Aliases for TRIM22 Gene
Aliases for TRIM22 Gene
External Ids for TRIM22 Gene
- HGNC: 16379
- Entrez Gene: 10346
- Ensembl: ENSG00000132274
- OMIM: 606559
- UniProtKB: Q8IYM9
Previous GeneCards Identifiers for TRIM22 Gene
- GC11P006459
- GC11P006013
- GC11P005670
- GC11P005675
- GC11P005371
Summaries for TRIM22 Gene
-
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
GeneCards Summary for TRIM22 Gene
TRIM22 (Tripartite Motif Containing 22) is a Protein Coding gene. Diseases associated with TRIM22 include Rubella and Bare Lymphocyte Syndrome, Type Ii. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription corepressor activity. An important paralog of this gene is TRIM6-TRIM34.
UniProtKB/Swiss-Prot for TRIM22 Gene
-
Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity.
Additional gene information for TRIM22 Gene
- Monarch Initiative
- Search for TRIM22 at DataMed
- Search for TRIM22 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM22 Gene
Genomics for TRIM22 Gene
GeneHancer (GH) Regulatory Elements for TRIM22 Gene
Promoters and enhancers for TRIM22 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TRIM22 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for TRIM22 Gene
Genomic Locations for TRIM22 Gene
- chr11:5,689,587-5,737,089
- (GRCh38/hg38)
- Size:
- 47,503 bases
- Orientation:
- Plus strand
- chr11:5,710,817-5,758,319
- (GRCh37/hg19)
Genomic View for TRIM22 Gene
Genes around TRIM22 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p15.4 by Ensembl
- 11p15.4 by Entrez Gene
- 11p15.4 by HGNC
TRIM22 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TRIM22 Gene
Proteins for TRIM22 Gene
-
Protein details for TRIM22 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IYM9-TRI22_HUMAN
- Recommended name:
- E3 ubiquitin-protein ligase TRIM22
- Protein Accession:
- Q8IYM9
- Q05CQ0
- Q15521
Protein attributes for TRIM22 Gene
- Size:
- 498 amino acids
- Molecular mass:
- 56947 Da
- Quaternary structure:
-
- Homotrimer (PubMed:17156811). Interacts with HIV-1 Gag polyprotein; this interaction seems to reduce gag production or virus budding (PubMed:18389079). Interacts with EMCV protease 3C; this interaction leads to viral protease ubiquitination (PubMed:19218198).
- SequenceCaution:
-
- Sequence=CAA57684.1; Type=Frameshift; Positions=439; Evidence={ECO:0000305};
Protein Expression for TRIM22 Gene
Selected DME Specific Peptides for TRIM22 Gene
- Q8IYM9:
-
- PLSLDCGHSFCQAC
- CPICLEL
- CGHSFCQACITA
- GYWVIGL
Post-translational modifications for TRIM22 Gene
- Auto-ubiquitinated.
- Ubiquitination at isoforms=173 and isoforms=2396
- Modification sites at PhosphoSitePlus
Other Protein References for TRIM22 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for TRIM22
-
Abcam antibodies for TRIM22
- Invitrogen Antibodies for TRIM22
- GeneTex TRIM22 antibody for TRIM22
Protein Products
-
OriGene Purified Proteins for TRIM22
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- antibodies-online: Search results for 2 available TRIM22 Proteins ranked by validation data
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-
Quality Products:
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-
Abcam proteins for TRIM22
Assay Products
- antibodies-online: Search results for 5 available TRIM22 Elisa Kits ranked by validation data
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-
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Domains & Families for TRIM22 Gene
Gene Families for TRIM22 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for TRIM22 Gene
Suggested Antigen Peptide Sequences for TRIM22 Gene
Graphical View of Domain Structure for InterPro Entry
Q8IYM9UniProtKB/Swiss-Prot:
TRI22_HUMAN :- The C-terminal SPRY domain is required for the transcriptional suppressor activity, probably by mediating correct nuclear localization. Residues 491-494 are essential for nuclear localization and nuclear bodies formation.
- Belongs to the TRIM/RBCC family.
- Domain:
-
- The C-terminal SPRY domain is required for the transcriptional suppressor activity, probably by mediating correct nuclear localization. Residues 491-494 are essential for nuclear localization and nuclear bodies formation.
- The RING domain is essential for antiviral activity and for TRIM22 nuclear bodies (NB) formation but is not necessary for nuclear localization.
- Family:
-
- Belongs to the TRIM/RBCC family.
Function for TRIM22 Gene
Molecular function for TRIM22 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
- UniProtKB/Swiss-Prot Function:
- Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity.
- UniProtKB/Swiss-Prot Induction:
- By interferons alpha and beta. Up-regulated by p53/TP53. Dramatically induced by progesterone in MDA-MB-231-derived ABC28 cells and T47D cells.
Enzyme Numbers (IUBMB) for TRIM22 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003700 | DNA binding transcription factor activity | TAS | 7797467 |
| GO:0003714 | transcription corepressor activity | TAS | 7797467 |
| GO:0005515 | protein binding | IPI | 25127057 |
| GO:0008270 | zinc ion binding | IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
Phenotypes for TRIM22 Gene
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-
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miRNA for TRIM22 Gene
- miRTarBase miRNAs that target TRIM22
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TRIM22
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
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No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM22 Gene
Localization for TRIM22 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TRIM22 Gene
- Cytoplasm. Nucleus. Nucleus speckle. Nucleus, Cajal body. Note=Localizes predominantly to the nucleus, found in cytoplasm to some extent. Forms distinct nuclear bodies that undergo dynamic changes during cell cycle progression. Nuclear bodies start to form in the early G0/G1 phase but become speckle-like in the S-phase and completely dispersed in mitosis. 35% of TRIM22 nuclear bodies overlap or are found adjacent to Cajal bodies.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
- Nuclear bodies (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005634 | nucleus | IDA,TAS | 17156811 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IDA,IEA | 17156811 |
| GO:0005794 | Golgi apparatus | IDA | -- |
Pathways & Interactions for TRIM22 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Interferon gamma signaling | ||
| 2 | Cytokine Signaling in Immune system | ||
| 3 | Innate Immune System |
.61
|
|
Pathways by source for TRIM22 Gene
4 Reactome pathways for TRIM22 Gene
UniProtKB/Swiss-Prot Q8IYM9-TRI22_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for TRIM22 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | TAS | 7797467 |
| GO:0006955 | immune response | TAS | 7797467 |
| GO:0009615 | response to virus | TAS | 7797467 |
| GO:0010508 | positive regulation of autophagy | IMP | 26347139 |
No data available for SIGNOR curated interactions for TRIM22 Gene
Transcripts for TRIM22 Gene
mRNA/cDNA for TRIM22 Gene
- (2) REFSEQ mRNAs :
- (218) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for TRIM22
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- Overview of 40 available TRIM22 gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRIM22
- GenScript: Design CRISPR guide RNA sequences for TRIM22
miRNA Products
- Search ViGene Biosciences for TRIM22
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TRIM22
- Browse OriGene Inhibitory RNA Products For TRIM22
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- Overview of 40 available TRIM22 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TRIM22 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for TRIM22
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TRIM22
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TRIM22
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||
| SP2: | - | - | - | ||||||||||||
| SP3: | - | ||||||||||||||
| SP4: | - |
Expression for TRIM22 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
-
Ovary (Reproductive System)
- Mature Granulosa Cells Antral Follicle
- Bone (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Spleen (Hematopoietic System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Thymus (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for TRIM22 Gene
This gene is overexpressed in Whole Blood (x7.6).
This gene is overexpressed in Lymph node (20.4), Peripheral blood mononuclear cells (15.4), and CD8 Tcells (6.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRIM22 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of TRIM22 Gene:
TRIM22SOURCE GeneReport for Unigene cluster for TRIM22 Gene:
Hs.501778mRNA Expression by UniProt/SwissProt for TRIM22 Gene:
Q8IYM9-TRI22_HUMAN
Tissue specificity:
Strongly expressed in peripheral blood leukocytes, spleen, thymus, and ovary. Expressed at basal levels in other tissues.
Evidence on tissue expression from TISSUES for TRIM22 Gene
- Lung(4.4)
- Blood(2.3)
- Lymph node(2.1)
- Spleen(2.1)
- Intestine(2)
Primer Products
-
OriGene qPCR primer pairs for TRIM22
- genomics-online: primer clones - Search results for 40 available TRIM22 gene related products
- Overview of 40 available TRIM22 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM22 Gene
Orthologs for TRIM22 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TRIM22 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | TRIM22 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Trim34b 34 |
|
ManyToMany | |
| chicken (Gallus gallus) |
Aves | -- 34 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany |
- Species where no ortholog for TRIM22 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for TRIM22 Gene
Paralogs for TRIM22 Gene
(29) SIMAP similar genes for TRIM22 Gene using alignment to 11 proteins:
Variants for TRIM22 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000394056 | -- | 5,701,062(+) | T/C | intron_variant | |
| rs1000531907 | -- | 5,691,815(+) | T/A | intron_variant | |
| rs1000695921 | -- | 5,697,841(+) | C/T | intron_variant | |
| rs1000764078 | -- | 5,692,470(+) | G/T | intron_variant | |
| rs1001213271 | -- | 5,696,957(+) | A/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1607n54 | CNV | loss | 21841781 |
| dgv49e215 | CNV | deletion | 23714750 |
| esv2673191 | CNV | deletion | 23128226 |
| esv2744065 | CNV | deletion | 23290073 |
| esv2759801 | CNV | gain+loss | 17122850 |
| esv29417 | CNV | loss | 19812545 |
| esv988030 | CNV | gain | 20482838 |
| nsv1041568 | CNV | loss | 25217958 |
| nsv1046068 | CNV | gain | 25217958 |
| nsv1053414 | CNV | gain | 25217958 |
| nsv553241 | CNV | gain | 21841781 |
| nsv553273 | CNV | gain | 21841781 |
| nsv553274 | CNV | gain | 21841781 |
| nsv553277 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
91.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
9.11;
87.74% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TRIM22 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM22 Gene
Disorders for TRIM22 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| rubella |
|
|
| bare lymphocyte syndrome, type ii |
|
Search TRIM22 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TRIM22
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM22 Gene
Publications for TRIM22 Gene
- The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A … Ballabio A (The EMBO journal 2001) 2 3 4 58
- Rubella vaccine-induced cellular immunity: evidence of associations with polymorphisms in the Toll-like, vitamin A and D receptors, and innate immune response genes. (PMID: 19902255) Ovsyannikova IG … Poland GA (Human genetics 2010) 3 44 58
- B30.2/SPRY domain in tripartite motif-containing 22 is essential for the formation of distinct nuclear bodies. (PMID: 19481078) Sivaramakrishnan G … Lin VC (FEBS letters 2009) 3 4 58
- TRIM22 E3 ubiquitin ligase activity is required to mediate antiviral activity against encephalomyocarditis virus. (PMID: 19218198) Eldin P … Mechti N (The Journal of general virology 2009) 3 4 58
- Tripartite motif-containing 22 inhibits the activity of hepatitis B virus core promoter, which is dependent on nuclear-located RING domain. (PMID: 19585648) Gao B … Xiong S (Hepatology (Baltimore, Md.) 2009) 3 4 58
Products for TRIM22 Gene
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 69 available TRIM22 Antibodies ranked by validation data
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Sources for TRIM22 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
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