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The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
TRIM22 (Tripartite Motif Containing 22) is a Protein Coding gene. Diseases associated with TRIM22 include Rubella and Hepatitis B. Among its related pathways are Interferon gamma signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription corepressor activity. An important paralog of this gene is TRIM34.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003714 | transcription corepressor activity | TAS | 7797467 |
GO:0005515 | protein binding | IPI | 25127057 |
GO:0008270 | zinc ion binding | IEA | -- |
GO:0016740 | transferase activity | IEA | -- |
GO:0019901 | protein kinase binding | IPI | 25127057 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | TAS,IDA | 17156811 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IEA,IDA | 17156811 |
GO:0005794 | Golgi apparatus | IDA | -- |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Interferon gamma signaling | ||
2 | Cytokine Signaling in Immune system | ||
3 | Innate Immune System |
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|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000209 | protein polyubiquitination | IBA | 21873635 |
GO:0006355 | regulation of transcription, DNA-templated | TAS | 7797467 |
GO:0006955 | immune response | TAS | 7797467 |
GO:0009615 | response to virus | TAS | 7797467 |
GO:0010468 | regulation of gene expression | IBA | 21873635 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||
SP2: | - | - | - | ||||||||||||
SP3: | - | ||||||||||||||
SP4: | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TRIM22 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TRIM22 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Trim34b 31 |
|
ManyToMany | |
Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
713987 | Benign: not provided | 5,696,550(+) | C/T | SYNONYMOUS_VARIANT | |
rs1063303 | - | p.Arg242Thr | |||
rs12364019 | - | p.Arg321Lys | |||
rs2291843 | - | p.Thr232Ala | |||
rs7935564 | - | p.Asp155Asn |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1607n54 | CNV | loss | 21841781 |
dgv49e215 | CNV | deletion | 23714750 |
esv2673191 | CNV | deletion | 23128226 |
esv2744065 | CNV | deletion | 23290073 |
esv2759801 | CNV | gain+loss | 17122850 |
esv29417 | CNV | loss | 19812545 |
esv988030 | CNV | gain | 20482838 |
nsv1041568 | CNV | loss | 25217958 |
nsv1046068 | CNV | gain | 25217958 |
nsv1053414 | CNV | gain | 25217958 |
nsv553241 | CNV | gain | 21841781 |
nsv553273 | CNV | gain | 21841781 |
nsv553274 | CNV | gain | 21841781 |
nsv553277 | CNV | gain | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
rubella |
|
|
hepatitis b |
|
|
bare lymphocyte syndrome, type ii |
|