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The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014]
TRIB3 (Tribbles Pseudokinase 3) is a Protein Coding gene. Diseases associated with TRIB3 include Diabetes Mellitus, Noninsulin-Dependent. Among its related pathways are RET signaling and CD28 co-stimulation. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein kinase binding. An important paralog of this gene is TRIB1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003714 | transcription corepressor activity | IEA,ISS | -- |
GO:0004672 | protein kinase activity | IEA | -- |
GO:0004860 | protein kinase inhibitor activity | IEA | -- |
GO:0005515 | protein binding | IPI | 12743605 |
GO:0005524 | ATP binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,ISS | -- |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0005886 | plasma membrane | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
|
2 | CD28 co-stimulation | ||
3 | GAB1 signalosome |
.89
|
|
4 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||
5 | Downstream signaling events of B Cell Receptor (BCR) |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 15775988 |
GO:0006468 | protein phosphorylation | IEA | -- |
GO:0006469 | negative regulation of protein kinase activity | IEA,IDA | 12791994 |
GO:0006915 | apoptotic process | IEA | -- |
GO:0010506 | regulation of autophagy | IEA,ISS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Methylphenidate | Approved, Investigational | Pharma | 431 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||
SP5: | - | - | |||||||||||||||||||||||||||||||
SP6: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TRIB3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TRIB3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TRIB3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Trib3 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Trib3 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | TRIB3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | -- 31 |
|
ManyToMany | |
Lizard (Anolis carolinensis) |
Reptilia | TRIB3 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | trib3 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | trbl 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | nipi-3 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8356 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 20 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
710947 | Benign: not provided | 388,091(+) | C/T | SYNONYMOUS_VARIANT | |
733898 | Benign: not provided | 396,363(+) | G/A | SYNONYMOUS_VARIANT | |
rs757496714 | A glioblastoma multiforme sample | p.Thr60Ile | |||
rs2295490 | - | p.Gln84Arg | |||
rs35051116 | - | p.Arg153His |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv4219n100 | CNV | gain | 25217958 |
dgv773e199 | CNV | deletion | 23128226 |
esv2057444 | CNV | deletion | 18987734 |
esv2657243 | CNV | deletion | 23128226 |
esv3644950 | CNV | loss | 21293372 |
esv3644951 | CNV | loss | 21293372 |
esv3644952 | CNV | gain | 21293372 |
esv3644953 | CNV | gain | 21293372 |
esv3893263 | CNV | loss | 25118596 |
nsv1065287 | CNV | loss | 25217958 |
nsv1109346 | CNV | deletion | 24896259 |
nsv458839 | CNV | loss | 19166990 |
nsv458841 | CNV | loss | 19166990 |
nsv458842 | CNV | loss | 19166990 |
nsv470534 | CNV | loss | 18288195 |
nsv510777 | CNV | deletion | 20534489 |
nsv519415 | CNV | loss | 19592680 |
nsv585169 | CNV | loss | 21841781 |
nsv585170 | CNV | loss | 21841781 |
nsv585171 | CNV | loss | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
diabetes mellitus, noninsulin-dependent |
|