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The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Although the function of the protein is unknown, the RING domain suggests that the protein may have DNA-binding activity. The gene localizes to the major histocompatibility complex (MHC) class I region on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2011]
TRIM26 (Tripartite Motif Containing 26) is a Protein Coding gene. Diseases associated with TRIM26 include Neural Tube Defects. Among its related pathways are Interferon gamma signaling and Innate Immune System. An important paralog of this gene is TRIM10.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | NAS | 8530076 |
GO:0005515 | protein binding | IPI | 21516116 |
GO:0008270 | zinc ion binding | IEA | -- |
GO:0016740 | transferase activity | IEA | -- |
GO:0046872 | metal ion binding | IEA,NAS | 8530076 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005575 | cellular_component | ND | -- |
GO:0005634 | nucleus | IEA | -- |
GO:0005737 | cytoplasm | IEA,IBA | 21873635 |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Interferon gamma signaling | ||
2 | Cytokine Signaling in Immune system | ||
3 | Innate Immune System |
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|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002376 | immune system process | IEA | -- |
GO:0010468 | regulation of gene expression | IBA | 21873635 |
GO:0016567 | protein ubiquitination | IBA | 21873635 |
GO:0045087 | innate immune response | IEA,IDA | 18248090 |
GO:0046597 | negative regulation of viral entry into host cell | IDA | 18248090 |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TRIM26 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TRIM26 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Trim26 30 17 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TRIM26 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Trim26 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | TRIM26 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs17194565 | - | p.Gln197His |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2731777 | CNV | deletion | 23290073 |
esv3411275 | CNV | duplication | 20981092 |
nsv1074389 | CNV | deletion | 25765185 |
nsv1122126 | CNV | deletion | 24896259 |
nsv1144137 | CNV | deletion | 24896259 |
nsv601264 | CNV | loss | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
neural tube defects |
|
|