Aliases for TRH Gene
External Ids for TRH Gene
Previous GeneCards Identifiers for TRH Gene
This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The human proprotein contains six thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as prolactin. Deficiency of this hormone has been associated with hypothalamic hypothyroidism. [provided by RefSeq, May 2013]
GeneCards Summary for TRH Gene
TRH (Thyrotropin Releasing Hormone) is a Protein Coding gene. Diseases associated with TRH include Thyrotropin-Releasing Hormone Deficiency and Hyperprolactinemia. Among its related pathways are Signaling by GPCR and Development_Leptin signaling via JAK/STAT and MAPK cascades. Gene Ontology (GO) annotations related to this gene include neuropeptide hormone activity and thyrotropin-releasing hormone activity.
UniProtKB/Swiss-Prot Summary for TRH Gene
As a component of the hypothalamic-pituitary-thyroid axis, it controls the secretion of thyroid-stimulating hormone (TSH) and is involved in thyroid hormone synthesis regulation. It also operates as modulator of hair growth. It promotes hair-shaft elongation, prolongs the hair cycle growth phase (anagen) and antagonizes its termination (catagen) by TGFB2. It stimulates proliferation and inhibits apoptosis of hair matrix keratinocytes.