TRIM24 Gene (Protein Coding)

Tripartite Motif Containing 24

GC07P138460
GIFtS:
44
The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripar... See more...

Aliases for TRIM24 Gene

Aliases for TRIM24 Gene

  • Tripartite Motif Containing 24 2 3 5
  • RNF82 2 3 4
  • TIF1A 2 3 4
  • RING-Type E3 Ubiquitin Transferase TIF1-Alpha 3 4
  • Transcription Intermediary Factor 1-Alpha 3 4
  • Transcriptional Intermediary Factor 1 2 3
  • E3 Ubiquitin-Protein Ligase TRIM24 3 4
  • RING Finger Protein 82 3 4
  • TIF1-Alpha 3 4
  • HTIF1 2 3
  • TIF1 3 4
  • Tripartite Motif-Containing Protein 24 4
  • Tripartite Motif-Containing 24 2
  • EC 2.3.2.27 4
  • TIF1ALPHA 3
  • EC 6.3.2 50
  • TRIM24 5
  • Tif1a 2
  • PTC6 3
  • TF1A 3

External Ids for TRIM24 Gene

Previous HGNC Symbols for TRIM24 Gene

  • TIF1

Previous GeneCards Identifiers for TRIM24 Gene

  • GC07P137603
  • GC07P137795
  • GC07P138144
  • GC07P132454

Summaries for TRIM24 Gene

Entrez Gene Summary for TRIM24 Gene

  • The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM24 Gene

TRIM24 (Tripartite Motif Containing 24) is a Protein Coding gene. Diseases associated with TRIM24 include Differentiated Thyroid Carcinoma and Cerebellar Agenesis. Among its related pathways are Regulation of Androgen receptor activity and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and chromatin binding. An important paralog of this gene is TRIM33.

UniProtKB/Swiss-Prot Summary for TRIM24 Gene

  • Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity).

Gene Wiki entry for TRIM24 Gene

Additional gene information for TRIM24 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRIM24 Gene

Genomics for TRIM24 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for TRIM24 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH07J138457 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 256.7 +1.1 1053 7 SP1 ZNF207 NCOR1 IKZF1 MYC ZNF600 ZNF580 ZNF592 POLR2A CEBPA TRIM24 MN298114-239 MN298678-075 LUC7L2 UBN2 ENSG00000239254 HSALNG0061676 SVOPL
GH07J138349 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 17.4 -107.8 -107818 4.9 NCOR1 MYC IKZF1 SSRP1 ZNF592 ZMYM3 CEBPA NFIC CHD4 MXD4 LUC7L2 UBN2 TTC26 TRIM24 ENSG00000271537 DGKI SVOPL CREB3L2 piR-50443-346 piR-41420-006
GH07J137974 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 14.6 -475.5 -475452 21 BCLAF1 SP1 MYC NCOR1 IKZF1 SSRP1 JUND ZNF592 ZMYM3 POLR2A lnc-DGKI-1 TRIM24 CREB3L2 CREB3L2-AS1 RF00017-6130 DGKI
GH07J138477 Enhancer 1.2 Ensembl ENCODE dbSUPER 17.5 +20.0 20042 8.2 SSRP1 ZMYM3 CEBPA CHD4 MXD4 BCL11A FOXA1 HOMEZ ZNF217 IRF2 TRIM24 SNODB413 MN298114-239 SVOPL
GH07J137995 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 7.6 -460.7 -460674 7.6 BCLAF1 SP1 ZNF654 NCOR1 MYC ZNF600 IKZF1 JUND ZNF592 ATF2 CREB3L2 TRIM24 AKR1D1 RF00017-6130 lnc-AKR1D1-3 DGKI
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRIM24 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRIM24

Top Transcription factor binding sites by QIAGEN in the TRIM24 gene promoter:
  • CBF(2)
  • CUTL1
  • GR
  • GR-alpha
  • MRF-2
  • NF-Y
  • Nkx2-5

Genomic Locations for TRIM24 Gene

Latest Assembly
chr7:138,460,259-138,589,996
(GRCh38/hg38)
Size:
129,738 bases
Orientation:
Plus strand

Previous Assembly
chr7:138,145,004-138,274,741
(GRCh37/hg19 by Entrez Gene)
Size:
129,738 bases
Orientation:
Plus strand

chr7:138,145,079-138,274,738
(GRCh37/hg19 by Ensembl)
Size:
129,660 bases
Orientation:
Plus strand

Genomic View for TRIM24 Gene

Genes around TRIM24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM24 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TRIM24 Gene

Proteins for TRIM24 Gene

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  • Protein details for TRIM24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15164-TIF1A_HUMAN
    Recommended name:
    Transcription intermediary factor 1-alpha
    Protein Accession:
    O15164
    Secondary Accessions:
    • A4D1R7
    • A4D1R8
    • O95854

