The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefS... See more...

Aliases for TRIM15 Gene

Aliases for TRIM15 Gene

  • Tripartite Motif Containing 15 2 3 5
  • Zinc Finger Protein 178 2 3 4
  • RNF93 2 3 4
  • ZNFB7 2 3 4
  • Tripartite Motif-Containing Protein 15 3 4
  • RING Finger Protein 93 3 4
  • Zinc Finger Protein B7 3 4
  • ZNF178 3 4
  • Tripartite Motif-Containing 15 2
  • TRIM15 5

External Ids for TRIM15 Gene

Previous HGNC Symbols for TRIM15 Gene

  • ZNF178

Previous GeneCards Identifiers for TRIM15 Gene

  • GC06P030215
  • GC06P029901
  • GC06P030237
  • GC06P030238
  • GC06P030130
  • GC06P029929
  • GC06P030282
  • GC06P030318
  • GC06P032268
  • GC06P032441
  • GC06P032570
  • GC06P033227
  • GC06P030368
  • GC06P030518
  • GC06P030727
  • GC06P030884
  • GC06P031042
  • GC06P031193
  • GC06P031396
  • GC06P032038

Summaries for TRIM15 Gene

Entrez Gene Summary for TRIM15 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM15 Gene

TRIM15 (Tripartite Motif Containing 15) is a Protein Coding gene. An important paralog of this gene is TRIM41.

Gene Wiki entry for TRIM15 Gene

Additional gene information for TRIM15 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRIM15 Gene

Genomics for TRIM15 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TRIM15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J030162 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 600.7 +0.6 579 2.8 ZNF221 HNRNPL GATAD2A PRDM10 REST ZNF629 NFKBIZ ZNF692 RCOR2 RBFOX2 TRIM10 TRIM15 piR-61101-576 MDC1 HCG18 GTF2H4 PPP1R10 ZNRD1ASP TRIM39 HLA-U
GH06J030161 Promoter 0.6 EPDnew 600.7 -2.0 -1975 0.1 TAL1 TCF12 CBFA2T2 TRIM10 TRIM15 piR-31534-591 TRIM40
GH06J030133 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 12 -27.6 -27594 4.2 GATAD2A ATF7 TFE3 SOX13 ZNF7 RXRB IRF2 CEBPA FOXK2 KMT2B TRIM40 NONHSAG045567.2 TRIM31 HLA-K HLA-A ENSG00000237669 TRIM31-AS1 TRIM10 TRIM15 PPP1R10
GH06J030129 Enhancer 1.2 Ensembl ENCODE 12.1 -32.4 -32388 3.2 GATAD2A CTCF PRDM10 TFE3 RFX1 NFKBIZ ZNF692 RCOR2 JUND STAT3 TRIM40 TRIM31 TRIM31-AS1 TRIM10 TRIM15 HLA-A HCG18 ENSG00000252228 lnc-TRIM31-2
GH06J030127 Enhancer 0.3 Ensembl 12.1 -35.2 -35206 0.4 EZH2 SIN3A lnc-TRIM31-2 piR-48958 piR-50202 piR-54266 TRIM31-AS1 TRIM10 TRIM15 HCG18 ENSG00000252228 TRIM40
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRIM15 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRIM15

Top Transcription factor binding sites by QIAGEN in the TRIM15 gene promoter:
  • AML1a
  • Arnt
  • c-Ets-1
  • E2F
  • E2F-1
  • Max1
  • MyoD
  • MZF-1
  • Nkx2-5

Genomic Locations for TRIM15 Gene

Genomic Locations for TRIM15 Gene
chr6:30,163,206-30,172,693
(GRCh38/hg38)
Size:
9,488 bases
Orientation:
Plus strand
chr6:30,130,983-30,140,473
(GRCh37/hg19)
Size:
9,491 bases
Orientation:
Plus strand

Genomic View for TRIM15 Gene

Genes around TRIM15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for TRIM15 Gene

  • Protein details for TRIM15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C019-TRI15_HUMAN
    Recommended name:
    Tripartite motif-containing protein 15
    Protein Accession:
    Q9C019
    Secondary Accessions:
    • A2BEC9
    • O95604
    • Q8IUX9
    • Q9C018

    Protein attributes for TRIM15 Gene

    Size:
    465 amino acids
    Molecular mass:
    52113 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRIM15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM15 Gene

Post-translational modifications for TRIM15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM15 Gene

No data available for DME Specific Peptides for TRIM15 Gene

Domains & Families for TRIM15 Gene

Gene Families for TRIM15 Gene

Protein Domains for TRIM15 Gene

InterPro:
Blocks:
  • Zn-finger, RING
  • Butyrophylin C-terminal DUF signature
  • SPRY-associated domain
  • B-box zinc finger signature
ProtoNet:

Suggested Antigen Peptide Sequences for TRIM15 Gene

GenScript: Design optimal peptide antigens:
  • Zn-finger protein (Q0EFD1_HUMAN)
  • Tripartite motif-containing 15 (Q5SPM4_HUMAN)
  • cDNA FLJ75016, highly similar to Homo sapiens tripartite motif-containing 15 (TRIM15), transcript variant 1, mRNA (Q5SRL0_HUMAN)
  • Zinc finger protein B7 (TRI15_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9C019

UniProtKB/Swiss-Prot:

TRI15_HUMAN :
  • Belongs to the TRIM/RBCC family.
Family:
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM15: view

Function for TRIM15 Gene

Phenotypes From GWAS Catalog for TRIM15 Gene

Gene Ontology (GO) - Molecular Function for TRIM15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IBA 21873635
genes like me logo Genes that share ontologies with TRIM15: view
genes like me logo Genes that share phenotypes with TRIM15: view

Animal Models for TRIM15 Gene

MGI Knock Outs for TRIM15:
  • Trim15 Trim15<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM15

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TRIM15 Gene

Localization for TRIM15 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM15 gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centriolar satellite (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRIM15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with TRIM15: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM15 Gene

Pathways & Interactions for TRIM15 Gene

PathCards logo

SuperPathways for TRIM15 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007500 mesodermal cell fate determination TAS 10207104
GO:0010468 regulation of gene expression IBA 21873635
GO:0016567 protein ubiquitination IBA 21873635
GO:0032481 positive regulation of type I interferon production IMP 23077300
GO:0045087 innate immune response IMP 18248090
genes like me logo Genes that share ontologies with TRIM15: view

No data available for Pathways by source and SIGNOR curated interactions for TRIM15 Gene

Drugs & Compounds for TRIM15 Gene

No Compound Related Data Available

Transcripts for TRIM15 Gene

mRNA/cDNA for TRIM15 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM15

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM15 Gene

No ASD Table

Relevant External Links for TRIM15 Gene

GeneLoc Exon Structure for
TRIM15

Expression for TRIM15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRIM15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM15 Gene

This gene is overexpressed in Colon - Transverse (x18.0), Liver (x16.0), Small Intestine - Terminal Ileum (x10.5), and Kidney - Cortex (x5.6).

Protein differential expression in normal tissues from HIPED for TRIM15 Gene

This gene is overexpressed in Oral epithelium (28.4), Kidney (25.3), and Ovary (15.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRIM15 Gene



Protein tissue co-expression partners for TRIM15 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRIM15

SOURCE GeneReport for Unigene cluster for TRIM15 Gene:

Hs.591789

Evidence on tissue expression from TISSUES for TRIM15 Gene

  • Intestine(4.4)
genes like me logo Genes that share expression patterns with TRIM15: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM15 Gene

Orthologs for TRIM15 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRIM15 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TRIM15 30 31
  • 99.07 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TRIM15 30 31
  • 86.98 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC100910806 30
  • 79.6 (n)
Mouse
(Mus musculus)
Mammalia Trim15 30 17 31
  • 78.75 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TRIM15 31
  • 63 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TRIM15 31
  • 53 (a)
OneToOne
Species where no ortholog for TRIM15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TRIM15 Gene

ENSEMBL:
Gene Tree for TRIM15 (if available)
TreeFam:
Gene Tree for TRIM15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRIM15: view image

Paralogs for TRIM15 Gene

(8) SIMAP similar genes for TRIM15 Gene using alignment to 4 proteins:

  • TRI15_HUMAN
  • A6NL11_HUMAN
  • H0Y5R0_HUMAN
  • Q5SRL0_HUMAN
genes like me logo Genes that share paralogs with TRIM15: view

Variants for TRIM15 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRIM15 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs17194460 - p.Ile29Val
rs17194467 - p.Ala42Thr
rs17194474 - p.Glu84Gln
rs34823152 - p.Leu235Val
rs929156 - p.Ser324Asn

Additional dbSNP identifiers (rs#s) for TRIM15 Gene

Structural Variations from Database of Genomic Variants (DGV) for TRIM15 Gene

Variant ID Type Subtype PubMed ID
esv2731777 CNV deletion 23290073
esv3411275 CNV duplication 20981092
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1144137 CNV deletion 24896259
nsv601264 CNV loss 21841781

Variation tolerance for TRIM15 Gene

Residual Variation Intolerance Score: 84.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.63; 82.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM15 Gene

Disorders for TRIM15 Gene

Additional Disease Information for TRIM15

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for TRIM15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM15 Gene

Publications for TRIM15 Gene

  1. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A … Ballabio A (The EMBO journal 2001) 2 3 4
  2. Isolation of novel non-HLA gene fragments from the hemochromatosis region (6p21.3) by cDNA hybridization selection. (PMID: 8304341) Goei VL … Gruen JR (American journal of human genetics 1994) 2 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  4. Refining the association of MHC with multiple sclerosis in African Americans. (PMID: 20466734) McElroy JP … Gourraud PA (Human molecular genetics 2010) 3 41
  5. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 41

Products for TRIM15 Gene

Sources for TRIM15 Gene