Aliases for TRIM32 Gene
External Ids for TRIM32 Gene
Previous HGNC Symbols for TRIM32 Gene
Previous GeneCards Identifiers for TRIM32 Gene
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes. [provided by RefSeq, Jul 2008]
GeneCards Summary for TRIM32 Gene
TRIM32 (Tripartite Motif Containing 32) is a Protein Coding gene. Diseases associated with TRIM32 include Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 8 and Bardet-Biedl Syndrome 11. Among its related pathways are Class I MHC mediated antigen processing and presentation and Cytosolic sensors of pathogen-associated DNA. Gene Ontology (GO) annotations related to this gene include RNA binding and ubiquitin-protein transferase activity. An important paralog of this gene is TRIM2.
UniProtKB/Swiss-Prot Summary for TRIM32 Gene
Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May ubiquitinate BBS2. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo.