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The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype. [provided by RefSeq, Jul 2008]
TRIM29 (Tripartite Motif Containing 29) is a Protein Coding gene. Diseases associated with TRIM29 include Ataxia-Telangiectasia. Among its related pathways are Interferon gamma signaling and Hematopoietic Stem Cell Differentiation. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and p53 binding. An important paralog of this gene is MEFV.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002039 | p53 binding | IEA | -- |
GO:0003700 | DNA-binding transcription factor activity | TAS | 8188213 |
GO:0005515 | protein binding | IPI | 16189514 |
GO:0008270 | zinc ion binding | IEA | -- |
GO:0042802 | identical protein binding | IPI | 16189514 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005764 | lysosome | IEA | -- |
GO:0005912 | adherens junction | HDA | 25468996 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Interferon gamma signaling | ||
2 | DNA Damage | ||
3 | Cytokine Signaling in Immune system | ||
4 | Innate Immune System |
.61
|
|
5 | Hematopoietic Stem Cell Differentiation |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
GO:0002376 | immune system process | IEA | -- |
GO:0006366 | transcription by RNA polymerase II | TAS | 8188213 |
GO:0045087 | innate immune response | IEA | -- |
GO:0098609 | cell-cell adhesion | IEA | -- |
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18a | · | 18b | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP15: | - |
ExUns: | 18c | · | 18d | · | 18e | · | 18f | · | 18g | ^ | 19a | · | 19b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||
SP2: | |||||||||||||
SP3: | |||||||||||||
SP4: | |||||||||||||
SP5: | |||||||||||||
SP6: | |||||||||||||
SP7: | |||||||||||||
SP8: | |||||||||||||
SP9: | |||||||||||||
SP10: | |||||||||||||
SP11: | |||||||||||||
SP12: | |||||||||||||
SP13: | - | - | - | - | - | ||||||||
SP14: | |||||||||||||
SP15: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TRIM29 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TRIM29 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TRIM29 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Trim29 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Trim29 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | TRIM29 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | TRIM29 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | TRIM29 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | TRIM29 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | trim29 30 |
|
||
Str.3257 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | MGC53484 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | TRIM29 (38 of 87) 31 |
|
OneToMany | |
ftr19 31 31 |
|
OneToMany | |||
TRIM29 (55 of 87) 31 |
|
OneToMany | |||
CABZ01034858.1 31 |
|
OneToMany | |||
ftr10 31 |
|
OneToMany | |||
CABZ01034857.1 31 |
|
OneToMany | |||
ftr05 31 |
|
OneToMany | |||
ftr27 31 |
|
OneToMany | |||
TRIM29 (71 of 87) 31 |
|
OneToMany | |||
ftr08 31 |
|
OneToMany | |||
ftr26 31 31 |
|
OneToMany | |||
ftr09 31 |
|
OneToMany | |||
ftr03 31 |
|
OneToMany | |||
ftr69 31 |
|
OneToMany | |||
ftr46 31 |
|
OneToMany | |||
ftr04 31 |
|
OneToMany | |||
ftr28l 31 |
|
OneToMany | |||
TRIM29 (61 of 87) 31 |
|
OneToMany | |||
ftr15 31 |
|
OneToMany | |||
ftr06 31 |
|
OneToMany | |||
ftr67 31 |
|
OneToMany | |||
TRIM29 (36 of 87) 31 |
|
OneToMany | |||
TRIM29 (50 of 87) 31 |
|
OneToMany | |||
TRIM29 (86 of 87) 31 |
|
OneToMany | |||
ftr50 31 |
|
OneToMany | |||
ftr13 31 |
|
OneToMany | |||
TRIM29 (20 of 87) 31 |
|
OneToMany | |||
ftr35 31 |
|
OneToMany | |||
TRIM29 (84 of 87) 31 |
|
OneToMany | |||
ftr61 31 |
|
OneToMany | |||
ftr22 31 |
|
OneToMany | |||
ftr38 31 |
|
OneToMany | |||
ftr64 31 |
|
OneToMany | |||
ftr01 31 |
|
OneToMany | |||
ftr14l 31 |
|
OneToMany | |||
ftr12 31 |
|
OneToMany | |||
ftr30 31 |
|
OneToMany | |||
TRIM29 (44 of 87) 31 |
|
OneToMany | |||
ftr65 31 |
|
OneToMany | |||
ftr02 31 |
|
OneToMany | |||
ftr34 31 |
|
OneToMany | |||
ftr07 31 |
|
OneToMany | |||
ftr23 31 |
|
OneToMany | |||
ftr33 31 |
|
OneToMany | |||
ftr82 31 |
|
OneToMany | |||
ftr72 31 |
|
OneToMany | |||
ftr14 31 |
|
OneToMany | |||
TRIM29 (87 of 87) 31 |
|
OneToMany | |||
ftr24 31 |
|
OneToMany | |||
ftr51 31 |
|
OneToMany | |||
ftr36 31 |
|
OneToMany | |||
ftr29 31 |
|
OneToMany | |||
CR352329.1 31 |
|
OneToMany | |||
ftr83 31 |
|
OneToMany | |||
TRIM29 (16 of 87) 31 |
|
OneToMany | |||
ftr41 31 |
|
OneToMany | |||
ftr58 31 |
|
OneToMany | |||
ftr53 31 |
|
OneToMany | |||
ftr56 31 |
|
OneToMany | |||
TRIM29 (85 of 87) 31 |
|
OneToMany | |||
TRIM29 (42 of 87) 31 |
|
OneToMany | |||
ftr37 31 |
|
OneToMany | |||
ftr11 31 |
|
OneToMany | |||
ftr42 31 |
|
OneToMany | |||
ftr73 31 |
|
OneToMany | |||
ftr43 31 |
|
OneToMany | |||
ftr66 31 |
|
OneToMany | |||
ftr16 31 |
|
OneToMany | |||
ftr57 31 |
|
OneToMany | |||
TRIM29 (19 of 87) 31 |
|
OneToMany | |||
ftr76 31 |
|
OneToMany | |||
TRIM29 (18 of 87) 31 |
|
OneToMany | |||
ftr59 31 |
|
OneToMany | |||
TRIM29 (41 of 87) 31 |
|
OneToMany | |||
ftr55 31 |
|
OneToMany | |||
TRIM29 (63 of 87) 31 |
|
OneToMany | |||
TRIM29 (15 of 87) 31 |
|
OneToMany | |||
ftr54 31 |
|
OneToMany | |||
TRIM29 (35 of 87) 31 |
|
OneToMany | |||
TRIM29 (5 of 87) 31 |
|
OneToMany | |||
ftr79 31 |
|
OneToMany | |||
ftr32 31 |
|
OneToMany | |||
TRIM29 (14 of 87) 31 |
|
OneToMany | |||
TRIM29 (31 of 87) 31 |
|
OneToMany | |||
TRIM29 (82 of 87) 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
710126 | Benign: not provided | 120,137,390(-) | G/C | SYNONYMOUS_VARIANT | |
781049 | Benign: not provided | 120,125,683(-) | G/T | INTRON_VARIANT | |
rs112973609 | A breast cancer sample | p.Ser514Phe |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2673699 | CNV | deletion | 23128226 |
esv2745143 | CNV | deletion | 23290073 |
esv3548424 | CNV | deletion | 23714750 |
esv3627899 | CNV | loss | 21293372 |
nsv1050132 | CNV | gain | 25217958 |
nsv472657 | CNV | novel sequence insertion | 20440878 |
Disorder | Aliases | PubMed IDs |
---|---|---|
ataxia-telangiectasia |
|
|