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The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
TRIM15 (Tripartite Motif Containing 15) is a Protein Coding gene. An important paralog of this gene is TRIM41.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IEA,IPI | 25416956 |
GO:0008270 | zinc ion binding | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
GO:0061630 | ubiquitin protein ligase activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007500 | mesodermal cell fate determination | TAS | 10207104 |
GO:0010468 | regulation of gene expression | IBA | 21873635 |
GO:0016567 | protein ubiquitination | IBA | 21873635 |
GO:0032481 | positive regulation of type I interferon production | IMP | 23077300 |
GO:0045087 | innate immune response | IMP | 18248090 |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TRIM15 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TRIM15 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | LOC100910806 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Trim15 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TRIM15 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | TRIM15 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs17194460 | - | p.Ile29Val | |||
rs17194467 | - | p.Ala42Thr | |||
rs17194474 | - | p.Glu84Gln | |||
rs34823152 | - | p.Leu235Val | |||
rs929156 | - | p.Ser324Asn |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2731777 | CNV | deletion | 23290073 |
esv3411275 | CNV | duplication | 20981092 |
nsv1074389 | CNV | deletion | 25765185 |
nsv1122126 | CNV | deletion | 24896259 |
nsv1144137 | CNV | deletion | 24896259 |
nsv601264 | CNV | loss | 21841781 |
No disorders were found for TRIM15 Gene.