Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate ... See more...
Aliases for TRIB3 Gene
Aliases for TRIB3 Gene
External Ids for TRIB3 Gene
- HGNC: 16228
- Entrez Gene: 57761
- Ensembl: ENSG00000101255
- OMIM: 607898
- UniProtKB: Q96RU7
Previous HGNC Symbols for TRIB3 Gene
- C20orf97
Previous GeneCards Identifiers for TRIB3 Gene
- GC20P000357
- GC20P000309
Summaries for TRIB3 Gene
-
The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014]
GeneCards Summary for TRIB3 Gene
TRIB3 (Tribbles Pseudokinase 3) is a Protein Coding gene. Diseases associated with TRIB3 include Diabetes Mellitus, Noninsulin-Dependent. Among its related pathways are RET signaling and CD28 co-stimulation. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein kinase binding. An important paralog of this gene is TRIB1.
UniProtKB/Swiss-Prot Summary for TRIB3 Gene
-
Inactive protein kinase which acts as a regulator of the integrated stress response (ISR), a process for adaptation to various stress (PubMed:15781252, PubMed:15775988). Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress (PubMed:15781252, PubMed:15775988). May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells (PubMed:15781252, PubMed:15775988). Acts as a negative feedback regulator of the ATF4-dependent transcription during the ISR: while TRIB3 expression is promoted by ATF4, TRIB3 protein interacts with ATF4 and inhibits ATF4 transcription activity (By similarity). Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation (By similarity). May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1 (By similarity). Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity (PubMed:12736262). Interacts with MAPK kinases and regulates activation of MAP kinases (PubMed:15299019). Can inhibit APOBEC3A editing of nuclear DNA (PubMed:22977230).
Additional gene information for TRIB3 Gene
- HGNC(16228)
- Entrez Gene(57761)
- Ensembl(ENSG00000101255)
- OMIM(607898)
- UniProtKB(Q96RU7)
- Open Targets Platform(ENSG00000101255)
- Monarch Initiative
- Search for TRIB3 at DataMed
- Search for TRIB3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRIB3 Gene
Genomics for TRIB3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TRIB3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TRIB3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRIB3
- Top Transcription factor binding sites by QIAGEN in the TRIB3 gene promoter:
-
- AP-1
- ATF-2
- c-Fos
- c-Jun
Genomic Locations for TRIB3 Gene
Genomic Locations for TRIB3 Gene
- chr20:362,835-397,559
- (GRCh38/hg38)
- Size:
- 34,725 bases
- Orientation:
- Plus strand
- chr20:361,261-378,203
- (GRCh37/hg19)
- Size:
- 16,943 bases
- Orientation:
- Plus strand
Genomic View for TRIB3 Gene
Genes around TRIB3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20p13 by HGNC
- 20p13 by Entrez Gene
- 20p13 by Ensembl
TRIB3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TRIB3 Gene
Proteins for TRIB3 Gene
-
Protein details for TRIB3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96RU7-TRIB3_HUMAN
- Recommended name:
- Tribbles homolog 3
- Protein Accession:
- Q96RU7
- Q53GU4
- Q53ZW7
- Q6I9Y9
- Q8TAI6
- Q9H5M8
- Q9NUD2
Protein attributes for TRIB3 Gene
- Size:
- 358 amino acids
- Molecular mass:
- 39578 Da
- Quaternary structure:
-
- Interacts with AKT1, AKT2, MAP2K1 and MAP2K7 (PubMed:15299019). Interacts with ATF4 (PubMed:12743605). Interacts with DDIT3/CHOP and inhibits its interaction with EP300/P300 (PubMed:15775988, PubMed:17872950). Interacts with APOBEC3C (PubMed:22977230). Interacts (via N-terminus) with APOBEC3A (PubMed:22977230). Interacts with RELA (PubMed:12736262).
