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Aliases for TRIM10 Gene

Aliases for TRIM10 Gene

  • Tripartite Motif Containing 10 2 3 5
  • B30-RING Finger Protein 3 4
  • RFB30 3 4
  • RNF9 3 4
  • Tripartite Motif-Containing Protein 10 3
  • Tripartite Motif-Containing 10 2
  • Hematopoietic RING Finger 1 3
  • Tripartite Motif Protein 10 3
  • Ring Finger Protein 9 3
  • RING Finger Protein 9 4
  • Zn-Finger Protein 3
  • HERF1 3

External Ids for TRIM10 Gene

Previous HGNC Symbols for TRIM10 Gene

  • RNF9

Previous GeneCards Identifiers for TRIM10 Gene

  • GC06M030204
  • GC06M029890
  • GC06M030225
  • GC06M030227
  • GC06M030119
  • GC06M029918

Summaries for TRIM10 Gene

Entrez Gene Summary for TRIM10 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic bodies. Studies in mice suggest that this protein plays a role in terminal differentiation of erythroid cells. Alternate splicing of this gene generates two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM10 Gene

TRIM10 (Tripartite Motif Containing 10) is a Protein Coding gene. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. An important paralog of this gene is TRIM15.

UniProtKB/Swiss-Prot for TRIM10 Gene

  • Seems to play an important role in erythropoiesis.

Additional gene information for TRIM10 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM10 Gene

Genomics for TRIM10 Gene

GeneHancer (GH) Regulatory Elements for TRIM10 Gene

Promoters and enhancers for TRIM10 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I030162 Promoter/Enhancer 1.5 EPDnew ENCODE 550.8 -0.3 -326 2.8 ZFP64 ARID4B DMAP1 YY1 SLC30A9 ZNF213 ZNF302 SP3 SP5 ZC3H11A TRIM10 TRIM15 MDC1 GTF2H4 HCG18 ZNRD1ASP PPP1R10 TRIM39 ETF1P1 PAIP1P1
GH06I030160 Promoter 0.5 EPDnew 550.8 +2.5 2521 0.1 TRIM10 TRIM15 TRIM40
GH06I029963 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 13.9 +197.2 197191 4.8 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 HLA-A HLA-K HCG4P3 ZNRD1 HLA-W TRIM39 HLA-H PPP1R10 MDC1 DHX16
GH06I030133 Promoter/Enhancer 1.4 EPDnew ENCODE 12 +27.8 27828 4.2 FOXA2 ARID4B DMAP1 ETS1 SLC30A9 ATF7 RUNX3 SP5 MIER2 PPARG TRIM40 TRIM31 HLA-K HLA-A HCG4P3 TRIM31-AS1 TRIM10 TRIM15 PPP1R10 TRIM39
GH06I030129 Enhancer 1.2 Ensembl ENCODE 12.1 +32.5 32532 3.1 HDGF PKNOX1 MLX ARNT ARID4B FEZF1 ZNF2 IRF4 ZNF143 DEK TRIM40 TRIM31 TRIM31-AS1 TRIM10 TRIM15 HLA-A HCG18 ENSG00000252228 GC06M030355
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRIM10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRIM10 gene promoter:

Genomic Locations for TRIM10 Gene

Genomic Locations for TRIM10 Gene
11,502 bases
Minus strand

Genomic View for TRIM10 Gene

Genes around TRIM10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for TRIM10 Gene

  • Protein details for TRIM10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tripartite motif-containing protein 10
    Protein Accession:
    Secondary Accessions:
    • A6NF84
    • Q5SRJ5
    • Q5SRK8
    • Q86Z08
    • Q96QB6
    • Q9C023
    • Q9C024

    Protein attributes for TRIM10 Gene

    481 amino acids
    Molecular mass:
    55037 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRIM10 Gene


neXtProt entry for TRIM10 Gene

Post-translational modifications for TRIM10 Gene

No Post-translational modifications

Other Protein References for TRIM10 Gene

No data available for DME Specific Peptides for TRIM10 Gene

Domains & Families for TRIM10 Gene

Gene Families for TRIM10 Gene

Suggested Antigen Peptide Sequences for TRIM10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRIM/RBCC family.
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM10: view

Function for TRIM10 Gene

Molecular function for TRIM10 Gene

UniProtKB/Swiss-Prot Function:
Seems to play an important role in erythropoiesis.

Phenotypes From GWAS Catalog for TRIM10 Gene

Gene Ontology (GO) - Molecular Function for TRIM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM10: view
genes like me logo Genes that share phenotypes with TRIM10: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM10 Gene

Localization for TRIM10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM10 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM10 gene
Compartment Confidence
nucleus 3
cytosol 1

Gene Ontology (GO) - Cellular Components for TRIM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with TRIM10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TRIM10 Gene

Pathways & Interactions for TRIM10 Gene

genes like me logo Genes that share pathways with TRIM10: view

Pathways by source for TRIM10 Gene

Gene Ontology (GO) - Biological Process for TRIM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0030218 erythrocyte differentiation IEA --
GO:0045087 innate immune response IEA --
GO:0046597 negative regulation of viral entry into host cell IEA --
genes like me logo Genes that share ontologies with TRIM10: view

No data available for SIGNOR curated interactions for TRIM10 Gene

Drugs & Compounds for TRIM10 Gene

No Compound Related Data Available

Transcripts for TRIM10 Gene

Unigene Clusters for TRIM10 Gene

Tripartite motif containing 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM10 Gene

No ASD Table

Relevant External Links for TRIM10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM10 Gene

This gene is overexpressed in Whole Blood (x15.7), Liver (x8.8), Colon - Transverse (x8.6), and Kidney - Cortex (x7.1).

Protein differential expression in normal tissues from HIPED for TRIM10 Gene

This gene is overexpressed in Fetal Liver (68.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIM10 Gene

Protein tissue co-expression partners for TRIM10 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRIM10 Gene:


SOURCE GeneReport for Unigene cluster for TRIM10 Gene:


Evidence on tissue expression from TISSUES for TRIM10 Gene

  • Blood(4.3)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with TRIM10: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM10 Gene

Orthologs for TRIM10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRIM10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRIM10 33 34
  • 98.82 (n)
(Bos Taurus)
Mammalia TRIM10 33 34
  • 86.56 (n)
(Mus musculus)
Mammalia Trim10 33 16 34
  • 82.99 (n)
(Canis familiaris)
Mammalia TRIM10 33 34
  • 82.7 (n)
(Rattus norvegicus)
Mammalia Trim10 33
  • 82.01 (n)
(Monodelphis domestica)
Mammalia TRIM10 34
  • 76 (a)
Species where no ortholog for TRIM10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM10 Gene

Gene Tree for TRIM10 (if available)
Gene Tree for TRIM10 (if available)

Paralogs for TRIM10 Gene

(18) SIMAP similar genes for TRIM10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRIM10: view

Variants for TRIM10 Gene

Sequence variations from dbSNP and Humsavar for TRIM10 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000254148 -- 30,160,560(-) T/G coding_sequence_variant, missense_variant
rs1000408129 -- 30,157,002(-) G/A coding_sequence_variant, stop_gained
rs1000806121 -- 30,164,911(-) C/T upstream_transcript_variant
rs1000862230 -- 30,156,823(-) A/C intron_variant
rs1001514069 -- 30,162,116(-) A/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM10 Gene

Variant ID Type Subtype PubMed ID
nsv601264 CNV loss 21841781
nsv1144137 CNV deletion 24896259
nsv1122126 CNV deletion 24896259
nsv1074389 CNV deletion 25765185
esv3411275 CNV duplication 20981092
esv2731777 CNV deletion 23290073

Variation tolerance for TRIM10 Gene

Residual Variation Intolerance Score: 87.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.12; 75.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM10 Gene

Disorders for TRIM10 Gene

Additional Disease Information for TRIM10

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TRIM10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM10 Gene

Publications for TRIM10 Gene

  1. Cloning, structural analysis, and mapping of the B30 and B7 multigenic families to the major histocompatibility complex (MHC) and other chromosomal regions. (PMID: 9271628) Henry J … Pontarotti P (Immunogenetics 1997) 2 3 4 58
  2. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 44 58
  3. Common genetic variation and the control of HIV-1 in humans. (PMID: 20041166) Fellay J … NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI) (PLoS genetics 2009) 3 44 58
  4. Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity. (PMID: 16702430) Shiina T … Bahram S (Genetics 2006) 3 4 58
  5. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A … Ballabio A (The EMBO journal 2001) 3 4 58

Products for TRIM10 Gene

Sources for TRIM10 Gene

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