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Aliases for TRIM34 Gene

Aliases for TRIM34 Gene

  • Tripartite Motif Containing 34 2 3 5
  • Interferon-Responsive Finger Protein 1 3 4
  • RNF21 3 4
  • IFP1 3 4
  • Ring Finger Protein 21, Interferon-Responsive 3
  • Tripartite Motif-Containing Protein 34 3
  • Tripartite Motif-Containing 34 2
  • RING Finger Protein 21 4
  • EC 6.3.2 56

External Ids for TRIM34 Gene

Previous HGNC Symbols for TRIM34 Gene

  • RNF21

Previous GeneCards Identifiers for TRIM34 Gene

  • GC11P006372
  • GC11P005920
  • GC11P005583
  • GC11P005582
  • GC11P005584
  • GC11P005574
  • GC11P005602
  • GC11P005300
  • GC11P005619

Summaries for TRIM34 Gene

Entrez Gene Summary for TRIM34 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. Expression of this gene is up-regulated by interferon. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from the upstream TRIM6 gene has also been observed, which results in a fusion product from these neighboring family members. [provided by RefSeq, Oct 2010]

GeneCards Summary for TRIM34 Gene

TRIM34 (Tripartite Motif Containing 34) is a Protein Coding gene. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. An important paralog of this gene is TRIM6-TRIM34.

UniProtKB/Swiss-Prot for TRIM34 Gene

  • May function as antiviral protein and may contribute to the defense against retroviral infections.

Additional gene information for TRIM34 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM34 Gene

Genomics for TRIM34 Gene

GeneHancer (GH) Regulatory Elements for TRIM34 Gene

Promoters and enhancers for TRIM34 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I005623 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 558 +5.7 5672 3.2 HDAC1 PKNOX1 SMAD1 SREBF2 ZBTB40 IRF4 RAD21 RFX5 YY1 FOS TRIM34 ENSG00000239920 TRIM5 TRIM22 OR51B2 OR56B4 OR56A1 OR56A3 OR52N4 OR51Q1
GH11I005618 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.6 585 3.8 TFAP4 FOXA2 TEAD4 TAL1 SIN3A RARA ZNF7 TCF12 CTBP1 FOXK2 TRIM34 TRIM5 UBQLNL ENSG00000239920 HBG2 TRIM6 TRIM22 TRIM6-TRIM34 GC11P005579
GH11I006479 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 9.9 +861.7 861668 3.6 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 TIMM10B ARFIP2 ENSG00000283977 FAM160A2 APBB1 SMPD1 TRIM34 GC11P006473 TRIM3
GH11I006233 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 9.9 +615.1 615085 2.5 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 FAM160A2 CNGA4 RRP8 APBB1 LOC644169 ENSG00000254641 CCKBR TRIM34 GC11M006236
GH11I005269 Promoter 1 EPDnew 9.9 -349.8 -349801 0.1 HDAC1 HNRNPUL1 MEIS2 PKNOX1 SMAD1 NFATC3 TAF9B ETV1 POLR2B MTA3 HBE1 FAM160A2 HBBP1 HBD HBB ENSG00000221031 HBG1 OR51V1 OR51B4 TRIM34
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRIM34 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRIM34 gene promoter:

Genomic Locations for TRIM34 Gene

Genomic Locations for TRIM34 Gene
24,635 bases
Plus strand

Genomic View for TRIM34 Gene

Genes around TRIM34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM34 Gene

Proteins for TRIM34 Gene

  • Protein details for TRIM34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tripartite motif-containing protein 34
    Protein Accession:
    Secondary Accessions:
    • D3DQS7
    • Q9C016
    • Q9HCR0
    • Q9HCR1
    • Q9HCR2

    Protein attributes for TRIM34 Gene

    488 amino acids
    Molecular mass:
    56864 Da
    Quaternary structure:
    • Homotrimer. Interacts (via the B30.2/SPRY domain) with HIV-1 capsid complexes (PubMed:17156811). Interacts (via B-box and SPRY domain) with TRIM5 (PubMed:21680743, PubMed:17156811).
    • Sequence=AAG53517.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB17050.1; Type=Miscellaneous discrepancy; Note=The in vivo relevance of this transcript of the TRIM6 (AC Q9C030) and TRIM34 genes creating a chimeric protein of 842 residues is uncertain.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRIM34 Gene

    Alternative splice isoforms for TRIM34 Gene


neXtProt entry for TRIM34 Gene

Selected DME Specific Peptides for TRIM34 Gene


Post-translational modifications for TRIM34 Gene

Other Protein References for TRIM34 Gene

Domains & Families for TRIM34 Gene

Gene Families for TRIM34 Gene

Suggested Antigen Peptide Sequences for TRIM34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRIM/RBCC family.
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM34: view

Function for TRIM34 Gene

Molecular function for TRIM34 Gene

UniProtKB/Swiss-Prot Function:
May function as antiviral protein and may contribute to the defense against retroviral infections.
UniProtKB/Swiss-Prot Induction:
Isoform 1 is up-regulated by interferons.

Enzyme Numbers (IUBMB) for TRIM34 Gene

Gene Ontology (GO) - Molecular Function for TRIM34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM34: view
genes like me logo Genes that share phenotypes with TRIM34: view

Animal Model Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRIM34 Gene

Localization for TRIM34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM34 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM34 gene
Compartment Confidence
cytosol 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRIM34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IDA,IEA 17156811
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TRIM34: view

Pathways & Interactions for TRIM34 Gene

genes like me logo Genes that share pathways with TRIM34: view

Pathways by source for TRIM34 Gene

Gene Ontology (GO) - Biological Process for TRIM34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051091 positive regulation of DNA binding transcription factor activity IDA 23077300
GO:0051607 defense response to virus IEA --
GO:0060333 interferon-gamma-mediated signaling pathway TAS --
GO:0070206 protein trimerization IDA 17156811
genes like me logo Genes that share ontologies with TRIM34: view

No data available for SIGNOR curated interactions for TRIM34 Gene

Drugs & Compounds for TRIM34 Gene

No Compound Related Data Available

Transcripts for TRIM34 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM34 Gene

No ASD Table

Relevant External Links for TRIM34 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM34 Gene

Protein differential expression in normal tissues from HIPED for TRIM34 Gene

This gene is overexpressed in Fetal testis (36.4) and Fetal heart (21.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIM34 Gene

Protein tissue co-expression partners for TRIM34 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRIM34 Gene:


mRNA Expression by UniProt/SwissProt for TRIM34 Gene:

Tissue specificity: Isoform 1 is the most abundant form. It is highly expressed in the placenta, spleen, colon and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for TRIM34 Gene

  • Lymph node(4)
  • Thyroid gland(4)
genes like me logo Genes that share expression patterns with TRIM34: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM34 Gene

Orthologs for TRIM34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM34 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRIM34 33 34
  • 99.52 (n)
(Bos Taurus)
Mammalia -- 34
  • 42 (a)
(Mus musculus)
Mammalia Trim34a 34
  • 28 (a)
(Gallus gallus)
Aves -- 34
  • 14 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 14 (a)
Species where no ortholog for TRIM34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM34 Gene

Gene Tree for TRIM34 (if available)
Gene Tree for TRIM34 (if available)

Paralogs for TRIM34 Gene

(18) SIMAP similar genes for TRIM34 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRIM34: view

Variants for TRIM34 Gene

Sequence variations from dbSNP and Humsavar for TRIM34 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs193920907 uncertain-significance, Malignant tumor of prostate 5,632,327(+) G/A 5_prime_UTR_variant
rs1000011327 -- 5,630,522(+) G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000043628 -- 5,630,215(+) A/T genic_upstream_transcript_variant, intron_variant
rs1000139707 -- 5,629,996(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000165634 -- 5,627,135(+) T/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM34 Gene

Variant ID Type Subtype PubMed ID
nsv553273 CNV gain 21841781
nsv553241 CNV gain 21841781
nsv1122581 CNV deletion 24896259
nsv1053414 CNV gain 25217958
nsv1048608 CNV gain 25217958
nsv1048455 CNV gain 25217958
nsv1046068 CNV gain 25217958
nsv1041568 CNV loss 25217958
esv3891920 CNV loss 25118596
esv3625241 CNV loss 21293372
esv3625239 CNV loss 21293372

Variation tolerance for TRIM34 Gene

Residual Variation Intolerance Score: 74.2% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM34 Gene

Disorders for TRIM34 Gene

Additional Disease Information for TRIM34

No disorders were found for TRIM34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM34 Gene

Publications for TRIM34 Gene

  1. Unique features of TRIM5alpha among closely related human TRIM family members. (PMID: 17156811) Li X … Sodroski J (Virology 2007) 3 4 22 58
  2. Molecular cloning of ring finger protein 21 (RNF21)/interferon-responsive finger protein (ifp1), which possesses two RING-B box-coiled coil domains in tandem. (PMID: 11013086) Orimo A … Muramatsu M (Genomics 2000) 3 4 22 58
  3. Determinants of the higher order association of the restriction factor TRIM5alpha and other tripartite motif (TRIM) proteins. (PMID: 21680743) Li X … Sodroski J (The Journal of biological chemistry 2011) 3 4 58
  4. Functional replacement of the RING, B-box 2, and coiled-coil domains of tripartite motif 5alpha (TRIM5alpha) by heterologous TRIM domains. (PMID: 16775307) Li X … Sodroski J (Journal of virology 2006) 3 22 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for TRIM34 Gene

Sources for TRIM34 Gene

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