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TRIM26 Gene(Protein Coding)

Tripartite Motif Containing 26

GCID:
GC06M030184
GIFtS:
45
Genes Participants
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Aliases for TRIM26 Gene

Aliases for TRIM26 Gene

  • Tripartite Motif Containing 26 2 3 5
  • Zinc Finger Protein 173 3 4
  • RING Finger Protein 95 3 4
  • Acid Finger Protein 3 4
  • ZNF173 3 4
  • RNF95 3 4
  • AFP 3 4
  • Widely Expressed Acid Zinc Finger Protein 3
  • Tripartite Motif-Containing Protein 26 3
  • Tripartite Motif-Containing 26 2
  • EC 2.3.2.27 4

External Ids for TRIM26 Gene

Previous HGNC Symbols for TRIM26 Gene

  • ZNF173

Previous GeneCards Identifiers for TRIM26 Gene

  • GC06M030236
  • GC06M029922
  • GC06M030258
  • GC06M030260
  • GC06M030152
  • GC06M029951

Summaries for TRIM26 Gene

Entrez Gene Summary for TRIM26 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Although the function of the protein is unknown, the RING domain suggests that the protein may have DNA-binding activity. The gene localizes to the major histocompatibility complex (MHC) class I region on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for TRIM26 Gene

TRIM26 (Tripartite Motif Containing 26) is a Protein Coding gene. Diseases associated with TRIM26 include Neural Tube Defects. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. An important paralog of this gene is TRIM10.

UniProtKB/Swiss-Prot for TRIM26 Gene

  • E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs). Promotes nuclear IRF3 ubiquitination and proteasomal degradation. Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1.

Additional gene information for TRIM26 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM26 Gene

Genomics for TRIM26 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for TRIM26 Gene

Promoters and enhancers for TRIM26 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH06I030210 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 575 +0.6 605 4.1 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF213 ZNF143 TRIM26 PIR43263 HLA-U DHX16 HLA-W MICD TRIM39 ZNRD1 PPP1R10 PAIP1P1
GH06I030611 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 51.6 -402.1 -402058 8.7 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 PPP1R10 MRPS18B DDX39B MDC1 TRIM39 ABCF1 NRM DHX16 ZNRD1 TRIM26
GH06I030715 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 53.1 -506.0 -506032 7.7 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 MDC1 TUBB DDX39B TRIM39 DHX16 LY6G5B PPP1R10 ZNRD1 PAIP1P1 NRM
GH06I030907 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 52.2 -695.0 -694963 2.2 CLOCK DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 GTF2H4 VARS2 GC06P031581 MDC1 DDX39B LY6G5B TRIM39 LSM2 PPP1R10 HCG18
GH06I030678 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 26.8 -471.8 -471832 13.5 MLX DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 NRM PPP1R10 DHX16 MDC1 DDX39B TRIM39 LY6G5B IER3 TRIM26 PAIP1P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRIM26 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRIM26 gene promoter:

Genomic Locations for TRIM26 Gene

Genomic Locations for TRIM26 Gene
chr6:30,184,453-30,213,494
(GRCh38/hg38)
Size:
29,042 bases
Orientation:
Minus strand
chr6:30,152,232-30,181,271
(GRCh37/hg19)

Genomic View for TRIM26 Gene

Genes around TRIM26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM26 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TRIM26 Gene

Proteins for TRIM26 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for TRIM26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12899-TRI26_HUMAN
    Recommended name:
    Tripartite motif-containing protein 26
    Protein Accession:
    Q12899
    Secondary Accessions:
    • A6NG96
    • Q5SRL2

    Protein attributes for TRIM26 Gene

    Size:
    539 amino acids
    Molecular mass:
    62166 Da
    Quaternary structure:
    • Interacts with TBK1; this interaction bridges together TBK1 and NEMO in order to activate TBK1.

neXtProt entry for TRIM26 Gene

Protein Expression for TRIM26 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for TRIM26 Gene

  • Autoubiquitinates upon viral infection. In turn, autoubiquitinated TRIM26 recruits NEMO and bridges TBK1-NEMO interaction.
  • Ubiquitination at isoforms=245 and posLast=449449
  • Modification sites at PhosphoSitePlus

Other Protein References for TRIM26 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM26 Gene

Domains & Families for TRIM26 Gene

Gene Families for TRIM26 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TRIM26 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TRIM26 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q12899

UniProtKB/Swiss-Prot:

TRI26_HUMAN :
  • Belongs to the TRIM/RBCC family.
Family:
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM26: view

Function for TRIM26 Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for TRIM26 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs). Promotes nuclear IRF3 ubiquitination and proteasomal degradation. Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1.

