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Aliases for TRIM14 Gene

Aliases for TRIM14 Gene

  • Tripartite Motif Containing 14 2 3 5
  • Tripartite Motif-Containing 14 2
  • KIAA0129 4

External Ids for TRIM14 Gene

Previous GeneCards Identifiers for TRIM14 Gene

  • GC09M091671
  • GC09M092581
  • GC09M094304
  • GC09M096226
  • GC09M096211
  • GC09M097926
  • GC09M099871
  • GC09M100831
  • GC09M070431

Summaries for TRIM14 Gene

Entrez Gene Summary for TRIM14 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies and its function has not been determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

GeneCards Summary for TRIM14 Gene

TRIM14 (Tripartite Motif Containing 14) is a Protein Coding gene. Diseases associated with TRIM14 include Bone Cancer. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. An important paralog of this gene is BSPRY.

UniProtKB/Swiss-Prot for TRIM14 Gene

  • Plays a role in the innate immune defense against viruses. Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways (PubMed:24379373). Positively regulates the cGAS-induced type I interferon signaling pathway by stabilizing cGAS/MB21D1 and inhibiting its autophagic degradation (PubMed:27666593).

Additional gene information for TRIM14 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM14 Gene

Genomics for TRIM14 Gene

GeneHancer (GH) Regulatory Elements for TRIM14 Gene

Promoters and enhancers for TRIM14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I098117 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 559.7 -0.8 -817 5.6 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 TRIM14 NCBP1 ZNF322P1 TSTD2 ENSG00000254633 CORO2A ANKS6 CCDC180 LOC105376171 XPA
GH09I098070 Enhancer 1.3 Ensembl ENCODE dbSUPER 20.4 +45.7 45672 5.7 HDGF PKNOX1 CLOCK FOXA2 YBX1 ZNF121 ZNF207 ZNF143 FOS RXRA TRIM14 TBC1D2 RNU6-918P CORO2A TSTD2 HEMGN NANS PIR35853 GC09M098251 GC09M098254
GH09I098187 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.5 -71.5 -71481 6.2 CLOCK ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF213 E2F8 ZNF143 SP3 CORO2A TBC1D2 TRIM14 PIR60537
GH09I098080 Enhancer 1 ENCODE dbSUPER 20.6 +37.2 37164 3.5 FOXA2 RAD21 RARA YY1 TCF12 FOS SMARCC1 RXRA CEBPB ZEB2 GC09M098251 GC09M098254 PIR35853 TRIM14 TBC1D2 NANS
GH09I098141 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12 -25.5 -25529 6.4 PKNOX1 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 YY1 SLC30A9 ZNF121 TRIM14 CORO2A TBC1D2 NANS PIR60537
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRIM14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRIM14 gene promoter:

Genomic Locations for TRIM14 Gene

Genomic Locations for TRIM14 Gene
chr9:98,069,275-98,119,408
(GRCh38/hg38)
Size:
50,134 bases
Orientation:
Minus strand
chr9:100,831,557-100,881,494
(GRCh37/hg19)

Genomic View for TRIM14 Gene

Genes around TRIM14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM14 Gene

Proteins for TRIM14 Gene

  • Protein details for TRIM14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14142-TRI14_HUMAN
    Recommended name:
    Tripartite motif-containing protein 14
    Protein Accession:
    Q14142
    Secondary Accessions:
    • A8K9W0
    • E7EQC4
    • F8W956
    • Q548W9
    • Q5TBQ8
    • Q6ZWL7
    • Q9BRD8
    • Q9C020

    Protein attributes for TRIM14 Gene

    Size:
    442 amino acids
    Molecular mass:
    49773 Da
    Quaternary structure:
    • Interacts with MAVS (PubMed:24379373). Interacts with WRNIP1 and PPP6C; these interactions positively regulate the RIG-I/DDX58 signaling pathway (PubMed:29053956). Interacts with cGAS/MB21D1; this interaction stabilizes cGAS/MB21D1 and promotes type I interferon production (PubMed:27666593). Interacts with USP14; this interaction mediates the cleavage of Lys-48-linked ubiquitination of cGAS/MB21D1 (PubMed:27666593). Interacts with SPI1 (By similarity).

