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Aliases for TRIM32 Gene

Aliases for TRIM32 Gene

  • Tripartite Motif Containing 32 2 3 5
  • RING-Type E3 Ubiquitin Transferase TRIM32 3 4
  • Tripartite Motif-Containing Protein 32 3 4
  • 72 KDa Tat-Interacting Protein 3 4
  • HT2A 3 4
  • Limb Girdle Muscular Dystrophy 2H (Autosomal Recessive) 2
  • E3 Ubiquitin-Protein Ligase TRIM32 3
  • TAT-Interactive Protein, 72-KD 3
  • Tripartite Motif-Containing 32 2
  • Zinc-Finger Protein HT2A 3
  • Zinc Finger Protein HT2A 4
  • EC 4
  • LGMD2H 3
  • BBS11 3
  • TATIP 3

External Ids for TRIM32 Gene

Previous HGNC Symbols for TRIM32 Gene

  • LGMD2H

Previous GeneCards Identifiers for TRIM32 Gene

  • GC09P110277
  • GC09P111098
  • GC09P112903
  • GC09P114825
  • GC09P116529
  • GC09P118489
  • GC09P119449
  • GC09P089054

Summaries for TRIM32 Gene

Entrez Gene Summary for TRIM32 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM32 Gene

TRIM32 (Tripartite Motif Containing 32) is a Protein Coding gene. Diseases associated with TRIM32 include Muscular Dystrophy, Limb-Girdle, Type 2H and Bardet-Biedl Syndrome 11. Among its related pathways are Class I MHC mediated antigen processing and presentation and Ubiquitin mediated proteolysis. Gene Ontology (GO) annotations related to this gene include RNA binding and ubiquitin-protein transferase activity. An important paralog of this gene is NHLRC4.

UniProtKB/Swiss-Prot for TRIM32 Gene

  • Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May ubiquitinate BBS2. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo.

Gene Wiki entry for TRIM32 Gene

Additional gene information for TRIM32 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM32 Gene

Genomics for TRIM32 Gene

GeneHancer (GH) Regulatory Elements for TRIM32 Gene

Promoters and enhancers for TRIM32 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J116686 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 650.7 +1.2 1211 4.6 PKNOX1 ATF1 ZFP64 SIN3A DMAP1 YY1 GLIS2 ZNF143 ZNF207 ATF7 ASTN2 TRIM32 ASTN2-AS1 PAPPA GC09P116705
GH09J116661 Enhancer 0.8 Ensembl ENCODE 12.1 -26.1 -26101 0.4 CTCF ZNF654 TRIM22 REST ZNF384 RAD21 RFX5 SMC3 ZNF143 MIXL1 TRIM32 ASTN2 ENSG00000230894 PAPPA LOC105376240
GH09J116662 Enhancer 0.2 ENCODE 12.2 -24.1 -24145 2.1 ASTN2 TRIM32 ENSG00000230894 PAPPA LOC105376240
GH09J116643 Enhancer 0.2 ENCODE 11.6 -43.2 -43153 0.6 ASTN2 TRIM32 PAPPA ENSG00000230894 ASTN2-AS1 LOC105376240
GH09J116717 Enhancer 0.2 ENCODE 11.2 +30.1 30075 0.2 TRIM32 ASTN2 GC09P116707 PIR58420 LOC105376239
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRIM32 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRIM32 gene promoter:
  • GATA-2
  • GATA-1
  • HSF2
  • GATA-3
  • HOXA3
  • USF-1
  • USF1

Genomic Locations for TRIM32 Gene

Genomic Locations for TRIM32 Gene
13,999 bases
Plus strand
13,999 bases
Plus strand

Genomic View for TRIM32 Gene

Genes around TRIM32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM32 Gene

Proteins for TRIM32 Gene

  • Protein details for TRIM32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase TRIM32
    Protein Accession:
    Secondary Accessions:
    • Q9NQP8

    Protein attributes for TRIM32 Gene

    653 amino acids
    Molecular mass:
    71989 Da
    Quaternary structure:
    • Interacts with DTNBP1. It self-associates.

    Three dimensional structures from OCA and Proteopedia for TRIM32 Gene

neXtProt entry for TRIM32 Gene

Post-translational modifications for TRIM32 Gene

  • Ubiquitinated.
  • Ubiquitination at isoforms=627, posLast=506506, isoforms=471, isoforms=282, isoforms=215, posLast=204204, and posLast=175175
  • Modification sites at PhosphoSitePlus

Other Protein References for TRIM32 Gene

No data available for DME Specific Peptides for TRIM32 Gene

Domains & Families for TRIM32 Gene

Gene Families for TRIM32 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TRIM32 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRIM/RBCC family.
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM32: view

Function for TRIM32 Gene

Molecular function for TRIM32 Gene

UniProtKB/Swiss-Prot Function:
Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May ubiquitinate BBS2. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo.
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Enzyme Numbers (IUBMB) for TRIM32 Gene

Gene Ontology (GO) - Molecular Function for TRIM32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity TAS 7778269
GO:0003723 RNA binding ISS --
GO:0004842 ubiquitin-protein transferase activity IEA,IDA 19349376
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with TRIM32: view
genes like me logo Genes that share phenotypes with TRIM32: view

Human Phenotype Ontology for TRIM32 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TRIM32 Gene

MGI Knock Outs for TRIM32:

Animal Model Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for TRIM32 Gene

Localization for TRIM32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM32 Gene

Cytoplasm. Note=Localized in cytoplasmic bodies, often located around the nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM32 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRIM32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus TAS,ISS --
GO:0005737 cytoplasm IEA,IDA 19349376
GO:0005829 cytosol TAS --
GO:0005863 colocalizes_with striated muscle myosin thick filament ISS --
genes like me logo Genes that share ontologies with TRIM32: view

Pathways & Interactions for TRIM32 Gene

genes like me logo Genes that share pathways with TRIM32: view

UniProtKB/Swiss-Prot Q13049-TRI32_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for TRIM32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IDA 18632609
GO:0001894 tissue homeostasis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IMP 19349376
GO:0007014 actin ubiquitination IEA --
GO:0009411 response to UV ISS --
genes like me logo Genes that share ontologies with TRIM32: view

No data available for SIGNOR curated interactions for TRIM32 Gene

Drugs & Compounds for TRIM32 Gene

(3) Drugs for TRIM32 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(1) Additional Compounds for TRIM32 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
genes like me logo Genes that share compounds with TRIM32: view

Transcripts for TRIM32 Gene

mRNA/cDNA for TRIM32 Gene

Unigene Clusters for TRIM32 Gene

Tripartite motif containing 32:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM32 Gene

No ASD Table

Relevant External Links for TRIM32 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM32 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM32 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRIM32 Gene

This gene is overexpressed in Breast (23.8), Lung (9.6), and Bone (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRIM32 Gene

Protein tissue co-expression partners for TRIM32 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRIM32 Gene:


SOURCE GeneReport for Unigene cluster for TRIM32 Gene:


mRNA Expression by UniProt/SwissProt for TRIM32 Gene:

Tissue specificity: Spleen, thymus, prostate, testis, ovary, intestine, colon and skeletal muscle.

Evidence on tissue expression from TISSUES for TRIM32 Gene

  • Skin(4.2)
  • Nervous system(2.6)
  • Muscle(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM32 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • head
  • jaw
  • mandible
  • maxilla
  • middle ear
  • mouth
  • neck
  • olfactory bulb
  • pituitary gland
  • skull
  • tooth
  • breast
  • bronchus
  • clavicle
  • heart
  • heart valve
  • lung
  • scapula
  • biliary tract
  • gallbladder
  • kidney
  • liver
  • pancreas
  • ovary
  • pelvis
  • penis
  • prostate
  • testicle
  • ureter
  • urethra
  • urinary bladder
  • uterus
  • vagina
  • vulva
  • arm
  • digit
  • finger
  • foot
  • hand
  • humerus
  • lower limb
  • shin
  • shoulder
  • toe
  • upper limb
  • blood
  • blood vessel
  • hair
  • peripheral nerve
  • peripheral nervous system
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with TRIM32: view

No data available for mRNA differential expression in normal tissues for TRIM32 Gene

Orthologs for TRIM32 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM32 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRIM32 34 33
  • 99.69 (n)
(Canis familiaris)
Mammalia TRIM32 34 33
  • 91.04 (n)
(Rattus norvegicus)
Mammalia Trim32 33
  • 88.45 (n)
(Mus musculus)
Mammalia Trim32 16 34 33
  • 87.99 (n)
(Ornithorhynchus anatinus)
Mammalia TRIM32 34
  • 86 (a)
(Bos Taurus)
Mammalia TRIM32 34 33
  • 85.96 (n)
(Gallus gallus)
Aves TRIM32 33
  • 74.77 (n)
(Anolis carolinensis)
Reptilia TRIM32 34
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia trim32 33
  • 66.72 (n)
(Danio rerio)
Actinopterygii trim32 34 33
  • 63.89 (n)
Species where no ortholog for TRIM32 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM32 Gene

Gene Tree for TRIM32 (if available)
Gene Tree for TRIM32 (if available)
Evolutionary constrained regions (ECRs) for TRIM32: view image

Paralogs for TRIM32 Gene

Paralogs for TRIM32 Gene

(1) SIMAP similar genes for TRIM32 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TRIM32: view

Variants for TRIM32 Gene

Sequence variations from dbSNP and Humsavar for TRIM32 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs111033570 pathogenic, Sarcotubular myopathy, Myopathy, Bardet-Biedl syndrome, Limb-girdle muscular dystrophy 2H (LGMD2H) [MIM:254110] 116,699,201(+) G/A coding_sequence_variant, missense_variant
rs111033571 pathogenic, Bardet-Biedl syndrome 11, Bardet-Biedl syndrome, Bardet-Biedl syndrome 11 (BBS11) [MIM:615988] 116,698,130(+) C/T coding_sequence_variant, missense_variant
rs116058338 uncertain-significance, Limb-Girdle Muscular Dystrophy, Recessive, Bardet-Biedl syndrome 116,700,396(+) C/G 3_prime_UTR_variant
rs117599771 likely-benign, not specified, Bardet-Biedl syndrome 116,698,300(+) G/C coding_sequence_variant, missense_variant
rs121434447 pathogenic, uncertain-significance, Sarcotubular myopathy, not specified, Limb-girdle muscular dystrophy 2H (LGMD2H) [MIM:254110] 116,698,923(+) G/A coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM32 Gene

Variant ID Type Subtype PubMed ID
nsv831702 CNV gain 17160897
nsv7434 OTHER inversion 18451855
nsv615255 CNV loss 21841781
nsv475016 CNV novel sequence insertion 20440878
nsv1047432 CNV loss 25217958
nsv1047284 CNV loss 25217958
nsv1043149 CNV loss 25217958
esv3573372 CNV loss 25503493
dgv7708n100 CNV loss 25217958

Variation tolerance for TRIM32 Gene

Residual Variation Intolerance Score: 13.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.61; 30.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM32 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM32 Gene

Disorders for TRIM32 Gene

MalaCards: The human disease database

(15) MalaCards diseases for TRIM32 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
muscular dystrophy, limb-girdle, type 2h
  • lgmd2h
bardet-biedl syndrome 11
  • bbs11
bardet-biedl syndrome
  • biedl-bardet syndrome
  • muscular diseases
bardet-biedl syndrome 1
  • bbs1
- elite association - COSMIC cancer census association via MalaCards


  • Limb-girdle muscular dystrophy 2H (LGMD2H) [MIM:254110]: An autosomal recessive degenerative myopathy characterized by pelvic girdle, shoulder girdle and quadriceps muscle weakness. Clinical phenotype and severity are highly variable. Disease progression is slow and most patients remain ambulatory into the sixth decade of life. {ECO:0000269 PubMed:11822024, ECO:0000269 PubMed:17994549}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Bardet-Biedl syndrome 11 (BBS11) [MIM:615988]: A syndrome characterized by usually severe pigmentary retinopathy, early-onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. Bardet-Biedl syndrome inheritance is autosomal recessive, but three mutated alleles (two at one locus, and a third at a second locus) may be required for clinical manifestation of some forms of the disease. {ECO:0000269 PubMed:16606853}. Note=The disease is caused by mutations affecting the gene represented in this entry. It has been suggested that TRIM32 might be the E3 ubiquitin ligase for BBS2, a component of the BBSome complex involved in ciliogenesis, that is ubiquitinated and degraded by the proteasome (PubMed:22500027). {ECO:0000269 PubMed:22500027}.

Additional Disease Information for TRIM32

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TRIM32: view

No data available for Genatlas for TRIM32 Gene

Publications for TRIM32 Gene

  1. Identification of a novel human zinc finger protein that specifically interacts with the activation domain of lentiviral Tat proteins. (PMID: 7778269) Fridell RA … Cullen BR (Virology 1995) 2 3 4 22 58
  2. Mutations that impair interaction properties of TRIM32 associated with limb-girdle muscular dystrophy 2H. (PMID: 17994549) Saccone V … Nigro V (Human mutation 2008) 3 4 22 58
  3. Homozygosity mapping with SNP arrays identifies TRIM32, an E3 ubiquitin ligase, as a Bardet-Biedl syndrome gene (BBS11). (PMID: 16606853) Chiang AP … Sheffield VC (Proceedings of the National Academy of Sciences of the United States of America 2006) 2 3 4 58
  4. Limb-girdle muscular dystrophy type 2H associated with mutation in TRIM32, a putative E3-ubiquitin-ligase gene. (PMID: 11822024) Frosk P … Wrogemann K (American journal of human genetics 2002) 3 4 22 58
  5. Simultaneous mutation detection in 90 retinal disease genes in multiple patients using a custom-designed 300-kb retinal resequencing chip. (PMID: 20801516) Booij JC … Florijn RJ (Ophthalmology 2011) 3 44 58

Products for TRIM32 Gene

Sources for TRIM32 Gene

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