The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of rad... See more...

Aliases for TRIM29 Gene

Aliases for TRIM29 Gene

  • Tripartite Motif Containing 29 2 3 5
  • Ataxia-Telangiectasia Group D-Associated Protein 2 3
  • Tripartite Motif-Containing Protein 29 3 4
  • Tripartite Motif Protein TRIM29 2 3
  • ATDC 3 4
  • Ataxia Telangiectasia Group D-Associated Protein 4
  • Tripartite Motif-Containing 29 2

External Ids for TRIM29 Gene

Previous GeneCards Identifiers for TRIM29 Gene

  • GC11M121981
  • GC11M121493
  • GC11M120015
  • GC11M119520
  • GC11M119521
  • GC11M119487
  • GC11M115921
  • GC11M119981

Summaries for TRIM29 Gene

Entrez Gene Summary for TRIM29 Gene

  • The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM29 Gene

TRIM29 (Tripartite Motif Containing 29) is a Protein Coding gene. Diseases associated with TRIM29 include Ataxia-Telangiectasia. Among its related pathways are Hematopoietic Stem Cell Differentiation and Innate Immune System. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and p53 binding. An important paralog of this gene is TRIM7.

UniProtKB/Swiss-Prot Summary for TRIM29 Gene

  • Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of proinflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of TMEM173/STING in a similar way, leading to its degradation.

Gene Wiki entry for TRIM29 Gene

Additional gene information for TRIM29 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRIM29 Gene

Genomics for TRIM29 Gene

GeneHancer (GH) Regulatory Elements for TRIM29 Gene

Promoters and enhancers for TRIM29 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRIM29 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRIM29

Top Transcription factor binding sites by QIAGEN in the TRIM29 gene promoter:
  • AREB6
  • E47
  • Egr-2
  • Egr-3
  • FOXI1
  • GATA-2
  • HFH-3
  • S8
  • Tal-1beta

Genomic Locations for TRIM29 Gene

Genomic Locations for TRIM29 Gene
chr11:120,111,286-120,185,529
(GRCh38/hg38)
Size:
74,244 bases
Orientation:
Minus strand
chr11:119,981,983-120,056,237
(GRCh37/hg19)
Size:
74,255 bases
Orientation:
Minus strand

Genomic View for TRIM29 Gene

Genes around TRIM29 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM29 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM29 Gene

Proteins for TRIM29 Gene

  • Protein details for TRIM29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14134-TRI29_HUMAN
    Recommended name:
    Tripartite motif-containing protein 29
    Protein Accession:
    Q14134
    Secondary Accessions:
    • Q96AA9
    • Q9BZY7

    Protein attributes for TRIM29 Gene

    Size:
    588 amino acids
    Molecular mass:
    65835 Da
    Quaternary structure:
    • Interacts with VIM and HINT1 (PubMed:7644499). Interacts with IKBKG/NEMO (PubMed:27695001). Interacts with TMEM173/STING (PubMed:29038422).

    Three dimensional structures from OCA and Proteopedia for TRIM29 Gene

    Alternative splice isoforms for TRIM29 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM29 Gene

Post-translational modifications for TRIM29 Gene

  • Constitutively phosphorylated by PKC on serine/threonine in A431 cells.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TRIM29 Gene

Domains & Families for TRIM29 Gene

Gene Families for TRIM29 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TRIM29 Gene

Blocks:
  • B-box zinc finger signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TRIM29 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ52831, highly similar to Tripartite motif-containing protein 29 (B7Z8U9_HUMAN)
  • TRIM29 protein (Q0P6H7_HUMAN)
  • Ataxia telangiectasia group D-associated protein (TRI29_HUMAN)
genes like me logo Genes that share domains with TRIM29: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TRIM29 Gene

Function for TRIM29 Gene

Molecular function for TRIM29 Gene

UniProtKB/Swiss-Prot Function:
Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of proinflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of TMEM173/STING in a similar way, leading to its degradation.

Phenotypes From GWAS Catalog for TRIM29 Gene

Gene Ontology (GO) - Molecular Function for TRIM29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IEA --
GO:0003700 DNA-binding transcription factor activity TAS 8188213
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
GO:0042802 identical protein binding IPI 16189514
genes like me logo Genes that share ontologies with TRIM29: view
genes like me logo Genes that share phenotypes with TRIM29: view

Animal Models for TRIM29 Gene

MGI Knock Outs for TRIM29:
  • Trim29 Trim29<tm1a(EUCOMM)Wtsi>
  • Trim29 Trim29<tm1b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIM29 Gene

Localization for TRIM29 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM29 Gene

Cytoplasm. Lysosome. Note=Colocalizes with intermediate filaments.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM29 gene
Compartment Confidence
nucleus 4
cytosol 3
lysosome 3
cytoskeleton 2
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRIM29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005764 lysosome IEA --
GO:0005913 cell-cell adherens junction HDA 25468996
genes like me logo Genes that share ontologies with TRIM29: view

