Aliases for TRIM26 Gene
External Ids for TRIM26 Gene
Previous HGNC Symbols for TRIM26 Gene
Previous GeneCards Identifiers for TRIM26 Gene
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Although the function of the protein is unknown, the RING domain suggests that the protein may have DNA-binding activity. The gene localizes to the major histocompatibility complex (MHC) class I region on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2011]
GeneCards Summary for TRIM26 Gene
TRIM26 (Tripartite Motif Containing 26) is a Protein Coding gene. Diseases associated with TRIM26 include Neural Tube Defects. Among its related pathways are Interferon gamma signaling and Innate Immune System. An important paralog of this gene is TRIM10.
UniProtKB/Swiss-Prot Summary for TRIM26 Gene
E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs). Promotes nuclear IRF3 ubiquitination and proteasomal degradation. Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1.