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Aliases for TRG Gene

Aliases for TRG Gene

  • T Cell Receptor Gamma Locus 2 3
  • T-Cell Antigen Receptor, Gamma Polypeptide 2 3
  • T-Cell Receptor, Gamma Cluster 2 3
  • T-Cell Rearranging Gene, Gamma 2 3
  • TCRG, TRG@ 2 3
  • TCRG 3
  • TRG@ 3

External Ids for TRG Gene

Previous HGNC Symbols for TRG Gene

  • TCRG
  • TRG@

Previous GeneCards Identifiers for TRG Gene

  • GC07M038284

Summaries for TRG Gene

Entrez Gene Summary for TRG Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor gamma locus. The gamma locus includes V (variable), J (joining), and C (constant) segments. During T cell development, the gamma chain is synthesized by a recombination event at the DNA level joining a V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random addition of nucleotides by terminal deoxynucleotidyltransferase. Several V segments of the gamma locus are known to be incapable of encoding a protein and are considered pseudogenes. Somatic rearrangement of the gamma locus has been observed in T cells derived from patients with T cell leukemia and ataxia telangiectasia. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRG Gene

TRG (T Cell Receptor Gamma Locus) is a Protein Coding gene. Diseases associated with TRG include Precursor T-Cell Acute Lymphoblastic Leukemia and Cytophagic Histiocytic Panniculitis.

Gene Wiki entry for TRG Gene

Additional gene information for TRG Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRG Gene

Genomics for TRG Gene

GeneHancer (GH) Regulatory Elements for TRG Gene

Promoters and enhancers for TRG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I038366 Enhancer 1.2 Ensembl ENCODE dbSUPER 550.8 -0.7 -689 4.2 HDGF RB1 NFXL1 YBX1 IRF4 RAD21 ZNF143 ATF7 BCLAF1 IKZF2 TRG TRGV1 TRGV4 TRGV5P TRGV3 AMPH TRG-AS1 RN7SL83P
GH07I038362 Enhancer 1 Ensembl ENCODE dbSUPER 0.8 +4.9 4860 2 SMARCA5 CTCF ZNF146 RB1 TRIM22 NFXL1 RAD21 ZNF366 POLR2A IKZF1 GC07P038364 TRGV2 TRGV4 TRGV5P TRGV3 GC07P038360 TRG TRG-AS1
GH07I038334 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 0.3 +31.7 31714 3.7 HDGF PKNOX1 ARNT SIN3A ZNF2 POLR2B E2F8 ZNF143 ZNF263 SP3 TRGV7 ENSG00000272908 TRGV5 TRGV5P STARD3NL AMPH TRGV6 TRG
GH07I038357 Enhancer 1.1 Ensembl ENCODE dbSUPER 0.4 +8.4 8354 3.8 CTCF RB1 BACH1 NFXL1 CC2D1A CTBP1 ZBTB48 EGR1 ZNF143 ZNF444 TRGV3 GC07P038357 GC07P038360 TRGV4 TRGV5P TRGV5 AMPH TRGV7 TRG TRG-AS1
GH07I038329 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 0.3 +37.0 36979 2.6 HDAC1 ZNF335 ZNF143 ATF7 CAVIN1 ELF1 HDAC8 ZNF592 MEF2D NFIC ENSG00000272908 TRGV8 STARD3NL TRGV5P TARP GC07P038328 TRGV7 TRG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRG on UCSC Golden Path with GeneCards custom track

Genomic Locations for TRG Gene

Genomic Locations for TRG Gene
chr7:38,240,024-38,368,055
(GRCh38/hg38)
Size:
128,032 bases
Orientation:
Minus strand
chr7:38,279,625-38,407,656
(GRCh37/hg19)

Genomic View for TRG Gene

Genes around TRG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRG Gene

Proteins for TRG Gene

Post-translational modifications for TRG Gene

No Post-translational modifications

No data available for DME Specific Peptides for TRG Gene

Domains & Families for TRG Gene

Gene Families for TRG Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRG: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TRG Gene

Function for TRG Gene

Phenotypes From GWAS Catalog for TRG Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRG Gene

Localization for TRG Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TRG Gene

Pathways & Interactions for TRG Gene

No Data Available

Interacting Proteins for TRG Gene

Gene Ontology (GO) - Biological Process for TRG Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRG Gene

Drugs & Compounds for TRG Gene

(1) Drugs for TRG Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for TRG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TRG: view

Transcripts for TRG Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TRG Gene

No ASD Table

Relevant External Links for TRG Gene

GeneLoc Exon Structure for
TRG
ECgene alternative splicing isoforms for
TRG

No data available for mRNA/cDNA for TRG Gene

Expression for TRG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRG Gene

NURSA nuclear receptor signaling pathways regulating expression of TRG Gene:

TRG
genes like me logo Genes that share expression patterns with TRG: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRG Gene

Orthologs for TRG Gene

No data available for Orthologs and Evolution for TRG Gene

Paralogs for TRG Gene

No data available for Paralogs for TRG Gene

Variants for TRG Gene

Additional Variant Information for TRG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRG Gene

Disorders for TRG Gene

MalaCards: The human disease database

(8) MalaCards diseases for TRG Gene - From: Orphanet, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
precursor t-cell acute lymphoblastic leukemia
  • precursor t-cell acute lymphoblastic leukemia/lymphoma
cytophagic histiocytic panniculitis
  • chp
angioimmunoblastic lymphadenopathy with dysproteinemia
  • angioimmunoblastic with dysproteinemia lymphadenopathy
subcutaneous panniculitis-like t-cell lymphoma
  • sptcl
mycosis fungoides
  • mf
- elite association - COSMIC cancer census association via MalaCards
Search TRG in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with TRG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRG Gene

Publications for TRG Gene

  1. Characterization of the androgen-regulated prostate-specific T cell receptor gamma-chain alternate reading frame protein (TARP) promoter. (PMID: 12865322) Cheng WS … Essand M (Endocrinology 2003) 3 22 58
  2. Molecular mapping of the human T cell receptor gamma (TRG) genes and linkage of the variable and constant regions. (PMID: 2526744) Lefranc MP … Lefranc G (European journal of immunology 1989) 2 3 58
  3. Characterization of an expressed CD3-associated Ti gamma-chain reveals C gamma domain polymorphism. (PMID: 3102973) Littman DR … Weiss A (Nature 1987) 2 3 58
  4. The Role of Th-17 Cells and γδ T-Cells in Modulating the Systemic Inflammatory Response to Severe Burn Injury. (PMID: 28368347) Kim A … Vandervord J (International journal of molecular sciences 2017) 3 58
  5. Bacterial Vaginosis Is Associated with Loss of Gamma Delta T Cells in the Female Reproductive Tract in Women in the Miami Women Interagency HIV Study (WIHS): A Cross Sectional Study. (PMID: 27078021) Alcaide ML … Fischl MA (PloS one 2016) 3 58

Products for TRG Gene

Sources for TRG Gene

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