Aliases for TRHR Gene
External Ids for TRHR Gene
Previous GeneCards Identifiers for TRHR Gene
This gene encodes a G protein-coupled receptor for thyrotropin-releasing hormone (TRH). Upon binding to TRH, this receptor activates the inositol phospholipid-calcium-protein kinase C transduction pathway. Mutations in this gene have been associated with generalized thyrotropin-releasing hormone resistance. [provided by RefSeq, Sep 2011]
GeneCards Summary for TRHR Gene
TRHR (Thyrotropin Releasing Hormone Receptor) is a Protein Coding gene. Diseases associated with TRHR include Hypothyroidism, Congenital, Nongoitrous, 7 and Hypothyroidism. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and thyrotropin-releasing hormone receptor activity. An important paralog of this gene is NMUR2.
UniProtKB/Swiss-Prot Summary for TRHR Gene
Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.
Thyrotropin-releasing hormone (TRH) receptors are Gq/11-protein-coupled receptors that promote thyroid-stimulating hormone (TSH) and prolactin (PRL) release. Two TRH receptor subtypes, TRH1 and TRH2, have been identified in rats but only TRH1 has been found in humans.