    Alternative splice isoforms for TRIM14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM14 Gene

Post-translational modifications for TRIM14 Gene

  • Ubiquitinated (PubMed:24379373). Undergoes Lys-63-linked polyubiquitination; this modification allows IKBKG/NEMO recruitment to MAVS.
  • Ubiquitination at posLast=7777
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TRIM14 Gene

Domains & Families for TRIM14 Gene

Gene Families for TRIM14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TRIM14 Gene

Graphical View of Domain Structure for InterPro Entry

Q14142

UniProtKB/Swiss-Prot:

TRI14_HUMAN :
  • The B-box zinc finger is responsible for inhibition of SPI1-mediated transcriptional activation.
  • Belongs to the TRIM/RBCC family.
Domain:
  • The B-box zinc finger is responsible for inhibition of SPI1-mediated transcriptional activation.
Family:
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM14: view

Function for TRIM14 Gene

Molecular function for TRIM14 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the innate immune defense against viruses. Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways (PubMed:24379373). Positively regulates the cGAS-induced type I interferon signaling pathway by stabilizing cGAS/MB21D1 and inhibiting its autophagic degradation (PubMed:27666593).
UniProtKB/Swiss-Prot Induction:
By interferons alpha and gamma.

Phenotypes From GWAS Catalog for TRIM14 Gene

Gene Ontology (GO) - Molecular Function for TRIM14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM14: view
genes like me logo Genes that share phenotypes with TRIM14: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM14 Gene

Localization for TRIM14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM14 Gene

Mitochondrion outer membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM14 gene
Compartment Confidence
mitochondrion 4
nucleus 4
cytosol 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRIM14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005741 mitochondrial outer membrane IEA --
genes like me logo Genes that share ontologies with TRIM14: view

Pathways & Interactions for TRIM14 Gene

genes like me logo Genes that share pathways with TRIM14: view

Pathways by source for TRIM14 Gene

Gene Ontology (GO) - Biological Process for TRIM14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032897 negative regulation of viral transcription IDA 18248090
GO:0045087 innate immune response IDA 18248090
GO:0051091 positive regulation of DNA binding transcription factor activity IDA 23077300
GO:0051092 positive regulation of NF-kappaB transcription factor activity IDA 23077300
genes like me logo Genes that share ontologies with TRIM14: view

No data available for SIGNOR curated interactions for TRIM14 Gene

Drugs & Compounds for TRIM14 Gene

No Compound Related Data Available

Transcripts for TRIM14 Gene

Unigene Clusters for TRIM14 Gene

Tripartite motif containing 14:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM14 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10
SP1: - - - - - -
SP2: - - - - -
SP3: -
SP4: - - - - - - - -
SP5: - -
SP6: - - -
SP7: - -
SP8:

Relevant External Links for TRIM14 Gene

GeneLoc Exon Structure for
TRIM14
ECgene alternative splicing isoforms for
TRIM14

Expression for TRIM14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM14 Gene

Protein differential expression in normal tissues from HIPED for TRIM14 Gene

This gene is overexpressed in Heart (26.9), CD8 Tcells (17.9), and Monocytes (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRIM14 Gene



Protein tissue co-expression partners for TRIM14 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRIM14 Gene:

TRIM14

SOURCE GeneReport for Unigene cluster for TRIM14 Gene:

Hs.575631

mRNA Expression by UniProt/SwissProt for TRIM14 Gene:

Q14142-TRI14_HUMAN
Tissue specificity: Highest expression in liver; undetectable in skeletal muscle.

Evidence on tissue expression from TISSUES for TRIM14 Gene

  • Bone marrow(4.2)
  • Eye(4.1)
  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with TRIM14: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM14 Gene

Orthologs for TRIM14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM14 33 34
  • 98.64 (n)
dog
(Canis familiaris)
Mammalia TRIM14 33 34
  • 86.88 (n)
cow
(Bos Taurus)
Mammalia TRIM14 33 34
  • 84.49 (n)
mouse
(Mus musculus)
Mammalia Trim14 33 16 34
  • 81.21 (n)
rat
(Rattus norvegicus)
Mammalia Trim14 33
  • 80.28 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM14 34
  • 59 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRIM14 34
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIM14 33 34
  • 57.66 (n)
lizard
(Anolis carolinensis)
Reptilia TRIM14 34
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493056 33
  • 57.41 (n)
zebrafish
(Danio rerio)
Actinopterygii TRIM14 (11 of 17) 34
  • 33 (a)
OneToMany
TRIM14 (5 of 17) 34
  • 32 (a)
OneToMany
TRIM14 (12 of 17) 34
  • 31 (a)
OneToMany
TRIM14 (17 of 17) 34
  • 31 (a)
OneToMany
TRIM14 (3 of 17) 34
  • 31 (a)
OneToMany
TRIM14 (9 of 17) 34
  • 31 (a)
OneToMany
TRIM14 (8 of 17) 34
  • 30 (a)
OneToMany
TRIM14 (10 of 17) 34
  • 29 (a)
OneToMany
TRIM14 (13 of 17) 34
  • 29 (a)
OneToMany
TRIM14 (14 of 17) 34
  • 28 (a)
OneToMany
TRIM14 (2 of 17) 34
  • 27 (a)
OneToMany
TRIM14 (1 of 17) 34
  • 25 (a)
OneToMany
TRIM14 (16 of 17) 34
  • 25 (a)
OneToMany
TRIM14 (4 of 17) 34
  • 25 (a)
OneToMany
TRIM14 (6 of 17) 34
  • 24 (a)
OneToMany
TRIM14 (7 of 17) 34
  • 24 (a)
OneToMany
TRIM14 (15 of 17) 34
  • 18 (a)
OneToMany
Species where no ortholog for TRIM14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM14 Gene

ENSEMBL:
Gene Tree for TRIM14 (if available)
TreeFam:
Gene Tree for TRIM14 (if available)

Paralogs for TRIM14 Gene

Paralogs for TRIM14 Gene

(1) SIMAP similar genes for TRIM14 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TRIM14: view

Variants for TRIM14 Gene

Sequence variations from dbSNP and Humsavar for TRIM14 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs140402727 pathogenic, Spondyloepimetaphyseal dysplasia Genevieve type 98,078,196(-) G/A/T downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs779218846 pathogenic, Spondyloepimetaphyseal dysplasia Genevieve type 98,077,018(-) G/A/T genic_downstream_transcript_variant, intron_variant
rs878852980 pathogenic, Spondyloepimetaphyseal dysplasia Genevieve type 98,076,967(-) G/T genic_downstream_transcript_variant, intron_variant
rs878852981 pathogenic, Spondyloepimetaphyseal dysplasia Genevieve type 98,078,306(-) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs878852982 pathogenic, Spondyloepimetaphyseal dysplasia Genevieve type 98,080,921(-) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM14 Gene

Variant ID Type Subtype PubMed ID
dgv1495e214 CNV loss 21293372
esv3573304 CNV loss 25503493
esv3621201 CNV gain 21293372
esv3621204 CNV loss 21293372
nsv614935 CNV loss 21841781
nsv6628 CNV insertion 18451855

Variation tolerance for TRIM14 Gene

Residual Variation Intolerance Score: 42.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM14 Gene

Disorders for TRIM14 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRIM14 Gene - From: DISEASES

Disorder Aliases PubMed IDs
bone cancer
  • bone neoplasm
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TRIM14

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TRIM14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM14 Gene

Publications for TRIM14 Gene

  1. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A … Ballabio A (The EMBO journal 2001) 2 3 4 58
  2. Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling. (PMID: 29053956) Tan P … Wang RF (Molecular cell 2017) 3 4 58
  3. TRIM14 is a mitochondrial adaptor that facilitates retinoic acid-inducible gene-I-like receptor-mediated innate immune response. (PMID: 24379373) Zhou Z … Wang J (Proceedings of the National Academy of Sciences of the United States of America 2014) 3 4 58
  4. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PMID: 18978678) Vieira AR … Marazita ML (Genetics in medicine : official journal of the American College of Medical Genetics 2008) 3 44 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for TRIM14 Gene

Sources for TRIM14 Gene

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