Aliases for TRIM28 Gene
Aliases for TRIM28 Gene
- Tripartite Motif Containing 28 2 3 5
- Protein Phosphatase 1, Regulatory Subunit 157 2 3
- RING-Type E3 Ubiquitin Transferase TIF1-Beta 3 4
- E3 SUMO-Protein Ligase TRIM28 3 4
- KRAB-Interacting Protein 1 3 4
- Nuclear Corepressor KAP-1 3 4
- RING Finger Protein 96 3 4
- TIF1-Beta 3 4
- KRIP-1 3 4
- KAP-1 3 4
- RNF96 3 4
- TIF1B 3 4
External Ids for TRIM28 Gene
- HGNC: 16384
- Entrez Gene: 10155
- Ensembl: ENSG00000130726
- OMIM: 601742
- UniProtKB: Q13263
Previous GeneCards Identifiers for TRIM28 Gene
- GC19P059954
- GC19P059509
- GC19P063731
- GC19P063747
- GC19P063553
- GC19P059055
- GC19P055366
Summaries for TRIM28 Gene
-
The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008]
GeneCards Summary for TRIM28 Gene
TRIM28 (Tripartite Motif Containing 28) is a Protein Coding gene. Among its related pathways are Mesodermal Commitment Pathway and Gene Expression. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is TRIM33.
UniProtKB/Swiss-Prot for TRIM28 Gene
-
Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at Lys-9 (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 Lys-9 and Lys-14 acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). Acts as a corepressor for ZFP568 (By similarity).
Additional gene information for TRIM28 Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM28 Gene
Genomics for TRIM28 Gene
GeneHancer (GH) Regulatory Elements for TRIM28 Gene
Promoters and enhancers for TRIM28 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TRIM28 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the TRIM28 gene promoter:
Regulatory Element Products
Genomic Locations for TRIM28 Gene
Genomic Locations for TRIM28 Gene
- chr19:58,544,091-58,550,722
- (GRCh38/hg38)
- Size:
- 6,632 bases
- Orientation:
- Plus strand
- chr19:59,055,458-59,062,089
- (GRCh37/hg19)
Genomic View for TRIM28 Gene
Genes around TRIM28 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.43 by Ensembl
- 19q13.43 by Entrez Gene
- 19q13.4 by HGNC
TRIM28 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TRIM28 Gene
Proteins for TRIM28 Gene
-
Protein details for TRIM28 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13263-TIF1B_HUMAN
- Recommended name:
- Transcription intermediary factor 1-beta
- Protein Accession:
- Q13263
- O00677
- Q7Z632
- Q93040
- Q96IM1
Protein attributes for TRIM28 Gene
- Size:
- 835 amino acids
- Molecular mass:
- 88550 Da
- Quaternary structure:
-
- Interacts with SETX (PubMed:23149945). Oligomer; the RBCC domain homotrimerizes and interacts with one molecule of KRAB to form the KRAB-KAP1 corepressor complex. Binding to a KRAB domain is an absolute requirement for silencing gene expression. Interacts with CEBPB and NR3C1. Interacts with a number of KRAB-ZFP proteins including ZNF10, ZFP53, ZFP68, ZNF382 and ZNF256. Interacts with NCOR1, NR3C1 and CHD3. Interacts with CEBPB (via the RING-type and PHD-type zinc fingers). Component of a ternary complex that includes TRIM28, a HP1 protein (CBX1, CBX3 OR CBX5), a KRAB domain-containing protein, and DNA. Interacts with CBX5 (via the PxVxL motif); the interaction occurs in interphase nuclei and competes for binding POGZ. Interacts with POGZ; the interaction competes for interaction with CBX5. Interacts with SETDB1; the interaction is enhanced by KAP1 sumoylation, stimulates SETB1 histone methyltransferase activity and gene silencing. Interacts (via the PHD-type zinc finger) with UBE2I; the interaction is required for sumoylation and repressor activity. Component of the TRIM28/KAP1-ERBB4-MDM2 complex involved in connecting growth factor and DNA damage responses. Interacts directly with ERBB4; the interaction represses ERBB4-mediated transcription activity. Interacts with MDM2; the interaction contributes to p53/TP53 inactivation. Component of the TRIM28/KAP1-MDM2-p53/TP53; involved in regulating p53/TP53 stabilization and activity. Interacts (via the leucine zipper alpha helical coiled-coil) with E2F1 (central region); the interaction inhibits E2F1 acetylation and transcriptional activity. Interacts with PPP1CA; the interaction dephosphorylates TRIM28 at Ser-824 and forms a complex at the p21 promoter site. Interacts with PPP1CB; the interaction is weak but is increased on dephosphorylation at Ser-824. Interacts with FES/FPS. Interacts with SMARCAD1. Interacts with, and sumoylates IRF7. Interacts with MAGEC2. Part of a complex composed of TRIM28, HDAC1, HDAC2 and EHMT2. Interacts with AICDA (By similarity). Interacts (via the RBCC domain) with KOX1 (via the KRAB domain), ZNF268 (via the KRAB domain) and ZNF300 (via the KRAB domain); the interactions increase KOX1, ZNF268 and ZNF300 nuclear localization activities. The large PER complex involved in the histone methylation is composed of at least PER2, CBX3, TRIM28, SUV39H1 and/or SUV39H2; CBX3 mediates the formation of the complex. Interacts with isoform 2 of ZFP90. Forms a complex with FOXP3 in the presence of isoform 2 of ZFP90. Interacts with NR4A3; the interactions potentiates NR4A3 activity on NurRE promoter (By similarity). Interacts (unphosphorylated or phosphorylated form) with ZBTB1 (via BTB domain) (PubMed:24657165). Probably part of a corepressor complex containing ZNF304, TRIM28, SETDB1 and DNMT1 (PubMed:24623306). Interacts with ATRX. Forms a complex with ATRX, SETDB1 and ZNF274 (PubMed:27029610). Interacts with ZFP568; the interaction mediates ZFP568 transcriptional repression activity (By similarity). Interacts with RRP1B (PubMed:19710015).
Protein Expression for TRIM28 Gene
Post-translational modifications for TRIM28 Gene
- ATM-induced phosphorylation on Ser-824 represses sumoylation leading to the de-repression of expression of a subset of genes involved in cell cycle control and apoptosis in response to genotoxic stress. Dephosphorylation by the phosphatases, PPP1CA and PP1CB forms, allows sumoylation and expression of TRIM28 target genes.
- Auto-ubiquitinated; enhanced by MAGEA2 and MAGEC2.
- Citrullinated by PADI4.
- Sumoylation/desumoylation events regulate TRIM28-mediated transcriptional repression. Sumoylation is required for interaction with CHD3 and SETDB1 and the corepressor activity. Represses and is repressed by Ser-824 phosphorylation. Enhances the TRIM28 corepressor activity, inhibiting transcriptional activity of a number of genes including GADD45A and CDKN1A/p21. Lys-554, Lys-779 and Lys-804 are the major sites of sumoylation. In response to Dox-induced DNA damage, enhanced phosphorylation on Ser-824 prevents sumoylation and allows de-repression of CDKN1A/p21.
- Ubiquitination at posLast=3131, isoforms=127, isoforms=2213, isoforms=2238, posLast=254254, posLast=261261, isoforms=2272, isoforms=2304, isoforms=2319, posLast=337337, posLast=340340, isoforms=2366, posLast=377377, isoforms=2400, isoforms=2407, posLast=434434, posLast=469469, isoforms=2750, posLast=770770, and posLast=774774
Other Protein References for TRIM28 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for TRIM28 (KAP1)
- Cell Signaling Technology (CST) Antibodies for TRIM28 (TIF1B)
-
Custom Antibody ServicesOriGene Antibodies for TRIM28
- Novus Biologicals Antibodies for TRIM28
-
Abcam antibodies for TRIM28
- Invitrogen Antibodies for TRIM28
- GeneTex TRIM28 antibody for TRIM28
-
Custom Antibody ServicesProSci Antibodies for TRIM28
-
Santa Cruz Biotechnology (SCBT) Antibodies for TRIM28
- Sino Biological Antibodies for TRIM28
Protein Products
-
OriGene Purified Proteins for TRIM28
- Search Origene for MassSpec and Protein Over-expression Lysates for TRIM28
- Origene Custom Protein Services for TRIM28
- ProSpec Recombinant Proteins for TRIM28
-
Cloud-Clone Corp. Proteins for TRIM28
- Search GeneTex for Proteins for TRIM28
-
Abcam proteins for TRIM28
Assay Products
No data available for DME Specific Peptides for TRIM28 Gene
Domains & Families for TRIM28 Gene
Gene Families for TRIM28 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for TRIM28 Gene
Suggested Antigen Peptide Sequences for TRIM28 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q13263UniProtKB/Swiss-Prot:
TIF1B_HUMAN :- The HP1 box is both necessary and sufficient for HP1 binding.
- Belongs to the TRIM/RBCC family.
- Domain:
-
- The HP1 box is both necessary and sufficient for HP1 binding.
- The PHD-type zinc finger enhances CEBPB transcriptional activity. The PHD-type zinc finger, the HP1 box and the bromo domain, function together to assemble the machinery required for repression of KRAB domain-containing proteins. Acts as an intramolecular SUMO E3 ligase for autosumoylation of bromodomain.
- The RING-finger-B Box-coiled-coil/tripartite motif (RBCC/TRIM motif) is required for interaction with the KRAB domain of KRAB-zinc finger proteins. Binds four zinc ions per molecule. The RING finger and the N-terminal of the leucine zipper alpha helical coiled-coil region of RBCC are required for oligomerization.
- Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain.
- Family:
-
- Belongs to the TRIM/RBCC family.
Function for TRIM28 Gene
Molecular function for TRIM28 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
- UniProtKB/Swiss-Prot Function:
- Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at Lys-9 (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 Lys-9 and Lys-14 acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). Acts as a corepressor for ZFP568 (By similarity).
Enzyme Numbers (IUBMB) for TRIM28 Gene
Phenotypes From GWAS Catalog for TRIM28 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001105 | RNA polymerase II transcription coactivator activity | ISS | -- |
| GO:0003677 | DNA binding | IDA | 9016654 |
| GO:0003682 | chromatin binding | IDA | 27029610 |
| GO:0003700 | contributes_to DNA binding transcription factor activity | ISS | -- |
| GO:0003713 | transcription coactivator activity | IEA | -- |
Phenotypes for TRIM28 Gene
- MGI mutant phenotypes for TRIM28:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for TRIM28:
-
- Decreased hepcidin::fluc mRNA expression
- shRNA abundance <= 50%
- Decreased ionizing radiation sensitivity
- Decreased viability ratio
- Decreased NF-kappaB reporter expression
- Decreased number of cells in monopolar arrest with EMD534085 (a Kinesin-5 inhibitor)
- Decreased viability after Maraba virus infection
- Decreased vesicular stomatitis virus (VSV) infection
- Wnt reporter downregulated
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased cell migration
- Increased cell death HMECs cells
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Decreased influenza A virus infection
- Decreased viability
- Increased simian virus 40 (SV40) infection
Animal Models for TRIM28 Gene
- MGI Knock Outs for TRIM28:
-
- Trim28 tm1.2Ipc
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TRIM28
-
-
ViGene Biosciences lentiviral particle packaged cDNA for TRIM28 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TRIM28 gene
- Search ViGene Biosciences for TRIM28
CRISPR Products
-
OriGene CRISPR knockouts for TRIM28
- genomics-online: gRNA clones - Search results for available TRIM28 gene related products
- Applied Biological Materials CRISPR for TRIM28
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRIM28
- GenScript: Design CRISPR guide RNA sequences for TRIM28
miRNA for TRIM28 Gene
- miRTarBase miRNAs that target TRIM28
-
- hsa-mir-877-3p (MIRT037068)
- hsa-mir-744-5p (MIRT037599)
- hsa-mir-505-5p (MIRT037943)
- hsa-mir-423-5p (MIRT038141)
- hsa-mir-93-3p (MIRT038878)
- hsa-mir-505-3p (MIRT041001)
- hsa-mir-193b-3p (MIRT041271)
- hsa-mir-484 (MIRT041711)
- hsa-mir-149-5p (MIRT045571)
- hsa-mir-221-3p (MIRT046915)
- hsa-mir-183-5p (MIRT047101)
- hsa-mir-92a-3p (MIRT049122)
- hsa-mir-30a-5p (MIRT049953)
- hsa-mir-15a-5p (MIRT051347)
- hsa-let-7b-5p (MIRT052068)
- hsa-mir-6819-5p (MIRT465266)
- hsa-mir-6812-5p (MIRT465267)
- hsa-mir-6737-5p (MIRT465268)
- hsa-mir-6857-5p (MIRT465269)
- hsa-mir-491-5p (MIRT465270)
- hsa-mir-542-3p (MIRT465271)
- hsa-mir-6747-5p (MIRT465272)
- hsa-mir-608 (MIRT465273)
- hsa-mir-4651 (MIRT465274)
- hsa-mir-4664-5p (MIRT465275)
- hsa-mir-342-5p (MIRT465276)
- hsa-mir-4450 (MIRT465277)
- hsa-mir-4745-5p (MIRT465278)
- hsa-mir-4481 (MIRT465279)
- hsa-mir-6890-5p (MIRT465280)
- hsa-mir-4733-3p (MIRT465281)
- hsa-mir-6753-5p (MIRT465282)
- hsa-mir-1296-3p (MIRT465283)
- hsa-mir-4700-3p (MIRT465284)
- hsa-mir-1233-5p (MIRT736274)
- hsa-mir-1587 (MIRT737922)
- hsa-mir-1972 (MIRT738684)
- hsa-mir-3190-5p (MIRT740974)
- hsa-mir-3620-5p (MIRT741750)
- hsa-mir-378g (MIRT742770)
- hsa-mir-3919 (MIRT742965)
- hsa-mir-3925-5p (MIRT743009)
- hsa-mir-4270 (MIRT743605)
- hsa-mir-4436a (MIRT744445)
- hsa-mir-4441 (MIRT744572)
- hsa-mir-4492 (MIRT745304)
- hsa-mir-4498 (MIRT745385)
- hsa-mir-4505 (MIRT745545)
- hsa-mir-4650-5p (MIRT746526)
- hsa-mir-4656 (MIRT746660)
- hsa-mir-4675 (MIRT746891)
- hsa-mir-4717-5p (MIRT747527)
- hsa-mir-4741 (MIRT748128)
- hsa-mir-4755-3p (MIRT748375)
- hsa-mir-4773 (MIRT748701)
- hsa-mir-5000-3p (MIRT749332)
- hsa-mir-5001-5p (MIRT749378)
- hsa-mir-5702 (MIRT751344)
- hsa-mir-5787 (MIRT751494)
- hsa-mir-6754-5p (MIRT754747)
- hsa-mir-6777-5p (MIRT755399)
- hsa-mir-6778-5p (MIRT755469)
- hsa-mir-6829-5p (MIRT757117)
- hsa-mir-7113-5p (MIRT759128)
- hsa-mir-762 (MIRT759520)
miRNA Products
- Search ViGene Biosciences for TRIM28
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TRIM28
- Browse OriGene Inhibitory RNA Products For TRIM28
- genomics-online: shRNA clones - Search results for available TRIM28 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TRIM28 gene
Clone Products
- Sino Biological Human cDNA Clone for TRIM28
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TRIM28
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TRIM28
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TRIM28
- genomics-online: cdna clones - Search results for available TRIM28 gene related products
- orf clones - Search results for available TRIM28 gene related products
- Applied Biological Materials Clones for TRIM28
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for TRIM28
-
ViGene Biosciences adenoviral particle packaged cDNA for TRIM28 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TRIM28 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TRIM28 gene
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIM28 Gene
Localization for TRIM28 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TRIM28 Gene
- Nucleus. Note=Associated with centromeric heterochromatin during cell differentiation through CBX1. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000785 | chromatin | IEA | -- |
| GO:0005622 | intracellular | IEA | -- |
| GO:0005634 | nucleus | ISS | -- |
| GO:0005654 | nucleoplasm | TAS,IDA | -- |
| GO:0005719 | nuclear euchromatin | IEA | -- |
Pathways & Interactions for TRIM28 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Gene Expression |
.48
|
|
| 2 | Chromatin Regulation / Acetylation | ||
| 3 | DNA Damage | ||
| 4 | ATM Signaling Network in Development and Disease | ||
| 5 | C-MYB transcription factor network | ||
Pathways by source for TRIM28 Gene
2 Cell Signaling Technology pathways for TRIM28 Gene
2 Reactome pathways for TRIM28 Gene
UniProtKB/Swiss-Prot Q13263-TIF1B_HUMAN
- Pathway: Protein modification; protein sumoylation.
Interacting Proteins for TRIM28 Gene
Selected Interacting proteins:
ENSP00000253024
Q13263-TIF1B_HUMAN
for TRIM28 Gene via
STRING
MINT
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0001837 | epithelial to mesenchymal transition | ISS | -- |
| GO:0006281 | DNA repair | IDA | 17178852 |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
Transcripts for TRIM28 Gene
mRNA/cDNA for TRIM28 Gene
- (1) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (1386) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TRIM28 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TRIM28
- genomics-online: gRNA clones - Search results for available TRIM28 gene related products
- Applied Biological Materials CRISPR for TRIM28
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRIM28
- GenScript: Design CRISPR guide RNA sequences for TRIM28
miRNA Products
- Search ViGene Biosciences for TRIM28
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TRIM28
- Browse OriGene Inhibitory RNA Products For TRIM28
- genomics-online: shRNA clones - Search results for available TRIM28 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TRIM28 gene
Clone Products
- Sino Biological Human cDNA Clone for TRIM28
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TRIM28
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TRIM28
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TRIM28
- genomics-online: cdna clones - Search results for available TRIM28 gene related products
- orf clones - Search results for available TRIM28 gene related products
- Applied Biological Materials Clones for TRIM28
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: |
| ExUns: | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | ^ | 20a | · | 20b | · | 20c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||
| SP2: | |||||||||||||||||||||
| SP3: | |||||||||||||||||||||
| SP4: | |||||||||||||||||||||
| SP5: | |||||||||||||||||||||
| SP6: | |||||||||||||||||||||
| SP7: | |||||||||||||||||||||
| SP8: | |||||||||||||||||||||
| SP9: | |||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | ||||||||||||||
| SP11: | |||||||||||||||||||||
| SP12: | |||||||||||||||||||||
| SP13: | |||||||||||||||||||||
| SP14: | |||||||||||||||||||||
| SP15: |
Expression for TRIM28 Gene
This gene is overexpressed in Lymph node (9.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRIM28 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of TRIM28 Gene:
TRIM28SOURCE GeneReport for Unigene cluster for TRIM28 Gene:
Hs.467408mRNA Expression by UniProt/SwissProt for TRIM28 Gene:
Q13263-TIF1B_HUMAN
Tissue specificity:
Expressed in all tissues tested including spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes.
Evidence on tissue expression from TISSUES for TRIM28 Gene
- Skin(4.9)
- Blood(4.6)
- Nervous system(4.6)
- Liver(4.5)
- Lung(4.4)
- Spleen(4.4)
- Intestine(3.7)
- Eye(3.6)
- Pancreas(3.4)
- Heart(2.4)
- Kidney(2.4)
- Muscle(2.4)
- Bone marrow(2.2)
- Lymph node(2.1)
Primer Products
-
OriGene qPCR primer pairs for TRIM28
-
OriGene qPCR primer pairs and template standards for TRIM28
- genomics-online: primer clones - Search results for available TRIM28 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM28 Gene
Orthologs for TRIM28 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TRIM28 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | TRIM28 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | TRIM28 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Trim28 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Trim28 33 16 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | TRIM28 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | TRIM28 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100489687 33 |
|
||
| Str.3172 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.18843 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | trim33l 34 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | bon 35 |
|
|
|
| mei-P26 34 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | nhl-2 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.9380 34 |
|
OneToMany |
- Species where no ortholog for TRIM28 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for TRIM28 Gene
Variants for TRIM28 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs193921106 | uncertain-significance, Malignant tumor of prostate | 58,550,038(+) | G/T | intron_variant | |
| rs398122526 | not-provided, Familial colorectal cancer | 58,548,431(+) | C/G/T | intron_variant | |
| rs1000017709 | -- | 58,544,053(+) | C/T | upstream_transcript_variant | |
| rs1000381582 | -- | 58,546,755(+) | G/A | intron_variant | |
| rs1000432480 | -- | 58,546,620(+) | C/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3687n100 | CNV | gain | 25217958 |
| dgv3688n100 | CNV | gain | 25217958 |
| nsv1057077 | CNV | gain | 25217958 |
| nsv1057206 | CNV | gain | 25217958 |
| nsv1144885 | CNV | deletion | 24896259 |
| nsv1160670 | CNV | deletion | 26073780 |
| nsv515731 | CNV | gain+loss | 19592680 |
| nsv828657 | CNV | gain | 20364138 |
| nsv952156 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
4.17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.10;
22.43% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TRIM28 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TRIM28
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM28 Gene
Disorders for TRIM28 Gene
Additional Disease Information for TRIM28
No disorders were found for TRIM28 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM28 Gene
Publications for TRIM28 Gene
- Solution structure of the PHD domain from the KAP-1 corepressor: structural determinants for PHD, RING and LIM zinc-binding domains. (PMID: 11226167) Capili AD … Borden KL (The EMBO journal 2001) 2 3 4 22 58
- SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1. (PMID: 20424263) Li X … Ann DK (Science signaling 2010) 3 4 22 58
- Structural insights into human KAP1 PHD finger-bromodomain and its role in gene silencing. (PMID: 18488044) Zeng L … Zhou MM (Nature structural & molecular biology 2008) 3 4 22 58
- A novel GDNF-inducible gene, BMZF3, encodes a transcriptional repressor associated with KAP-1. (PMID: 18060868) Suzuki C … Takahashi M (Biochemical and biophysical research communications 2008) 3 4 22 58
- Regulation of E2F1 function by the nuclear corepressor KAP1. (PMID: 17704056) Wang C … Chen J (The Journal of biological chemistry 2007) 3 4 22 58
Products for TRIM28 Gene
- R&D Systems Antibodies for TRIM28 (KAP1)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
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- Browse Proteome Profiler Antibody Arrays
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- Custom Antibody ServicesOriGene Antibodies for TRIM28
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for TRIM28
- Search Origene for MassSpec and Protein Over-expression Lysates for TRIM28
- Origene Custom Protein Services for TRIM28
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TRIM28
- Browse OriGene Inhibitory RNA Products For TRIM28
- OriGene qPCR primer pairs and template standards for TRIM28
- OriGene qPCR primer pairs for TRIM28
- OriGene CRISPR knockouts for TRIM28
- OriGene ORF clones in human for TRIM28
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TRIM28
- GenScript: Next-day shipping of latest version cDNA ORF clones for TRIM28 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for TRIM28
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- GenScript: Design CRISPR guide RNA sequences for TRIM28
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for TRIM28
- Cell Signaling Technology (CST) Antibodies for TRIM28 (TIF1B)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for TRIM28
- Browse Sino Biological Cell Lysates
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- Sino Biological Antibodies for TRIM28
- Browse Sino Biological Assays
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- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for TRIM28
- Novus Biologicals lysates and proteins for TRIM28
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for TRIM28
- Abcam proteins for TRIM28
- Find your target
- Browse Primary Antibodies
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- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for TRIM28
- Browse Antibodies at Cloud-Clone Corp.
- Cloud-Clone Corp. Proteins for TRIM28
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for TRIM28
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for TRIM28
- VectorBuilder custom plasmid, inducible vectors for TRIM28
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TRIM28
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TRIM28
- antibodies-online: Search results for available TRIM28 related products ranked by validation data
- antibodies-online: Search results for available TRIM28 related products ranked by validation data
- antibodies-online: Search results for available TRIM28 related products ranked by validation data
- GeneTex TRIM28 antibody for TRIM28
- Search GeneTex for Proteins for TRIM28
- ViGene Biosciences adenoviral particle packaged cDNA for TRIM28 gene
- ViGene Biosciences lentiviral particle packaged cDNA for TRIM28 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TRIM28 gene
- Search ViGene Biosciences for TRIM28
- Santa Cruz Biotechnology (SCBT) Antibodies for TRIM28
- Search Santa Cruz Biotechnology (SCBT) for TRIM28 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TRIM28
- Custom Antibody ServicesProSci Antibodies for TRIM28
- Search for TRIM28 Proteins at ProSci
- Horizon Cell Lines for TRIM28
- genomics-online: cdna clones - Search results for available TRIM28 gene related products
- orf clones - Search results for available TRIM28 gene related products
- genomics-online: gRNA clones - Search results for available TRIM28 gene related products
- genomics-online: primer clones - Search results for available TRIM28 gene related products
- genomics-online: shRNA clones - Search results for available TRIM28 gene related products
Sources for TRIM28 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew