TRIM22 Gene (Protein Coding)

Tripartite Motif Containing 22

GC11P005689
GIFtS:
40
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting th... See more...

Aliases for TRIM22 Gene

Aliases for TRIM22 Gene

  • Tripartite Motif Containing 22 2 3 5
  • RING-Type E3 Ubiquitin Transferase TRIM22 3 4
  • Tripartite Motif-Containing Protein 22 3 4
  • 50 KDa-Stimulated Trans-Acting Factor 3 4
  • E3 Ubiquitin-Protein Ligase TRIM22 3 4
  • RING Finger Protein 94 3 4
  • Staf-50 3 4
  • STAF50 3 4
  • RNF94 3 4
  • Stimulated Trans-Acting Factor (50 KDa) 3
  • Tripartite Motif Protein TRIM22 3
  • Tripartite Motif-Containing 22 2
  • Tripartite Binding Motif 22 3
  • EC 2.3.2.27 4
  • GPSTAF50 3
  • EC 6.3.2 54

External Ids for TRIM22 Gene

Previous GeneCards Identifiers for TRIM22 Gene

  • GC11P006459
  • GC11P006013
  • GC11P005670
  • GC11P005675
  • GC11P005667
  • GC11P005371

Summaries for TRIM22 Gene

Entrez Gene Summary for TRIM22 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

GeneCards Summary for TRIM22 Gene

TRIM22 (Tripartite Motif Containing 22) is a Protein Coding gene. Diseases associated with TRIM22 include Rubella and Bare Lymphocyte Syndrome, Type Ii. Among its related pathways are Interferon gamma signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription corepressor activity. An important paralog of this gene is TRIM6-TRIM34.

UniProtKB/Swiss-Prot Summary for TRIM22 Gene

  • Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity.

Gene Wiki entry for TRIM22 Gene

Additional gene information for TRIM22 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRIM22 Gene

Genomics for TRIM22 Gene

GeneHancer (GH) Regulatory Elements for TRIM22 Gene

Promoters and enhancers for TRIM22 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRIM22 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRIM22 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • FosB
  • Fra-1
  • IRF-1
  • IRF-2
  • JunB
  • JunD
  • p53

Genomic Locations for TRIM22 Gene

Genomic Locations for TRIM22 Gene
chr11:5,689,587-5,737,089
(GRCh38/hg38)
Size:
47,503 bases
Orientation:
Plus strand
chr11:5,710,817-5,758,319
(GRCh37/hg19)
Size:
47,503 bases
Orientation:
Plus strand

Genomic View for TRIM22 Gene

Genes around TRIM22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM22 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TRIM22 Gene

Proteins for TRIM22 Gene

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  • Protein details for TRIM22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYM9-TRI22_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM22
    Protein Accession:
    Q8IYM9
    Secondary Accessions:
    • Q05CQ0
    • Q15521

    Protein attributes for TRIM22 Gene

    Size:
    498 amino acids
    Molecular mass:
    56947 Da
    Quaternary structure:
    • Homotrimer (PubMed:17156811).
    • (Microbial infection) Interacts with HIV-1 Gag polyprotein; this interaction seems to reduce gag production or virus budding.
    • (Microbial infection) Interacts with EMCV protease 3C; this interaction leads to viral protease ubiquitination.
    SequenceCaution:
    • Sequence=CAA57684.1; Type=Frameshift; Positions=439; Evidence={ECO:0000305};

    Alternative splice isoforms for TRIM22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM22 Gene

Protein Expression for TRIM22 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for TRIM22 Gene

Q8IYM9:
  • PLSLDCGHSFCQAC
  • CPICLEL
  • CGHSFCQACITA
  • GYWVIGL

Post-translational modifications for TRIM22 Gene

Other Protein References for TRIM22 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for TRIM22 Gene

Gene Families for TRIM22 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for TRIM22 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TRIM22 Gene

GenScript: Design optimal peptide antigens:
  • Tripartite motif-containing 22, isoform CRA_b (D3DQT0_HUMAN)
  • Tripartite motif-containing 22, isoform CRA_a (D3DQT1_HUMAN)
  • Tripartite binding motif 22 (Q4A1P5_HUMAN)
  • Tripartite motif-containing protein 22 (TRI22_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IYM9

UniProtKB/Swiss-Prot:

TRI22_HUMAN :
  • The C-terminal SPRY domain is required for the transcriptional suppressor activity, probably by mediating correct nuclear localization. Residues 491-494 are essential for nuclear localization and nuclear bodies formation.
  • Belongs to the TRIM/RBCC family.
Domain:
  • The C-terminal SPRY domain is required for the transcriptional suppressor activity, probably by mediating correct nuclear localization. Residues 491-494 are essential for nuclear localization and nuclear bodies formation.
  • The RING domain is essential for antiviral activity and for TRIM22 nuclear bodies (NB) formation but is not necessary for nuclear localization.
Family:
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM22: view

Function for TRIM22 Gene

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  2. CRISPR
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Molecular function for TRIM22 Gene

UniProtKB/Swiss-Prot Function:
Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27;.
UniProtKB/Swiss-Prot Induction:
By interferons alpha and beta. Up-regulated by p53/TP53. Dramatically induced by progesterone in MDA-MB-231-derived ABC28 cells and T47D cells.

Enzyme Numbers (IUBMB) for TRIM22 Gene

Phenotypes From GWAS Catalog for TRIM22 Gene

Gene Ontology (GO) - Molecular Function for TRIM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity TAS 7797467
GO:0005515 protein binding IPI 25127057
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0019901 protein kinase binding IPI 25127057
genes like me logo Genes that share ontologies with TRIM22: view
genes like me logo Genes that share phenotypes with TRIM22: view

Animal Model Products

CRISPR Products

miRNA for TRIM22 Gene

miRTarBase miRNAs that target TRIM22

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM22 Gene

Localization for TRIM22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM22 Gene

Cytoplasm. Nucleus. Nucleus speckle. Nucleus, Cajal body. Note=Localizes predominantly to the nucleus, found in cytoplasm to some extent. Forms distinct nuclear bodies that undergo dynamic changes during cell cycle progression. Nuclear bodies start to form in the early G0/G1 phase but become speckle-like in the S-phase and completely dispersed in mitosis. 35% of TRIM22 nuclear bodies overlap or are found adjacent to Cajal bodies.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM22 gene
Compartment Confidence
nucleus 5
cytosol 4
golgi apparatus 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRIM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,IDA 17156811
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA,IEA 17156811
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TRIM22: view

Pathways & Interactions for TRIM22 Gene

genes like me logo Genes that share pathways with TRIM22: view

Pathways by source for TRIM22 Gene

UniProtKB/Swiss-Prot Q8IYM9-TRI22_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for TRIM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated TAS 7797467
GO:0006955 immune response TAS 7797467
GO:0009615 response to virus TAS 7797467
GO:0010508 positive regulation of autophagy IMP 26347139
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with TRIM22: view

No data available for SIGNOR curated interactions for TRIM22 Gene

Drugs & Compounds for TRIM22 Gene

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  1. Drug

(19) Drugs for TRIM22 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(14) Additional Compounds for TRIM22 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TRIM22: view

Transcripts for TRIM22 Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
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mRNA/cDNA for TRIM22 Gene

(2) REFSEQ mRNAs :
(19) Additional mRNA sequences :
(218) Selected AceView cDNA sequences:
(11) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM22 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1: - -
SP2: - - -
SP3: -
SP4: -

Relevant External Links for TRIM22 Gene

GeneLoc Exon Structure for
TRIM22
ECgene alternative splicing isoforms for
TRIM22

Expression for TRIM22 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM22 Gene

mRNA expression in normal human tissues for TRIM22 Gene
mRNA expression by GTEx for TRIM22 GenemRNA expression by BioGPS for TRIM22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM22 Gene

This gene is overexpressed in Whole Blood (x7.6).

Protein differential expression in normal tissues from HIPED for TRIM22 Gene

This gene is overexpressed in Lymph node (20.4), Peripheral blood mononuclear cells (15.4), and CD8 Tcells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRIM22 Gene



Protein tissue co-expression partners for TRIM22 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRIM22 Gene:

TRIM22

SOURCE GeneReport for Unigene cluster for TRIM22 Gene:

Hs.501778

mRNA Expression by UniProt/SwissProt for TRIM22 Gene:

Q8IYM9-TRI22_HUMAN
Tissue specificity: Strongly expressed in peripheral blood leukocytes, spleen, thymus, and ovary. Expressed at basal levels in other tissues.

Evidence on tissue expression from TISSUES for TRIM22 Gene

  • Lung(4.4)
  • Blood(2.4)
  • Lymph node(2.1)
  • Spleen(2.1)
  • Intestine(2)
genes like me logo Genes that share expression patterns with TRIM22: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM22 Gene

Orthologs for TRIM22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia TRIM22 33 32
  • 99.6 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia TRIM22 33 32
  • 79.08 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Trim34b 33
  • 54 (a)
 ManyToMany
chicken
(Gallus gallus)
 Aves -- 33
  • 30 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia -- 33
  • 31 (a)
 OneToMany
Species where no ortholog for TRIM22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM22 Gene

ENSEMBL:
Gene Tree for TRIM22 (if available)
TreeFam:
Gene Tree for TRIM22 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRIM22: view image

Paralogs for TRIM22 Gene

Paralogs for TRIM22 Gene

(29) SIMAP similar genes for TRIM22 Gene using alignment to 11 proteins:

  • TRI22_HUMAN
  • C9J060_HUMAN
  • C9JIU5_HUMAN
  • C9JWC5_HUMAN
  • D3DQT0_HUMAN
  • D3DQT1_HUMAN
  • H7BZD3_HUMAN
  • H7C262_HUMAN
  • H7C2K0_HUMAN
  • H7C376_HUMAN
  • Q4A1P5_HUMAN
genes like me logo Genes that share paralogs with TRIM22: view

Variants for TRIM22 Gene

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Sequence variations from dbSNP and Humsavar for TRIM22 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000394056 -- 5,701,062(+) T/C intron_variant
rs1000531907 -- 5,691,815(+) T/A intron_variant
rs1000695921 -- 5,697,841(+) C/T intron_variant
rs1000764078 -- 5,692,470(+) G/T intron_variant
rs1001213271 -- 5,696,957(+) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM22 Gene

Variant ID Type Subtype PubMed ID
dgv1607n54 CNV loss 21841781
dgv49e215 CNV deletion 23714750
esv2673191 CNV deletion 23128226
esv2744065 CNV deletion 23290073
esv2759801 CNV gain+loss 17122850
esv29417 CNV loss 19812545
esv988030 CNV gain 20482838
nsv1041568 CNV loss 25217958
nsv1046068 CNV gain 25217958
nsv1053414 CNV gain 25217958
nsv553241 CNV gain 21841781
nsv553273 CNV gain 21841781
nsv553274 CNV gain 21841781
nsv553277 CNV gain 21841781

Variation tolerance for TRIM22 Gene

Residual Variation Intolerance Score: 91.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.11; 87.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM22 Gene

Human Gene Mutation Database (HGMD)
TRIM22
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM22 Gene

Disorders for TRIM22 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TRIM22 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
rubella
  • german measles
bare lymphocyte syndrome, type ii
  • bls, type ii
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TRIM22

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TRIM22: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM22 Gene

Publications for TRIM22 Gene

  1. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A … Ballabio A (The EMBO journal 2001) 2 3 4 56
  2. Rubella vaccine-induced cellular immunity: evidence of associations with polymorphisms in the Toll-like, vitamin A and D receptors, and innate immune response genes. (PMID: 19902255) Ovsyannikova IG … Poland GA (Human genetics 2010) 3 43 56
  3. TRIM22 E3 ubiquitin ligase activity is required to mediate antiviral activity against encephalomyocarditis virus. (PMID: 19218198) Eldin P … Mechti N (The Journal of general virology 2009) 3 4 56
  4. B30.2/SPRY domain in tripartite motif-containing 22 is essential for the formation of distinct nuclear bodies. (PMID: 19481078) Sivaramakrishnan G … Lin VC (FEBS letters 2009) 3 4 56
  5. Tripartite motif-containing 22 inhibits the activity of hepatitis B virus core promoter, which is dependent on nuclear-located RING domain. (PMID: 19585648) Gao B … Xiong S (Hepatology (Baltimore, Md.) 2009) 3 4 56

ExternalLinks

View latest publications for TRIM22 gene in Mastermind

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