The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Although the function of the protein is unknown, the RING domain suggests that the protein may have DNA-binding activity. The gene... See more...

Aliases for TRIM26 Gene

Aliases for TRIM26 Gene

  • Tripartite Motif Containing 26 2 3 5
  • RNF95 2 3 4
  • Tripartite Motif-Containing Protein 26 3 4
  • Zinc Finger Protein 173 3 4
  • RING Finger Protein 95 3 4
  • Acid Finger Protein 3 4
  • ZNF173 3 4
  • AFP 3 4
  • Widely Expressed Acid Zinc Finger Protein 3
  • Tripartite Motif-Containing 26 2
  • EC 2.3.2.27 4
  • TRIM26 5

External Ids for TRIM26 Gene

Previous HGNC Symbols for TRIM26 Gene

  • ZNF173

Previous GeneCards Identifiers for TRIM26 Gene

  • GC06M030236
  • GC06M029922
  • GC06M030258
  • GC06M030260
  • GC06M030152
  • GC06M029951

Summaries for TRIM26 Gene

Entrez Gene Summary for TRIM26 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Although the function of the protein is unknown, the RING domain suggests that the protein may have DNA-binding activity. The gene localizes to the major histocompatibility complex (MHC) class I region on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for TRIM26 Gene

TRIM26 (Tripartite Motif Containing 26) is a Protein Coding gene. Diseases associated with TRIM26 include Neural Tube Defects. Among its related pathways are Interferon gamma signaling and Innate Immune System. An important paralog of this gene is TRIM10.

UniProtKB/Swiss-Prot Summary for TRIM26 Gene

  • E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs). Promotes nuclear IRF3 ubiquitination and proteasomal degradation. Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRIM26 Gene

Genomics for TRIM26 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TRIM26 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRIM26 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRIM26

Top Transcription factor binding sites by QIAGEN in the TRIM26 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • LCR-F1
  • Nkx2-5
  • POU2F1
  • POU2F1a

Genomic Locations for TRIM26 Gene

Genomic Locations for TRIM26 Gene
chr6:30,184,453-30,213,435
(GRCh38/hg38)
Size:
28,983 bases
Orientation:
Minus strand
chr6:30,152,232-30,181,271
(GRCh37/hg19)
Size:
29,040 bases
Orientation:
Minus strand

Genomic View for TRIM26 Gene

Genes around TRIM26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for TRIM26 Gene

  • Protein details for TRIM26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12899-TRI26_HUMAN
    Recommended name:
    Tripartite motif-containing protein 26
    Protein Accession:
    Q12899
    Secondary Accessions:
    • A6NG96
    • Q5SRL2

    Protein attributes for TRIM26 Gene

    Size:
    539 amino acids
    Molecular mass:
    62166 Da
    Quaternary structure:
    • Interacts with TBK1; this interaction bridges together TBK1 and NEMO in order to activate TBK1 (PubMed:26611359). Interacts with INCA1 (PubMed:21750715).

neXtProt entry for TRIM26 Gene

Post-translational modifications for TRIM26 Gene

  • Autoubiquitinates upon viral infection. In turn, autoubiquitinated TRIM26 recruits NEMO and bridges TBK1-NEMO interaction.
  • Ubiquitination at Lys245 and Lys449
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TRIM26 Gene

Domains & Families for TRIM26 Gene

Gene Families for TRIM26 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for TRIM26 Gene

InterPro:
Blocks:
  • Zn-finger, RING
  • Butyrophylin C-terminal DUF signature
  • SPRY-associated domain
  • B-box zinc finger signature
ProtoNet:

Suggested Antigen Peptide Sequences for TRIM26 Gene

GenScript: Design optimal peptide antigens:
  • Zn-finger protein (Q5SRL2_HUMAN)
  • Zinc finger protein 173 (TRI26_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q12899

UniProtKB/Swiss-Prot:

TRI26_HUMAN :
  • Belongs to the TRIM/RBCC family.
Family:
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM26: view

Function for TRIM26 Gene

Molecular function for TRIM26 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs). Promotes nuclear IRF3 ubiquitination and proteasomal degradation. Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence={ECO:0000269|PubMed:26611359};.

Enzyme Numbers (IUBMB) for TRIM26 Gene

Phenotypes From GWAS Catalog for TRIM26 Gene

Gene Ontology (GO) - Molecular Function for TRIM26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 8530076
GO:0005515 protein binding IPI 21516116
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA,NAS 8530076
genes like me logo Genes that share ontologies with TRIM26: view
genes like me logo Genes that share phenotypes with TRIM26: view

Animal Model Products

CRISPR Products

miRNA for TRIM26 Gene

miRTarBase miRNAs that target TRIM26

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM26

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM26 Gene

Localization for TRIM26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM26 Gene

Cytoplasm. Nucleus. Note=Viral infection mediates TRIM26 nuclear translocation. {ECO:0000269 PubMed:25763818}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM26 gene
Compartment Confidence
nucleus 4
cytosol 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRIM26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA,IBA 21873635
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TRIM26: view

Pathways & Interactions for TRIM26 Gene

genes like me logo Genes that share pathways with TRIM26: view

Pathways by source for TRIM26 Gene

Gene Ontology (GO) - Biological Process for TRIM26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0010468 regulation of gene expression IBA 21873635
GO:0016567 protein ubiquitination IBA 21873635
GO:0045087 innate immune response IEA,IDA 18248090
GO:0046597 negative regulation of viral entry into host cell IDA 18248090
genes like me logo Genes that share ontologies with TRIM26: view

No data available for SIGNOR curated interactions for TRIM26 Gene

Drugs & Compounds for TRIM26 Gene

No Compound Related Data Available

Transcripts for TRIM26 Gene

mRNA/cDNA for TRIM26 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM26

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM26 Gene

No ASD Table

Relevant External Links for TRIM26 Gene

GeneLoc Exon Structure for
TRIM26

Expression for TRIM26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRIM26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRIM26 Gene

This gene is overexpressed in Pancreas (8.6), NK cells (7.1), Peripheral blood mononuclear cells (6.6), and CD8 Tcells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRIM26 Gene



Protein tissue co-expression partners for TRIM26 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRIM26

SOURCE GeneReport for Unigene cluster for TRIM26 Gene:

Hs.731863

Evidence on tissue expression from TISSUES for TRIM26 Gene

  • Blood(4.4)
  • Nervous system(4.4)
  • Skin(4.2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with TRIM26: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM26 Gene

Orthologs for TRIM26 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRIM26 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TRIM26 30 31
  • 99.26 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TRIM26 30 31
  • 92.15 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Trim26 30 17 31
  • 85.28 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TRIM26 30 31
  • 84.91 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Trim26 30
  • 84.29 (n)
Oppossum
(Monodelphis domestica)
Mammalia TRIM26 31
  • 74 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 42 (a)
OneToMany
-- 31
  • 42 (a)
OneToMany
Species where no ortholog for TRIM26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TRIM26 Gene

ENSEMBL:
Gene Tree for TRIM26 (if available)
TreeFam:
Gene Tree for TRIM26 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRIM26: view image

Paralogs for TRIM26 Gene

(24) SIMAP similar genes for TRIM26 Gene using alignment to 5 proteins:

  • TRI26_HUMAN
  • A2AE48_HUMAN
  • A2AE50_HUMAN
  • A2AE51_HUMAN
  • Q5SPU2_HUMAN
genes like me logo Genes that share paralogs with TRIM26: view

Variants for TRIM26 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRIM26 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs17194565 - p.Gln197His

Additional dbSNP identifiers (rs#s) for TRIM26 Gene

Structural Variations from Database of Genomic Variants (DGV) for TRIM26 Gene

Variant ID Type Subtype PubMed ID
esv2731777 CNV deletion 23290073
esv3411275 CNV duplication 20981092
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1144137 CNV deletion 24896259
nsv601264 CNV loss 21841781

Variation tolerance for TRIM26 Gene

Residual Variation Intolerance Score: 47.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.27; 62.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM26 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM26 Gene

Disorders for TRIM26 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRIM26 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
neural tube defects
  • neural tube defects, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TRIM26

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TRIM26: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM26 Gene

Publications for TRIM26 Gene

  1. Cloning of a new "finger" protein gene (ZNF173) within the class I region of the human MHC. (PMID: 8530076) Chu TW … Gruen JR (Genomics 1995) 2 3 4 23
  2. Autoubiquitination of TRIM26 links TBK1 to NEMO in RLR-mediated innate antiviral immune response. (PMID: 26611359) Ran Y … Wang YY (Journal of molecular cell biology 2016) 3 4
  3. TRIM26 negatively regulates interferon-β production and antiviral response through polyubiquitination and degradation of nuclear IRF3. (PMID: 25763818) Wang P … Gao C (PLoS pathogens 2015) 3 4
  4. The inhibitor of growth protein 5 (ING5) depends on INCA1 as a co-factor for its antiproliferative effects. (PMID: 21750715) Zhang F … Müller-Tidow C (PloS one 2011) 3 4
  5. Genome-wide association study identifies five new schizophrenia loci. (PMID: 21926974) Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium (Nature genetics 2011) 3 41

Products for TRIM26 Gene

Sources for TRIM26 Gene