This gene encodes a protein that functions as an E3 ubiquitin-protein ligase. This gene shows altered expression in certain tumors and may be a negative regulator of cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016] See more...

Aliases for TRIM31 Gene

Aliases for TRIM31 Gene

  • Tripartite Motif Containing 31 2 3 5
  • C6orf13 2 3 4
  • RNF 2 3 4
  • RING-Type E3 Ubiquitin Transferase TRIM31 3 4
  • Tripartite Motif-Containing Protein 31 3 4
  • E3 Ubiquitin-Protein Ligase TRIM31 3 4
  • HCG1 2 3
  • HCGI 2 3
  • Tripartite Motif-Containing 31 2
  • EC 2.3.2.27 4
  • TRIM31 5

External Ids for TRIM31 Gene

Previous GeneCards Identifiers for TRIM31 Gene

  • GC06M030155
  • GC06M029841
  • GC06M030176
  • GC06M030178
  • GC06M030073
  • GC06M029887
  • GC06M030129
  • GC06M030103
  • GC06M030433
  • GC06M030483
  • GC06M030516
  • GC06M030652
  • GC06M030108
  • GC06M030170
  • GC06M030218
  • GC06M030244
  • GC06M030278
  • GC06M030312
  • GC06M030355
  • GC06M030393

Summaries for TRIM31 Gene

Entrez Gene Summary for TRIM31 Gene

  • This gene encodes a protein that functions as an E3 ubiquitin-protein ligase. This gene shows altered expression in certain tumors and may be a negative regulator of cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for TRIM31 Gene

TRIM31 (Tripartite Motif Containing 31) is a Protein Coding gene. Diseases associated with TRIM31 include Frontometaphyseal Dysplasia and Pseudopapilledema. Among its related pathways are Interferon gamma signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is TRIM26.

UniProtKB/Swiss-Prot Summary for TRIM31 Gene

  • Regulator of Src-induced anchorage independent cell growth (By similarity). May have E3 ubiquitin-protein ligase activity.

Gene Wiki entry for TRIM31 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRIM31 Gene

Genomics for TRIM31 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TRIM31 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J030111 Promoter/Enhancer 1.1 Ensembl ENCODE 608 +0.4 437 2.9 SP1 GATAD2A RELA RXRB TCF12 IKZF2 ZNF600 PKNOX1 CEBPA CEBPB TRIM31 lnc-RNF39-5 HLA-U HLA-H ZFP57 ZNRD1ASP HCG4 RNF39 HCG18 HLA-A
GH06J030114 Enhancer 0.3 Ensembl 608 -1.3 -1311 0.4 SCRT2 TRIM31 lnc-RNF39-5 HLA-U piR-50528 TRIM31-AS1 TRIM40
GH06J030133 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 47 -22.5 -22522 4.2 GATAD2A ATF7 TFE3 SOX13 ZNF7 RXRB IRF2 CEBPA FOXK2 KMT2B TRIM40 NONHSAG045567.2 TRIM31 HLA-K HLA-A ENSG00000237669 TRIM31-AS1 TRIM10 TRIM15 PPP1R10
GH06J030210 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 24.2 -100.3 -100341 5.1 BRCA1 SP1 HNRNPL CREB1 PRDM10 ZNF629 TFE3 NFKBIZ RFX5 KDM1A TRIM26 lnc-TRIM10-1 lnc-TRIM15-2 piR-32264 HLA-U PPP1R10 HLA-K TRIM39 MDC1 PAIP1P1
GH06J030129 Enhancer 1.2 Ensembl ENCODE 30.5 -17.7 -17728 3.2 GATAD2A CTCF PRDM10 TFE3 RFX1 NFKBIZ ZNF692 RCOR2 JUND STAT3 TRIM40 TRIM31 TRIM31-AS1 TRIM10 TRIM15 HLA-A HCG18 ENSG00000252228 lnc-TRIM31-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRIM31 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRIM31

Top Transcription factor binding sites by QIAGEN in the TRIM31 gene promoter:
  • AML1a
  • GATA-2
  • GATA-3
  • NF-kappaB
  • NF-kappaB1
  • PPAR-gamma1
  • PPAR-gamma2
  • RelA

Genomic Locations for TRIM31 Gene

Genomic Locations for TRIM31 Gene
chr6:30,102,892-30,113,090
(GRCh38/hg38)
Size:
10,199 bases
Orientation:
Minus strand
chr6:30,070,674-30,080,883
(GRCh37/hg19)
Size:
10,210 bases
Orientation:
Minus strand

Genomic View for TRIM31 Gene

Genes around TRIM31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for TRIM31 Gene

  • Protein details for TRIM31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZY9-TRI31_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM31
    Protein Accession:
    Q9BZY9
    Secondary Accessions:
    • A6NLX6
    • A9R9Q4
    • Q53H52
    • Q5RI37
    • Q5SRJ7
    • Q5SRJ8
    • Q5SS28
    • Q96AK4
    • Q96AP8
    • Q99579
    • Q9BZY8

    Protein attributes for TRIM31 Gene

    Size:
    425 amino acids
    Molecular mass:
    48244 Da
    Quaternary structure:
    • Interacts with isoform p52shc of SHC1 (By similarity). May form oligomers.
    SequenceCaution:
    • Sequence=AAH16866.1; Type=Erroneous initiation; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform Beta]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Three dimensional structures from OCA and Proteopedia for TRIM31 Gene

    Alternative splice isoforms for TRIM31 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM31 Gene

Post-translational modifications for TRIM31 Gene

Other Protein References for TRIM31 Gene

No data available for DME Specific Peptides for TRIM31 Gene

Domains & Families for TRIM31 Gene

Gene Families for TRIM31 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for TRIM31 Gene

InterPro:
Blocks:
  • Zn-finger, RING
  • B-box zinc finger signature
ProtoNet:

Suggested Antigen Peptide Sequences for TRIM31 Gene

GenScript: Design optimal peptide antigens:
  • Tripartite motif-containing 31 gamma (C4B4E3_HUMAN)
  • cDNA FLJ75322, highly similar to Homo sapiens tripartite motif-containing 31, transcript variant 1, mRNA (Q2L6J1_HUMAN)
  • Tripartite motif-containing protein 31 (TRI31_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BZY9

UniProtKB/Swiss-Prot:

TRI31_HUMAN :
  • Belongs to the TRIM/RBCC family.
Family:
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM31: view

Function for TRIM31 Gene

Molecular function for TRIM31 Gene

UniProtKB/Swiss-Prot Function:
Regulator of Src-induced anchorage independent cell growth (By similarity). May have E3 ubiquitin-protein ligase activity.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27;.

Enzyme Numbers (IUBMB) for TRIM31 Gene

Phenotypes From GWAS Catalog for TRIM31 Gene

Gene Ontology (GO) - Molecular Function for TRIM31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IBA 21873635
genes like me logo Genes that share ontologies with TRIM31: view
genes like me logo Genes that share phenotypes with TRIM31: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TRIM31

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM31

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM31 Gene

Localization for TRIM31 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM31 Gene

Cytoplasm. Mitochondrion. Note=Predominantly expressed in the cytoplasm but a fraction is associated with the mitochondria.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM31 gene
Compartment Confidence
cytosol 5
mitochondrion 4
nucleus 4
plasma membrane 2
extracellular 2
golgi apparatus 2
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for TRIM31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IBA 21873635
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0016604 nuclear body IBA --
genes like me logo Genes that share ontologies with TRIM31: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TRIM31 Gene

Pathways & Interactions for TRIM31 Gene

genes like me logo Genes that share pathways with TRIM31: view

Pathways by source for TRIM31 Gene

UniProtKB/Swiss-Prot Q9BZY9-TRI31_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for TRIM31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010468 regulation of gene expression IBA 21873635
GO:0016567 protein ubiquitination IEA --
GO:0032897 negative regulation of viral transcription IDA 18248090
GO:0045087 innate immune response IMP 18248090
GO:0046597 negative regulation of viral entry into host cell IMP 18248090
genes like me logo Genes that share ontologies with TRIM31: view

No data available for SIGNOR curated interactions for TRIM31 Gene

Drugs & Compounds for TRIM31 Gene

No Compound Related Data Available

Transcripts for TRIM31 Gene

mRNA/cDNA for TRIM31 Gene

1 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM31

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM31 Gene

No ASD Table

Relevant External Links for TRIM31 Gene

GeneLoc Exon Structure for
TRIM31

Expression for TRIM31 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRIM31 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM31 Gene

This gene is overexpressed in Colon - Transverse (x23.0), Bladder (x9.6), Small Intestine - Terminal Ileum (x5.6), and Stomach (x4.3).

Protein differential expression in normal tissues from HIPED for TRIM31 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRIM31 Gene



Protein tissue co-expression partners for TRIM31 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRIM31

SOURCE GeneReport for Unigene cluster for TRIM31 Gene:

Hs.493275

mRNA Expression by UniProt/SwissProt for TRIM31 Gene:

Q9BZY9-TRI31_HUMAN
Tissue specificity: Up-regulated in gastric adenocarcinomas.

Evidence on tissue expression from TISSUES for TRIM31 Gene

  • Intestine(4.6)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with TRIM31: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM31 Gene

Orthologs for TRIM31 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRIM31 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TRIM31 30 31
  • 99.14 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TRIM31 30 31
  • 73.51 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Trim31 30 17 31
  • 70.04 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Trim31 30
  • 67.37 (n)
Species where no ortholog for TRIM31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TRIM31 Gene

ENSEMBL:
Gene Tree for TRIM31 (if available)
TreeFam:
Gene Tree for TRIM31 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRIM31: view image

Paralogs for TRIM31 Gene

(11) SIMAP similar genes for TRIM31 Gene using alignment to 3 proteins:

  • TRI31_HUMAN
  • C4B4E3_HUMAN
  • Q2L6J1_HUMAN
genes like me logo Genes that share paralogs with TRIM31: view

Variants for TRIM31 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRIM31 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
710431 Likely Benign: not provided 30,103,586(-) C/A NONSENSE,NON_CODING_TRANSCRIPT_VARIANT
712613 Likely Benign: not provided 30,110,485(-) T/C MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
768071 Benign: not provided 30,110,458(-) T/C MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
776117 Benign: not provided 30,110,488(-) A/G MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
776118 Benign: not provided 30,112,427(-) T/C MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT

Additional dbSNP identifiers (rs#s) for TRIM31 Gene

Structural Variations from Database of Genomic Variants (DGV) for TRIM31 Gene

Variant ID Type Subtype PubMed ID
esv2731777 CNV deletion 23290073
esv3411275 CNV duplication 20981092
esv3608503 CNV gain 21293372
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1144137 CNV deletion 24896259
nsv601264 CNV loss 21841781

Variation tolerance for TRIM31 Gene

Residual Variation Intolerance Score: 92.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.41; 81.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM31 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM31

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM31 Gene

Disorders for TRIM31 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TRIM31 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
frontometaphyseal dysplasia
  • fmd
pseudopapilledema
moyamoya disease 1
  • mymy1
gastric adenocarcinoma
  • adenocarcinoma of stomach
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TRIM31

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TRIM31: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM31 Gene

Publications for TRIM31 Gene

  1. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A … Ballabio A (The EMBO journal 2001) 2 3 4
  2. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 41
  3. Characterization of TRIM31, upregulated in gastric adenocarcinoma, as a novel RBCC protein. (PMID: 18773414) Sugiura T … Miyamoto K (Journal of cellular biochemistry 2008) 3 4
  4. An unappreciated role for RNA surveillance. (PMID: 14759258) Hillman RT … Brenner SE (Genome biology 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for TRIM31 Gene

  • Signalway Proteins for TRIM31

Sources for TRIM31 Gene