    Protein attributes for TRIM24 Gene

    Size:
    1050 amino acids
    Molecular mass:
    116831 Da
    Quaternary structure:
    • Interacts with CARM1, NCOA2/GRIP1, PML, KAT5/TIP60, BRD7, CBX1, CBX3 and CBX5. Part of a coactivator complex containing TRIM24, NCOA2 and CARM1 (By similarity). Interacts with NR3C2/MCR. Interacts with the ligand-binding domain of estrogen receptors (in vitro). Interaction with DNA-bound estrogen receptors requires the presence of estradiol. Interacts with AR and p53/TP53. Interacts (via bromo domain) with histone H3 (via N-terminus), provided that it is not methylated at 'Lys-4' (H3K4me0). Does not interact with histone H3 that is methylated at 'Lys-4' (H3K4me1, H3K4me2 or H3K4me3). Interacts (via bromo domain) with histone H3 (via N-terminus) that is acetylated at 'Lys-23' (H3K23ac). Has the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has very low affinity for histone H3 that is methylated at 'Lys-9' (H3K9me), or acetylated at both 'Lys-9' (H3K9ac) and 'Lys-14' (H3K14ac), or acetylated at 'Lys-27' (H3K27ac) (in vitro). Interacts with TRIM16.

    Three dimensional structures from OCA and Proteopedia for TRIM24 Gene

    Alternative splice isoforms for TRIM24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM24 Gene

Protein Expression for TRIM24 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for TRIM24 Gene

O15164:
  • GSSTALLYSKRLIT
  • DDPNEDWCAVCQNGG

Post-translational modifications for TRIM24 Gene

Other Protein References for TRIM24 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for TRIM24 Gene

Gene Families for TRIM24 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for TRIM24 Gene

InterPro:
Blocks:
  • Zn-finger, RING
  • Zn-finger-like, PHD finger
  • Bromodomain signature
  • B-box zinc finger signature
  • B-box, C-terminal

Suggested Antigen Peptide Sequences for TRIM24 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ53462, highly similar to Transcription intermediary factor 1-alpha (B4DYZ9_HUMAN)
  • Tripartite motif-containing protein 24 (TIF1A_HUMAN)
genes like me logo Genes that share domains with TRIM24: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TRIM24 Gene

Function for TRIM24 Gene

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  6. Cell Lines for research

Molecular function for TRIM24 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27;.
UniProtKB/Swiss-Prot Induction:
Up-regulated in some cases of breast cancer.

Enzyme Numbers (IUBMB) for TRIM24 Gene

Phenotypes From GWAS Catalog for TRIM24 Gene

Gene Ontology (GO) - Molecular Function for TRIM24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IPI 19556538
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IDA 21164480
GO:0003713 transcription coactivator activity TAS,IDA 21164480
GO:0004672 protein kinase activity IEA --
genes like me logo Genes that share ontologies with TRIM24: view
genes like me logo Genes that share phenotypes with TRIM24: view

Animal Models for TRIM24 Gene

MGI Knock Outs for TRIM24:

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM24

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIM24 Gene

Localization for TRIM24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM24 Gene

Nucleus. Cytoplasm. Note=Colocalizes with sites of active transcription. Detected both in nucleus and cytoplasm in some breast cancer samples. Predominantly nuclear.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM24 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 2
cytoskeleton 2
plasma membrane 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRIM24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IBA --
GO:0000791 euchromatin IEA --
GO:0005634 nucleus TAS,IDA 21164480
GO:0005654 nucleoplasm IDA --
GO:0005726 perichromatin fibrils IEA --
genes like me logo Genes that share ontologies with TRIM24: view

Pathways & Interactions for TRIM24 Gene

genes like me logo Genes that share pathways with TRIM24: view

Pathways by source for TRIM24 Gene

1 BioSystems pathway for TRIM24 Gene
1 R&D Systems pathway for TRIM24 Gene
1 Qiagen pathway for TRIM24 Gene
  • Transcriptional Regulatory Network in Embryonic Stem Cell

UniProtKB/Swiss-Prot O15164-TIF1A_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for TRIM24 Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for TRIM24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription by RNA polymerase II TAS 9115274
GO:0006468 protein phosphorylation IEA --
GO:0008285 negative regulation of cell proliferation IEA --
GO:0010628 positive regulation of gene expression IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with TRIM24: view

Drugs & Compounds for TRIM24 Gene

Products:

  1. Drug products for research

(3) Drugs for TRIM24 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for TRIM24 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TRIM24: view

Transcripts for TRIM24 Gene

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mRNA/cDNA for TRIM24 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM24

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM24 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b
SP1: - - -
SP2: - -
SP3: - -
SP4:

Relevant External Links for TRIM24 Gene

GeneLoc Exon Structure for
TRIM24

Expression for TRIM24 Gene

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  1. Primer products for research
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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRIM24 Gene

mRNA expression in normal human tissues for TRIM24 Gene
mRNA expression by GTEx for TRIM24 GenemRNA expression by BioGPS for TRIM24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRIM24 Gene

This gene is overexpressed in Bone marrow stromal cell (53.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRIM24 Gene



Protein tissue co-expression partners for TRIM24 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRIM24

SOURCE GeneReport for Unigene cluster for TRIM24 Gene:

Hs.490287

Evidence on tissue expression from TISSUES for TRIM24 Gene

  • Liver(4.5)
  • Thyroid gland(4.4)
  • Nervous system(3.4)
  • Blood(2.2)
  • Muscle(2.2)
  • Kidney(2.1)
  • Skin(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM24 Gene

Germ Layers:
  • endoderm
Systems:
  • endocrine
Regions:
Head and neck:
  • neck
  • thyroid
genes like me logo Genes that share expression patterns with TRIM24: view

Primer products for research

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRIM24 Gene

Orthologs for TRIM24 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIM24 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia TRIM24 29 30
  • 99.84 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia -- 30
  • 97 (a)
 OneToMany
-- 30
  • 95 (a)
 OneToMany
TRIM24 29
  • 93.9 (n)
-- 30
  • 75 (a)
 OneToMany
Cow
(Bos Taurus)
 Mammalia TRIM24 29 30
  • 93.05 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia TRIM24 30
  • 90 (a)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Trim24 29 16 30
  • 89.26 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia TRIM24 30
  • 83 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves TRIM24 29 30
  • 78.94 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia TRIM24 30
  • 79 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia trim24 29
  • 67.69 (n)
Zebrafish
(Danio rerio)
 Actinopterygii trim24 30
  • 39 (a)
 ManyToMany
Fruit Fly
(Drosophila melanogaster)
 Insecta mei-P26 30
  • 14 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea nhl-2 30
  • 15 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.9380 30
  • 22 (a)
 OneToMany
Species where no ortholog for TRIM24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TRIM24 Gene

ENSEMBL:
Gene Tree for TRIM24 (if available)
TreeFam:
Gene Tree for TRIM24 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRIM24: view image
Alliance of Genome Resources:
Additional Orthologs for TRIM24

Paralogs for TRIM24 Gene

Paralogs for TRIM24 Gene

(1) SIMAP similar genes for TRIM24 Gene using alignment to 1 proteins:

  • TIF1A_HUMAN
genes like me logo Genes that share paralogs with TRIM24: view

Variants for TRIM24 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRIM24 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs61751967 Benign: not provided 138,580,592(+) C/G
NM_015905.3(TRIM24):c.2616C>G (p.Asp872Glu) 		MISSENSE
VAR_042382 An ovarian serous carcinoma sample p.Ile320Thr
VAR_042383 A lung squamous cell carcinoma sample p.Thr403Asn
rs34585297 -- p.Arg1009Ser
rs35356723 -- p.Asn796Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TRIM24 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TRIM24 Gene

Variant ID Type Subtype PubMed ID
esv2292840 CNV deletion 18987734
esv2677536 CNV deletion 23128226
esv2735212 CNV deletion 23290073
esv34048 CNV loss 18971310
esv3615194 CNV loss 21293372
nsv1030956 CNV gain 25217958
nsv5968 CNV insertion 18451855
nsv831153 CNV loss 17160897
nsv981589 CNV duplication 23825009

Variation tolerance for TRIM24 Gene

Residual Variation Intolerance Score: 14.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.88; 35.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM24
Leiden Open Variation Database (LOVD)
TRIM24

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM24 Gene

Disorders for TRIM24 Gene

MalaCards: The human disease database

(7) MalaCards diseases for TRIM24 Gene - From: ORP, COP, and GCD

Disorder Aliases PubMed IDs
differentiated thyroid carcinoma
  • papillary or follicular thyroid carcinoma
cerebellar agenesis
lung squamous cell carcinoma
  • epidermoid cell carcinoma of the lung
childhood type dermatomyositis
  • childhood dermatomyositis
adult dermatomyositis
  • adult onset dermatomyositis
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

TIF1A_HUMAN
  • Note=A chromosomal aberration involving TRIM24/TIF1 is found in papillary thyroid carcinomas (PTCs). Translocation t(7;10)(q32;q11) with RET. The translocation generates the TRIM24/RET (PTC6) oncogene. {ECO:0000269 PubMed:10439047}.

Additional Disease Information for TRIM24

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TRIM24: view

No data available for Genatlas for TRIM24 Gene

Publications for TRIM24 Gene

  1. The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas. (PMID: 10439047) Klugbauer S … Rabes HM (Oncogene 1999) 3 4 22 72
  2. Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1. (PMID: 9115274) Thénot S … Cavaillès V (The Journal of biological chemistry 1997) 2 3 4 22
  3. TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells. (PMID: 19909775) Kikuchi M … Hatakeyama S (Biochimica et biophysica acta 2009) 3 4 22
  4. Trim24 targets endogenous p53 for degradation. (PMID: 19556538) Allton K … Barton MC (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 4 22
  5. TIF1gamma, a novel member of the transcriptional intermediary factor 1 family. (PMID: 10022127) Venturini L … de Thé H (Oncogene 1999) 3 4 22

ExternalLinks

View latest publications for TRIM24 gene in Mastermind

Products for TRIM24 Gene

Sources for TRIM24 Gene