Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of rad... See more...
Aliases for TRIM29 Gene
Aliases for TRIM29 Gene
External Ids for TRIM29 Gene
- HGNC: 17274
- Entrez Gene: 23650
- Ensembl: ENSG00000137699
- OMIM: 610658
- UniProtKB: Q14134
Previous GeneCards Identifiers for TRIM29 Gene
- GC11M121981
- GC11M121493
- GC11M120015
- GC11M119520
- GC11M119521
- GC11M119487
- GC11M115921
- GC11M119981
Summaries for TRIM29 Gene
-
The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype. [provided by RefSeq, Jul 2008]
GeneCards Summary for TRIM29 Gene
TRIM29 (Tripartite Motif Containing 29) is a Protein Coding gene. Diseases associated with TRIM29 include Ataxia-Telangiectasia. Among its related pathways are Interferon gamma signaling and Hematopoietic Stem Cell Differentiation. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and p53 binding. An important paralog of this gene is MEFV.
UniProtKB/Swiss-Prot Summary for TRIM29 Gene
-
Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of proinflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.
Additional gene information for TRIM29 Gene
- HGNC(17274)
- Entrez Gene(23650)
- Ensembl(ENSG00000137699)
- OMIM(610658)
- UniProtKB(Q14134)
- Open Targets Platform(ENSG00000137699)
- Search for TRIM29 at DataMed
- Search for TRIM29 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRIM29 Gene
Genomics for TRIM29 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TRIM29 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TRIM29 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRIM29
- Top Transcription factor binding sites by QIAGEN in the TRIM29 gene promoter:
-
- AREB6
- E47
- Egr-2
- Egr-3
- FOXI1
- GATA-2
- HFH-3
- S8
- Tal-1beta
Genomic Locations for TRIM29 Gene
Genomic Locations for TRIM29 Gene
- chr11:120,111,286-120,185,529
- (GRCh38/hg38)
- Size:
- 74,244 bases
- Orientation:
- Minus strand
- chr11:119,981,983-120,056,237
- (GRCh37/hg19)
- Size:
- 74,255 bases
- Orientation:
- Minus strand
Genomic View for TRIM29 Gene
Genes around TRIM29 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q23.3 by HGNC
- 11q23.3 by Entrez Gene
- 11q23.3 by Ensembl
TRIM29 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TRIM29 Gene
Proteins for TRIM29 Gene
-
Protein details for TRIM29 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14134-TRI29_HUMAN
- Recommended name:
- Tripartite motif-containing protein 29
- Protein Accession:
- Q14134
- Q96AA9
- Q9BZY7
Protein attributes for TRIM29 Gene
- Size:
- 588 amino acids
- Molecular mass:
- 65835 Da
- Quaternary structure:
-
- Interacts with VIM and HINT1 (PubMed:7644499). Interacts with IKBKG/NEMO (PubMed:27695001). Interacts with STING1 (PubMed:29038422).
Protein Expression for TRIM29 Gene
Post-translational modifications for TRIM29 Gene
- Constitutively phosphorylated by PKC on serine/threonine in A431 cells.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for TRIM29 Gene
Antibody Products
- G Biosciences Immunotag™ TRIM29 Antibody
- NSJ Bioreagents TRIM29 Antibody (Mouse Monoclonal)
- Novus Biologicals Antibodies for TRIM29
-
Abcam antibodies for TRIM29
- Invitrogen Antibodies for TRIM29 (AFLGC-Trim29)
-
Santa Cruz Biotechnology (SCBT) Antibodies for TRIM29
- Sino Biological Antibodies for TRIM29
Protein Products
-
OriGene Purified Proteins for TRIM29
- Search Origene for MassSpec and Protein Over-expression Lysates for TRIM29
- Origene Custom Protein Services for TRIM29
-
Signalway Proteins for TRIM29
-
Abcam proteins for TRIM29
No data available for DME Specific Peptides for TRIM29 Gene
Domains & Families for TRIM29 Gene
Gene Families for TRIM29 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for TRIM29 Gene
Suggested Antigen Peptide Sequences for TRIM29 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ52831, highly similar to Tripartite motif-containing protein 29 (B7Z8U9_HUMAN)
- TRIM29 protein (Q0P6H7_HUMAN)
- Ataxia telangiectasia group D-associated protein (TRI29_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TRIM29 Gene
Function for TRIM29 Gene
Molecular function for TRIM29 Gene
- UniProtKB/Swiss-Prot Function:
- Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of proinflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.
