Aliases for TRIM2 Gene
External Ids for TRIM2 Gene
Previous GeneCards Identifiers for TRIM2 Gene
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
GeneCards Summary for TRIM2 Gene
TRIM2 (Tripartite Motif Containing 2) is a Protein Coding gene. Diseases associated with TRIM2 include Charcot-Marie-Tooth Disease, Axonal, Type 2R and Axonal Neuropathy. Among its related pathways are Innate Immune System and Interferon gamma signaling. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is TRIM3.
UniProtKB/Swiss-Prot Summary for TRIM2 Gene
UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance.