Aliases for TRIAP1 Gene
External Ids for TRIAP1 Gene
Previous GeneCards Identifiers for TRIAP1 Gene
GeneCards Summary for TRIAP1 Gene
TRIAP1 (TP53 Regulated Inhibitor Of Apoptosis 1) is a Protein Coding gene. Diseases associated with TRIAP1 include Cone-Rod Dystrophy 1 and Spastic Ataxia 5. Among its related pathways are TP53 Regulates Transcription of Cell Death Genes and Gene Expression. Gene Ontology (GO) annotations related to this gene include p53 binding and phosphatidic acid transporter activity.
UniProtKB/Swiss-Prot Summary for TRIAP1 Gene
Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane (PubMed:23931759). Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo) (PubMed:26071602). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis (PubMed:15735003).