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The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting th... See more...
Aliases for TRIM22 Gene
Aliases for TRIM22 Gene
External Ids for TRIM22 Gene
- HGNC: 16379
- Entrez Gene: 10346
- Ensembl: ENSG00000132274
- OMIM: 606559
- UniProtKB: Q8IYM9
Previous GeneCards Identifiers for TRIM22 Gene
- GC11P006459
- GC11P006013
- GC11P005670
- GC11P005675
- GC11P005667
- GC11P005371
Summaries for TRIM22 Gene
-
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
GeneCards Summary for TRIM22 Gene
TRIM22 (Tripartite Motif Containing 22) is a Protein Coding gene. Diseases associated with TRIM22 include Rubella and Hepatitis B. Among its related pathways are Interferon gamma signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription corepressor activity. An important paralog of this gene is TRIM34.
UniProtKB/Swiss-Prot Summary for TRIM22 Gene
-
Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity.
Additional gene information for TRIM22 Gene
- HGNC(16379)
- Entrez Gene(10346)
- Ensembl(ENSG00000132274)
- OMIM(606559)
- UniProtKB(Q8IYM9)
- Open Targets Platform(ENSG00000132274)
- Monarch Initiative
- Search for TRIM22 at DataMed
- Search for TRIM22 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRIM22 Gene
Genomics for TRIM22 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TRIM22 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TRIM22 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRIM22
- Top Transcription factor binding sites by QIAGEN in the TRIM22 gene promoter:
-
- AP-1
- c-Fos
- c-Jun
- FosB
- Fra-1
- IRF-1
- IRF-2
- JunB
- JunD
- p53
Genomic Locations for TRIM22 Gene
Genomic Locations for TRIM22 Gene
- chr11:5,689,697-5,737,089
- (GRCh38/hg38)
- Size:
- 47,393 bases
- Orientation:
- Plus strand
- chr11:5,710,817-5,758,319
- (GRCh37/hg19)
- Size:
- 47,503 bases
- Orientation:
- Plus strand
Genomic View for TRIM22 Gene
Genes around TRIM22 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p15.4 by HGNC
- 11p15.4 by Entrez Gene
- 11p15.4 by Ensembl
TRIM22 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TRIM22 Gene
Proteins for TRIM22 Gene
-
Protein details for TRIM22 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IYM9-TRI22_HUMAN
- Recommended name:
- E3 ubiquitin-protein ligase TRIM22
- Protein Accession:
- Q8IYM9
- Q05CQ0
- Q15521
Protein attributes for TRIM22 Gene
- Size:
- 498 amino acids
- Molecular mass:
- 56947 Da
- Quaternary structure:
-
- Homotrimer (PubMed:17156811).
- (Microbial infection) Interacts with HIV-1 Gag polyprotein; this interaction seems to reduce gag production or virus budding.
- (Microbial infection) Interacts with EMCV protease 3C; this interaction leads to viral protease ubiquitination.
- SequenceCaution:
-
- Sequence=CAA57684.1; Type=Frameshift; Evidence={ECO:0000305};
Protein Expression for TRIM22 Gene
Selected DME Specific Peptides for TRIM22 Gene
- Q8IYM9:
-
- PLSLDCGHSFCQAC
- CPICLEL
- CGHSFCQACITA
- GYWVIGL
Post-translational modifications for TRIM22 Gene
- Auto-ubiquitinated.
-
Ubiquitination at Lys173 and Lys396
- NX_Q8IYM9 (NX_Q8IYM9-1)
- Modification sites at PhosphoSitePlus
Other Protein References for TRIM22 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences STAF50 / TRIM22 Antibody
- Creative Diagnostics Anti-TRIM22 monoclonal antibody, clone 2E4
- Novus Biologicals Antibodies for TRIM22
-
Abcam antibodies for TRIM22
- Invitrogen Antibodies for TRIM22 (AFLGC-TRIM22)
Protein Products
- Creative Biomart Recombinant Human TRIM22 Protein, GST-His-tagged
-
OriGene Purified Proteins for TRIM22
- Search Origene for MassSpec and Protein Over-expression Lysates for TRIM22
- Origene Custom Protein Services for TRIM22
- antibodies-online: Show 2 available TRIM22 Proteins ranked by validation data
- Compare Top TRIM22 Proteins
-
Quality Products:
-
Signalway Proteins for TRIM22
-
Abcam proteins for TRIM22
Assay Products
- antibodies-online: Show 5 available TRIM22 Elisa Kits ranked by validation data
- Compare Top TRIM22 Elisa Kits
-
Quality Products:
-
Signalway ELISA kits for TRIM22
Domains & Families for TRIM22 Gene
Gene Families for TRIM22 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for TRIM22 Gene
- InterPro:
- Blocks:
-
- Zn-finger, RING
- Butyrophylin C-terminal DUF signature
- B-box zinc finger signature
- ProtoNet:
Suggested Antigen Peptide Sequences for TRIM22 Gene
- GenScript: Design optimal peptide antigens:
-
- Tripartite motif-containing 22, isoform CRA_b (D3DQT0_HUMAN)
- Tripartite motif-containing 22, isoform CRA_a (D3DQT1_HUMAN)
- Tripartite binding motif 22 (Q4A1P5_HUMAN)
- Tripartite motif-containing protein 22 (TRI22_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8IYM9UniProtKB/Swiss-Prot:
TRI22_HUMAN :- The C-terminal SPRY domain is required for the transcriptional suppressor activity, probably by mediating correct nuclear localization. Residues 491-494 are essential for nuclear localization and nuclear bodies formation.
- Belongs to the TRIM/RBCC family.
- Domain:
-
- The C-terminal SPRY domain is required for the transcriptional suppressor activity, probably by mediating correct nuclear localization. Residues 491-494 are essential for nuclear localization and nuclear bodies formation.
- The RING domain is essential for antiviral activity and for TRIM22 nuclear bodies (NB) formation but is not necessary for nuclear localization.
- Family:
-
- Belongs to the TRIM/RBCC family.
Function for TRIM22 Gene
Molecular function for TRIM22 Gene
- UniProtKB/Swiss-Prot Function:
- Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27;.
- UniProtKB/Swiss-Prot Induction:
- By interferons alpha and beta. Up-regulated by p53/TP53. Dramatically induced by progesterone in MDA-MB-231-derived ABC28 cells and T47D cells.
Enzyme Numbers (IUBMB) for TRIM22 Gene
Phenotypes From GWAS Catalog for TRIM22 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003714 | transcription corepressor activity | TAS | 7797467 |
| GO:0005515 | protein binding | IPI | 25127057 |
| GO:0008270 | zinc ion binding | IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0019901 | protein kinase binding | IPI | 25127057 |
Phenotypes for TRIM22 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TRIM22 - Select products 50% OFF >
- * TRIM22 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TRIM22
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TRIM22
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRIM22
miRNA for TRIM22 Gene
- miRTarBase miRNAs that target TRIM22
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TRIM22
- Browse OriGene Inhibitory RNA Products For TRIM22
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM22
Clone Products
- Applied Biological Materials (abm): Clones for TRIM22 - Select products 50% OFF >
- * TRIM22 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for TRIM22
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TRIM22
Cell Line Products
-
Horizon Cell Lines for TRIM22
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM22 Gene
Localization for TRIM22 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TRIM22 Gene
- Cytoplasm. Nucleus. Nucleus speckle. Nucleus, Cajal body. Note=Localizes predominantly to the nucleus, found in cytoplasm to some extent. Forms distinct nuclear bodies that undergo dynamic changes during cell cycle progression. Nuclear bodies start to form in the early G0/G1 phase but become speckle-like in the S-phase and completely dispersed in mitosis. 35% of TRIM22 nuclear bodies overlap or are found adjacent to Cajal bodies.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| golgi apparatus | 4 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
- Nuclear bodies (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | TAS,IDA | 17156811 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 17156811 |
| GO:0005794 | Golgi apparatus | IDA | -- |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for TRIM22 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Interferon gamma signaling | ||
| 2 | Cytokine Signaling in Immune system | ||
| 3 | Innate Immune System |
.61
|
|
Pathways by source for TRIM22 Gene
4 Reactome pathways for TRIM22 Gene
UniProtKB/Swiss-Prot Q8IYM9-TRI22_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for TRIM22 Gene
Selected Interacting proteins:
Q8IYM9-TRI22_HUMAN
ENSP00000369299
for TRIM22 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for TRIM22
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000209 | protein polyubiquitination | IBA | 21873635 |
| GO:0006355 | regulation of transcription, DNA-templated | TAS | 7797467 |
| GO:0006955 | immune response | TAS | 7797467 |
| GO:0009615 | response to virus | TAS | 7797467 |
| GO:0010468 | regulation of gene expression | IBA | 21873635 |
No data available for SIGNOR curated interactions for TRIM22 Gene
Drugs & Compounds for TRIM22 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
- Creative Biomart Recombinant Human TRIM22 Protein, GST-His-tagged
Transcripts for TRIM22 Gene
mRNA/cDNA for TRIM22 Gene
- 2 REFSEQ mRNAs :
- 19 NCBI additional mRNA sequence :
- 11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000379965 2888 nts (view in UCSC)
- ENST00000414641 897 nts (view in UCSC)
- ENST00000414897 655 nts (view in UCSC)
- ENST00000425490 812 nts (view in UCSC)
- ENST00000429063 1241 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TRIM22 - Select products 50% OFF >
- * TRIM22 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TRIM22
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TRIM22
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRIM22
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TRIM22
- Browse OriGene Inhibitory RNA Products For TRIM22
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM22
Clone Products
- Applied Biological Materials (abm): Clones for TRIM22 - Select products 50% OFF >
- * TRIM22 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for TRIM22
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TRIM22
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||
| SP2: | - | - | - | ||||||||||||
| SP3: | - | ||||||||||||||
| SP4: | - |
Relevant External Links for TRIM22 Gene
- GeneLoc Exon Structure for
- TRIM22
Expression for TRIM22 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
-
Ovary (Reproductive System)
- Mature Granulosa Cells Antral Follicle
- Bone (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Spleen (Hematopoietic System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Thymus (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for TRIM22 Gene
This gene is overexpressed in Whole Blood (x7.6).
This gene is overexpressed in Lymph node (20.4), Peripheral blood mononuclear cells (15.4), and CD8 Tcells (6.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRIM22 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRIM22
SOURCE GeneReport for Unigene cluster for TRIM22 Gene:
Hs.501778mRNA Expression by UniProt/SwissProt for TRIM22 Gene:
Q8IYM9-TRI22_HUMAN
Tissue specificity:
Strongly expressed in peripheral blood leukocytes, spleen, thymus, and ovary. Expressed at basal levels in other tissues.
Evidence on tissue expression from TISSUES for TRIM22 Gene
- Lung(4.5)
- Spleen(3)
- Lymph node(3)
- Blood(2.9)
- Intestine(2.7)
- Bone marrow(2.4)
- Kidney(2.3)
- Nervous system(2.3)
- Skin(2.3)
- Liver(2.3)
- Heart(2)
Primer Products
-
OriGene qPCR primer pairs for TRIM22
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM22 Gene
Orthologs for TRIM22 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TRIM22 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | TRIM22 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Trim34b 31 |
|
ManyToMany | |
| Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany |
- Species where no ortholog for TRIM22 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- Cow (Bos Taurus)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for TRIM22 Gene
- ENSEMBL:
- Gene Tree for TRIM22 (if available)
- TreeFam:
- Gene Tree for TRIM22 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TRIM22: view image
Paralogs for TRIM22 Gene
Paralogs for TRIM22 Gene
- TRIM34 5
- TRIM6-TRIM34 5
- TRIM6 5
- TRIM5 5
- TRIM21 5
- TRIM68 5
- TRIM27 5
- TRIM38 5
- TRIM58 5
- MEFV 5
- TRIM10 5
- TRIM26 5
- TRIM39 5
- TRIM7 5
- TRIM72 5
- TRIM60 5
- TRIM41 5
- TRIML1 5
- TRIM11 5
- TRIM50 5
- TRIM69 5
- TRIM75P 5
- TRIM62 5
- TRIM71 5
- TRIM17 5
- TRIM9 5
- TRIM4 5
- TRIM64B 5
- TRIM64 5
- TRIM64C 5
- TRIM32 5
- MID2 5
- TRIM25 5
- TRIM2 5
- TRIM3 5
- TRIM16 5
- MID1 5
- TRIM39-RPP21 5
- TRIM67 5
- TRIML2 5
- TRIM56 5
- TRIM42 5
- TRIM15 5
- TRIM47 5
- TRIM35 5
- TRIM29 5
- TRIM77 5
- TRIM33 5
- TRIM49B 5
- TRIM51 5
- TRIM24 5
- TRIM43B 5
- TRIM43 5
- TRIM14 5
- TRIM49 5
- TRIM49D1 5
- TRIM49D2 5
- TRIM49C 5
- TRIM31 5
- TRIM65 5
- TRIM66 5
- TRIM51GP 5
- RNF39 5
- TRIM8 5
- TRIM46 5
- TRIM28 5
- TRIM13 5
- TRIM54 5
- TRIM73 5
- TRIM40 5
- TRIM55 5
- TRIM37 5
- TRIM74 5
- TRIM36 5
- TRIM45 5
- TRIM63 5
- TRIM16L 5
- TRIM52 5
- PML 5
- TRIM61 5
- TRIM48 5
- ENSG00000239920 5
- BSPRY 5
- TRIM44 5
(29) SIMAP similar genes for TRIM22 Gene using alignment to 11 proteins:
- TRI22_HUMAN
- C9J060_HUMAN
- C9JIU5_HUMAN
- C9JWC5_HUMAN
- D3DQT0_HUMAN
- D3DQT1_HUMAN
- H7BZD3_HUMAN
- H7C262_HUMAN
- H7C2K0_HUMAN
- H7C376_HUMAN
- Q4A1P5_HUMAN