Enzyme Numbers (IUBMB) for TRIM26 Gene

Phenotypes From GWAS Catalog for TRIM26 Gene

Gene Ontology (GO) - Molecular Function for TRIM26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 8530076
GO:0005515 protein binding IPI 21516116
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA,NAS 8530076
genes like me logo Genes that share ontologies with TRIM26: view
genes like me logo Genes that share phenotypes with TRIM26: view

Animal Model Products

miRNA for TRIM26 Gene

miRTarBase miRNAs that target TRIM26

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM26 Gene

Localization for TRIM26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM26 Gene

Cytoplasm. Nucleus. Note=Viral infection mediates TRIM26 nuclear translocation. {ECO:0000269 PubMed:25763818}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM26 gene
Compartment Confidence
cytosol 5
nucleus 4
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRIM26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TRIM26: view

Pathways & Interactions for TRIM26 Gene

genes like me logo Genes that share pathways with TRIM26: view

Pathways by source for TRIM26 Gene

Gene Ontology (GO) - Biological Process for TRIM26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045087 innate immune response IEA,IDA 18248090
GO:0046597 negative regulation of viral entry into host cell IDA 18248090
GO:0051091 positive regulation of DNA binding transcription factor activity IDA 23077300
GO:0060333 interferon-gamma-mediated signaling pathway TAS --
GO:1902187 negative regulation of viral release from host cell IDA 18248090
genes like me logo Genes that share ontologies with TRIM26: view

No data available for SIGNOR curated interactions for TRIM26 Gene

Drugs & Compounds for TRIM26 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for TRIM26 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for TRIM26 Gene

(10) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(226) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRIM26 Gene

Tripartite motif containing 26:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM26 Gene

No ASD Table

Relevant External Links for TRIM26 Gene

GeneLoc Exon Structure for
TRIM26
ECgene alternative splicing isoforms for
TRIM26

Expression for TRIM26 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM26 Gene

mRNA expression in normal human tissues for TRIM26 Gene
mRNA expression by BioGPS for TRIM26 GenemRNA expression by GTEx for TRIM26 Gene

Protein differential expression in normal tissues from HIPED for TRIM26 Gene

This gene is overexpressed in Pancreas (8.6), NK cells (7.1), Peripheral blood mononuclear cells (6.6), and CD8 Tcells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRIM26 Gene



Protein tissue co-expression partners for TRIM26 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRIM26 Gene:

TRIM26

SOURCE GeneReport for Unigene cluster for TRIM26 Gene:

Hs.731863

Evidence on tissue expression from TISSUES for TRIM26 Gene

  • Blood(4.2)
  • Nervous system(4.2)
  • Skin(4)
genes like me logo Genes that share expression patterns with TRIM26: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM26 Gene

Orthologs for TRIM26 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRIM26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia TRIM26 33 34
  • 99.26 (n)
cow
(Bos Taurus)
 Mammalia TRIM26 33 34
  • 92.15 (n)
mouse
(Mus musculus)
 Mammalia Trim26 33 16 34
  • 85.28 (n)
dog
(Canis familiaris)
 Mammalia TRIM26 33 34
  • 84.91 (n)
rat
(Rattus norvegicus)
 Mammalia Trim26 33
  • 84.29 (n)
oppossum
(Monodelphis domestica)
 Mammalia TRIM26 34
  • 74 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 34
  • 42 (a)
 OneToMany
-- 34
  • 42 (a)
 OneToMany
Species where no ortholog for TRIM26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM26 Gene

ENSEMBL:
Gene Tree for TRIM26 (if available)
TreeFam:
Gene Tree for TRIM26 (if available)

Paralogs for TRIM26 Gene

Variants for TRIM26 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for TRIM26 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000016876 -- 30,215,443(-) T/C upstream_transcript_variant
rs1000036075 -- 30,192,149(-) G/A intron_variant
rs1000275815 -- 30,208,045(-) G/A intron_variant
rs1000407444 -- 30,212,013(-) G/C intron_variant
rs1000429375 -- 30,201,363(-) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM26 Gene

Variant ID Type Subtype PubMed ID
esv2731777 CNV deletion 23290073
esv3411275 CNV duplication 20981092
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1144137 CNV deletion 24896259
nsv601264 CNV loss 21841781

Variation tolerance for TRIM26 Gene

Residual Variation Intolerance Score: 47.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.27; 62.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM26 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM26 Gene

Disorders for TRIM26 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRIM26 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
neural tube defects
  • neural tube defects, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TRIM26

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TRIM26: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM26 Gene

Publications for TRIM26 Gene

  1. Cloning of a new "finger" protein gene (ZNF173) within the class I region of the human MHC. (PMID: 8530076) Chu TW … Gruen JR (Genomics 1995) 2 3 4 22 58
  2. Autoubiquitination of TRIM26 links TBK1 to NEMO in RLR-mediated innate antiviral immune response. (PMID: 26611359) Ran Y … Wang YY (Journal of molecular cell biology 2016) 3 4 58
  3. TRIM26 negatively regulates interferon-β production and antiviral response through polyubiquitination and degradation of nuclear IRF3. (PMID: 25763818) Wang P … Gao C (PLoS pathogens 2015) 3 4 58
  4. Genome-wide association study identifies five new schizophrenia loci. (PMID: 21926974) Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium (Nature genetics 2011) 3 44 58
  5. A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01. (PMID: 20593013) Cree BA … IMSGC (PloS one 2010) 3 44 58

Products for TRIM26 Gene

Sources for TRIM26 Gene