This gene encodes a nuclear protein with 3' to 5' exonuclease activity. The encoded protein participates in double-stranded DNA break repair, and may interact with DNA polymerase delta. [provided by RefSeq, Nov 2012] See more...

Aliases for TREX2 Gene

Aliases for TREX2 Gene

  • Three Prime Repair Exonuclease 2 2 3 4 5
  • 3'-5' Exonuclease TREX2 Long Form 3
  • 3'-5' Exonuclease TREX2 4
  • EC 3.1.11.2 4

External Ids for TREX2 Gene

Previous GeneCards Identifiers for TREX2 Gene

  • GC0XM146847
  • GC0XM149165
  • GC0XM150295
  • GC0XM151178
  • GC0XM152231
  • GC0XM152363
  • GC0XM152710
  • GC0XM141369

Summaries for TREX2 Gene

Entrez Gene Summary for TREX2 Gene

  • This gene encodes a nuclear protein with 3' to 5' exonuclease activity. The encoded protein participates in double-stranded DNA break repair, and may interact with DNA polymerase delta. [provided by RefSeq, Nov 2012]

GeneCards Summary for TREX2 Gene

TREX2 (Three Prime Repair Exonuclease 2) is a Protein Coding gene. Diseases associated with TREX2 include Laryngeal Benign Neoplasm and Chilblain Lupus 1. Among its related pathways are Chks in Checkpoint Regulation. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and magnesium ion binding. An important paralog of this gene is TREX1.

UniProtKB/Swiss-Prot Summary for TREX2 Gene

  • Exonuclease with a preference for double-stranded DNA with mismatched 3' termini. May play a role in DNA repair.

Gene Wiki entry for TREX2 Gene

Additional gene information for TREX2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TREX2 Gene

Genomics for TREX2 Gene

GeneHancer (GH) Regulatory Elements for TREX2 Gene

Promoters and enhancers for TREX2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ153469 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 508.2 -0.2 -210 3.2 CTCF NRF1 SP1 PHF8 ZFX REST POLR2A ZBTB11 ZNF423 AFF1 TREX2 lnc-PNMA6E-1 HAUS7 ENSG00000224963
GH0XJ153455 Promoter 0.3 EPDnew 500.4 +14.8 14836 0.1 TREX2 DNASE1L1 lnc-PNMA6E-1 HSALNG0140758 HAUS7
GH0XJ153493 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 4.4 -25.7 -25734 5.4 NRF1 CTCF ZIC2 REST ZNF341 ZNF263 RAD21 ZNF335 NFIB GLIS1 HAUS7 BGN lnc-ATP2B3-2 ZFP92 TREX2 NONHSAG055547.2
GH0XJ153459 Enhancer 0.7 Ensembl ENCODE 6.3 +10.3 10252 1.8 CTCF SMC3 MAZ ZNF654 RAD21 JUN CTCFL ZNF143 ZBTB33 TRIM22 TREX2 KRT18P48 lnc-PNMA6E-1 HSALNG0140758 HAUS7
GH0XJ153462 Promoter 0.3 EPDnew 7.7 +7.9 7907 0.1 HAUS7 TREX2 lnc-PNMA6E-1 HSALNG0140758
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TREX2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TREX2

Top Transcription factor binding sites by QIAGEN in the TREX2 gene promoter:
  • AREB6
  • E47
  • FOXL1
  • GR
  • GR-alpha
  • NF-kappaB1
  • NRSF form 1
  • NRSF form 2
  • Pax-5
  • POU2F1a

Genomic Locations for TREX2 Gene

Genomic Locations for TREX2 Gene
chrX:153,444,720-153,470,587
(GRCh38/hg38)
Size:
25,868 bases
Orientation:
Minus strand
chrX:152,710,178-152,736,045
(GRCh37/hg19)
Size:
25,868 bases
Orientation:
Minus strand

Genomic View for TREX2 Gene

Genes around TREX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TREX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TREX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TREX2 Gene

Proteins for TREX2 Gene

  • Protein details for TREX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQ50-TREX2_HUMAN
    Recommended name:
    Three prime repair exonuclease 2
    Protein Accession:
    Q9BQ50
    Secondary Accessions:
    • Q45F08
    • Q9UN77

    Protein attributes for TREX2 Gene

    Size:
    236 amino acids
    Molecular mass:
    25922 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • [Isoform 1]: Only supported by readthrough transcripts formed via the splicing of exons from UCHL5IP and TREX2 genes.