Phenotypes From GWAS Catalog for TRIM29 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002039 | p53 binding | IEA | -- |
| GO:0003700 | DNA-binding transcription factor activity | TAS | 8188213 |
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0008270 | zinc ion binding | IEA | -- |
| GO:0042802 | identical protein binding | IPI | 16189514 |
Phenotypes for TRIM29 Gene
- MGI mutant phenotypes for TRIM29:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for TRIM29:
Animal Models for TRIM29 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TRIM29 - Select products 50% OFF >
- * TRIM29 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TRIM29
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TRIM29
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRIM29
miRNA for TRIM29 Gene
- miRTarBase miRNAs that target TRIM29
-
- hsa-miR-124-3p (MIRT002561)
- hsa-miR-335-5p (MIRT018621)
- hsa-miR-122-5p (MIRT023394)
- hsa-miR-4526 (MIRT569600)
- hsa-miR-1228-5p (MIRT569601)
- hsa-miR-1268b (MIRT569602)
- hsa-miR-1268a (MIRT569603)
- hsa-miR-8085 (MIRT569604)
- hsa-miR-6853-5p (MIRT569605)
- hsa-miR-6731-5p (MIRT569606)
- hsa-miR-6836-5p (MIRT569607)
- hsa-miR-6132 (MIRT569608)
- hsa-miR-4524a-3p (MIRT569609)
- hsa-miR-6746-5p (MIRT569610)
- hsa-miR-761 (MIRT569611)
- hsa-miR-3619-5p (MIRT569612)
- hsa-miR-214-3p (MIRT569613)
- hsa-miR-6510-5p (MIRT569614)
- hsa-miR-15b-5p (MIRT731380)
- hsa-miR-185-5p (MIRT731749)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TRIM29
- Browse OriGene Inhibitory RNA Products For TRIM29
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM29
Clone Products
- Applied Biological Materials (abm): Clones for TRIM29 - Select products 50% OFF >
- * TRIM29 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for TRIM29
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TRIM29
Cell Line Products
-
Horizon Cell Lines for TRIM29
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIM29 Gene
Localization for TRIM29 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TRIM29 Gene
- Cytoplasm. Lysosome. Note=Colocalizes with intermediate filaments.
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| cytoskeleton | 3 |
| cytosol | 3 |
| lysosome | 3 |
| plasma membrane | 1 |
| extracellular | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
- Intermediate filaments (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005764 | lysosome | IEA | -- |
| GO:0005912 | adherens junction | HDA | 25468996 |
Pathways & Interactions for TRIM29 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Interferon gamma signaling | ||
| 2 | DNA Damage | ||
| 3 | Cytokine Signaling in Immune system | ||
| 4 | Innate Immune System |
.61
|
|
| 5 | Hematopoietic Stem Cell Differentiation | ||
Pathways by source for TRIM29 Gene
1 BioSystems pathway for TRIM29 Gene
4 Reactome pathways for TRIM29 Gene
1 Cell Signaling Technology pathway for TRIM29 Gene
Interacting Proteins for TRIM29 Gene
Selected Interacting proteins:
Q14134-TRI29_HUMAN
ENSP00000343129
for TRIM29 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for TRIM29
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0006366 | transcription by RNA polymerase II | TAS | 8188213 |
| GO:0045087 | innate immune response | IEA | -- |
| GO:0098609 | cell-cell adhesion | IEA | -- |
No data available for SIGNOR curated interactions for TRIM29 Gene
Transcripts for TRIM29 Gene
mRNA/cDNA for TRIM29 Gene
- 3 REFSEQ mRNAs :
- 16 NCBI additional mRNA sequence :
- 21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000341846 2977 nts (view in UCSC)
- ENST00000475051 1702 nts (view in UCSC)
- ENST00000524664 285 nts (view in UCSC)
- ENST00000524816 1632 nts (view in UCSC)
- ENST00000524956 314 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TRIM29 - Select products 50% OFF >
- * TRIM29 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TRIM29
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TRIM29
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRIM29
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TRIM29
- Browse OriGene Inhibitory RNA Products For TRIM29
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM29
Clone Products
- Applied Biological Materials (abm): Clones for TRIM29 - Select products 50% OFF >
- * TRIM29 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for TRIM29
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TRIM29
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18a | · | 18b | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - |
| ExUns: | 18c | · | 18d | · | 18e | · | 18f | · | 18g | ^ | 19a | · | 19b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||
| SP2: | |||||||||||||
| SP3: | |||||||||||||
| SP4: | |||||||||||||
| SP5: | |||||||||||||
| SP6: | |||||||||||||
| SP7: | |||||||||||||
| SP8: | |||||||||||||
| SP9: | |||||||||||||
| SP10: | |||||||||||||
| SP11: | |||||||||||||
| SP12: | |||||||||||||
| SP13: | - | - | - | - | - | ||||||||
| SP14: | |||||||||||||
| SP15: |
Relevant External Links for TRIM29 Gene
- GeneLoc Exon Structure for
- TRIM29
Expression for TRIM29 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Epithelial Cells
- Basal Cells Trachea
- Dental Placode Cells Dental Placode
-
Ovary (Reproductive System)
- Cumulus Cells Antral Follicle
-
Lung (Respiratory System)
- Basal Cells Trachea
-
Tooth (Integumentary System)
- Dental Placode Cells Dental Placode
-
Hair (Integumentary System)
- Bulge Stem Cells Bulge
- Gut Tube (Gastrointestinal Tract)
- Thymus (Hematopoietic System)
- Eye (Sensory Organs)
-
Placenta (Extraembryonic Tissues)
-
Tonsil (Hematopoietic System)
-
Esophagus (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for TRIM29 Gene
This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x13.2), Esophagus - Mucosa (x12.8), Skin - Not Sun Exposed (Suprapubic) (x11.4), and Vagina (x5.5).
This gene is overexpressed in Cervix (30.0), Hair follicle (21.7), and Nasal epithelium (11.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRIM29 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRIM29
SOURCE GeneReport for Unigene cluster for TRIM29 Gene:
Hs.504115mRNA Expression by UniProt/SwissProt for TRIM29 Gene:
Q14134-TRI29_HUMAN
Tissue specificity:
Expressed in placenta, prostate and thymus.
Evidence on tissue expression from TISSUES for TRIM29 Gene
- Skin(4.5)
- Blood(3)
- Intestine(2.4)
- Nervous system(2.1)
- Lung(2.1)
Primer Products
-
OriGene qPCR primer pairs for TRIM29
-
OriGene qPCR primer pairs and template standards for TRIM29
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM29 Gene
Orthologs for TRIM29 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TRIM29 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | TRIM29 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | TRIM29 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Trim29 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Trim29 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | TRIM29 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | TRIM29 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | TRIM29 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | TRIM29 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | trim29 30 |
|
||
| Str.3257 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC53484 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | TRIM29 (38 of 87) 31 |
|
OneToMany | |
| ftr19 31 31 |
|
OneToMany | |||
| TRIM29 (55 of 87) 31 |
|
OneToMany | |||
| CABZ01034858.1 31 |
|
OneToMany | |||
| ftr10 31 |
|
OneToMany | |||
| CABZ01034857.1 31 |
|
OneToMany | |||
| ftr05 31 |
|
OneToMany | |||
| ftr27 31 |
|
OneToMany | |||
| TRIM29 (71 of 87) 31 |
|
OneToMany | |||
| ftr08 31 |
|
OneToMany | |||
| ftr26 31 31 |
|
OneToMany | |||
| ftr09 31 |
|
OneToMany | |||
| ftr03 31 |
|
OneToMany | |||
| ftr69 31 |
|
OneToMany | |||
| ftr46 31 |
|
OneToMany | |||
| ftr04 31 |
|
OneToMany | |||
| ftr28l 31 |
|
OneToMany | |||
| TRIM29 (61 of 87) 31 |
|
OneToMany | |||
| ftr15 31 |
|
OneToMany | |||
| ftr06 31 |
|
OneToMany | |||
| ftr67 31 |
|
OneToMany | |||
| TRIM29 (36 of 87) 31 |
|
OneToMany | |||
| TRIM29 (50 of 87) 31 |
|
OneToMany | |||
| TRIM29 (86 of 87) 31 |
|
OneToMany | |||
| ftr50 31 |
|
OneToMany | |||
| ftr13 31 |
|
OneToMany | |||
| TRIM29 (20 of 87) 31 |
|
OneToMany | |||
| ftr35 31 |
|
OneToMany | |||
| TRIM29 (84 of 87) 31 |
|
OneToMany | |||
| ftr61 31 |
|
OneToMany | |||
| ftr22 31 |
|
OneToMany | |||
| ftr38 31 |
|
OneToMany | |||
| ftr64 31 |
|
OneToMany | |||
| ftr01 31 |
|
OneToMany | |||
| ftr14l 31 |
|
OneToMany | |||
| ftr12 31 |
|
OneToMany | |||
| ftr30 31 |
|
OneToMany | |||
| TRIM29 (44 of 87) 31 |
|
OneToMany | |||
| ftr65 31 |
|
OneToMany | |||
| ftr02 31 |
|
OneToMany | |||
| ftr34 31 |
|
OneToMany | |||
| ftr07 31 |
|
OneToMany | |||
| ftr23 31 |
|
OneToMany | |||
| ftr33 31 |
|
OneToMany | |||
| ftr82 31 |
|
OneToMany | |||
| ftr72 31 |
|
OneToMany | |||
| ftr14 31 |
|
OneToMany | |||
| TRIM29 (87 of 87) 31 |
|
OneToMany | |||
| ftr24 31 |
|
OneToMany | |||
| ftr51 31 |
|
OneToMany | |||
| ftr36 31 |
|
OneToMany | |||
| ftr29 31 |
|
OneToMany | |||
| CR352329.1 31 |
|
OneToMany | |||
| ftr83 31 |
|
OneToMany | |||
| TRIM29 (16 of 87) 31 |
|
OneToMany | |||
| ftr41 31 |
|
OneToMany | |||
| ftr58 31 |
|
OneToMany | |||
| ftr53 31 |
|
OneToMany | |||
| ftr56 31 |
|
OneToMany | |||
| TRIM29 (85 of 87) 31 |
|
OneToMany | |||
| TRIM29 (42 of 87) 31 |
|
OneToMany | |||
| ftr37 31 |
|
OneToMany | |||
| ftr11 31 |
|
OneToMany | |||
| ftr42 31 |
|
OneToMany | |||
| ftr73 31 |
|
OneToMany | |||
| ftr43 31 |
|
OneToMany | |||
| ftr66 31 |
|
OneToMany | |||
| ftr16 31 |
|
OneToMany | |||
| ftr57 31 |
|
OneToMany | |||
| TRIM29 (19 of 87) 31 |
|
OneToMany | |||
| ftr76 31 |
|
OneToMany | |||
| TRIM29 (18 of 87) 31 |
|
OneToMany | |||
| ftr59 31 |
|
OneToMany | |||
| TRIM29 (41 of 87) 31 |
|
OneToMany | |||
| ftr55 31 |
|
OneToMany | |||
| TRIM29 (63 of 87) 31 |
|
OneToMany | |||
| TRIM29 (15 of 87) 31 |
|
OneToMany | |||
| ftr54 31 |
|
OneToMany | |||
| TRIM29 (35 of 87) 31 |
|
OneToMany | |||
| TRIM29 (5 of 87) 31 |
|
OneToMany | |||
| ftr79 31 |
|
OneToMany | |||
| ftr32 31 |
|
OneToMany | |||
| TRIM29 (14 of 87) 31 |
|
OneToMany | |||
| TRIM29 (31 of 87) 31 |
|
OneToMany | |||
| TRIM29 (82 of 87) 31 |
|
OneToMany |
- Species where no ortholog for TRIM29 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for TRIM29 Gene
- ENSEMBL:
- Gene Tree for TRIM29 (if available)
- TreeFam:
- Gene Tree for TRIM29 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TRIM29: view image
Paralogs for TRIM29 Gene
Paralogs for TRIM29 Gene
- MEFV 5
- TRIM25 5
- TRIM58 5
- TRIM34 5
- TRIM6 5
- TRIM6-TRIM34 5
- TRIM10 5
- TRIM26 5
- TRIM38 5
- TRIM9 5
- TRIM21 5
- TRIM22 5
- TRIM5 5
- MID1 5
- TRIM27 5
- TRIM67 5
- TRIM62 5
- TRIM7 5
- TRIML1 5
- TRIM71 5
- TRIM42 5
- TRIM69 5
- MID2 5
- TRIM24 5
- TRIM72 5
- TRIM39 5
- TRIM47 5
- TRIM41 5
- TRIM11 5
- TRIM33 5
- TRIM56 5
- TRIM50 5
- TRIM16 5
- TRIM68 5
- TRIM75P 5
- TRIM14 5
- TRIM66 5
- TRIM17 5
- TRIM3 5
- TRIM32 5
- TRIM4 5
- TRIM60 5
- TRIM15 5
- TRIML2 5
- TRIM77 5
- TRIM36 5
- TRIM2 5
- TRIM28 5
- TRIM51 5
- TRIM43B 5
- TRIM43 5
- TRIM39-RPP21 5
- TRIM46 5
- TRIM51GP 5
- TRIM49B 5
- TRIM31 5
- TRIM65 5
- TRIM8 5
- TRIM35 5
- TRIM49 5
- TRIM49D1 5
- TRIM49D2 5
- TRIM49C 5
- TRIM64C 5
- TRIM13 5
- TRIM45 5
- TRIM40 5
- TRIM64B 5
- TRIM64 5
- PML 5
- RNF39 5
- TRIM55 5
- TRIM54 5
- TRIM16L 5
- TRIM63 5
- TRIM37 5
- TRIM73 5
- TRIM52 5
- TRIM74 5
- TRIM44 5
- TRIM48 5
- TRIM61 5
- BSPRY 5
- ENSG00000239920 5
Variants for TRIM29 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRIM29 Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 710126 | Benign: not provided | 120,137,390(-) | G/C | SYNONYMOUS_VARIANT | |
| 781049 | Benign: not provided | 120,125,683(-) | G/T | INTRON_VARIANT | |
| rs112973609 | A breast cancer sample | p.Ser514Phe |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2673699 | CNV | deletion | 23128226 |
| esv2745143 | CNV | deletion | 23290073 |
| esv3548424 | CNV | deletion | 23714750 |
| esv3627899 | CNV | loss | 21293372 |
| nsv1050132 | CNV | gain | 25217958 |
| nsv472657 | CNV | novel sequence insertion | 20440878 |
Residual Variation Intolerance Score:
62.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.51;
64.60% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TRIM29 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TRIM29
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM29 Gene
Disorders for TRIM29 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ataxia-telangiectasia |
|
|
Search TRIM29 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TRIM29
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM29 Gene
Publications for TRIM29 Gene
- The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A … Ballabio A (The EMBO journal 2001) 2 3 4
- Expression of the ATDC (ataxia telangiectasia group D-complementing) gene in A431 human squamous carcinoma cells. (PMID: 8647648) Laderoute KR … Kapp LN (International journal of cancer 1996) 3 4 23
- TRIM29 promotes DNA virus infections by inhibiting innate immune response. (PMID: 29038422) Xing J … Zhang Z (Nature communications 2017) 3 4
- Identification of a role for TRIM29 in the control of innate immunity in the respiratory tract. (PMID: 27695001) Xing J … Zhang Z (Nature immunology 2016) 3 4
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
ExternalLinks
Products for TRIM29 Gene
- Custom Antibody ServicesOriGene Antibodies for TRIM29
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for TRIM29
- Search Origene for MassSpec and Protein Over-expression Lysates for TRIM29
- Origene Custom Protein Services for TRIM29
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TRIM29
- Browse OriGene Inhibitory RNA Products For TRIM29
- OriGene qPCR primer pairs for TRIM29
- OriGene qPCR primer pairs and template standards for TRIM29
- OriGene CRISPR knockouts for TRIM29
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TRIM29
- Sino Biological Human cDNA Clone for TRIM29
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for TRIM29
- Browse Sino Biological Assays
- Browse Antibodies
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for TRIM29
- Novus Biologicals proteins and lysates for TRIM29
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for TRIM29
- Abcam proteins for TRIM29
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for TRIM29 (AFLGC-Trim29)
- VectorBuilder Custom and pre-made DNA vectors for TRIM29 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for TRIM29 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for TRIM29 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for TRIM29 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for TRIM29
- antibodies-online: Show 27 available TRIM29 Antibodies ranked by validation data
- Compare Top TRIM29 Antibodies
- antibodies-online: Search results for available TRIM29 related products ranked by validation data
- antibodies-online: Show 5 available TRIM29 Proteins ranked by validation data
- Compare Top TRIM29 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for TRIM29
- Search Santa Cruz Biotechnology (SCBT) for TRIM29 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TRIM29
- Horizon Cell Lines for TRIM29
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TRIM29
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TRIM29
- Search GeneCopoeia for miRNA 3'UTR Target clone products for TRIM29
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM29
- Signalway Proteins for TRIM29
Sources for TRIM29 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB