Aliases for TRIM29 Gene
External Ids for TRIM29 Gene
Previous GeneCards Identifiers for TRIM29 Gene
The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype. [provided by RefSeq, Jul 2008]
GeneCards Summary for TRIM29 Gene
TRIM29 (Tripartite Motif Containing 29) is a Protein Coding gene. Diseases associated with TRIM29 include Ataxia-Telangiectasia. Among its related pathways are Hematopoietic Stem Cell Differentiation and Innate Immune System. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and p53 binding. An important paralog of this gene is TRIM7.
UniProtKB/Swiss-Prot Summary for TRIM29 Gene
Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of proinflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of TMEM173/STING in a similar way, leading to its degradation.