Pathways & Interactions for TRIM29 Gene

genes like me logo Genes that share pathways with TRIM29: view

Pathways by source for TRIM29 Gene

1 Cell Signaling Technology pathway for TRIM29 Gene

Gene Ontology (GO) - Biological Process for TRIM29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0002376 immune system process IEA --
GO:0006366 transcription by RNA polymerase II TAS 8188213
GO:0045087 innate immune response IEA --
GO:0098609 cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with TRIM29: view

No data available for SIGNOR curated interactions for TRIM29 Gene

Drugs & Compounds for TRIM29 Gene

No Compound Related Data Available

Transcripts for TRIM29 Gene

mRNA/cDNA for TRIM29 Gene

3 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM29 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ·
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - - - - -
SP7: - - - - -
SP8: -
SP9: - - -
SP10: - -
SP11: - - -
SP12: - -
SP13: - -
SP14:
SP15: -

ExUns: 18c · 18d · 18e · 18f · 18g ^ 19a · 19b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - - - - -
SP14:
SP15:

Relevant External Links for TRIM29 Gene

GeneLoc Exon Structure for
TRIM29

Expression for TRIM29 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRIM29 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM29 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x13.2), Esophagus - Mucosa (x12.8), Skin - Not Sun Exposed (Suprapubic) (x11.4), and Vagina (x5.5).

Protein differential expression in normal tissues from HIPED for TRIM29 Gene

This gene is overexpressed in Cervix (30.0), Hair follicle (21.7), and Nasal epithelium (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRIM29 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRIM29

SOURCE GeneReport for Unigene cluster for TRIM29 Gene:

Hs.504115

mRNA Expression by UniProt/SwissProt for TRIM29 Gene:

Q14134-TRI29_HUMAN
Tissue specificity: Expressed in placenta, prostate and thymus.

Evidence on tissue expression from TISSUES for TRIM29 Gene

  • Skin(4.3)
  • Blood(2.3)
genes like me logo Genes that share expression patterns with TRIM29: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM29 Gene

Orthologs for TRIM29 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM29 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM29 31 30
  • 99.49 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM29 31 30
  • 89.61 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TRIM29 31 30
  • 88.93 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Trim29 17 31 30
  • 86.71 (n)
rat
(Rattus norvegicus)
Mammalia Trim29 30
  • 86.43 (n)
oppossum
(Monodelphis domestica)
Mammalia TRIM29 31
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM29 31
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIM29 31 30
  • 67.73 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIM29 31
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trim29 30
  • 59.13 (n)
Str.3257 30
African clawed frog
(Xenopus laevis)
Amphibia MGC53484 30
zebrafish
(Danio rerio)
Actinopterygii TRIM29 (38 of 87) 31
  • 30 (a)
OneToMany
ftr19 31 31
  • 29 (a)
OneToMany
TRIM29 (55 of 87) 31
  • 29 (a)
OneToMany
CABZ01034858.1 31
  • 29 (a)
OneToMany
ftr10 31
  • 28 (a)
OneToMany
CABZ01034857.1 31
  • 28 (a)
OneToMany
ftr05 31
  • 27 (a)
OneToMany
ftr27 31
  • 27 (a)
OneToMany
TRIM29 (71 of 87) 31
  • 27 (a)
OneToMany
ftr08 31
  • 26 (a)
OneToMany
ftr26 31 31
  • 26 (a)
OneToMany
ftr09 31
  • 26 (a)
OneToMany
ftr03 31
  • 26 (a)
OneToMany
ftr69 31
  • 25 (a)
OneToMany
ftr46 31
  • 25 (a)
OneToMany
ftr04 31
  • 25 (a)
OneToMany
ftr28l 31
  • 25 (a)
OneToMany
TRIM29 (61 of 87) 31
  • 24 (a)
OneToMany
ftr15 31
  • 24 (a)
OneToMany
ftr06 31
  • 24 (a)
OneToMany
ftr67 31
  • 24 (a)
OneToMany
TRIM29 (36 of 87) 31
  • 24 (a)
OneToMany
TRIM29 (50 of 87) 31
  • 24 (a)
OneToMany
TRIM29 (86 of 87) 31
  • 24 (a)
OneToMany
ftr50 31
  • 23 (a)
OneToMany
ftr13 31
  • 23 (a)
OneToMany
TRIM29 (20 of 87) 31
  • 22 (a)
OneToMany
ftr35 31
  • 22 (a)
OneToMany
TRIM29 (84 of 87) 31
  • 22 (a)
OneToMany
ftr61 31
  • 22 (a)
OneToMany
ftr22 31
  • 22 (a)
OneToMany
ftr38 31
  • 22 (a)
OneToMany
ftr64 31
  • 22 (a)
OneToMany
ftr01 31
  • 22 (a)
OneToMany
ftr14l 31
  • 22 (a)
OneToMany
ftr12 31
  • 21 (a)
OneToMany
ftr30 31
  • 21 (a)
OneToMany
TRIM29 (44 of 87) 31
  • 21 (a)
OneToMany
ftr65 31
  • 21 (a)
OneToMany
ftr02 31
  • 21 (a)
OneToMany
ftr34 31
  • 21 (a)
OneToMany
ftr07 31
  • 21 (a)
OneToMany
ftr23 31
  • 21 (a)
OneToMany
ftr33 31
  • 21 (a)
OneToMany
ftr82 31
  • 21 (a)
OneToMany
ftr72 31
  • 21 (a)
OneToMany
ftr14 31
  • 21 (a)
OneToMany
TRIM29 (87 of 87) 31
  • 21 (a)
OneToMany
ftr24 31
  • 21 (a)
OneToMany
ftr51 31
  • 21 (a)
OneToMany
ftr36 31
  • 21 (a)
OneToMany
ftr29 31
  • 21 (a)
OneToMany
CR352329.1 31
  • 21 (a)
OneToMany
ftr83 31
  • 20 (a)
OneToMany
TRIM29 (16 of 87) 31
  • 20 (a)
OneToMany
ftr41 31
  • 20 (a)
OneToMany
ftr58 31
  • 20 (a)
OneToMany
ftr53 31
  • 20 (a)
OneToMany
ftr56 31
  • 20 (a)
OneToMany
TRIM29 (85 of 87) 31
  • 20 (a)
OneToMany
TRIM29 (42 of 87) 31
  • 20 (a)
OneToMany
ftr37 31
  • 20 (a)
OneToMany
ftr11 31
  • 20 (a)
OneToMany
ftr42 31
  • 20 (a)
OneToMany
ftr73 31
  • 20 (a)
OneToMany
ftr43 31
  • 20 (a)
OneToMany
ftr66 31
  • 20 (a)
OneToMany
ftr16 31
  • 20 (a)
OneToMany
ftr57 31
  • 19 (a)
OneToMany
TRIM29 (19 of 87) 31
  • 19 (a)
OneToMany
ftr76 31
  • 19 (a)
OneToMany
TRIM29 (18 of 87) 31
  • 19 (a)
OneToMany
ftr59 31
  • 19 (a)
OneToMany
TRIM29 (41 of 87) 31
  • 18 (a)
OneToMany
ftr55 31
  • 18 (a)
OneToMany
TRIM29 (63 of 87) 31
  • 18 (a)
OneToMany
TRIM29 (15 of 87) 31
  • 18 (a)
OneToMany
ftr54 31
  • 17 (a)
OneToMany
TRIM29 (35 of 87) 31
  • 17 (a)
OneToMany
TRIM29 (5 of 87) 31
  • 17 (a)
OneToMany
ftr79 31
  • 17 (a)
OneToMany
ftr32 31
  • 16 (a)
OneToMany
TRIM29 (14 of 87) 31
  • 14 (a)
OneToMany
TRIM29 (31 of 87) 31
  • 14 (a)
OneToMany
TRIM29 (82 of 87) 31
  • 13 (a)
OneToMany
Species where no ortholog for TRIM29 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM29 Gene

ENSEMBL:
Gene Tree for TRIM29 (if available)
TreeFam:
Gene Tree for TRIM29 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRIM29: view image

Paralogs for TRIM29 Gene

genes like me logo Genes that share paralogs with TRIM29: view

Variants for TRIM29 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRIM29 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
710126 Benign: not provided 120,137,390(-) G/C SYNONYMOUS_VARIANT
781049 Benign: not provided 120,125,683(-) G/T INTRON_VARIANT
rs112973609 A breast cancer sample p.Ser514Phe

Additional dbSNP identifiers (rs#s) for TRIM29 Gene

Structural Variations from Database of Genomic Variants (DGV) for TRIM29 Gene

Variant ID Type Subtype PubMed ID
esv2673699 CNV deletion 23128226
esv2745143 CNV deletion 23290073
esv3548424 CNV deletion 23714750
esv3627899 CNV loss 21293372
nsv1050132 CNV gain 25217958
nsv472657 CNV novel sequence insertion 20440878

Variation tolerance for TRIM29 Gene

Residual Variation Intolerance Score: 62.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.51; 64.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM29 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM29

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM29 Gene

Disorders for TRIM29 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRIM29 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ataxia-telangiectasia
  • at
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TRIM29

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TRIM29: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM29 Gene

Publications for TRIM29 Gene

  1. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A … Ballabio A (The EMBO journal 2001) 2 3 4 54
  2. Expression of the ATDC (ataxia telangiectasia group D-complementing) gene in A431 human squamous carcinoma cells. (PMID: 8647648) Laderoute KR … Kapp LN (International journal of cancer 1996) 3 4 23 54
  3. TRIM29 promotes DNA virus infections by inhibiting innate immune response. (PMID: 29038422) Xing J … Zhang Z (Nature communications 2017) 3 4 54
  4. Identification of a role for TRIM29 in the control of innate immunity in the respiratory tract. (PMID: 27695001) Xing J … Zhang Z (Nature immunology 2016) 3 4 54
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54

Products for TRIM29 Gene

Sources for TRIM29 Gene