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This gene encodes a protein that functions as an E3 ubiquitin-protein ligase. This gene shows altered expression in certain tumors and may be a negative regulator of cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
TRIM31 (Tripartite Motif Containing 31) is a Protein Coding gene. Diseases associated with TRIM31 include Frontometaphyseal Dysplasia and Pseudopapilledema. Among its related pathways are Interferon gamma signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is TRIM26.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 16189514 |
GO:0008270 | zinc ion binding | IEA | -- |
GO:0016740 | transferase activity | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
GO:0061630 | ubiquitin protein ligase activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA,IBA | 21873635 |
GO:0005739 | mitochondrion | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0016604 | nuclear body | IBA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Interferon gamma signaling | ||
2 | Cytokine Signaling in Immune system | ||
3 | Innate Immune System |
.61
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GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0010468 | regulation of gene expression | IBA | 21873635 |
GO:0016567 | protein ubiquitination | IEA | -- |
GO:0032897 | negative regulation of viral transcription | IDA | 18248090 |
GO:0045087 | innate immune response | IMP | 18248090 |
GO:0046597 | negative regulation of viral entry into host cell | IMP | 18248090 |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TRIM31 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TRIM31 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Trim31 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Trim31 30 |
|
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
710431 | Likely Benign: not provided | 30,103,586(-) | C/A | NONSENSE,NON_CODING_TRANSCRIPT_VARIANT | |
712613 | Likely Benign: not provided | 30,110,485(-) | T/C | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
768071 | Benign: not provided | 30,110,458(-) | T/C | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
776117 | Benign: not provided | 30,110,488(-) | A/G | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
776118 | Benign: not provided | 30,112,427(-) | T/C | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2731777 | CNV | deletion | 23290073 |
esv3411275 | CNV | duplication | 20981092 |
esv3608503 | CNV | gain | 21293372 |
nsv1074389 | CNV | deletion | 25765185 |
nsv1122126 | CNV | deletion | 24896259 |
nsv1144137 | CNV | deletion | 24896259 |
nsv601264 | CNV | loss | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
frontometaphyseal dysplasia |
|
|
pseudopapilledema |
|
|
moyamoya disease 1 |
|
|
gastric adenocarcinoma |
|
|