Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TRIM2 Gene

Aliases for TRIM2 Gene

  • Tripartite Motif Containing 2 2 3 5
  • RING-Type E3 Ubiquitin Transferase TRIM2 3 4
  • E3 Ubiquitin-Protein Ligase TRIM2 3 4
  • RING Finger Protein 86 3 4
  • RNF86 3 4
  • Tripartite Motif-Containing Protein 2 3
  • Tripartite Motif Protein TRIM2 3
  • Tripartite Motif-Containing 2 2
  • EC 2.3.2.27 4
  • KIAA0517 4
  • CMT2R 3

External Ids for TRIM2 Gene

Previous GeneCards Identifiers for TRIM2 Gene

  • GC04P154972
  • GC04P154462
  • GC04P154703
  • GC04P154483
  • GC04P154345
  • GC04P154073
  • GC04P149803

Summaries for TRIM2 Gene

Entrez Gene Summary for TRIM2 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

GeneCards Summary for TRIM2 Gene

TRIM2 (Tripartite Motif Containing 2) is a Protein Coding gene. Diseases associated with TRIM2 include Charcot-Marie-Tooth Disease, Axonal, Type 2R and Axonal Neuropathy. Among its related pathways are Innate Immune System and Interferon gamma signaling. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is TRIM3.

UniProtKB/Swiss-Prot for TRIM2 Gene

  • UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance.

Additional gene information for TRIM2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM2 Gene

Genomics for TRIM2 Gene

GeneHancer (GH) Regulatory Elements for TRIM2 Gene

Promoters and enhancers for TRIM2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J153202 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 669 +54.1 54064 7.3 PKNOX1 SMAD1 FOXA2 ARNT SIN3A FEZF1 ZNF121 GLIS2 FOS ATF7 TRIM2 RNU6-1196P ENSG00000201786 GC04M153170 LOC105377496
GH04J153151 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 655.7 +0.9 865 3.1 SIN3A FEZF1 GLI4 GLIS2 ZNF213 SP3 ATF4 GLIS1 MYNN PRDM4 TRIM2 GC04M153152 ARFIP1 MND1 RNU6-1196P ENSG00000201786
GH04J153256 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 667.2 +105.6 105570 2.4 SIN3A FEZF1 BATF IRF4 RFX5 ZNF366 ZNF143 FOS JUNB ZEB2 TRIM2 GC04M153247 RNU6-1196P
GH04J153218 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 28.9 +69.1 69068 6.4 FOXA2 SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF213 ZNF548 FOS SP3 ARFIP1 TRIM2 MIR4453HG RNU6-1196P ENSG00000201786 TIGD4 MND1 RNF175 GC04M153170 LOC105377496
GH04J153247 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 31.5 +97.1 97081 3 SIN3A BMI1 ZNF335 GLIS2 EGR1 SCRT2 RUNX3 EGR2 SP3 ZNF398 GC04M153247 LOC105377496 TRIM2 MND1 TMEM131L TIGD4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRIM2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRIM2 gene promoter:
  • NF-Y
  • CBF(2)
  • MyoD
  • Zic3
  • Ik-1
  • ATF6
  • YY1
  • RORalpha1
  • Pax-4a
  • AP-4

Genomic Locations for TRIM2 Gene

Genomic Locations for TRIM2 Gene
chr4:153,152,342-153,339,322
(GRCh38/hg38)
Size:
186,981 bases
Orientation:
Plus strand
chr4:154,073,494-154,260,474
(GRCh37/hg19)
Size:
186,981 bases
Orientation:
Plus strand

Genomic View for TRIM2 Gene

Genes around TRIM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM2 Gene

Proteins for TRIM2 Gene

  • Protein details for TRIM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C040-TRIM2_HUMAN
    Recommended name:
    Tripartite motif-containing protein 2
    Protein Accession:
    Q9C040
    Secondary Accessions:
    • D3DP09
    • O60272
    • Q9BSI9
    • Q9UFZ1

