This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the n... See more...

Aliases for TRIM21 Gene

Aliases for TRIM21 Gene

  • Tripartite Motif Containing 21 2 3 5
  • E3 Ubiquitin-Protein Ligase TRIM21 2 3 4
  • RNF81 2 3 4
  • RO52 2 3 4
  • Sjogren Syndrome Antigen A1 (52kDa, Ribonucleoprotein Autoantigen SS-A/Ro) 2 3
  • 52 KDa Ribonucleoprotein Autoantigen Ro/SS-A 3 4
  • RING-Type E3 Ubiquitin Transferase TRIM21 3 4
  • Tripartite Motif-Containing Protein 21 3 4
  • Sjoegren Syndrome Type A Antigen 3 4
  • RING Finger Protein 81 3 4
  • 52 KDa Ro Protein 3 4
  • Ro/SSA 52kDa 2 3
  • Ro(SS-A) 3 4
  • SSA1 3 4
  • SS-A 3 4
  • Tripartite Motif-Containing 21 2
  • Sicca Syndrome Antigen A 3
  • EC 2.3.2.27 4
  • Ro/SSA 3
  • TRIM21 5
  • SSA 3

External Ids for TRIM21 Gene

Previous HGNC Symbols for TRIM21 Gene

  • SSA1

Previous GeneCards Identifiers for TRIM21 Gene

  • GC11M004363
  • GC11M004064
  • GC11M004406

Summaries for TRIM21 Gene

Entrez Gene Summary for TRIM21 Gene

  • This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM21 Gene

TRIM21 (Tripartite Motif Containing 21) is a Protein Coding gene. Diseases associated with TRIM21 include Heart Block, Congenital and Sjogren Syndrome. Among its related pathways are Interferon gamma signaling and Cytosolic sensors of pathogen-associated DNA. Gene Ontology (GO) annotations related to this gene include identical protein binding and ligase activity. An important paralog of this gene is TRIM58.

UniProtKB/Swiss-Prot Summary for TRIM21 Gene

  • E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2. Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1 and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of IRF3, hence attenuating type I interferon (IFN)-dependent immune responses (PubMed:26347139).

Gene Wiki entry for TRIM21 Gene

Additional gene information for TRIM21 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRIM21 Gene

Genomics for TRIM21 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TRIM21 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J004392 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 607 +0.0 1 2.2 SP1 LARP7 PRDM1 ZNF143 ZIC2 PKNOX1 PATZ1 SMAD5 IRF2 POLR2A OR52K3P TRIM21 lnc-OR52K2-1 OR52K2 NONHSAG007490.2 OR52B4
GH11J004493 Enhancer 0.9 FANTOM5 ENCODE 9.7 -99.5 -99452 0.5 CTCF ZNF143 REST RAD21 IKZF2 TRIM22 EED HMBOX1 CTBP1 GATAD2B OR52K2 OR52B4 TRIM21 OR51F1 HSALNG0082349 OR52K1 OR52M2P OR52M1
GH11J004456 Enhancer 0.8 FANTOM5 ENCODE 7.8 -62.0 -61965 0.3 ETV6 CTCF SPI1 GABPA MAX POLR2A MYC GABPB1 OR52K3P OR52K1 TRIM21 OR52K2
GH11J004480 Enhancer 1 FANTOM5 Ensembl ENCODE 4.8 -88.6 -88599 5 PRDM10 ZNF692 JUND NFE2 ZNF316 FOS FOSL1 MYNN SPI1 ZFP69B OR52K1 OR52K3P TRIM68 TRIM21 OR51F2 OR52K2 OR51D1 OR51T1 OR51G1 HSALNG0082349
GH11J003644 Promoter/Enhancer 0.9 EPDnew ENCODE 4.9 +748.7 748722 1.4 IKZF1 NR2C1 HDAC1 MEF2D TRIM28 TRIM24 ZFHX2 NR2F1 FOXA1 NR2F6 ART1 TRIM21 ART5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRIM21 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRIM21

Top Transcription factor binding sites by QIAGEN in the TRIM21 gene promoter:
  • AML1a
  • AREB6
  • c-Rel
  • Evi-1
  • Pax-2
  • Pax-2a
  • Pax-2b
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for TRIM21 Gene

Genomic Locations for TRIM21 Gene
chr11:4,384,897-4,393,702
(GRCh38/hg38)
Size:
8,806 bases
Orientation:
Minus strand
chr11:4,406,127-4,414,926
(GRCh37/hg19)
Size:
8,800 bases
Orientation:
Minus strand

Genomic View for TRIM21 Gene

Genes around TRIM21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM21 Gene

Proteins for TRIM21 Gene

  • Protein details for TRIM21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19474-RO52_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM21
    Protein Accession:
    P19474
    Secondary Accessions:
    • Q5XPV5
    • Q96RF8

    Protein attributes for TRIM21 Gene

    Size:
    475 amino acids
    Molecular mass:
    54170 Da
    Quaternary structure:
    • Homotrimer (PubMed:17156811) (PubMed:26347139). Interacts (via C-terminus) with IRF8 (via C-terminus) (By similarity). Component of a SCF(SKP2)-like complex containing CUL1, SKP1, TRIM21 and SKP2. Interacts with CALR, CUL1, FBXW11, HSPA5, IKBKB, IRF3, SKP1 and VCP. Interacts with SKP2; the interaction with SKP2 does not depend on an intact F-box domain. Interacts (via N-terminus and C-terminus) with DCP2 (via N-terminus and C-terminus). Interacts with ULK1, BECN1 and with ATG8 family members, including GABARAP, GABARAPL1, GABARAPL2 and MAP1LC3C/LC3C. Interacts with TRIM21 and SQSTM1/sequestosome 1. Interacts with IRF3 (PubMed:26347139).

    Three dimensional structures from OCA and Proteopedia for TRIM21 Gene

    Alternative splice isoforms for TRIM21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM21 Gene

Post-translational modifications for TRIM21 Gene

  • Autoubiquitinated; does not lead to its proteasomal degradation. Deubiquitinated by USP4; leading to its stabilization.
  • Ubiquitination at Lys260
  • Modification sites at PhosphoSitePlus

Other Protein References for TRIM21 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM21 Gene

Domains & Families for TRIM21 Gene

Gene Families for TRIM21 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for TRIM21 Gene

InterPro:
Blocks:
  • Zn-finger, RING
  • Butyrophylin C-terminal DUF signature
  • SPRY-associated domain
  • B-box zinc finger signature
ProtoNet:

Suggested Antigen Peptide Sequences for TRIM21 Gene

GenScript: Design optimal peptide antigens:
  • Tripartite motif-containing protein 21 (RO52_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P19474

UniProtKB/Swiss-Prot:

RO52_HUMAN :
  • The coiled-coil is necessary for the cytoplasmic localization. The B30.2/SPRY domain is necessary for the cytoplasmic localization, the interaction with IRF3 and for the IRF3-driven interferon beta promoter activity. The RING-type zinc finger is necessary for ubiquitination and for the IRF3-driven interferon beta promoter activity. Interacts with SKP2 and CUL1 in a RING finger-independent manner.
  • Belongs to the TRIM/RBCC family.
Domain:
  • The coiled-coil is necessary for the cytoplasmic localization. The B30.2/SPRY domain is necessary for the cytoplasmic localization, the interaction with IRF3 and for the IRF3-driven interferon beta promoter activity. The RING-type zinc finger is necessary for ubiquitination and for the IRF3-driven interferon beta promoter activity. Interacts with SKP2 and CUL1 in a RING finger-independent manner.
Family:
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM21: view

Function for TRIM21 Gene

Molecular function for TRIM21 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2. Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1 and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of IRF3, hence attenuating type I interferon (IFN)-dependent immune responses (PubMed:26347139).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27;.
UniProtKB/Swiss-Prot Induction:
Up-regulated by isoform 2 of XBP1. Up-regulated by IFNG/interferon-gamma, with a peak after 2-4 hours of treatment in monocytes/macrophages.

Enzyme Numbers (IUBMB) for TRIM21 Gene

Phenotypes From GWAS Catalog for TRIM21 Gene

Gene Ontology (GO) - Molecular Function for TRIM21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IEA --
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005515 protein binding IPI 8666824
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with TRIM21: view
genes like me logo Genes that share phenotypes with TRIM21: view

Animal Models for TRIM21 Gene

MGI Knock Outs for TRIM21:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM21

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIM21 Gene

Localization for TRIM21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM21 Gene

Cytoplasm. Cytoplasmic vesicle, autophagosome. Nucleus. Cytoplasm, P-body. Note=Enters the nucleus upon exposure to nitric oxide. Localizes to small dot- or rod-like structures in the cytoplasm, called processing bodies (P-bodies) that are located underneath the plasma membrane and also diffusely in the cytoplasm. They are located along the microtubules and are highly motile in cells. Colocalizes with DCP2 in P-bodies.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM21 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TRIM21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IEA --
GO:0005634 nucleus IEA,IDA 18845142
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 16316627
GO:0005776 autophagosome IEA --
genes like me logo Genes that share ontologies with TRIM21: view

Pathways & Interactions for TRIM21 Gene

genes like me logo Genes that share pathways with TRIM21: view

UniProtKB/Swiss-Prot P19474-RO52_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for TRIM21 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for TRIM21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IDA,TAS --
GO:0006513 protein monoubiquitination IDA 16297862
GO:0007049 cell cycle IEA --
GO:0010468 regulation of gene expression IBA 21873635
GO:0010508 positive regulation of autophagy IMP 26347139
genes like me logo Genes that share ontologies with TRIM21: view

Drugs & Compounds for TRIM21 Gene

(2) Drugs for TRIM21 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for TRIM21 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TRIM21: view

Transcripts for TRIM21 Gene

mRNA/cDNA for TRIM21 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM21

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM21 Gene

No ASD Table

Relevant External Links for TRIM21 Gene

GeneLoc Exon Structure for
TRIM21

Expression for TRIM21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRIM21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM21 Gene

This gene is overexpressed in Whole Blood (x9.0).

