Aliases for TRIM22 Gene
External Ids for TRIM22 Gene
Previous GeneCards Identifiers for TRIM22 Gene
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
GeneCards Summary for TRIM22 Gene
TRIM22 (Tripartite Motif Containing 22) is a Protein Coding gene. Diseases associated with TRIM22 include Rubella and Bare Lymphocyte Syndrome, Type Ii. Among its related pathways are Interferon gamma signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription corepressor activity. An important paralog of this gene is TRIM6-TRIM34.
UniProtKB/Swiss-Prot Summary for TRIM22 Gene
Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity.