Aliases for TRIM16L Gene

Aliases for TRIM16L Gene

  • Tripartite Motif Containing 16 Like 2 3 5
  • TRIM70 2 3 4
  • Tripartite Motif-Containing Protein 16-Like Protein 3 4
  • Tripartite Motif-Containing Protein 70 3 4
  • Tripartite Motif-Containing 16-Like 2
  • Tripartite Motif Protein 70 3
  • TRIM16L 5

External Ids for TRIM16L Gene

Previous GeneCards Identifiers for TRIM16L Gene

  • GC17P018547
  • GC17P018602

Summaries for TRIM16L Gene

GeneCards Summary for TRIM16L Gene

TRIM16L (Tripartite Motif Containing 16 Like) is a Protein Coding gene.

Additional gene information for TRIM16L Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRIM16L Gene

Genomics for TRIM16L Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TRIM16L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J018697 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 258.7 +0.1 103 1.4 ZBTB10 SIX5 ZNF217 ELF1 THAP11 GABPA HCFC1 SAP130 KMT2B GABPB1 TRIM16L lnc-FBXW10-3 FBXW10 piR-55985-076
GH17J018721 Promoter/Enhancer 1.2 EPDnew Ensembl dbSUPER 262.7 +24.4 24403 1.2 ZNF316 NFE2 SMARCE1 DPF2 ZBTB8A MAFK PRDM10 EMSY TRIM16L MK280144-257 ENSG00000265693 FBXW10 lnc-FBXW10-3
GH17J018699 Promoter 0.3 EPDnew 250.7 +1.2 1183 0.1 TRIM16L lnc-FBXW10-3 FBXW10 piR-55985-076
GH17J018700 Enhancer 0.2 Ensembl 250.7 +1.9 1903 0.2 TRIM16L lnc-FBXW10-3 piR-55985-076 FBXW10
GH17J018780 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 6.9 +83.6 83603 2.8 ZSCAN16 ZBTB10 SP1 FEZF1 SIX5 NR2C1 MNT ZNF217 ZBTB7B ZEB1 TVP23B NONHSAG020915.2 MAPK7 FOXO3B SMCR8 ZNF286B DRG2 LOC100419436 ENSG00000262202 TOP3A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRIM16L on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRIM16L

Top Transcription factor binding sites by QIAGEN in the TRIM16L gene promoter:
  • c-Myc
  • c-Rel
  • E47
  • Hand1
  • Hlf
  • HNF-1
  • HNF-1A
  • Max1
  • Tal-1beta

Genomic Locations for TRIM16L Gene

Latest Assembly
chr17:18,697,998-18,736,119
(GRCh38/hg38)
Size:
38,122 bases
Orientation:
Plus strand

Previous Assembly
chr17:18,601,311-18,639,425
(GRCh37/hg19 by Entrez Gene)
Size:
38,115 bases
Orientation:
Plus strand

chr17:18,601,311-18,639,431
(GRCh37/hg19 by Ensembl)
Size:
38,121 bases
Orientation:
Plus strand

Genomic View for TRIM16L Gene

Genes around TRIM16L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM16L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM16L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM16L Gene

Proteins for TRIM16L Gene

  • Protein details for TRIM16L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q309B1-TR16L_HUMAN
    Recommended name:
    Tripartite motif-containing protein 16-like protein
    Protein Accession:
    Q309B1
    Secondary Accessions:
    • A0PK10
    • B2RUW6
    • B4DQK2
    • B4DWQ8

    Protein attributes for TRIM16L Gene

    Size:
    348 amino acids
    Molecular mass:
    40306 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRIM16L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM16L Gene

Post-translational modifications for TRIM16L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TRIM16L Gene

Domains & Families for TRIM16L Gene

Gene Families for TRIM16L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TRIM16L Gene

InterPro:
Blocks:
  • Butyrophylin C-terminal DUF signature
ProtoNet:

Suggested Antigen Peptide Sequences for TRIM16L Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57635, moderately similar to Tripartite motif-containing protein 16 (B4DWQ8_HUMAN)
  • Tripartite motif-containing protein 70 (TR16L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q309B1

UniProtKB/Swiss-Prot:

TR16L_HUMAN :
  • Belongs to the TRIM/RBCC family.
Family:
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM16L: view

Function for TRIM16L Gene

Phenotypes From GWAS Catalog for TRIM16L Gene

Phenotypes for TRIM16L Gene

GenomeRNAi human phenotypes for TRIM16L:
genes like me logo Genes that share phenotypes with TRIM16L: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM16L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM16L Gene

Localization for TRIM16L Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM16L Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM16L gene
Compartment Confidence
plasma membrane 4
cytosol 4
nucleus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRIM16L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with TRIM16L: view

Pathways & Interactions for TRIM16L Gene

PathCards logo

SuperPathways for TRIM16L Gene

No Data Available

Interacting Proteins for TRIM16L Gene

Gene Ontology (GO) - Biological Process for TRIM16L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRIM16L Gene

Drugs & Compounds for TRIM16L Gene

No Compound Related Data Available

Transcripts for TRIM16L Gene

mRNA/cDNA for TRIM16L Gene

9 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM16L

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM16L Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13a · 13b · 13c
SP1: - - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - -
SP7: -
SP8: -
SP9:

Relevant External Links for TRIM16L Gene

GeneLoc Exon Structure for
TRIM16L

Expression for TRIM16L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRIM16L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRIM16L Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRIM16L Gene



Protein tissue co-expression partners for TRIM16L Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRIM16L

SOURCE GeneReport for Unigene cluster for TRIM16L Gene:

Hs.745311

Evidence on tissue expression from TISSUES for TRIM16L Gene

  • Nervous system(4.2)
  • Lung(2.5)
genes like me logo Genes that share expression patterns with TRIM16L: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM16L Gene

Orthologs for TRIM16L Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM16L Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TRIM16L 30 31
  • 98.66 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 66 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Trim16 31
  • 53 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 41 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 35 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii trim16 31
  • 27 (a)
OneToMany
Species where no ortholog for TRIM16L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TRIM16L Gene

ENSEMBL:
Gene Tree for TRIM16L (if available)
TreeFam:
Gene Tree for TRIM16L (if available)

Paralogs for TRIM16L Gene

(2) SIMAP similar genes for TRIM16L Gene using alignment to 7 proteins:

  • TR16L_HUMAN
  • C9JWX7_HUMAN
  • I3L1X9_HUMAN
  • I3L2F3_HUMAN
  • I3L3K9_HUMAN
  • J3KPT5_HUMAN
  • J3KSX4_HUMAN
genes like me logo Genes that share paralogs with TRIM16L: view

No data available for Paralogs for TRIM16L Gene

Variants for TRIM16L Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TRIM16L Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TRIM16L Gene

Variant ID Type Subtype PubMed ID
dgv564e214 CNV gain 21293372
esv1199476 CNV deletion 17803354
esv3554224 CNV deletion 23714750
esv3640164 CNV gain 21293372
nsv1055999 CNV gain 25217958
nsv1057803 CNV loss 25217958
nsv1060744 CNV gain 25217958
nsv1063354 CNV gain 25217958
nsv1075927 CNV duplication 25765185
nsv112212 CNV deletion 16902084
nsv1131301 CNV deletion 24896259
nsv499818 OTHER inversion 21111241
nsv523721 CNV gain 19592680
nsv833389 CNV gain 17160897
nsv9504 CNV gain+loss 18304495
nsv960430 CNV duplication 23825009
nsv962278 CNV duplication 23825009

Variation tolerance for TRIM16L Gene

Residual Variation Intolerance Score: 91.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.82; 83.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM16L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM16L

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRIM16L Gene

Disorders for TRIM16L Gene

Additional Disease Information for TRIM16L

No disorders were found for TRIM16L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM16L Gene

Publications for TRIM16L Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3
  4. TRIM59 Promotes the Proliferation and Migration of Non-Small Cell Lung Cancer Cells by Upregulating Cell Cycle Related Proteins. (PMID: 26599082) Zhan W … Wang JB (PloS one 2015) 3
  5. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4

Products for TRIM16L Gene

Sources for TRIM16L Gene