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The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripar... See more...
Aliases for TRIM24 Gene
Aliases for TRIM24 Gene
External Ids for TRIM24 Gene
- HGNC: 11812
- Entrez Gene: 8805
- Ensembl: ENSG00000122779
- OMIM: 603406
- UniProtKB: O15164
Previous HGNC Symbols for TRIM24 Gene
- TIF1
Previous GeneCards Identifiers for TRIM24 Gene
- GC07P137603
- GC07P137795
- GC07P138144
- GC07P132454
Summaries for TRIM24 Gene
-
The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for TRIM24 Gene
TRIM24 (Tripartite Motif Containing 24) is a Protein Coding gene. Diseases associated with TRIM24 include Differentiated Thyroid Carcinoma and Cerebellar Agenesis. Among its related pathways are Oncogenic MAPK signaling and Signaling by FGFR2 in disease. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and chromatin binding. An important paralog of this gene is TRIM33.
UniProtKB/Swiss-Prot Summary for TRIM24 Gene
-
Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity).
Additional gene information for TRIM24 Gene
- HGNC(11812)
- Entrez Gene(8805)
- Ensembl(ENSG00000122779)
- OMIM(603406)
- UniProtKB(O15164)
- Open Targets Platform(ENSG00000122779)
- Monarch Initiative
- Search for TRIM24 at DataMed
- Search for TRIM24 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRIM24 Gene
Genomics for TRIM24 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TRIM24 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TRIM24 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRIM24
- Top Transcription factor binding sites by QIAGEN in the TRIM24 gene promoter:
-
- CBF(2)
- CUTL1
- GR
- GR-alpha
- MRF-2
- NF-Y
- Nkx2-5
Genomic Locations for TRIM24 Gene
Genomic Locations for TRIM24 Gene
- chr7:138,460,259-138,589,996
- (GRCh38/hg38)
- Size:
- 129,738 bases
- Orientation:
- Plus strand
- chr7:138,145,079-138,274,738
- (GRCh37/hg19)
- Size:
- 129,660 bases
- Orientation:
- Plus strand
Genomic View for TRIM24 Gene
Genes around TRIM24 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q33-q34 by HGNC
- 7q33-q34 by Entrez Gene
- 7q33 by Ensembl
TRIM24 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TRIM24 Gene
Proteins for TRIM24 Gene
-
Protein details for TRIM24 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O15164-TIF1A_HUMAN
- Recommended name:
- Transcription intermediary factor 1-alpha
- Protein Accession:
- O15164
- A4D1R7
- A4D1R8
- O95854
Protein attributes for TRIM24 Gene
- Size:
- 1050 amino acids
- Molecular mass:
- 116831 Da
- Quaternary structure:
-
- Interacts with CARM1, NCOA2/GRIP1, PML, KAT5/TIP60, BRD7, CBX1, CBX3 and CBX5. Part of a coactivator complex containing TRIM24, NCOA2 and CARM1 (By similarity). Interacts with NR3C2/MCR. Interacts with the ligand-binding domain of estrogen receptors (in vitro). Interaction with DNA-bound estrogen receptors requires the presence of estradiol. Interacts with AR and p53/TP53. Interacts (via bromo domain) with histone H3 (via N-terminus), provided that it is not methylated at 'Lys-4' (H3K4me0). Does not interact with histone H3 that is methylated at 'Lys-4' (H3K4me1, H3K4me2 or H3K4me3). Interacts (via bromo domain) with histone H3 (via N-terminus) that is acetylated at 'Lys-23' (H3K23ac). Has the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has very low affinity for histone H3 that is methylated at 'Lys-9' (H3K9me), or acetylated at both 'Lys-9' (H3K9ac) and 'Lys-14' (H3K14ac), or acetylated at 'Lys-27' (H3K27ac) (in vitro). Interacts with TRIM16.
Three dimensional structures from OCA and Proteopedia for TRIM24 Gene
Protein Expression for TRIM24 Gene
Selected DME Specific Peptides for TRIM24 Gene
- O15164:
-
- GSSTALLYSKRLIT
- DDPNEDWCAVCQNGG
Post-translational modifications for TRIM24 Gene
- Sumoylated.
-
Ubiquitination at Lys325, Lys341, and Lys458
- NX_O15164 (NX_O15164-1)
- Modification sites at PhosphoSitePlus
Other Protein References for TRIM24 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences TRIM24 / TIF1 Antibody (LS-B8396) and TRIM24 / TIF1 Antibody (LS-B10114)
- G Biosciences Immunotag™ TRIM24 Antibody
- Creative Diagnostics Anti-TRIM24 (internal region) polyclonal antibody
-
Custom Antibody ServicesOriGene Antibodies for TRIM24
- Novus Biologicals Antibodies for TRIM24
- Invitrogen Antibodies for TRIM24 (AFLGC-TRIM24)
-
Custom Antibody ServicesProSci Antibodies for TRIM24
-
Santa Cruz Biotechnology (SCBT) Antibodies for TRIM24
Protein Products
-
OriGene Purified Proteins for TRIM24
- Search Origene for MassSpec and Protein Over-expression Lysates for TRIM24
- Origene Custom Protein Services for TRIM24
- antibodies-online: Show 7 available TRIM24 Proteins ranked by validation data
- Compare Top TRIM24 Proteins
-
Quality Products:
-
Abcam proteins for TRIM24
Assay Products
-
Boster Bio ELISA Kits for TRIM24
Domains & Families for TRIM24 Gene
Gene Families for TRIM24 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Enzymes
- Plasma proteins
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for TRIM24 Gene
- InterPro:
- Blocks:
-
- Zn-finger, RING
- Zn-finger-like, PHD finger
- Bromodomain signature
- B-box zinc finger signature
- B-box, C-terminal
- ProtoNet:
Suggested Antigen Peptide Sequences for TRIM24 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ53462, highly similar to Transcription intermediary factor 1-alpha (B4DYZ9_HUMAN)
- Tripartite motif-containing protein 24 (TIF1A_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TRIM24 Gene
Function for TRIM24 Gene
Molecular function for TRIM24 Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27;.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated in some cases of breast cancer.
Enzyme Numbers (IUBMB) for TRIM24 Gene
Phenotypes From GWAS Catalog for TRIM24 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002039 | p53 binding | IPI | 19556538 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003682 | chromatin binding | IDA | 21164480 |
| GO:0003713 | transcription coactivator activity | TAS,IDA | 21164480 |
| GO:0004672 | protein kinase activity | IEA | -- |
Phenotypes for TRIM24 Gene
- MGI mutant phenotypes for TRIM24:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for TRIM24:
-
- no effect
- Increased cell death HMECs cells
- Decreased viability
- Decreased shRNA abundance (Z-score < -2)
- Increased IL-8 secretion
- Decreased Sindbis virus (SINV) infection
- Decreased viability after Maraba virus infection
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Increased caspase activity
- Synthetic lethal with imatinib mesylate
- Decreased vesicular stomatitis virus (VSV) infection
- Decreased viability in colon lineage; decreased viability in pancreas lineage
Animal Models for TRIM24 Gene
- MGI Knock Outs for TRIM24:
-
- Trim24 Trim24<tm1.1Los>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TRIM24 - Select products 50% OFF >
- * TRIM24 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TRIM24
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TRIM24
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRIM24
miRNA for TRIM24 Gene
- miRTarBase miRNAs that target TRIM24
-
- hsa-miR-155-5p (MIRT020969)
- hsa-miR-1-3p (MIRT024015)
- hsa-let-7b-5p (MIRT032466)
- hsa-miR-4477a (MIRT378711)
- hsa-miR-548at-5p (MIRT495392)
- hsa-miR-548ay-3p (MIRT495393)
- hsa-miR-548at-3p (MIRT495394)
- hsa-miR-548as-3p (MIRT495395)
- hsa-miR-548t-3p (MIRT495396)
- hsa-miR-548ap-3p (MIRT495397)
- hsa-miR-330-3p (MIRT495398)
- hsa-miR-548aa (MIRT495399)
- hsa-miR-6835-3p (MIRT495400)
- hsa-miR-6807-5p (MIRT509392)
- hsa-miR-2355-5p (MIRT509393)
- hsa-miR-7151-3p (MIRT509394)
- hsa-miR-5095 (MIRT509395)
- hsa-miR-1292-3p (MIRT509396)
- hsa-miR-3934-5p (MIRT509397)
- hsa-miR-552-3p (MIRT509398)
- hsa-miR-511-5p (MIRT733755)
- hsa-miR-155-3p (MIRT737909)
- hsa-miR-3124-3p (MIRT739993)
- hsa-miR-3685 (MIRT742213)
- hsa-miR-384 (MIRT742814)
- hsa-miR-892c-5p (MIRT760459)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TRIM24
- Browse OriGene Inhibitory RNA Products For TRIM24
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM24
Clone Products
- Applied Biological Materials (abm): Clones for TRIM24 - Select products 50% OFF >
- * TRIM24 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG211536
- MR211536
- MR211536L3
- MR211536L4
- MR231458
- MR231489
- RC205332
- RC205332L1
- RC205332L2
- RC205332L3
- RC205332L4
- RC218319
- RC218319L3
- RC218319L4
- RG205332
- RG218319
- RR206201
- RR206201L3
- RR206201L4
- MR211536L3V
- MR211536L4V
- RC205332L1V
- RC205332L2V
- RC205332L3V
- RC205332L4V
- RC218319L3V
- RC218319L4V
- RR206201L3V
- RR206201L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TRIM24
- Addgene plasmids for TRIM24
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TRIM24
Cell Line Products
-
Horizon Cell Lines for TRIM24
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIM24 Gene
Localization for TRIM24 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TRIM24 Gene
- Nucleus. Cytoplasm. Note=Colocalizes with sites of active transcription. Detected both in nucleus and cytoplasm in some breast cancer samples. Predominantly nuclear.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 2 |
| cytoskeleton | 2 |
| plasma membrane | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | TAS,IDA | 21164480 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005719 | nuclear euchromatin | IEA | -- |
| GO:0005726 | perichromatin fibrils | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for TRIM24 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | FGFR1 mutant receptor activation | ||
| 2 | HIV Life Cycle |
.45
|
|
| 3 | Oncogenic MAPK signaling | ||
| 4 | mTOR signaling pathway (KEGG) |
.38
|
|
| 5 | MAPK Erk Pathway |
.32
|
|
Pathways by source for TRIM24 Gene
1 Sino Biological pathway for TRIM24 Gene
1 BioSystems pathway for TRIM24 Gene
8 Reactome pathways for TRIM24 Gene
1 R&D Systems pathway for TRIM24 Gene
1 Qiagen pathway for TRIM24 Gene
- Transcriptional Regulatory Network in Embryonic Stem Cell
UniProtKB/Swiss-Prot O15164-TIF1A_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for TRIM24 Gene
Selected Interacting proteins:
O15164-TIF1A_HUMAN
ENSP00000340507
for TRIM24 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for TRIM24
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006366 | transcription by RNA polymerase II | TAS | 9115274 |
| GO:0006468 | protein phosphorylation | IEA | -- |
| GO:0008285 | negative regulation of cell proliferation | IEA | -- |
| GO:0010628 | positive regulation of gene expression | IEA | -- |
| GO:0016567 | protein ubiquitination | IEA | -- |
Transcripts for TRIM24 Gene
mRNA/cDNA for TRIM24 Gene
- 2 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000343526 8488 nts (view in UCSC)
- ENST00000415680 3799 nts (view in UCSC)
- ENST00000464210 545 nts (view in UCSC)
- ENST00000485318 539 nts (view in UCSC)
- ENST00000493595 811 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TRIM24 - Select products 50% OFF >
- * TRIM24 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TRIM24
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TRIM24
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRIM24
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TRIM24
- Browse OriGene Inhibitory RNA Products For TRIM24
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM24
Clone Products
- Applied Biological Materials (abm): Clones for TRIM24 - Select products 50% OFF >
- * TRIM24 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG211536
- MR211536
- MR211536L3
- MR211536L4
- MR231458
- MR231489
- RC205332
- RC205332L1
- RC205332L2
- RC205332L3
- RC205332L4
- RC218319
- RC218319L3
- RC218319L4
- RG205332
- RG218319
- RR206201
- RR206201L3
- RR206201L4
- MR211536L3V
- MR211536L4V
- RC205332L1V
- RC205332L2V
- RC205332L3V
- RC205332L4V
- RC218319L3V
- RC218319L4V
- RR206201L3V
- RR206201L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TRIM24
- Addgene plasmids for TRIM24
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TRIM24
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: |
Relevant External Links for TRIM24 Gene
- GeneLoc Exon Structure for
- TRIM24
Expression for TRIM24 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Blood (Hematopoietic System)
- Inner Cell Mass (Early Embryonic Tissues)
This gene is overexpressed in Bone marrow stromal cell (53.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRIM24 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRIM24
SOURCE GeneReport for Unigene cluster for TRIM24 Gene:
Hs.490287Evidence on tissue expression from TISSUES for TRIM24 Gene
- Liver(4.5)
- Thyroid gland(4.4)
- Nervous system(3.4)
- Blood(2.4)
- Muscle(2.3)
- Kidney(2.2)
- Skin(2.2)
- Lung(2.1)
- Spleen(2)
- Intestine(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM24 Gene
Germ Layers:
- endoderm
Systems:
- endocrine
Regions:
Head and neck:
- neck
- thyroid
Primer Products
-
OriGene qPCR primer pairs for TRIM24
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRIM24 Gene
Orthologs for TRIM24 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TRIM24 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| TRIM24 30 |
|
||||
| -- 31 |
|
OneToMany | |||
| Cow (Bos Taurus) |
Mammalia | TRIM24 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | TRIM24 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Trim24 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | TRIM24 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | TRIM24 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | TRIM24 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | trim24 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | trim24 31 |
|
ManyToMany | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | mei-P26 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | nhl-2 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.9380 31 |
|
OneToMany |
- Species where no ortholog for TRIM24 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for TRIM24 Gene
- ENSEMBL:
- Gene Tree for TRIM24 (if available)
- TreeFam:
- Gene Tree for TRIM24 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TRIM24: view image
Paralogs for TRIM24 Gene
Paralogs for TRIM24 Gene
- TRIM33 5
- TRIM66 5
- TRIM28 5
- TRIM46 5
- TRIM9 5
- TRIM37 5
- TRIM71 5
- TRIM36 5
- TRIM21 5
- TRIM72 5
- TRIM10 5
- TRIM27 5
- TRIM67 5
- TRIM62 5
- TRIM7 5
- TRIM41 5
- TRIM56 5
- TRIM3 5
- TRIM42 5
- TRIM69 5
- MID2 5
- TRIM34 5
- TRIM22 5
- TRIM75P 5
- TRIM6 5
- TRIM6-TRIM34 5
- TRIM5 5
- MID1 5
- MEFV 5
- TRIM26 5
- TRIM39 5
- TRIM38 5
- TRIML1 5
- TRIM58 5
- TRIM29 5
- TRIM11 5
- TRIM17 5
- TRIM2 5
- TRIM50 5
- TRIM16 5
- TRIM32 5
- TRIM4 5
- TRIM68 5
- TRIM45 5
- TRIM60 5
- TRIM15 5
- TRIM39-RPP21 5
- TRIM47 5
- TRIM25 5
- TRIM77 5
- TRIM51GP 5
- TRIM49B 5
- TRIM64C 5
- TRIM44 5
- TRIM13 5
- TRIM51 5
- TRIM43B 5
- TRIM43 5
- TRIM31 5
- TRIM65 5
- TRIM55 5
- TRIM35 5
- TRIM14 5
- TRIM49 5
- TRIM64B 5
- TRIM49D1 5
- TRIM49D2 5
- TRIM64 5
- TRIM49C 5
- PML 5
- TRIM54 5
- RNF39 5
- TRIM40 5
- TRIM8 5
- TRIML2 5
- TRIM73 5
- TRIM16L 5
- TRIM63 5
- TRIM52 5
- TRIM74 5
- TRIM48 5
- TRIM61 5
- BSPRY 5
- ENSG00000239920 5
(1) SIMAP similar genes for TRIM24 Gene using alignment to 1 proteins:
- TIF1A_HUMAN
Variants for TRIM24 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRIM24 Gene
| SNP ID | Clinical significance and condition | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 774456 | Benign: not provided | 138,580,592(+) | C/G | MISSENSE_VARIANT | |
| VAR_042382 | An ovarian serous carcinoma sample | p.Ile320Thr | |||
| VAR_042383 | A lung squamous cell carcinoma sample | p.Thr403Asn | |||
| rs34585297 | - | p.Arg1009Ser | |||
| rs35356723 | - | p.Asn796Ser |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2292840 | CNV | deletion | 18987734 |
| esv2677536 | CNV | deletion | 23128226 |
| esv2735212 | CNV | deletion | 23290073 |
| esv34048 | CNV | loss | 18971310 |
| esv3615194 | CNV | loss | 21293372 |
| nsv1030956 | CNV | gain | 25217958 |
| nsv5968 | CNV | insertion | 18451855 |
| nsv831153 | CNV | loss | 17160897 |
| nsv981589 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
14.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.88;
35.13% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TRIM24 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TRIM24
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM24 Gene
Disorders for TRIM24 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| differentiated thyroid carcinoma |
|
|
| cerebellar agenesis |
|
|
| lung squamous cell carcinoma |
|
|
| adult dermatomyositis |
|
|
| childhood type dermatomyositis |
|
|
Search TRIM24 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
TIF1A_HUMAN- Note=A chromosomal aberration involving TRIM24/TIF1 is found in papillary thyroid carcinomas (PTCs). Translocation t(7;10)(q32;q11) with RET. The translocation generates the TRIM24/RET (PTC6) oncogene. {ECO:0000269 PubMed:10439047}.
Additional Disease Information for TRIM24
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for TRIM24 Gene
Publications for TRIM24 Gene
- Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1. (PMID: 9115274) Thénot S … Cavaillès V (The Journal of biological chemistry 1997) 2 3 4 23
- TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells. (PMID: 19909775) Kikuchi M … Hatakeyama S (Biochimica et biophysica acta 2009) 3 4 23
- Trim24 targets endogenous p53 for degradation. (PMID: 19556538) Allton K … Barton MC (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 4 23
- The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas. (PMID: 10439047) Klugbauer S … Rabes HM (Oncogene 1999) 3 4 23
- TIF1gamma, a novel member of the transcriptional intermediary factor 1 family. (PMID: 10022127) Venturini L … de Thé H (Oncogene 1999) 3 4 23
ExternalLinks
Products for TRIM24 Gene
- Custom Antibody ServicesOriGene Antibodies for TRIM24
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for TRIM24
- Search Origene for MassSpec and Protein Over-expression Lysates for TRIM24
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for TRIM24
- Browse OriGene Inhibitory RNA Products For TRIM24
- OriGene qPCR primer pairs for TRIM24
- OriGene CRISPR knockouts for TRIM24
- MG211536
- MR211536
- MR211536L3
- MR211536L4
- MR231458
- MR231489
- RC205332
- RC205332L1
- RC205332L2
- RC205332L3
- RC205332L4
- RC218319
- RC218319L3
- RC218319L4
- RG205332
- RG218319
- RR206201
- RR206201L3
- RR206201L4
- MR211536L3V
- MR211536L4V
- RC205332L1V
- RC205332L2V
- RC205332L3V
- RC205332L4V
- RC218319L3V
- RC218319L4V
- RR206201L3V
- RR206201L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TRIM24
- Sino Biological Human cDNA Clone for TRIM24
- Browse Sino Biological Recombinant Proteins
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- High-throughput Antibody Production Service
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- Novus Biologicals proteins and lysates for TRIM24
- Browse Antibodies
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- Browse Primary Antibodies
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- Invitrogen Antibodies for TRIM24 (AFLGC-TRIM24)
- VectorBuilder Custom and pre-made DNA vectors for TRIM24 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for TRIM24 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for TRIM24 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for TRIM24 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for TRIM24
- Addgene plasmids for TRIM24
- antibodies-online: Show 40 available TRIM24 Antibodies ranked by validation data
- Compare Top TRIM24 Antibodies
- antibodies-online: Search results for available TRIM24 related products ranked by validation data
- antibodies-online: Show 7 available TRIM24 Proteins ranked by validation data
- Compare Top TRIM24 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for TRIM24
- Search Santa Cruz Biotechnology (SCBT) for TRIM24 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TRIM24
- Custom Antibody ServicesProSci Antibodies for TRIM24
- Search for TRIM24 Proteins at ProSci
- Horizon Cell Lines for TRIM24
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TRIM24
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TRIM24
- Search GeneCopoeia for miRNA 3'UTR Target clone products for TRIM24
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM24
Sources for TRIM24 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB