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Aliases for TRIL Gene

Aliases for TRIL Gene

  • TLR4 Interactor With Leucine Rich Repeats 2 3 5
  • Leucine-Rich Repeat-Containing Protein KIAA0644 4
  • KIAA0644 4

External Ids for TRIL Gene

Previous GeneCards Identifiers for TRIL Gene

  • GC07M028960
  • GC07M028992

Summaries for TRIL Gene

Entrez Gene Summary for TRIL Gene

  • TRIL is a component of the TLR4 (MIM 603030) complex and is induced in a number of cell types by lipopolysaccharide (LPS) (Carpenter et al., 2009 [PubMed 19710467]).[supplied by OMIM, Apr 2010]

GeneCards Summary for TRIL Gene

TRIL (TLR4 Interactor With Leucine Rich Repeats) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include lipopolysaccharide binding. An important paralog of this gene is LRIG2.

UniProtKB/Swiss-Prot for TRIL Gene

  • Component of the TLR4 signaling complex. Mediate the innate immune response to bacterial lipopolysaccharide (LPS) leading to cytokine secretion.

Gene Wiki entry for TRIL Gene

Additional gene information for TRIL Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIL Gene

Genomics for TRIL Gene

GeneHancer (GH) Regulatory Elements for TRIL Gene

Promoters and enhancers for TRIL Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I028955 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.8 798 4.2 ZFP64 ARID4B DMAP1 ZNF2 ZNF48 YY1 TCF12 SLC30A9 GLIS2 ZNF143 ENSG00000228421 GC07P028959 PIR62921 TRIL LOC107986703 ENSG00000233517 GC07P028823
GH07I029319 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 7.2 -361.6 -361588 0.8 EBF1 POLR2A IKZF1 RCOR1 IKZF2 EZH2 SPI1 CHD2 CHN2 CPVL LOC102724484 TRIL GC07P029212 GC07M029201
GH07I028953 Enhancer 0.7 Ensembl ENCODE 0.8 +4.6 4627 0.8 FOXA2 RXRA POLR2A RCOR1 NR2F2 CHD2 LOC107986703 ENSG00000233517 ENSG00000228421 TRIL GC07P028823
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRIL on UCSC Golden Path with GeneCards custom track

Genomic Locations for TRIL Gene

Genomic Locations for TRIL Gene
5,056 bases
Minus strand

Genomic View for TRIL Gene

Genes around TRIL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIL Gene

Proteins for TRIL Gene

  • Protein details for TRIL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TLR4 interactor with leucine rich repeats
    Protein Accession:
    Secondary Accessions:
    • A4D1A6
    • O75139

    Protein attributes for TRIL Gene

    811 amino acids
    Molecular mass:
    88723 Da
    Quaternary structure:
    • Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, MD-2 and TLR4. Interacts with TLR4; this interaction is greatly enhanced by LPS stimulation. Interacts with LPS.
    • Sequence=BAA31619.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAL24209.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for TRIL Gene

Post-translational modifications for TRIL Gene

Other Protein References for TRIL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIL Gene

Domains & Families for TRIL Gene

Gene Families for TRIL Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for TRIL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRIL: view

No data available for UniProtKB/Swiss-Prot for TRIL Gene

Function for TRIL Gene

Molecular function for TRIL Gene

UniProtKB/Swiss-Prot Function:
Component of the TLR4 signaling complex. Mediate the innate immune response to bacterial lipopolysaccharide (LPS) leading to cytokine secretion.
UniProtKB/Swiss-Prot Induction:
By bacterial lipopolysaccharides (LPS).

Phenotypes From GWAS Catalog for TRIL Gene

Gene Ontology (GO) - Molecular Function for TRIL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding IDA 19710467
genes like me logo Genes that share ontologies with TRIL: view

Phenotypes for TRIL Gene

GenomeRNAi human phenotypes for TRIL:
genes like me logo Genes that share phenotypes with TRIL: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIL Gene

Localization for TRIL Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIL Gene

Membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for TRIL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0046696 lipopolysaccharide receptor complex IDA 19710467
genes like me logo Genes that share ontologies with TRIL: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for TRIL Gene

Pathways & Interactions for TRIL Gene

No Data Available

Interacting Proteins for TRIL Gene

Gene Ontology (GO) - Biological Process for TRIL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0002718 regulation of cytokine production involved in immune response IDA 19710467
GO:0006954 inflammatory response IEA --
GO:0034142 toll-like receptor 4 signaling pathway IDA 19710467
GO:0045087 innate immune response IEA --
genes like me logo Genes that share ontologies with TRIL: view

No data available for Pathways by source and SIGNOR curated interactions for TRIL Gene

Drugs & Compounds for TRIL Gene

No Compound Related Data Available

Transcripts for TRIL Gene

mRNA/cDNA for TRIL Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(81) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRIL Gene

TLR4 interactor with leucine-rich repeats:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIL Gene

No ASD Table

Relevant External Links for TRIL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIL Gene

Protein differential expression in normal tissues from HIPED for TRIL Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRIL Gene

Protein tissue co-expression partners for TRIL Gene

NURSA nuclear receptor signaling pathways regulating expression of TRIL Gene:


SOURCE GeneReport for Unigene cluster for TRIL Gene:


mRNA Expression by UniProt/SwissProt for TRIL Gene:

Tissue specificity: Highly expressed in the brain, ovary, small intestine and spleen.
genes like me logo Genes that share expression patterns with TRIL: view

No data available for mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIL Gene

Orthologs for TRIL Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRIL 33
  • 99.47 (n)
(Canis familiaris)
Mammalia TRIL 33
  • 90.01 (n)
(Bos Taurus)
Mammalia TRIL 33
  • 89.08 (n)
(Rattus norvegicus)
Mammalia Tril 33
  • 85.46 (n)
(Mus musculus)
Mammalia Tril 33 16
  • 85.21 (n)
(Gallus gallus)
Aves TRIL 33
  • 70.14 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia tril 33
  • 55.58 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16263 33
Species where no ortholog for TRIL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIL Gene

Gene Tree for TRIL (if available)
Gene Tree for TRIL (if available)

Paralogs for TRIL Gene

(1) SIMAP similar genes for TRIL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRIL: view

Variants for TRIL Gene

Sequence variations from dbSNP and Humsavar for TRIL Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000458439 -- 28,954,645(-) G/A 3_prime_UTR_variant
rs1000730428 -- 28,960,357(-) G/T upstream_transcript_variant
rs1001652531 -- 28,955,396(-) C/A 3_prime_UTR_variant
rs1002025809 -- 28,955,076(-) T/G 3_prime_UTR_variant
rs1002499652 -- 28,959,451(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TRIL Gene

Variant ID Type Subtype PubMed ID
nsv524487 CNV loss 19592680

Additional Variant Information for TRIL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for TRIL Gene

Disorders for TRIL Gene

Additional Disease Information for TRIL

No disorders were found for TRIL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIL Gene

Publications for TRIL Gene

  1. TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain. (PMID: 19710467) Carpenter S … O'Neill LA (Journal of immunology (Baltimore, Md. : 1950) 2009) 2 3 4 58
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  3. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 3 4 58
  4. Joubert Syndrome in French Canadians and Identification of Mutations in CEP104. (PMID: 26477546) Srour M … Michaud JL (American journal of human genetics 2015) 4 58
  5. Toll-like receptor 3 (TLR3) signaling requires TLR4 Interactor with leucine-rich REPeats (TRIL). (PMID: 21911501) Carpenter S … O'Neill LA (The Journal of biological chemistry 2011) 3 58

Products for TRIL Gene

Sources for TRIL Gene

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