Protein Expression for TRIB3 Gene
Post-translational modifications for TRIB3 Gene
Other Protein References for TRIB3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ TRIB3 Antibody
- GeneTex Anti-TRIB3 antibody [N3C3]
-
Custom Antibody ServicesOriGene Antibodies for TRIB3
- Novus Biologicals Antibodies for TRIB3
-
Abcam antibodies for TRIB3
- Invitrogen Antibodies for TRIB3 (AFLGC-TRIB3)
-
Custom Antibody ServicesProSci Antibodies for TRIB3
-
Santa Cruz Biotechnology (SCBT) Antibodies for TRIB3
- Sino Biological Antibodies for TRIB3
Protein Products
-
OriGene Purified Proteins for TRIB3
- Search Origene for MassSpec and Protein Over-expression Lysates for TRIB3
- Origene Custom Protein Services for TRIB3
- Sino Biological Cell Lysates for TRIB3
- Sino Biological Recombinant Proteins for TRIB3
- ProSpec Recombinant Proteins for TRIB3
-
Abcam proteins for TRIB3
Assay Products
-
Signalway ELISA kits for TRIB3
No data available for DME Specific Peptides for TRIB3 Gene
Domains & Families for TRIB3 Gene
Gene Families for TRIB3 Gene
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for TRIB3 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TRIB3 Gene
- GenScript: Design optimal peptide antigens:
-
- p65-interacting inhibitor of NF-kappa-B (TRIB3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q96RU7UniProtKB/Swiss-Prot:
TRIB3_HUMAN :- The protein kinase domain is predicted to be catalytically inactive.
- Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.
- Domain:
-
- The protein kinase domain is predicted to be catalytically inactive.
- Family:
-
- Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.
Function for TRIB3 Gene
Molecular function for TRIB3 Gene
- UniProtKB/Swiss-Prot Function:
- Inactive protein kinase which acts as a regulator of the integrated stress response (ISR), a process for adaptation to various stress (PubMed:15781252, PubMed:15775988). Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress (PubMed:15781252, PubMed:15775988). May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells (PubMed:15781252, PubMed:15775988). Acts as a negative feedback regulator of the ATF4-dependent transcription during the ISR: while TRIB3 expression is promoted by ATF4, TRIB3 protein interacts with ATF4 and inhibits ATF4 transcription activity (By similarity). Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation (By similarity). May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1 (By similarity). Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity (PubMed:12736262). Interacts with MAPK kinases and regulates activation of MAP kinases (PubMed:15299019). Can inhibit APOBEC3A editing of nuclear DNA (PubMed:22977230).
- UniProtKB/Swiss-Prot Induction:
- By hypoxia, TNF, and by nutrient starvation. Expression is PI 3-kinase and/or NF-kappa-B-dependent. Induced by ER stress via ATF4-DDIT3/CHOP pathway and can downregulate its own induction by repression of ATF4-DDIT3/CHOP functions.
Phenotypes From GWAS Catalog for TRIB3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003714 | transcription corepressor activity | IEA,ISS | -- |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004860 | protein kinase inhibitor activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 12743605 |
| GO:0005524 | ATP binding | IEA | -- |
Phenotypes for TRIB3 Gene
- MGI mutant phenotypes for TRIB3:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for TRIB3:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- Decreased viability
- Decreased vaccinia virus (VACV) infection
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased NF-kappaB reporter expression
- Increased Nanog expression
- Decreased shRNA abundance (Z-score < -2)
- Increased viability with MLN4924 (a NAE inhibitor)
- Increased shRNA abundance (Z-score > 2)
- Decreased substrate adherent cell growth
- Upregulation of NF-kappaB pathway after LMP1 stimulation
- Increased nuclear migration speed
- Decreased vesicular stomatitis virus (VSV) infection
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
Animal Models for TRIB3 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for TRIB3
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TRIB3 - Select products 50% OFF >
- * TRIB3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TRIB3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TRIB3
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRIB3
miRNA for TRIB3 Gene
- miRTarBase miRNAs that target TRIB3
-
- hsa-miR-24-3p (MIRT003354)
- hsa-miR-335-5p (MIRT019155)
- hsa-miR-124-3p (MIRT023198)
- hsa-miR-215-5p (MIRT024900)
- hsa-miR-192-5p (MIRT026958)
- hsa-miR-26b-5p (MIRT030272)
- hsa-miR-31-5p (MIRT049873)
- hsa-miR-605-3p (MIRT370117)
- hsa-miR-940 (MIRT370119)
- hsa-miR-1827 (MIRT370120)
- hsa-miR-4434 (MIRT370121)
- hsa-miR-4516 (MIRT370123)
- hsa-miR-4722-5p (MIRT370125)
- hsa-miR-4768-3p (MIRT370126)
- hsa-miR-5703 (MIRT370127)
- hsa-miR-6770-5p (MIRT370129)
- hsa-miR-6808-5p (MIRT370131)
- hsa-miR-6893-5p (MIRT370133)
- hsa-miR-96-5p (MIRT438129)
- hsa-miR-219a-5p (MIRT438742)
- hsa-miR-8057 (MIRT465285)
- hsa-miR-4284 (MIRT465286)
- hsa-miR-493-3p (MIRT465287)
- hsa-miR-4277 (MIRT465288)
- hsa-miR-584-3p (MIRT465289)
- hsa-miR-4257 (MIRT465290)
- hsa-miR-6847-5p (MIRT465291)
- hsa-miR-5000-5p (MIRT465292)
- hsa-miR-4748 (MIRT465293)
- hsa-miR-4464 (MIRT465294)
- hsa-miR-5706 (MIRT561418)
- hsa-miR-4782-5p (MIRT561419)
- hsa-miR-516b-5p (MIRT561420)
- hsa-miR-1299 (MIRT561421)
- hsa-miR-3202 (MIRT561422)
- hsa-miR-4533 (MIRT561423)
- hsa-miR-6128 (MIRT561424)
- hsa-miR-875-3p (MIRT561425)
- hsa-miR-1237-3p (MIRT561426)
- mmu-miR-24-3p (MIRT732538)
- mmu-miR-24-2-5p (MIRT732864)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TRIB3
- Browse OriGene Inhibitory RNA Products For TRIB3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIB3
Clone Products
- Applied Biological Materials (abm): Clones for TRIB3 - Select products 50% OFF >
- * TRIB3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG204806
- MG226343
- MR204806
- MR204806L3
- MR204806L4
- MR226343
- MR226343L3
- MR226343L4
- RC206687
- RC206687L1
- RC206687L2
- RC206687L3
- RC206687L4
- RC237698
- RC237699
- RC237700
- RC237701
- RC237888
- RG206687
- RR212395
- RR212395L3
- RR212395L4
- MR204806L3V
- MR204806L4V
- MR226343L3V
- MR226343L4V
- RC206687L1V
- RC206687L2V
- RC206687L3V
- RC206687L4V
- RR212395L3V
- RR212395L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TRIB3
- Addgene plasmids for TRIB3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TRIB3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIB3 Gene
Localization for TRIB3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TRIB3 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 4 |
| cytosol | 4 |
| mitochondrion | 3 |
| extracellular | 2 |
| cytoskeleton | 2 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,ISS | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | TAS | -- |
Pathways & Interactions for TRIB3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
|
| 2 | CD28 co-stimulation | ||
| 3 | GAB1 signalosome |
.89
|
|
| 4 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||
| 5 | Downstream signaling events of B Cell Receptor (BCR) | ||
Pathways by source for TRIB3 Gene
3 BioSystems pathways for TRIB3 Gene
39 Reactome pathways for TRIB3 Gene
1 KEGG pathway for TRIB3 Gene
Interacting Proteins for TRIB3 Gene
Selected Interacting proteins:
Q96RU7-TRIB3_HUMAN
ENSP00000217233
for TRIB3 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for TRIB3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 15775988 |
| GO:0006468 | protein phosphorylation | IEA | -- |
| GO:0006469 | negative regulation of protein kinase activity | IEA,IDA | 12791994 |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0010506 | regulation of autophagy | IEA,ISS | -- |
Drugs & Compounds for TRIB3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Methylphenidate | Approved, Investigational | Pharma | 431 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for TRIB3 Gene
mRNA/cDNA for TRIB3 Gene
- 6 REFSEQ mRNAs :
- 14 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000217233 2095 nts (view in UCSC)
- ENST00000422053 1533 nts (view in UCSC)
- ENST00000449710 1070 nts (view in UCSC)
- ENST00000615226 877 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TRIB3 - Select products 50% OFF >
- * TRIB3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TRIB3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TRIB3
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRIB3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TRIB3
- Browse OriGene Inhibitory RNA Products For TRIB3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIB3
Clone Products
- Applied Biological Materials (abm): Clones for TRIB3 - Select products 50% OFF >
- * TRIB3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG204806
- MG226343
- MR204806
- MR204806L3
- MR204806L4
- MR226343
- MR226343L3
- MR226343L4
- RC206687
- RC206687L1
- RC206687L2
- RC206687L3
- RC206687L4
- RC237698
- RC237699
- RC237700
- RC237701
- RC237888
- RG206687
- RR212395
- RR212395L3
- RR212395L4
- MR204806L3V
- MR204806L4V
- MR226343L3V
- MR226343L4V
- RC206687L1V
- RC206687L2V
- RC206687L3V
- RC206687L4V
- RR212395L3V
- RR212395L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TRIB3
- Addgene plasmids for TRIB3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TRIB3
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||
| SP6: |
Relevant External Links for TRIB3 Gene
- GeneLoc Exon Structure for
- TRIB3
Expression for TRIB3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
-
Lung (Respiratory System)
- Basal Cells Respiratory Bronchioles
-
Epithelial Cells
- Basal Cells Respiratory Bronchioles
- Mesoderm (Gastrulation Derivatives)
- Neural Crest (Gastrulation Derivatives)
mRNA differential expression in normal tissues according to GTEx for TRIB3 Gene
This gene is overexpressed in Liver (x9.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRIB3 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRIB3
SOURCE GeneReport for Unigene cluster for TRIB3 Gene:
Hs.516826mRNA Expression by UniProt/SwissProt for TRIB3 Gene:
Q96RU7-TRIB3_HUMAN
Tissue specificity:
Highest expression in liver, pancreas, peripheral blood leukocytes and bone marrow. Also highly expressed in a number of primary lung, colon and breast tumors. Expressed in spleen, thymus, and prostate and is undetectable in other examined tissues, including testis, ovary, small intestine, colon, leukocyte, heart, brain, placenta, lung, skeletal muscle, and kidney.
Evidence on tissue expression from TISSUES for TRIB3 Gene
- Muscle(4.6)
- Liver(4.5)
- Lung(3)
- Skin(2.8)
- Intestine(2.7)
- Pancreas(2.6)
- Kidney(2.5)
- Thyroid gland(2.3)
- Blood(2.2)
- Nervous system(2.2)
Primer Products
-
OriGene qPCR primer pairs for TRIB3
-
OriGene qPCR primer pairs and template standards for TRIB3
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIB3 Gene
Orthologs for TRIB3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TRIB3 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | TRIB3 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | TRIB3 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Trib3 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Trib3 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | TRIB3 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | -- 31 |
|
ManyToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | TRIB3 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | trib3 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | trbl 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | nipi-3 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8356 31 |
|
OneToMany |
- Species where no ortholog for TRIB3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
Evolution for TRIB3 Gene
- ENSEMBL:
- Gene Tree for TRIB3 (if available)
- TreeFam:
- Gene Tree for TRIB3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TRIB3: view image
Paralogs for TRIB3 Gene
Variants for TRIB3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRIB3 Gene
| SNP ID | Clinical significance and condition | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 710947 | Benign: not provided | 388,091(+) | C/T | SYNONYMOUS_VARIANT | |
| 733898 | Benign: not provided | 396,363(+) | G/A | SYNONYMOUS_VARIANT | |
| rs757496714 | A glioblastoma multiforme sample | p.Thr60Ile | |||
| rs2295490 | - | p.Gln84Arg | |||
| rs35051116 | - | p.Arg153His |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4219n100 | CNV | gain | 25217958 |
| dgv773e199 | CNV | deletion | 23128226 |
| esv2057444 | CNV | deletion | 18987734 |
| esv2657243 | CNV | deletion | 23128226 |
| esv3644950 | CNV | loss | 21293372 |
| esv3644951 | CNV | loss | 21293372 |
| esv3644952 | CNV | gain | 21293372 |
| esv3644953 | CNV | gain | 21293372 |
| esv3893263 | CNV | loss | 25118596 |
| nsv1065287 | CNV | loss | 25217958 |
| nsv1109346 | CNV | deletion | 24896259 |
| nsv458839 | CNV | loss | 19166990 |
| nsv458841 | CNV | loss | 19166990 |
| nsv458842 | CNV | loss | 19166990 |
| nsv470534 | CNV | loss | 18288195 |
| nsv510777 | CNV | deletion | 20534489 |
| nsv519415 | CNV | loss | 19592680 |
| nsv585169 | CNV | loss | 21841781 |
| nsv585170 | CNV | loss | 21841781 |
| nsv585171 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
92.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.14;
80.69% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TRIB3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIB3 Gene
Disorders for TRIB3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| diabetes mellitus, noninsulin-dependent |
|
Search TRIB3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TRIB3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for TRIB3 Gene
Publications for TRIB3 Gene
- Association of TRB3 gene Q84R polymorphism with type 2 diabetes mellitus in Chinese population. (PMID: 19291425) Shi Z … Zhang J (Endocrine 2009) 3 23 41
- TRB3 is a PI 3-kinase dependent indicator for nutrient starvation. (PMID: 16129579) Schwarzer R … Kaufmann J (Cellular signalling 2006) 3 4 23
- The functional Q84R polymorphism of mammalian Tribbles homolog TRB3 is associated with insulin resistance and related cardiovascular risk in Caucasians from Italy. (PMID: 16123373) Prudente S … Trischitta V (Diabetes 2005) 3 23 41
- Characterization of human NIPK (TRB3, SKIP3) gene activation in stressful conditions. (PMID: 15781252) Ord D … Ord T (Biochemical and biophysical research communications 2005) 3 4 23
- TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death. (PMID: 15775988) Ohoka N … Hayashi H (The EMBO journal 2005) 3 4 23
ExternalLinks
Products for TRIB3 Gene
- Custom Antibody ServicesOriGene Antibodies for TRIB3
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for TRIB3
- Search Origene for MassSpec and Protein Over-expression Lysates for TRIB3
- Origene Custom Protein Services for TRIB3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TRIB3
- Browse OriGene Inhibitory RNA Products For TRIB3
- OriGene qPCR primer pairs for TRIB3
- OriGene qPCR primer pairs and template standards for TRIB3
- OriGene CRISPR knockouts for TRIB3
- MG204806
- MG226343
- MR204806
- MR204806L3
- MR204806L4
- MR226343
- MR226343L3
- MR226343L4
- RC206687
- RC206687L1
- RC206687L2
- RC206687L3
- RC206687L4
- RC237698
- RC237699
- RC237700
- RC237701
- RC237888
- RG206687
- RR212395
- RR212395L3
- RR212395L4
- MR204806L3V
- MR204806L4V
- MR226343L3V
- MR226343L4V
- RC206687L1V
- RC206687L2V
- RC206687L3V
- RC206687L4V
- RR212395L3V
- RR212395L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TRIB3
- Sino Biological Human cDNA Clone for TRIB3
- Sino Biological Cell Lysates for TRIB3
- Sino Biological Recombinant Proteins for TRIB3
- Sino Biological Antibodies for TRIB3
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for TRIB3
- Novus Biologicals proteins and lysates for TRIB3
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for TRIB3
- Abcam proteins for TRIB3
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for TRIB3
- Taconic Biosciences Mouse Models for TRIB3
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for TRIB3 (AFLGC-TRIB3)
- VectorBuilder Custom and pre-made DNA vectors for TRIB3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for TRIB3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for TRIB3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for TRIB3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for TRIB3
- Addgene plasmids for TRIB3
- antibodies-online: Show 55 available TRIB3 Antibodies ranked by validation data
- Compare Top TRIB3 Antibodies
- antibodies-online: Show 11 available TRIB3 Elisa Kits ranked by validation data
- Compare Top TRIB3 Elisa Kits
- Quality Products:
- antibodies-online: Show 10 available TRIB3 Proteins ranked by validation data
- Compare Top TRIB3 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for TRIB3
- Search Santa Cruz Biotechnology (SCBT) for TRIB3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TRIB3
- Custom Antibody ServicesProSci Antibodies for TRIB3
- Search for TRIB3 Proteins at ProSci
- Horizon Cell Lines for TRIB3
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TRIB3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TRIB3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for TRIB3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIB3
Sources for TRIB3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB