Aliases for TRIM3 Gene
External Ids for TRIM3 Gene
Previous HGNC Symbols for TRIM3 Gene
Previous GeneCards Identifiers for TRIM3 Gene
The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for TRIM3 Gene
TRIM3 (Tripartite Motif Containing 3) is a Protein Coding gene. Diseases associated with TRIM3 include Schizophrenia 8. Among its related pathways are Interferon gamma signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity and protein C-terminus binding. An important paralog of this gene is TRIM2.
UniProtKB/Swiss-Prot Summary for TRIM3 Gene
Probably involved in vesicular trafficking via its association with the CART complex (PubMed:15772161). The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Positively regulates motility of microtubule-dependent motor protein KIF21B (By similarity).