    Protein attributes for TRIM2 Gene

    Size:
    744 amino acids
    Molecular mass:
    81530 Da
    Quaternary structure:
    • Interacts with myosin V; myosin V may not be a substrate for ubiquitination (By similarity). Interacts with NEFL (By similarity). Interacts with phosphorylated BCL2L11.
    SequenceCaution:
    • Sequence=AAG53472.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA25443.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRIM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM2 Gene

Post-translational modifications for TRIM2 Gene

  • RING-type zinc finger-dependent and UBE2D1-dependent autoubiquitination.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TRIM2 Gene

Domains & Families for TRIM2 Gene

Gene Families for TRIM2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TRIM2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9C040

UniProtKB/Swiss-Prot:

TRIM2_HUMAN :
  • The interaction with myosin V is dependent upon its NHL repeats, which form a beta-propeller (NHL) domain containing six blades.
  • Belongs to the TRIM/RBCC family.
Domain:
  • The interaction with myosin V is dependent upon its NHL repeats, which form a beta-propeller (NHL) domain containing six blades.
Family:
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM2: view

Function for TRIM2 Gene

Molecular function for TRIM2 Gene

UniProtKB/Swiss-Prot Function:
UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance.
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Enzyme Numbers (IUBMB) for TRIM2 Gene

Phenotypes From GWAS Catalog for TRIM2 Gene

Gene Ontology (GO) - Molecular Function for TRIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity ISS --
GO:0005515 protein binding IPI,IEA 21478148
GO:0008270 zinc ion binding IEA,NAS 11331580
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM2: view
genes like me logo Genes that share phenotypes with TRIM2: view

Human Phenotype Ontology for TRIM2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM2

Clone Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM2 Gene

Localization for TRIM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM2 gene
Compartment Confidence
cytoskeleton 3
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TRIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA,IDA 11331580
genes like me logo Genes that share ontologies with TRIM2: view

Pathways & Interactions for TRIM2 Gene

genes like me logo Genes that share pathways with TRIM2: view

Pathways by source for TRIM2 Gene

UniProtKB/Swiss-Prot Q9C040-TRIM2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for TRIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0043523 regulation of neuron apoptotic process ISS --
genes like me logo Genes that share ontologies with TRIM2: view

No data available for SIGNOR curated interactions for TRIM2 Gene

Drugs & Compounds for TRIM2 Gene

No Compound Related Data Available

Transcripts for TRIM2 Gene

Unigene Clusters for TRIM2 Gene

Tripartite motif containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM2 Gene

No ASD Table

Relevant External Links for TRIM2 Gene

GeneLoc Exon Structure for
TRIM2
ECgene alternative splicing isoforms for
TRIM2

Expression for TRIM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.0).

Protein differential expression in normal tissues from HIPED for TRIM2 Gene

This gene is overexpressed in Fetal Brain (21.8), Brain (15.8), Frontal cortex (11.6), and Spinal cord (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRIM2 Gene



Protein tissue co-expression partners for TRIM2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRIM2 Gene:

TRIM2

SOURCE GeneReport for Unigene cluster for TRIM2 Gene:

Hs.435711

Evidence on tissue expression from TISSUES for TRIM2 Gene

  • Nervous system(4.9)
  • Liver(4.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM2 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • nervous
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • head
Limb:
  • foot
  • lower limb
General:
  • peripheral nerve
  • peripheral nervous system
genes like me logo Genes that share expression patterns with TRIM2: view

No data available for mRNA Expression by UniProt/SwissProt for TRIM2 Gene

Orthologs for TRIM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM2 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 98 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia TRIM2 34
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim2 16 34 33
  • 90.95 (n)
cow
(Bos Taurus)
Mammalia TRIM2 34 33
  • 90.91 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim2 33
  • 90.28 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM2 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIM2 34 33
  • 84.45 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIM2 34
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trim2 33
  • 78.67 (n)
zebrafish
(Danio rerio)
Actinopterygii trim2a 34 33
  • 74.25 (n)
OneToMany
trim2b 34
  • 70 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta brat 34 35
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nhl-3 34
  • 22 (a)
ManyToMany
ncl-1 34 35
  • 18 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 23 (a)
OneToMany
Species where no ortholog for TRIM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRIM2 Gene

ENSEMBL:
Gene Tree for TRIM2 (if available)
TreeFam:
Gene Tree for TRIM2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRIM2: view image

Paralogs for TRIM2 Gene

Paralogs for TRIM2 Gene

(7) SIMAP similar genes for TRIM2 Gene using alignment to 3 proteins:

  • TRIM2_HUMAN
  • C9J084_HUMAN
  • C9JVI3_HUMAN
genes like me logo Genes that share paralogs with TRIM2: view

Variants for TRIM2 Gene

Sequence variations from dbSNP and Humsavar for TRIM2 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs115515921 benign, Charcot-Marie-Tooth disease, axonal, type 2R 153,295,543(+) C/T coding_sequence_variant, genic_downstream_transcript_variant, synonymous_variant
rs116365246 likely-benign, Charcot-Marie-Tooth disease, axonal, type 2R 153,295,495(+) C/T coding_sequence_variant, genic_downstream_transcript_variant, synonymous_variant
rs116558260 benign, Charcot-Marie-Tooth disease, axonal, type 2R 153,295,603(+) C/A/T coding_sequence_variant, genic_downstream_transcript_variant, synonymous_variant
rs12644835 likely-benign, Charcot-Marie-Tooth disease, axonal, type 2R 153,275,897(+) C/T 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, synonymous_variant
rs142242737 likely-benign, Charcot-Marie-Tooth disease, axonal, type 2R 153,295,453(+) C/T coding_sequence_variant, genic_downstream_transcript_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM2 Gene

Variant ID Type Subtype PubMed ID
esv2119302 CNV deletion 18987734
esv2567648 CNV deletion 19546169
esv2662968 CNV deletion 23128226
esv2728552 CNV deletion 23290073
esv28591 CNV loss 19812545
esv3386287 CNV duplication 20981092
esv3602719 CNV loss 21293372
esv3602721 CNV loss 21293372
esv8682 CNV gain 19470904
nsv4556 CNV insertion 18451855
nsv509939 OTHER sequence alteration 20534489
nsv514259 CNV loss 21397061
nsv966329 CNV duplication 23825009

Variation tolerance for TRIM2 Gene

Residual Variation Intolerance Score: 3.98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM2 Gene

Human Gene Mutation Database (HGMD)
TRIM2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM2 Gene

Disorders for TRIM2 Gene

MalaCards: The human disease database

(16) MalaCards diseases for TRIM2 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search TRIM2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TRIM2_HUMAN
  • Charcot-Marie-Tooth disease 2R (CMT2R) [MIM:615490]: An axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced. {ECO:0000269 PubMed:23562820}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for TRIM2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TRIM2: view

No data available for Genatlas for TRIM2 Gene

Publications for TRIM2 Gene

  1. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A … Ballabio A (The EMBO journal 2001) 2 3 4 58
  2. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  3. Deficiency of the E3 ubiquitin ligase TRIM2 in early-onset axonal neuropathy. (PMID: 23562820) Ylikallio E … Tyynismaa H (Human molecular genetics 2013) 3 4 58
  4. Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection. (PMID: 21478148) Thompson S … Meller R (The Journal of biological chemistry 2011) 3 4 58
  5. Genome-wide association study of severity in multiple sclerosis. (PMID: 21654844) International Multiple Sclerosis Genetics Consortium (Genes and immunity 2011) 3 44 58

Products for TRIM2 Gene

Sources for TRIM2 Gene

Content
Loading form....