The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. Expression of this gene is up-regulated by interferon. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in... See more...

Aliases for TRIM34 Gene

Aliases for TRIM34 Gene

  • Tripartite Motif Containing 34 2 3 5
  • Tripartite Motif-Containing Protein 34 3 4
  • Interferon-Responsive Finger Protein 1 3 4
  • RNF21 3 4
  • IFP1 3 4
  • Ring Finger Protein 21, Interferon-Responsive 3
  • Tripartite Motif-Containing 34 2
  • RING Finger Protein 21 4
  • EC 6.3.2 51
  • TRIM34 5

External Ids for TRIM34 Gene

Previous HGNC Symbols for TRIM34 Gene

  • RNF21

Previous GeneCards Identifiers for TRIM34 Gene

  • GC11P006372
  • GC11P005920
  • GC11P005583
  • GC11P005582
  • GC11P005584
  • GC11P005574
  • GC11P005602
  • GC11P005300
  • GC11P005619

Summaries for TRIM34 Gene

Entrez Gene Summary for TRIM34 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. Expression of this gene is up-regulated by interferon. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from the upstream TRIM6 gene has also been observed, which results in a fusion product from these neighboring family members. [provided by RefSeq, Oct 2010]

GeneCards Summary for TRIM34 Gene

TRIM34 (Tripartite Motif Containing 34) is a Protein Coding gene. Diseases associated with TRIM34 include Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome. Among its related pathways are Interferon gamma signaling and Innate Immune System. An important paralog of this gene is TRIM6-TRIM34.

UniProtKB/Swiss-Prot Summary for TRIM34 Gene

  • May function as antiviral protein and may contribute to the defense against retroviral infections.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRIM34 Gene

Genomics for TRIM34 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TRIM34 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J005623 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 608 +5.7 5672 3.2 SP1 REST POLR2A STAT3 RELA PKNOX1 SMAD5 RCOR1 HDAC1 CEBPB TRIM34 lnc-OR52H1-1 TRIM5 TRIM22 OR51B2 OR56B4 OR56A1 OR56A3 OR52N4 OR51Q1
GH11J005618 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 600.7 +0.6 585 3.8 IKZF1 ZNF7 FOXA1 REST CEBPA EP300 SCRT2 SP1 CEBPB CTBP1 TRIM34 TRIM5 UBQLNL ENSG00000239920 HBG2 TRIM6 TRIM22 lnc-OR52H1-1 TRIM6-TRIM34
GH11J005631 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 600.4 +12.1 12139 1.8 RELA POLR2A RCOR1 TRIM22 YY1 SIN3A ARID3A PAX8 DPF2 RUNX3 TRIM34 FJ601666-011 lnc-OR52H1-1 TRIM6-TRIM34 ENSG00000239920 TRIM5
GH11J005815 Enhancer 1.1 FANTOM5 Ensembl ENCODE 3 +195.3 195337 3.4 JUND POLR2A IKZF2 HDAC1 EP300 CBX3 NFE2 ZNF316 MEF2D EP400 OR52N3P TRIM22 TRIM34 TRIM5 FAM160A2 OR52N5 OR52N2 piR-48209-082 OR52E6
GH11J006094 Enhancer 0.4 FANTOM5 Ensembl 3 +474.5 474537 1.4 MF281466-001 MF281466-002 OR56A1 OR52W1 FAM160A2 C11orf42 CAVIN3 TRIM5 TRIM34 OR52N1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRIM34 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRIM34

Top Transcription factor binding sites by QIAGEN in the TRIM34 gene promoter:
  • aMEF-2
  • CREB
  • deltaCREB
  • MEF-2
  • MEF-2A
  • STAT5A

Genomic Locations for TRIM34 Gene

Genomic Locations for TRIM34 Gene
chr11:5,619,764-5,644,398
(GRCh38/hg38)
Size:
24,635 bases
Orientation:
Plus strand
chr11:5,640,994-5,665,628
(GRCh37/hg19)
Size:
24,635 bases
Orientation:
Plus strand

Genomic View for TRIM34 Gene

Genes around TRIM34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM34 Gene

Proteins for TRIM34 Gene

  • Protein details for TRIM34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYJ4-TRI34_HUMAN
    Recommended name:
    Tripartite motif-containing protein 34
    Protein Accession:
    Q9BYJ4
    Secondary Accessions:
    • D3DQS7
    • Q9C016
    • Q9HCR0
    • Q9HCR1
    • Q9HCR2

    Protein attributes for TRIM34 Gene

    Size:
    488 amino acids
    Molecular mass:
    56864 Da
    Quaternary structure:
    • Homotrimer. Interacts (via the B30.2/SPRY domain) with HIV-1 capsid complexes (PubMed:17156811). Interacts (via B-box and SPRY domain) with TRIM5 (PubMed:21680743, PubMed:17156811).
    SequenceCaution:
    • Sequence=AAG53517.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB17050.1; Type=Miscellaneous discrepancy; Note=The in vivo relevance of this transcript of the TRIM6 (AC Q9C030) and TRIM34 genes creating a chimeric protein of 842 residues is uncertain.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRIM34 Gene

    Alternative splice isoforms for TRIM34 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM34 Gene

Selected DME Specific Peptides for TRIM34 Gene

Q9BYJ4:
  • CPICLEL
  • ICWLCERSQEHRGH
  • RVGVFLDYEA
  • AEKLEAD
  • GYWVIGL

Post-translational modifications for TRIM34 Gene

  • Ubiquitination at Lys173
  • Modification sites at PhosphoSitePlus

Other Protein References for TRIM34 Gene

Domains & Families for TRIM34 Gene

Gene Families for TRIM34 Gene

Protein Domains for TRIM34 Gene

Suggested Antigen Peptide Sequences for TRIM34 Gene

GenScript: Design optimal peptide antigens:
  • RING finger protein 21 (TRI34_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BYJ4

UniProtKB/Swiss-Prot:

TRI34_HUMAN :
  • Belongs to the TRIM/RBCC family.
Family:
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM34: view

Function for TRIM34 Gene

Molecular function for TRIM34 Gene

UniProtKB/Swiss-Prot Function:
May function as antiviral protein and may contribute to the defense against retroviral infections.
UniProtKB/Swiss-Prot Induction:
[Isoform 1]: is up-regulated by interferons.

Enzyme Numbers (IUBMB) for TRIM34 Gene

Phenotypes From GWAS Catalog for TRIM34 Gene

Gene Ontology (GO) - Molecular Function for TRIM34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0019901 protein kinase binding IBA 21873635
GO:0042802 identical protein binding IPI 17156811
genes like me logo Genes that share ontologies with TRIM34: view
genes like me logo Genes that share phenotypes with TRIM34: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM34

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRIM34 Gene

Localization for TRIM34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM34 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM34 gene
Compartment Confidence
cytosol 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRIM34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IBA 21873635
GO:0005737 cytoplasm IEA,IDA 17156811
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TRIM34: view

Pathways & Interactions for TRIM34 Gene

genes like me logo Genes that share pathways with TRIM34: view

Pathways by source for TRIM34 Gene

Gene Ontology (GO) - Biological Process for TRIM34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IBA 21873635
GO:0010468 regulation of gene expression IBA 21873635
GO:0010508 positive regulation of autophagy IBA 21873635
GO:0016567 protein ubiquitination IBA 21873635
GO:0032880 regulation of protein localization IBA 21873635
genes like me logo Genes that share ontologies with TRIM34: view

No data available for SIGNOR curated interactions for TRIM34 Gene

Drugs & Compounds for TRIM34 Gene

No Compound Related Data Available

Transcripts for TRIM34 Gene

mRNA/cDNA for TRIM34 Gene

4 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM34

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM34 Gene

No ASD Table

Relevant External Links for TRIM34 Gene

GeneLoc Exon Structure for
TRIM34

Expression for TRIM34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRIM34 Gene

Protein differential expression in normal tissues from HIPED for TRIM34 Gene

This gene is overexpressed in Fetal testis (36.4) and Fetal heart (21.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRIM34 Gene



Protein tissue co-expression partners for TRIM34 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRIM34

mRNA Expression by UniProt/SwissProt for TRIM34 Gene:

Q9BYJ4-TRI34_HUMAN
Tissue specificity: [Isoform 1]: is the most abundant form. It is highly expressed in the placenta, spleen, colon and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for TRIM34 Gene

  • Lymph node(4.1)
  • Thyroid gland(4)
genes like me logo Genes that share expression patterns with TRIM34: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM34 Gene

Orthologs for TRIM34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM34 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TRIM34 30 31
  • 99.52 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 31
  • 42 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Trim34a 31
  • 28 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 14 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 14 (a)
OneToMany
Species where no ortholog for TRIM34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TRIM34 Gene

ENSEMBL:
Gene Tree for TRIM34 (if available)
TreeFam:
Gene Tree for TRIM34 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRIM34: view image

Paralogs for TRIM34 Gene

(18) SIMAP similar genes for TRIM34 Gene using alignment to 1 proteins:

  • TRI34_HUMAN
genes like me logo Genes that share paralogs with TRIM34: view

Variants for TRIM34 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRIM34 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs193920907 Uncertain Significance: Malignant tumor of prostate 5,632,327(+) G/A MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT
rs16933844 - p.Asn404Lys
rs3740997 - p.Asp282His
rs6578670 - p.Thr276Ser

Additional dbSNP identifiers (rs#s) for TRIM34 Gene

Structural Variations from Database of Genomic Variants (DGV) for TRIM34 Gene

Variant ID Type Subtype PubMed ID
esv3625239 CNV loss 21293372
esv3625241 CNV loss 21293372
esv3891920 CNV loss 25118596
nsv1041568 CNV loss 25217958
nsv1046068 CNV gain 25217958
nsv1048455 CNV gain 25217958
nsv1048608 CNV gain 25217958
nsv1053414 CNV gain 25217958
nsv1122581 CNV deletion 24896259
nsv553241 CNV gain 21841781
nsv553273 CNV gain 21841781

Variation tolerance for TRIM34 Gene

Residual Variation Intolerance Score: 74.2% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM34

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM34 Gene

Disorders for TRIM34 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRIM34 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with TRIM34: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM34 Gene

Publications for TRIM34 Gene

  1. Unique features of TRIM5alpha among closely related human TRIM family members. (PMID: 17156811) Li X … Sodroski J (Virology 2007) 3 4 23
  2. Molecular cloning of ring finger protein 21 (RNF21)/interferon-responsive finger protein (ifp1), which possesses two RING-B box-coiled coil domains in tandem. (PMID: 11013086) Orimo A … Muramatsu M (Genomics 2000) 3 4 23
  3. Determinants of the higher order association of the restriction factor TRIM5alpha and other tripartite motif (TRIM) proteins. (PMID: 21680743) Li X … Sodroski J (The Journal of biological chemistry 2011) 3 4
  4. Functional replacement of the RING, B-box 2, and coiled-coil domains of tripartite motif 5alpha (TRIM5alpha) by heterologous TRIM domains. (PMID: 16775307) Li X … Sodroski J (Journal of virology 2006) 3 23
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for TRIM34 Gene

Sources for TRIM34 Gene