Aliases for TRIM14 Gene
External Ids for TRIM14 Gene
Previous GeneCards Identifiers for TRIM14 Gene
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies and its function has not been determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
GeneCards Summary for TRIM14 Gene
TRIM14 (Tripartite Motif Containing 14) is a Protein Coding gene. Diseases associated with TRIM14 include Bone Cancer. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. An important paralog of this gene is BSPRY.
UniProtKB/Swiss-Prot for TRIM14 Gene
Plays a role in the innate immune defense against viruses. Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways (PubMed:24379373). Positively regulates the cGAS-induced type I interferon signaling pathway by stabilizing cGAS/MB21D1 and inhibiting its autophagic degradation (PubMed:27666593).