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The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
TRIM24 (Tripartite Motif Containing 24) is a Protein Coding gene. Diseases associated with TRIM24 include Differentiated Thyroid Carcinoma and Cerebellar Agenesis. Among its related pathways are Oncogenic MAPK signaling and Signaling by FGFR2 in disease. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and chromatin binding. An important paralog of this gene is TRIM33.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002039 | p53 binding | IPI | 19556538 |
GO:0003677 | DNA binding | IEA | -- |
GO:0003682 | chromatin binding | IDA | 21164480 |
GO:0003713 | transcription coactivator activity | TAS,IDA | 21164480 |
GO:0004672 | protein kinase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | TAS,IDA | 21164480 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005719 | nuclear euchromatin | IEA | -- |
GO:0005726 | perichromatin fibrils | IEA | -- |
GO:0005737 | cytoplasm | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | FGFR1 mutant receptor activation | ||
2 | HIV Life Cycle |
.45
|
|
3 | Oncogenic MAPK signaling | ||
4 | mTOR signaling pathway (KEGG) |
.38
|
|
5 | MAPK Erk Pathway |
.32
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006366 | transcription by RNA polymerase II | TAS | 9115274 |
GO:0006468 | protein phosphorylation | IEA | -- |
GO:0008285 | negative regulation of cell proliferation | IEA | -- |
GO:0010628 | positive regulation of gene expression | IEA | -- |
GO:0016567 | protein ubiquitination | IEA | -- |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP4: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TRIM24 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
TRIM24 30 |
|
||||
-- 31 |
|
OneToMany | |||
Cow (Bos Taurus) |
Mammalia | TRIM24 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TRIM24 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Trim24 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | TRIM24 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | TRIM24 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | TRIM24 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | trim24 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | trim24 31 |
|
ManyToMany | |
Fruit Fly (Drosophila melanogaster) |
Insecta | mei-P26 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | nhl-2 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.9380 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 07 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
774456 | Benign: not provided | 138,580,592(+) | C/G | MISSENSE_VARIANT | |
VAR_042382 | An ovarian serous carcinoma sample | p.Ile320Thr | |||
VAR_042383 | A lung squamous cell carcinoma sample | p.Thr403Asn | |||
rs34585297 | - | p.Arg1009Ser | |||
rs35356723 | - | p.Asn796Ser |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2292840 | CNV | deletion | 18987734 |
esv2677536 | CNV | deletion | 23128226 |
esv2735212 | CNV | deletion | 23290073 |
esv34048 | CNV | loss | 18971310 |
esv3615194 | CNV | loss | 21293372 |
nsv1030956 | CNV | gain | 25217958 |
nsv5968 | CNV | insertion | 18451855 |
nsv831153 | CNV | loss | 17160897 |
nsv981589 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
differentiated thyroid carcinoma |
|
|
cerebellar agenesis |
|
|
lung squamous cell carcinoma |
|
|
adult dermatomyositis |
|
|
childhood type dermatomyositis |
|
|