Protein differential expression in normal tissues from HIPED for TRIM21 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.5), Lymph node (11.0), Heart (9.4), and Monocytes (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRIM21 Gene



Protein tissue co-expression partners for TRIM21 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRIM21

SOURCE GeneReport for Unigene cluster for TRIM21 Gene:

Hs.532357

mRNA Expression by UniProt/SwissProt for TRIM21 Gene:

P19474-RO52_HUMAN
Tissue specificity: Isoform 1 and isoform 2 are expressed in fetal and adult heart and fetal lung.

Evidence on tissue expression from TISSUES for TRIM21 Gene

  • Blood(4.6)
  • Pancreas(4.3)
  • Spleen(2.8)
  • Lymph node(2.8)
  • Skin(2.7)
  • Kidney(2.7)
  • Liver(2.7)
  • Bone marrow(2.6)
  • Nervous system(2.6)
  • Heart(2.6)
  • Muscle(2.6)
  • Lung(2.4)
  • Thyroid gland(2.4)
  • Intestine(2.4)
  • Eye(2.3)
  • Saliva(2.2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with TRIM21: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM21 Gene

Orthologs for TRIM21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM21 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TRIM21 30 31
  • 99.51 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TRIM21 30 31
  • 83.76 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TRIM21 30 31
  • 83.01 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Trim21 30
  • 77.61 (n)
Mouse
(Mus musculus)
Mammalia Trim21 30 17 31
  • 77.54 (n)
OneToOne
Chicken
(Gallus gallus)
Aves -- 31
  • 36 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 40 (a)
OneToMany
Species where no ortholog for TRIM21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TRIM21 Gene

ENSEMBL:
Gene Tree for TRIM21 (if available)
TreeFam:
Gene Tree for TRIM21 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRIM21: view image

Paralogs for TRIM21 Gene

genes like me logo Genes that share paralogs with TRIM21: view

Variants for TRIM21 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRIM21 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
781807 Benign: not provided 4,385,627(-) A/G SYNONYMOUS_VARIANT
782540 Benign: not provided 4,389,704(-) A/G SYNONYMOUS_VARIANT
rs1042302 - p.Pro52Ala
rs2554934 - p.Glu231Lys
rs2975162 - p.Gly96Arg

Additional dbSNP identifiers (rs#s) for TRIM21 Gene

Structural Variations from Database of Genomic Variants (DGV) for TRIM21 Gene

Variant ID Type Subtype PubMed ID
dgv1023n100 CNV loss 25217958
dgv1582n54 CNV loss 21841781
dgv1583n54 CNV loss 21841781
dgv180e214 CNV gain 21293372
dgv181e214 CNV loss 21293372
esv2759797 CNV gain+loss 17122850
esv3625179 CNV loss 21293372
esv3891912 CNV gain+loss 25118596
nsv1053120 CNV gain 25217958
nsv428248 CNV gain+loss 18775914
nsv469800 CNV gain+loss 16826518
nsv553159 CNV gain 21841781
nsv553162 CNV gain 21841781
nsv832054 CNV gain 17160897

Variation tolerance for TRIM21 Gene

Residual Variation Intolerance Score: 61.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM21 Gene

Human Gene Mutation Database (HGMD)
TRIM21
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM21 Gene

Disorders for TRIM21 Gene

MalaCards: The human disease database

(58) MalaCards diseases for TRIM21 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
heart block, congenital
  • congenital heart block
sjogren syndrome
  • sicca syndrome
lupus erythematosus
  • systemic lupus erythematosus
subacute cutaneous lupus erythematosus
  • lupus erythematosus cutaneous subacute
cutaneous lupus erythematosus
  • lupus erythematosus, cutaneous
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TRIM21

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TRIM21: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM21 Gene

Publications for TRIM21 Gene

  1. rs660 polymorphism in Ro52 (SSA1; TRIM21) is a marker for age-dependent tolerance induction and efficiency of alloimmunization in sickle cell disease. (PMID: 19201475) Tatari-Calderone Z … Vukmanovic S (Molecular immunology 2009) 3 23 41
  2. SSA/Ro52 autoantigen interacts with Dcp2 to enhance its decapping activity. (PMID: 18361920) Yamochi T … Morimoto C (Biochemical and biophysical research communications 2008) 3 4 23
  3. Ro52 functionally interacts with IgG1 and regulates its quality control via the ERAD system. (PMID: 18022694) Takahata M … Hatakeyama S (Molecular immunology 2008) 3 4 23
  4. Autoantigen Ro52 is an E3 ubiquitin ligase. (PMID: 16297862) Wada K … Kamitani T (Biochemical and biophysical research communications 2006) 3 4 23
  5. Oncogenic protein UnpEL/Usp4 deubiquitinates Ro52 by its isopeptidase activity. (PMID: 16316627) Wada K … Kamitani T (Biochemical and biophysical research communications 2006) 3 4 23

Products for TRIM21 Gene

Sources for TRIM21 Gene