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This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or prot... See more...
Aliases for TRIM37 Gene
Aliases for TRIM37 Gene
External Ids for TRIM37 Gene
- HGNC: 7523
- Entrez Gene: 4591
- Ensembl: ENSG00000108395
- OMIM: 605073
- UniProtKB: O94972
Previous HGNC Symbols for TRIM37 Gene
- MUL
Previous GeneCards Identifiers for TRIM37 Gene
- GC17M056903
- GC17M059637
- GC17M057401
- GC17M057549
- GC17M054430
- GC17M054414
- GC17M057059
- GC17M052420
Summaries for TRIM37 Gene
-
This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. [provided by RefSeq, Mar 2016]
GeneCards Summary for TRIM37 Gene
TRIM37 (Tripartite Motif Containing 37) is a Protein Coding gene. Diseases associated with TRIM37 include Mulibrey Nanism and Acid-Labile Subunit Deficiency. Among its related pathways are Chromatin Regulation / Acetylation and Innate Immune System. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and ligase activity. An important paralog of this gene is TRIM66.
UniProtKB/Swiss-Prot Summary for TRIM37 Gene
-
E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Has anti-HIV activity (PubMed:24317724).
Additional gene information for TRIM37 Gene
- HGNC(7523)
- Entrez Gene(4591)
- Ensembl(ENSG00000108395)
- OMIM(605073)
- UniProtKB(O94972)
- Open Targets Platform(ENSG00000108395)
- Monarch Initiative
- Search for TRIM37 at DataMed
- Search for TRIM37 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRIM37 Gene
Genomics for TRIM37 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TRIM37 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TRIM37 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRIM37
- Top Transcription factor binding sites by QIAGEN in the TRIM37 gene promoter:
-
- ATF6
- Cart-1
- CUTL1
- E47
- p53
- SREBP-1a
- SREBP-1b
- SREBP-1c
- Tal-1
Genomic Locations for TRIM37 Gene
Genomic Locations for TRIM37 Gene
- chr17:58,968,010-59,106,921
- (GRCh38/hg38)
- Size:
- 138,912 bases
- Orientation:
- Minus strand
- chr17:57,059,999-57,184,282
- (GRCh37/hg19)
- Size:
- 124,284 bases
- Orientation:
- Minus strand
Genomic View for TRIM37 Gene
Genes around TRIM37 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q22 by HGNC
- 17q22 by Entrez Gene
- 17q22 by Ensembl
TRIM37 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TRIM37 Gene
Proteins for TRIM37 Gene
-
Protein details for TRIM37 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O94972-TRI37_HUMAN
- Recommended name:
- E3 ubiquitin-protein ligase TRIM37
- Protein Accession:
- O94972
- A8K0V9
- A8K8U4
- A8MZ79
- B4DGZ3
- F8WEE6
- Q7Z3E6
- Q8IYF7
- Q8WYF7
Protein attributes for TRIM37 Gene
- Size:
- 964 amino acids
- Molecular mass:
- 107906 Da
- Quaternary structure:
-
- Associates with the PRC2/EED-EZH2 complex.
- SequenceCaution:
-
- Sequence=BAA74921.1; Type=Erroneous initiation; Evidence={ECO:0000305};
- Miscellaneous:
-
- Acts as a proto-oncogene via its ability to monoubiquinate 'Lys-119' of histone H2A (H2AK119Ub): overexpressed in a number of breast cancers and promotes transformation of cells by mediating silencing of tumor suppressor genes (PubMed:25470042).
Protein Expression for TRIM37 Gene
Post-translational modifications for TRIM37 Gene
- Auto-ubiquitinated.
-
Ubiquitination at Lys742
- NX_O94972 (NX_O94972-1)
- Modification sites at PhosphoSitePlus
Other Protein References for TRIM37 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_005257442.1
- XP_011523133.1
- XP_011523134.1
- XP_011523135.1
- XP_011523136.1
- XP_011523138.1
- XP_016880151.1
- XP_016880152.1
- XP_016880153.1
- XP_016880154.1
- XP_016880156.1
- XP_016880158.1
- XP_016880159.1
- XP_016880160.1
- XP_016880161.1
- XP_016880162.1
- XP_024306533.1
- NP_001005207.1
- NP_001307916.1
- NP_001307917.1
- NP_001307918.1
- NP_001307919.1
- NP_001340011.1
- NP_001340012.1
- NP_001340013.1
- NP_001340014.1
- NP_001340015.1
- NP_056109.1
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for TRIM37
- Novus Biologicals Antibodies for TRIM37
-
Abcam antibodies for TRIM37
- Invitrogen Antibodies for TRIM37 (AFLGC-TRIM37)
-
Santa Cruz Biotechnology (SCBT) Antibodies for TRIM37
- Sino Biological Antibodies for TRIM37
Protein Products
-
OriGene Purified Proteins for TRIM37
- Search Origene for MassSpec and Protein Over-expression Lysates for TRIM37
- Origene Custom Protein Services for TRIM37
- antibodies-online: Show 6 available TRIM37 Proteins ranked by validation data
- Compare Top TRIM37 Proteins
-
Quality Products:
-
Abcam proteins for TRIM37
No data available for DME Specific Peptides for TRIM37 Gene
Domains & Families for TRIM37 Gene
Gene Families for TRIM37 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for TRIM37 Gene
- InterPro:
- Blocks:
-
- Zn-finger, RING
- B-box zinc finger signature
- B-box, C-terminal
- Meprin/TRAF-like MATH
- ProtoNet:
Suggested Antigen Peptide Sequences for TRIM37 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ75453, highly similar to Homo sapiens tripartite motif-containing 37 (TRIM37), transcript variant 2, mRNA (A8K0V9_HUMAN)
- Tripartite motif-containing protein 37 (TRI37_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O94972- Family:
-
- Belongs to the TRIM/RBCC family.
Function for TRIM37 Gene
Molecular function for TRIM37 Gene
- UniProtKB/Swiss-Prot Function:
- E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Has anti-HIV activity (PubMed:24317724).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence={ECO:0000269|PubMed:15885686};.
- UniProtKB/Swiss-Prot Induction:
- Overexpressed in a number of breast cancer cell lines.
Enzyme Numbers (IUBMB) for TRIM37 Gene
Phenotypes From GWAS Catalog for TRIM37 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003682 | chromatin binding | IEA | -- |
| GO:0004842 | ubiquitin-protein transferase activity | IDA | 15885686 |
| GO:0005164 | tumor necrosis factor receptor binding | IBA,IPI | 11279055 |
| GO:0005515 | protein binding | IEA,IPI | 11279055 |
| GO:0008270 | zinc ion binding | IEA | -- |
Phenotypes for TRIM37 Gene
- MGI mutant phenotypes for TRIM37:
-
inferred from 1 alleles
- nervous system phenotype
- immune system phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- neoplasm
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- skeleton phenotype
- hematopoietic system phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for TRIM37:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- shRNA abundance <= 50%
- shRNA abundance <= 25%
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased S DNA content
- Increased centriole number
- Increased viability with MLN4924 (a NAE inhibitor)
- S arrest
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TRIM37 - Select products 50% OFF >
- * TRIM37 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TRIM37
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TRIM37
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRIM37
miRNA for TRIM37 Gene
- miRTarBase miRNAs that target TRIM37
-
- mmu-miR-30e-5p (MIRT013267)
- hsa-miR-124-3p (MIRT022999)
- hsa-miR-769-3p (MIRT039127)
- hsa-miR-30e-3p (MIRT044117)
- hsa-miR-183-5p (MIRT047093)
- hsa-miR-937-5p (MIRT500674)
- hsa-miR-4291 (MIRT500675)
- hsa-miR-19b-3p (MIRT500676)
- hsa-miR-19a-3p (MIRT500677)
- hsa-miR-4696 (MIRT500678)
- hsa-miR-5702 (MIRT500679)
- hsa-miR-7157-5p (MIRT500680)
- hsa-miR-4310 (MIRT500681)
- hsa-miR-545-3p (MIRT500682)
- hsa-miR-1179 (MIRT500683)
- hsa-miR-451b (MIRT500684)
- hsa-miR-519c-3p (MIRT500685)
- hsa-miR-519b-3p (MIRT500686)
- hsa-miR-519a-3p (MIRT500687)
- hsa-miR-7-2-3p (MIRT500688)
- hsa-miR-5688 (MIRT500689)
- hsa-miR-7-1-3p (MIRT500690)
- hsa-miR-495-3p (MIRT500691)
- hsa-miR-559 (MIRT500692)
- hsa-miR-548y (MIRT500693)
- hsa-miR-548w (MIRT500694)
- hsa-miR-548o-5p (MIRT500695)
- hsa-miR-548j-5p (MIRT500696)
- hsa-miR-548i (MIRT500697)
- hsa-miR-548h-5p (MIRT500698)
- hsa-miR-548d-5p (MIRT500699)
- hsa-miR-548c-5p (MIRT500700)
- hsa-miR-548bb-5p (MIRT500701)
- hsa-miR-548b-5p (MIRT500702)
- hsa-miR-548ay-5p (MIRT500703)
- hsa-miR-548au-5p (MIRT500704)
- hsa-miR-548as-5p (MIRT500705)
- hsa-miR-548ar-5p (MIRT500706)
- hsa-miR-548aq-5p (MIRT500707)
- hsa-miR-548ap-5p (MIRT500708)
- hsa-miR-548am-5p (MIRT500709)
- hsa-miR-548ak (MIRT500710)
- hsa-miR-548ae-5p (MIRT500711)
- hsa-miR-548ad-5p (MIRT500712)
- hsa-miR-548ab (MIRT500713)
- hsa-miR-548a-5p (MIRT500714)
- hsa-miR-7844-5p (MIRT500715)
- hsa-miR-548t-5p (MIRT500716)
- hsa-miR-548az-5p (MIRT500717)
- hsa-miR-548n (MIRT500718)
- hsa-miR-106b-5p (MIRT500719)
- hsa-miR-93-5p (MIRT500720)
- hsa-miR-526b-3p (MIRT500721)
- hsa-miR-519d-3p (MIRT500722)
- hsa-miR-20b-5p (MIRT500723)
- hsa-miR-20a-5p (MIRT500724)
- hsa-miR-17-5p (MIRT500725)
- hsa-miR-106a-5p (MIRT500726)
- hsa-miR-130a-3p (MIRT500727)
- hsa-miR-130b-3p (MIRT500728)
- hsa-miR-301b-3p (MIRT500729)
- hsa-miR-3666 (MIRT500730)
- hsa-miR-4295 (MIRT500731)
- hsa-miR-454-3p (MIRT500732)
- hsa-miR-301a-3p (MIRT500733)
- hsa-miR-142-3p (MIRT545473)
- hsa-miR-519d-5p (MIRT545474)
- hsa-miR-6080 (MIRT545475)
- hsa-miR-622 (MIRT545476)
- hsa-miR-4255 (MIRT545477)
- hsa-miR-6888-5p (MIRT545478)
- hsa-miR-4428 (MIRT545479)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TRIM37
- Browse OriGene Inhibitory RNA Products For TRIM37
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM37
Clone Products
- Applied Biological Materials (abm): Clones for TRIM37 - Select products 50% OFF >
- * TRIM37 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG211317
- MR211317
- MR211317L3
- MR211317L4
- RC205948
- RC205948L1
- RC205948L2
- RC205948L3
- RC205948L4
- RC224302
- RC224302L1
- RC224302L2
- RC224302L3
- RC224302L4
- RG205948
- RG224302
- RR205061
- RR205061L3
- RR205061L4
- MR211317L3V
- MR211317L4V
- RC205948L1V
- RC205948L2V
- RC205948L3V
- RC205948L4V
- RC224302L1V
- RC224302L2V
- RC224302L3V
- RC224302L4V
- RR205061L3V
- RR205061L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TRIM37
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TRIM37
No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM37 Gene
Localization for TRIM37 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TRIM37 Gene
- Cytoplasm, perinuclear region. Peroxisome. Note=Found in vesicles of the peroxisome. Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteasomal degradation. {ECO:0000269 PubMed:15885686}.
| Compartment | Confidence |
|---|---|
| peroxisome | 5 |
| cytosol | 5 |
| nucleus | 3 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA,IDA | 23769972 |
| GO:0005777 | peroxisome | IBA,IDA | 11938494 |
| GO:0005829 | cytosol | IDA | 11279055 |
| GO:0016235 | aggresome | IBA,IDA | 15885686 |
| GO:0035098 | colocalizes_with ESC/E(Z) complex | IDA | 25470042 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for TRIM37 Gene
Pathways & Interactions for TRIM37 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Chromatin Regulation / Acetylation | ||
| 3 | Ubiquitin mediated proteolysis | ||
| 4 | Innate Immune System |
.61
|
|
Pathways by source for TRIM37 Gene
4 Reactome pathways for TRIM37 Gene
1 KEGG pathway for TRIM37 Gene
1 Cell Signaling Technology pathway for TRIM37 Gene
UniProtKB/Swiss-Prot O94972-TRI37_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for TRIM37 Gene
Selected Interacting proteins:
O94972-TRI37_HUMAN
ENSP00000262294
for TRIM37 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for TRIM37
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 25470042 |
| GO:0016567 | protein ubiquitination | IEA | -- |
| GO:0032088 | negative regulation of NF-kappaB transcription factor activity | IBA,IDA | 11279055 |
| GO:0035518 | histone H2A monoubiquitination | IDA | 25470042 |
| GO:0036353 | histone H2A-K119 monoubiquitination | IDA | 25470042 |
No data available for SIGNOR curated interactions for TRIM37 Gene
Transcripts for TRIM37 Gene
mRNA/cDNA for TRIM37 Gene
- 11 REFSEQ mRNAs :
- 16 NCBI additional mRNA sequence :
- 14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000262294 4489 nts (view in UCSC)
- ENST00000393065 3548 nts (view in UCSC)
- ENST00000393066 3622 nts (view in UCSC)
- ENST00000577554 4310 nts (view in UCSC)
- ENST00000580122 482 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TRIM37 - Select products 50% OFF >
- * TRIM37 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
OriGene CRISPR knockouts for TRIM37
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TRIM37
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRIM37
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TRIM37
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Clone Products
- Applied Biological Materials (abm): Clones for TRIM37 - Select products 50% OFF >
- * TRIM37 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG211317
- MR211317
- MR211317L3
- MR211317L4
- RC205948
- RC205948L1
- RC205948L2
- RC205948L3
- RC205948L4
- RC224302
- RC224302L1
- RC224302L2
- RC224302L3
- RC224302L4
- RG205948
- RG224302
- RR205061
- RR205061L3
- RR205061L4
- MR211317L3V
- MR211317L4V
- RC205948L1V
- RC205948L2V
- RC205948L3V
- RC205948L4V
- RC224302L1V
- RC224302L2V
- RC224302L3V
- RC224302L4V
- RR205061L3V
- RR205061L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TRIM37
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TRIM37
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: |
| ExUns: | 19b | ^ | 20a | · | 20b | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26a | · | 26b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||
| SP2: | - | - | |||||||||||||||||
| SP3: | |||||||||||||||||||
| SP4: | |||||||||||||||||||
| SP5: | |||||||||||||||||||
| SP6: | |||||||||||||||||||
| SP7: | |||||||||||||||||||
| SP8: | |||||||||||||||||||
| SP9: | - |
Relevant External Links for TRIM37 Gene
- GeneLoc Exon Structure for
- TRIM37
Expression for TRIM37 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
- XY Germ Cells Testis Cord
-
Gonad
- XY Germ Cells Testis Cord
mRNA differential expression in normal tissues according to GTEx for TRIM37 Gene
This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.6).
This gene is overexpressed in Adipocyte (38.6) and Testis (16.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRIM37 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRIM37
SOURCE GeneReport for Unigene cluster for TRIM37 Gene:
Hs.579079mRNA Expression by UniProt/SwissProt for TRIM37 Gene:
O94972-TRI37_HUMAN
Tissue specificity:
Ubiquitous (PubMed:10888877). Highly expressed in testis, while it is weakly expressed in other tissues (PubMed:16310976).
Evidence on tissue expression from TISSUES for TRIM37 Gene
- Nervous system(5)
- Kidney(2.6)
- Blood(2.1)
- Intestine(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM37 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- integumentary
- nervous
- respiratory
- skeletal muscle
- skeleton
- urinary
Regions:
Head and neck:
- brain
- cheek
- chin
- cranial nerve
- ear
- eye
- eyelid
- face
- forehead
- head
- jaw
- larynx
- mandible
- maxilla
- mouth
- neck
- nose
- sinus
- skull
- tongue
- tooth
- vocal cord
Thorax:
- heart
- heart valve
- lung
Abdomen:
- kidney
- liver
General:
- blood vessel
- peripheral nerve
- peripheral nervous system
- skin
Primer Products
-
OriGene qPCR primer pairs for TRIM37
-
OriGene qPCR primer pairs and template standards for TRIM37
Gene Expression Assay Products
Orthologs for TRIM37 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TRIM37 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Dog (Canis familiaris) |
Mammalia | TRIM37 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | TRIM37 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Trim37 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Trim37 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | TRIM37 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | TRIM37 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | TRIM37 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | trim37 30 |
|
||
| Str.3537 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | trim37 30 31 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.7142 31 |
|
OneToOne |
- Species where no ortholog for TRIM37 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for TRIM37 Gene
- ENSEMBL:
- Gene Tree for TRIM37 (if available)
- TreeFam:
- Gene Tree for TRIM37 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TRIM37: view image
Paralogs for TRIM37 Gene
Paralogs for TRIM37 Gene
- TRIM66 5
- TRIM46 5
- TRIM36 5
- TRIM24 5
- TRIM33 5
- TRIM28 5
- TRIM9 5
- TRIM72 5
- TRIM34 5
- TRIM6 5
- TRIM6-TRIM34 5
- TRIM67 5
- TRIM58 5
- TRIM2 5
- TRIM3 5
- TRIM42 5
- TRIM50 5
- TRIM16 5
- TRIM32 5
- MID2 5
- TRIM21 5
- TRIM4 5
- TRIM68 5
- TRIM22 5
- TRIM60 5
- TRIM5 5
- MID1 5
- TRIM10 5
- TRIM15 5
- TRIM26 5
- TRIM39 5
- TRIM47 5
- TRIM27 5
- TRIM62 5
- TRIM7 5
- TRIM38 5
- TRIM14 5
- TRIM41 5
- TRIM71 5
- TRIM11 5
- TRIM17 5
- TRIM56 5
- TRIM64C 5
- TRIM69 5
- TRIM45 5
- TRIM43 5
- TRIM75P 5
- RNF39 5
- MEFV 5
- TRIM39-RPP21 5
- TRIM35 5
- TRIM25 5
- TRIML2 5
- TRIML1 5
- TRIM77 5
- TRIM64B 5
- TRIM64 5
- TRIM54 5
- TRIM51GP 5
- TRIM49B 5
- TRIM13 5
- TRIM51 5
- TRIM43B 5
- TRIM31 5
- TRIM65 5
- TRIM55 5
- TRIM29 5
- TRIM49 5
- TRIM49D1 5
- TRIM49D2 5
- TRIM49C 5
- PML 5
- TRIM16L 5
- TRIM44 5
- TRIM61 5
- TRIM40 5
- TRIM63 5
- TRIM8 5
- TRIM52 5
- TRIM73 5
- TRIM48 5
- BSPRY 5
- TRIM74 5
- ENSG00000239920 5
(1) SIMAP similar genes for TRIM37 Gene using alignment to 10 proteins:
- TRI37_HUMAN
- A8K0V9_HUMAN
- F8WEE6_HUMAN
- J3KS72_HUMAN
- J3KT32_HUMAN
- J3KT90_HUMAN
- J3QRK3_HUMAN
- J3QSA0_HUMAN
- J3QSF6_HUMAN
- J3QSH5_HUMAN
Variants for TRIM37 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRIM37 Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 666333 | Likely Pathogenic: Mulibrey nanism syndrome | 59,056,920(-) | G/GGCGAGTAAGTC | FRAMESHIFT_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
| 714801 | Likely Benign: not provided | 59,081,214(-) | G/T | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT | |
| 725928 | Likely Benign: not provided | 59,049,361(-) | C/T | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
| 728184 | Likely Benign: not provided | 59,028,482(-) | G/T | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
| 729956 | Benign: not provided | 59,061,055(-) | T/C | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3270n100 | CNV | gain | 25217958 |
| esv2421884 | CNV | deletion | 20811451 |
| esv2675820 | CNV | deletion | 23128226 |
| esv2758699 | CNV | gain | 17122850 |
| esv3554606 | CNV | deletion | 23714750 |
| esv3640900 | CNV | loss | 21293372 |
| esv3640901 | CNV | loss | 21293372 |
| nsv1065063 | CNV | gain | 25217958 |
| nsv1127585 | CNV | deletion | 24896259 |
| nsv1134660 | CNV | deletion | 24896259 |
| nsv507849 | OTHER | sequence alteration | 20534489 |
| nsv510719 | CNV | deletion | 20534489 |
| nsv514855 | CNV | loss | 21397061 |
| nsv828068 | CNV | loss | 20364138 |
| nsv828069 | CNV | loss | 20364138 |
| nsv833499 | CNV | loss | 17160897 |
| nsv9574 | CNV | loss | 18304495 |
| nsv962452 | CNV | deletion | 23825009 |
Residual Variation Intolerance Score:
6.25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.77;
47.17% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TRIM37 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM37 Gene
Disorders for TRIM37 Gene
(7) MalaCards diseases for TRIM37 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| mulibrey nanism |
|
|
| acid-labile subunit deficiency |
|
|
| peroxisomal disease |
|
|
| constrictive pericarditis |
|
|
| peliosis hepatis |
|
|
Search TRIM37 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
TRI37_HUMAN- Mulibrey nanism (MUL) [MIM:253250]: An autosomal recessive growth disorder characterized by severe growth failure of prenatal onset, constrictive pericardium and progressive cardiomyopathy, facial dysmorphism, and failure of sexual maturation. Additional clinical features include hepatomegaly, muscle hypotonia, J-shaped sella turcica, yellowish dots in the ocular fundi, hypoplasia of various endocrine glands, insulin resistance with type 2 diabetes, and an increased risk for Wilms' tumor. {ECO:0000269 PubMed:10888877, ECO:0000269 PubMed:12754710, ECO:0000269 PubMed:15108285, ECO:0000269 PubMed:15885686, ECO:0000269 PubMed:17100991, ECO:0000269 PubMed:17551331, ECO:0000269 PubMed:21865362, ECO:0000269 PubMed:23385855}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for TRIM37
No data available for Genatlas for TRIM37 Gene
Publications for TRIM37 Gene
- A novel mutation in TRIM37 is associated with mulibrey nanism in a Turkish boy. (PMID: 17551331) Doğanc T … Tekin M (Clinical dysmorphology 2007) 3 4 23
- Wilms' tumor and novel TRIM37 mutations in an Australian patient with mulibrey nanism. (PMID: 17100991) Hämäläinen RH … Lehesjoki AE (Clinical genetics 2006) 3 4 23
- Characterisation of the mulibrey nanism-associated TRIM37 gene: transcription initiation, promoter region and alternative splicing. (PMID: 16310976) Hämäläinen RH … Lehesjoki AE (Gene 2006) 3 4 23
- Novel mutations in the TRIM37 gene in Mulibrey Nanism. (PMID: 15108285) Hämäläinen RH … Lehesjoki AE (Human mutation 2004) 3 4 23
- A novel splice site mutation in the TRIM37 gene causes mulibrey nanism in a Turkish family with phenotypic heterogeneity. (PMID: 12754710) Jagiello P … Gencik M (Human mutation 2003) 3 4 23
ExternalLinks
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