Variants for TRIM22 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRIM22 Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 713987 | Benign: not provided | 5,696,550(+) | C/T | SYNONYMOUS_VARIANT | |
| rs1063303 | - | p.Arg242Thr | |||
| rs12364019 | - | p.Arg321Lys | |||
| rs2291843 | - | p.Thr232Ala | |||
| rs7935564 | - | p.Asp155Asn |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1607n54 | CNV | loss | 21841781 |
| dgv49e215 | CNV | deletion | 23714750 |
| esv2673191 | CNV | deletion | 23128226 |
| esv2744065 | CNV | deletion | 23290073 |
| esv2759801 | CNV | gain+loss | 17122850 |
| esv29417 | CNV | loss | 19812545 |
| esv988030 | CNV | gain | 20482838 |
| nsv1041568 | CNV | loss | 25217958 |
| nsv1046068 | CNV | gain | 25217958 |
| nsv1053414 | CNV | gain | 25217958 |
| nsv553241 | CNV | gain | 21841781 |
| nsv553273 | CNV | gain | 21841781 |
| nsv553274 | CNV | gain | 21841781 |
| nsv553277 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
91.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
9.11;
87.74% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TRIM22 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM22 Gene
Disorders for TRIM22 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| rubella |
|
|
| hepatitis b |
|
|
| bare lymphocyte syndrome, type ii |
|
Search TRIM22 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TRIM22
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM22 Gene
Publications for TRIM22 Gene
- The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A … Ballabio A (The EMBO journal 2001) 2 3 4
- Rubella vaccine-induced cellular immunity: evidence of associations with polymorphisms in the Toll-like, vitamin A and D receptors, and innate immune response genes. (PMID: 19902255) Ovsyannikova IG … Poland GA (Human genetics 2010) 3 41
- Tripartite motif-containing 22 inhibits the activity of hepatitis B virus core promoter, which is dependent on nuclear-located RING domain. (PMID: 19585648) Gao B … Xiong S (Hepatology (Baltimore, Md.) 2009) 3 4
- TRIM22 E3 ubiquitin ligase activity is required to mediate antiviral activity against encephalomyocarditis virus. (PMID: 19218198) Eldin P … Mechti N (The Journal of general virology 2009) 3 4
- B30.2/SPRY domain in tripartite motif-containing 22 is essential for the formation of distinct nuclear bodies. (PMID: 19481078) Sivaramakrishnan G … Lin VC (FEBS letters 2009) 3 4
ExternalLinks
Products for TRIM22 Gene
- Custom Antibody ServicesOriGene Antibodies for TRIM22
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for TRIM22
- Search Origene for MassSpec and Protein Over-expression Lysates for TRIM22
- Origene Custom Protein Services for TRIM22
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TRIM22
- Browse OriGene Inhibitory RNA Products For TRIM22
- OriGene qPCR primer pairs for TRIM22
- OriGene CRISPR knockouts for TRIM22
- OriGene ORF clones in human for TRIM22
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TRIM22
- Sino Biological Human cDNA Clone for TRIM22
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for TRIM22
- Novus Biologicals proteins and lysates for TRIM22
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- Invitrogen Antibodies for TRIM22 (AFLGC-TRIM22)
- VectorBuilder Custom and pre-made DNA vectors for TRIM22 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for TRIM22 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for TRIM22 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for TRIM22 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for TRIM22
- antibodies-online: Show 20 available TRIM22 Antibodies ranked by validation data
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- antibodies-online: Show 5 available TRIM22 Elisa Kits ranked by validation data
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- antibodies-online: Show 2 available TRIM22 Proteins ranked by validation data
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- Horizon Cell Lines for TRIM22
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TRIM22
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TRIM22
- Search GeneCopoeia for miRNA 3'UTR Target clone products for TRIM22
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM22
Sources for TRIM22 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB