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This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of ma... See more...
Aliases for TRIM27 Gene
Aliases for TRIM27 Gene
External Ids for TRIM27 Gene
- HGNC: 9975
- Entrez Gene: 5987
- Ensembl: ENSG00000204713
- OMIM: 602165
- UniProtKB: P14373
Previous HGNC Symbols for TRIM27 Gene
- RFP
Previous GeneCards Identifiers for TRIM27 Gene
- GC06M028979
- GC06M028870
- GC06M028678
Summaries for TRIM27 Gene
-
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for TRIM27 Gene
TRIM27 (Tripartite Motif Containing 27) is a Protein Coding gene. Diseases associated with TRIM27 include Differentiated Thyroid Carcinoma and Schaaf-Yang Syndrome. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ubiquitin-protein transferase activity. An important paralog of this gene is TRIM11.
UniProtKB/Swiss-Prot Summary for TRIM27 Gene
-
E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA.
Additional gene information for TRIM27 Gene
- HGNC(9975)
- Entrez Gene(5987)
- Ensembl(ENSG00000204713)
- OMIM(602165)
- UniProtKB(P14373)
- Open Targets Platform(ENSG00000204713)
- Monarch Initiative
- Search for TRIM27 at DataMed
- Search for TRIM27 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRIM27 Gene
Genomics for TRIM27 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TRIM27 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TRIM27 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRIM27
- Top Transcription factor binding sites by QIAGEN in the TRIM27 gene promoter:
-
- AP-1
- GATA-1
- MyoD
- SRY
Genomic Locations for TRIM27 Gene
Genomic Locations for TRIM27 Gene
- chr6:28,903,002-28,923,988
- (GRCh38/hg38)
- Size:
- 20,987 bases
- Orientation:
- Minus strand
- chr6:28,870,779-28,891,768
- (GRCh37/hg19)
- Size:
- 20,990 bases
- Orientation:
- Minus strand
Genomic View for TRIM27 Gene
Genes around TRIM27 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.1 by HGNC
- 6p22.1 by Entrez Gene
- 6p22.1 by Ensembl
TRIM27 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TRIM27 Gene
Proteins for TRIM27 Gene
-
Protein details for TRIM27 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P14373-TRI27_HUMAN
- Recommended name:
- Zinc finger protein RFP
- Protein Accession:
- P14373
- A2BE15
- Q5RJA8
- Q5ST26
- Q6LA73
- Q6NXR9
- Q9BZY6
- Q9UJL3
Protein attributes for TRIM27 Gene
- Size:
- 513 amino acids
- Molecular mass:
- 58490 Da
- Quaternary structure:
-
- Homomultimerizes. Interacts with PML, EIF3S6, EPC1, CHD4 and EID1. Interacts with MAGED4, MAGEF1 and MAGEL2. Interacts with herpes simplex virus protein ICP0.
Protein Expression for TRIM27 Gene
Post-translational modifications for TRIM27 Gene
Other Protein References for TRIM27 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for TRIM27
-
Abcam antibodies for TRIM27
- Invitrogen Antibodies for TRIM27 (AFLGC-TRIM27)
Protein Products
-
OriGene Purified Proteins for TRIM27
- Search Origene for MassSpec and Protein Over-expression Lysates for TRIM27
- Origene Custom Protein Services for TRIM27
- antibodies-online: Show 3 available RFP Proteins ranked by validation data
- Compare Top RFP Proteins
-
Quality Products:
-
Signalway Proteins for TRIM27
Assay Products
- antibodies-online: Show 6 available RFP Elisa Kits ranked by validation data
- Compare Top RFP Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for TRIM27 Gene
Domains & Families for TRIM27 Gene
Gene Families for TRIM27 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Enzymes
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for TRIM27 Gene
- InterPro:
- Blocks:
-
- Zn-finger, RING
- Butyrophylin C-terminal DUF signature
- SPRY-associated domain
- B-box zinc finger signature
- ProtoNet:
Suggested Antigen Peptide Sequences for TRIM27 Gene
- GenScript: Design optimal peptide antigens:
-
- Tripartite motif-containing 27 (A2ABL9_HUMAN)
- Tripartite motif-containing 27 (B0V264_HUMAN)
- Tripartite motif-containing 27 (B0V265_HUMAN)
- Tripartite motif-containing 27 (B0V266_HUMAN)
- Tripartite motif-containing protein 27 (TRI27_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P14373UniProtKB/Swiss-Prot:
TRI27_HUMAN :- The coiled-coil region mediates interaction with EPC1 and CHD4. The B box and coiled-coil domains mediate interaction with PML. The B box and the distal coiled-coil domains mediate homomultimerisation. The B30.2 domain mediates interaction with EIF3S6.
- Belongs to the TRIM/RBCC family.
- Domain:
-
- The coiled-coil region mediates interaction with EPC1 and CHD4. The B box and coiled-coil domains mediate interaction with PML. The B box and the distal coiled-coil domains mediate homomultimerisation. The B30.2 domain mediates interaction with EIF3S6.
- Family:
-
- Belongs to the TRIM/RBCC family.
Function for TRIM27 Gene
Molecular function for TRIM27 Gene
- UniProtKB/Swiss-Prot Function:
- E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27;.
Enzyme Numbers (IUBMB) for TRIM27 Gene
Phenotypes From GWAS Catalog for TRIM27 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | TAS | 3380101 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0004842 | ubiquitin-protein transferase activity | IMP | 23452853 |
| GO:0005515 | protein binding | IPI | 9570750 |
| GO:0008270 | zinc ion binding | IEA | -- |
Phenotypes for TRIM27 Gene
- MGI mutant phenotypes for TRIM27:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for TRIM27:
Animal Models for TRIM27 Gene
- MGI Knock Outs for TRIM27:
-
- Trim27 Trim27<tm1Sis>
Animal Model Products
-
Taconic Biosciences Mouse Models for TRIM27
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TRIM27 - Select products 50% OFF >
- * TRIM27 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TRIM27
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TRIM27
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRIM27
miRNA for TRIM27 Gene
- miRTarBase miRNAs that target TRIM27
-
- hsa-miR-421 (MIRT039436)
- hsa-miR-1260b (MIRT052686)
- hsa-miR-493-3p (MIRT563437)
- hsa-miR-4712-3p (MIRT563438)
- hsa-miR-548ah-5p (MIRT563439)
- hsa-miR-3609 (MIRT563440)
- hsa-miR-548m (MIRT563441)
- mmu-miR-1965 (MIRT585535)
- mmu-miR-1946a (MIRT585536)
- mmu-miR-546 (MIRT585537)
- mmu-miR-804 (MIRT596909)
- mmu-miR-3089-5p (MIRT596910)
- mmu-miR-1195 (MIRT596911)
- mmu-miR-665-3p (MIRT596912)
- mmu-miR-3096b-5p (MIRT596913)
- mmu-miR-690 (MIRT596914)
- mmu-miR-706 (MIRT596915)
- mmu-miR-10b-5p (MIRT596916)
- mmu-miR-10a-5p (MIRT596917)
- mmu-miR-339-5p (MIRT596918)
- hsa-miR-6878-3p (MIRT645239)
- hsa-miR-6735-3p (MIRT645240)
- hsa-miR-6832-3p (MIRT645241)
- hsa-miR-6504-3p (MIRT645242)
- hsa-miR-129-2-3p (MIRT645243)
- hsa-miR-129-1-3p (MIRT645244)
- hsa-miR-6856-3p (MIRT645245)
- hsa-miR-6833-3p (MIRT709734)
- hsa-miR-4768-5p (MIRT709735)
- hsa-miR-6873-3p (MIRT709736)
- hsa-miR-1229-3p (MIRT709737)
- hsa-miR-4666a-5p (MIRT709738)
- hsa-miR-942-5p (MIRT709739)
- hsa-miR-6870-3p (MIRT709740)
- hsa-miR-586 (MIRT709741)
- hsa-miR-27a-3p (MIRT735271)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TRIM27
- Browse OriGene Inhibitory RNA Products For TRIM27
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM27
Clone Products
- Applied Biological Materials (abm): Clones for TRIM27 - Select products 50% OFF >
- * TRIM27 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for TRIM27
- Addgene plasmids for TRIM27
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TRIM27
Cell Line Products
-
Horizon Cell Lines for TRIM27
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIM27 Gene
Localization for TRIM27 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TRIM27 Gene
- Nucleus. Cytoplasm. Nucleus, PML body. Early endosome. Note=Nuclear or cytoplasmic depending on the cell type (By similarity). Colocalized with PML and EIF3S6 in nuclear bodies. Recruited to retromer-containing endosomes via interaction with MAGEL2 (PubMed:23452853). {ECO:0000250, ECO:0000269 PubMed:23452853}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| endosome | 5 |
| cytosol | 5 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoli (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001650 | fibrillar center | IDA | -- |
| GO:0005634 | nucleus | IEA,IDA | 17156811 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005730 | nucleolus | IDA | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 17156811 |
Pathways & Interactions for TRIM27 Gene
Interacting Proteins for TRIM27 Gene
Selected Interacting proteins:
P14373-TRI27_HUMAN
ENSP00000366404
for TRIM27 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for TRIM27
SIGNOR curated interactions for TRIM27 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 10976108 |
| GO:0000209 | protein polyubiquitination | IBA | 21873635 |
| GO:0002820 | negative regulation of adaptive immune response | IMP | 22128329 |
| GO:0006469 | negative regulation of protein kinase activity | IDA | 22128329 |
| GO:0007283 | spermatogenesis | TAS | 3380101 |
No data available for Pathways by source for TRIM27 Gene
Transcripts for TRIM27 Gene
mRNA/cDNA for TRIM27 Gene
- 2 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000377194 2686 nts (view in UCSC)
- ENST00000377199 2963 nts (view in UCSC)
- ENST00000414543 1813 nts (view in UCSC)
- ENST00000467742 541 nts (view in UCSC)
- ENST00000481474 7006 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TRIM27 - Select products 50% OFF >
- * TRIM27 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TRIM27
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TRIM27
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRIM27
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TRIM27
- Browse OriGene Inhibitory RNA Products For TRIM27
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM27
Clone Products
- Applied Biological Materials (abm): Clones for TRIM27 - Select products 50% OFF >
- * TRIM27 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for TRIM27
- Addgene plasmids for TRIM27
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TRIM27
Relevant External Links for TRIM27 Gene
- GeneLoc Exon Structure for
- TRIM27
Expression for TRIM27 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Testis (Reproductive System)
- NULL (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for TRIM27 Gene
This gene is overexpressed in Whole Blood (x4.4).
This gene is overexpressed in Testis (16.2), Fetal ovary (14.2), Placenta (11.4), and Pancreas (8.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRIM27 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRIM27
SOURCE GeneReport for Unigene cluster for TRIM27 Gene:
Hs.440382mRNA Expression by UniProt/SwissProt for TRIM27 Gene:
P14373-TRI27_HUMAN
Tissue specificity:
Expressed in testis namely within the seminiferous tubules.
Evidence on tissue expression from TISSUES for TRIM27 Gene
- Nervous system(3.8)
- Lung(2.4)
- Intestine(2.1)
- Liver(2.1)
- Eye(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM27 Gene
Germ Layers:
- endoderm
Systems:
- endocrine
Regions:
Head and neck:
- neck
- thyroid
Primer Products
-
OriGene qPCR primer pairs for TRIM27
-
OriGene qPCR primer pairs and template standards for TRIM27
Gene Expression Assay Products
Orthologs for TRIM27 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TRIM27 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | TRIM27 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | TRIM27 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Trim27 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Trim27 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| Chicken (Gallus gallus) |
Aves | TRIM27 30 |
|
- Species where no ortholog for TRIM27 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for TRIM27 Gene
- ENSEMBL:
- Gene Tree for TRIM27 (if available)
- TreeFam:
- Gene Tree for TRIM27 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TRIM27: view image
Paralogs for TRIM27 Gene
Paralogs for TRIM27 Gene
- TRIM11 5
- TRIM17 5
- TRIM7 5
- TRIM4 5
- TRIM21 5
- TRIM60 5
- TRIM10 5
- TRIM58 5
- TRIM34 5
- TRIM6-TRIM34 5
- TRIM41 5
- TRIM68 5
- TRIM6 5
- TRIM26 5
- TRIM39 5
- MEFV 5
- TRIM38 5
- TRIM22 5
- TRIM75P 5
- TRIM72 5
- TRIM5 5
- TRIM50 5
- TRIM9 5
- TRIM15 5
- TRIM62 5
- TRIML1 5
- TRIM71 5
- TRIM32 5
- TRIM69 5
- TRIM67 5
- TRIM25 5
- TRIM56 5
- TRIM3 5
- MID1 5
- TRIM64B 5
- TRIM33 5
- TRIM2 5
- TRIM64C 5
- MID2 5
- TRIM39-RPP21 5
- TRIM47 5
- TRIM14 5
- TRIML2 5
- TRIM64 5
- TRIM24 5
- RNF39 5
- TRIM35 5
- TRIM66 5
- TRIM16 5
- TRIM77 5
- TRIM42 5
- TRIM49B 5
- TRIM51 5
- TRIM43B 5
- TRIM43 5
- TRIM65 5
- TRIM29 5
- TRIM49 5
- TRIM49D1 5
- TRIM49D2 5
- TRIM49C 5
- TRIM51GP 5
- TRIM31 5
- TRIM46 5
- TRIM28 5
- TRIM55 5
- TRIM8 5
- TRIM36 5
- TRIM54 5
- TRIM13 5
- TRIM45 5
- TRIM40 5
- TRIM37 5
- TRIM52 5
- TRIM73 5
- TRIM16L 5
- TRIM63 5
- TRIM74 5
- PML 5
- TRIM48 5
- TRIM61 5
- BSPRY 5
- TRIM44 5
- ENSG00000239920 5
(37) SIMAP similar genes for TRIM27 Gene using alignment to 2 proteins:
- TRI27_HUMAN
- H0Y551_HUMAN
Variants for TRIM27 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3608464 | CNV | gain | 21293372 |
| nsv1074388 | CNV | deletion | 25765185 |
| nsv1122126 | CNV | deletion | 24896259 |
| nsv1145096 | CNV | deletion | 24896259 |
| nsv462667 | CNV | gain | 19166990 |
| nsv5238 | CNV | insertion | 18451855 |
| nsv601212 | CNV | gain | 21841781 |
| nsv830622 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
22.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.83;
17.40% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TRIM27 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TRIM27
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRIM27 Gene
Disorders for TRIM27 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| differentiated thyroid carcinoma |
|
|
| schaaf-yang syndrome |
|
|
| ritscher-schinzel syndrome |
|
|
| prader-willi syndrome |
|
|
Search TRIM27 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
TRI27_HUMAN- Note=A chromosomal aberration involving TRIM27/RFP is found in papillary thyroid carcinomas (PTCs). Translocation t(6;10)(p21.3;q11.2) with RET. The translocation generates TRIM27/RET and delta TRIM27/RET oncogenes. {ECO:0000269 PubMed:12787916, ECO:0000269 PubMed:3037315}.
Additional Disease Information for TRIM27
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for TRIM27 Gene
Publications for TRIM27 Gene
- Selective ablation of retinoblastoma protein function by the RET finger protein. (PMID: 15837424) Krützfeldt M … Mittnacht S (Molecular cell 2005) 3 4 23
- Novel tumorigenic rearrangement, Delta rfp/ret, in a papillary thyroid carcinoma from externally irradiated patient. (PMID: 12787916) Saenko V … Yamashita S (Mutation research 2003) 3 4 23
- Mi-2 beta associates with BRG1 and RET finger protein at the distinct regions with transcriptional activating and repressing abilities. (PMID: 14530259) Shimono Y … Takahashi M (The Journal of biological chemistry 2003) 3 4 23
- The Ret finger protein induces apoptosis via its RING finger-B box-coiled-coil motif. (PMID: 12807881) Dho SH … Kwon KS (The Journal of biological chemistry 2003) 3 4 23
- Differential expression of RET finger protein in testicular germ cell tumors. (PMID: 12445133) Tezel G … Takahashi M (Pathology international 2002) 3 4 23
ExternalLinks
Products for TRIM27 Gene
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Sources for TRIM27 Gene
- (1) GeneCards
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- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
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- (67) Reactome
- (68) GeneGo (Thomson Reuters)
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- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
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- (78) RefSeq
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- (80) MaxQB
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- (83) Illumina
- (84) COMPARTMENTS
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- (89) antibodies-online
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- (100) DGIdb
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- (104) diseasecard
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- (115) NCBI Bookshelf
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