:
SP6:
SP7: - - - - - -
SP8: -
SP9:

ExUns: 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b
SP1: -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -

Relevant External Links for TRIM37 Gene

GeneLoc Exon Structure for
TRIM37
ECgene alternative splicing isoforms for
TRIM37

Expression for TRIM37 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM37 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM37 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.6).

Protein differential expression in normal tissues from HIPED for TRIM37 Gene

This gene is overexpressed in Adipocyte (38.6) and Testis (16.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRIM37 Gene



Protein tissue co-expression partners for TRIM37 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRIM37 Gene:

TRIM37

SOURCE GeneReport for Unigene cluster for TRIM37 Gene:

Hs.579079

mRNA Expression by UniProt/SwissProt for TRIM37 Gene:

O94972-TRI37_HUMAN
Tissue specificity: Ubiquitous (PubMed:10888877). Highly expressed in testis, while it is weakly expressed in other tissues (PubMed:16310976).

Evidence on tissue expression from TISSUES for TRIM37 Gene

  • Nervous system(5)
  • Blood(3.3)
  • Kidney(2.6)
  • Skin(2.2)
  • Lung(2.1)
  • Eye(2)
  • Heart(2)
  • Intestine(2)
  • Liver(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM37 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • integumentary
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cheek
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • larynx
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • sinus
  • skull
  • tongue
  • tooth
  • vocal cord
Thorax:
  • heart
  • heart valve
  • lung
Abdomen:
  • kidney
  • liver
General:
  • blood vessel
  • peripheral nerve
  • peripheral nervous system
  • skin
genes like me logo Genes that share expression patterns with TRIM37: view

Orthologs for TRIM37 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM37 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM37 33 32
  • 99.65 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 97 (a)
OneToMany
-- 33
  • 77 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TRIM37 33 32
  • 92.72 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TRIM37 33 32
  • 91.22 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Trim37 17 33 32
  • 88.75 (n)
rat
(Rattus norvegicus)
Mammalia Trim37 32
  • 88.54 (n)
oppossum
(Monodelphis domestica)
Mammalia TRIM37 33
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIM37 33 32
  • 75.28 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIM37 33
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trim37 32
  • 70.37 (n)
Str.3537 32
zebrafish
(Danio rerio)
Actinopterygii trim37 33 32
  • 63.24 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7142 33
  • 63 (a)
OneToOne
Species where no ortholog for TRIM37 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM37 Gene

ENSEMBL:
Gene Tree for TRIM37 (if available)
TreeFam:
Gene Tree for TRIM37 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRIM37: view image

Paralogs for TRIM37 Gene

(1) SIMAP similar genes for TRIM37 Gene using alignment to 10 proteins:

  • TRI37_HUMAN
  • A8K0V9_HUMAN
  • F8WEE6_HUMAN
  • J3KS72_HUMAN
  • J3KT32_HUMAN
  • J3KT90_HUMAN
  • J3QRK3_HUMAN
  • J3QSA0_HUMAN
  • J3QSF6_HUMAN
  • J3QSH5_HUMAN
genes like me logo Genes that share paralogs with TRIM37: view

Variants for TRIM37 Gene

Sequence variations from dbSNP and Humsavar for TRIM37 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs112762655 uncertain-significance, not provided, Mulibrey nanism syndrome 59,031,925(-) C/A/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs112918162 uncertain-significance, Mulibrey nanism syndrome 58,998,400(-) G/ 3_prime_UTR_variant, intron_variant, non_coding_transcript_variant
rs11541295 likely-benign, Mulibrey nanism syndrome 59,106,685(-) T/C 5_prime_UTR_variant, non_coding_transcript_variant
rs121908391 pathogenic, Mulibrey nanism syndrome, Mulibrey nanism (MUL) [MIM:253250] 59,084,045(-) C/G 5_prime_UTR_variant, coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant
rs12451581 uncertain-significance, Mulibrey nanism syndrome 58,998,293(-) G/A/C 3_prime_UTR_variant, intron_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM37 Gene

Variant ID Type Subtype PubMed ID
dgv3270n100 CNV gain 25217958
esv2421884 CNV deletion 20811451
esv2675820 CNV deletion 23128226
esv2758699 CNV gain 17122850
esv3554606 CNV deletion 23714750
esv3640900 CNV loss 21293372
esv3640901 CNV loss 21293372
nsv1065063 CNV gain 25217958
nsv1127585 CNV deletion 24896259
nsv1134660 CNV deletion 24896259
nsv507849 OTHER sequence alteration 20534489
nsv510719 CNV deletion 20534489
nsv514855 CNV loss 21397061
nsv828068 CNV loss 20364138
nsv828069 CNV loss 20364138
nsv833499 CNV loss 17160897
nsv9574 CNV loss 18304495
nsv962452 CNV deletion 23825009

Variation tolerance for TRIM37 Gene

Residual Variation Intolerance Score: 6.25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.77; 47.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM37 Gene

Human Gene Mutation Database (HGMD)
TRIM37
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM37

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM37 Gene

Disorders for TRIM37 Gene

MalaCards: The human disease database

(6) MalaCards diseases for TRIM37 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
mulibrey nanism
  • muscle-liver-brain-eye nanism
acid-labile subunit deficiency
  • aclsd
pontiac fever
constrictive pericarditis
  • pericarditis constrictive
peroxisomal disease
  • peroxisomal disorder
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

TRI37_HUMAN
  • Mulibrey nanism (MUL) [MIM:253250]: An autosomal recessive growth disorder characterized by severe growth failure of prenatal onset, constrictive pericardium and progressive cardiomyopathy, facial dysmorphism, and failure of sexual maturation. Additional clinical features include hepatomegaly, muscle hypotonia, J-shaped sella turcica, yellowish dots in the ocular fundi, hypoplasia of various endocrine glands, insulin resistance with type 2 diabetes, and an increased risk for Wilms' tumor. {ECO:0000269 PubMed:10888877, ECO:0000269 PubMed:12754710, ECO:0000269 PubMed:15108285, ECO:0000269 PubMed:15885686, ECO:0000269 PubMed:17100991, ECO:0000269 PubMed:17551331, ECO:0000269 PubMed:21865362, ECO:0000269 PubMed:23385855}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for TRIM37

genes like me logo Genes that share disorders with TRIM37: view

No data available for Genatlas for TRIM37 Gene

Publications for TRIM37 Gene

  1. A novel mutation in TRIM37 is associated with mulibrey nanism in a Turkish boy. (PMID: 17551331) Doğanc T … Tekin M (Clinical dysmorphology 2007) 3 4 23 56
  2. Wilms' tumor and novel TRIM37 mutations in an Australian patient with mulibrey nanism. (PMID: 17100991) Hämäläinen RH … Lehesjoki AE (Clinical genetics 2006) 3 4 23 56
  3. Characterisation of the mulibrey nanism-associated TRIM37 gene: transcription initiation, promoter region and alternative splicing. (PMID: 16310976) Hämäläinen RH … Lehesjoki AE (Gene 2006) 3 4 23 56
  4. Novel mutations in the TRIM37 gene in Mulibrey Nanism. (PMID: 15108285) Hämäläinen RH … Lehesjoki AE (Human mutation 2004) 3 4 23 56
  5. A novel splice site mutation in the TRIM37 gene causes mulibrey nanism in a Turkish family with phenotypic heterogeneity. (PMID: 12754710) Jagiello P … Gencik M (Human mutation 2003) 3 4 23 56

Products for TRIM37 Gene