    Three dimensional structures from OCA and Proteopedia for TREX2 Gene

    Alternative splice isoforms for TREX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TREX2 Gene

Post-translational modifications for TREX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TREX2 Gene

Antibody Products

  • Abcam antibodies for TREX2
  • Boster Bio Antibodies for TREX2
  • Santa Cruz Biotechnology (SCBT) Antibodies for TREX2

No data available for DME Specific Peptides for TREX2 Gene

Domains & Families for TREX2 Gene

Gene Families for TREX2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for TREX2 Gene

Blocks:
  • Exonuclease
  • Exonuclease, RNase T and DNA polymerase III
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TREX2 Gene

GenScript: Design optimal peptide antigens:
  • 3'-5' exonuclease TREX2 (TREX2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BQ50

UniProtKB/Swiss-Prot:

TREX2_HUMAN :
  • Belongs to the exonuclease superfamily. TREX family.
Family:
  • Belongs to the exonuclease superfamily. TREX family.
genes like me logo Genes that share domains with TREX2: view

Function for TREX2 Gene

Molecular function for TREX2 Gene

UniProtKB/Swiss-Prot Function:
Exonuclease with a preference for double-stranded DNA with mismatched 3' termini. May play a role in DNA repair.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.; EC=3.1.11.2;.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 7.5-8.0.;

Enzyme Numbers (IUBMB) for TREX2 Gene

Phenotypes From GWAS Catalog for TREX2 Gene

Gene Ontology (GO) - Molecular Function for TREX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 11279105
GO:0003676 nucleic acid binding IEA --
GO:0004518 nuclease activity IEA --
GO:0004527 exonuclease activity IEA --
GO:0008296 3'-5'-exodeoxyribonuclease activity IDA 11279105
genes like me logo Genes that share ontologies with TREX2: view
genes like me logo Genes that share phenotypes with TREX2: view

Animal Models for TREX2 Gene

MGI Knock Outs for TREX2:

Animal Model Products

CRISPR Products

miRNA for TREX2 Gene

miRTarBase miRNAs that target TREX2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TREX2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TREX2 Gene

Localization for TREX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TREX2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TREX2 gene
Compartment Confidence
nucleus 4
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TREX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TREX2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TREX2 Gene

Pathways & Interactions for TREX2 Gene

PathCards logo

SuperPathways for TREX2 Gene

SuperPathway Contained pathways
1 Chks in Checkpoint Regulation
.32
genes like me logo Genes that share pathways with TREX2: view

Pathways by source for TREX2 Gene

1 Qiagen pathway for TREX2 Gene
  • DNA Repair Mechanisms

Gene Ontology (GO) - Biological Process for TREX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006259 DNA metabolic process IDA 11279105
GO:0006281 DNA repair TAS,IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with TREX2: view

No data available for SIGNOR curated interactions for TREX2 Gene

Drugs & Compounds for TREX2 Gene

(1) Drugs for TREX2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
genes like me logo Genes that share compounds with TREX2: view

Transcripts for TREX2 Gene

mRNA/cDNA for TREX2 Gene

3 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TREX2

Alternative Splicing Database (ASD) splice patterns (SP) for TREX2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12 ^ 13a ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - -
SP7: - - - - - - -
SP8: - - - - -
SP9: - - - -
SP10: - - -
SP11:
SP12:

ExUns: 13b · 13c ^ 14 ^ 15a · 15b
SP1: - -
SP2:
SP3: -
SP4: - - -
SP5: - - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for TREX2 Gene

GeneLoc Exon Structure for
TREX2

Expression for TREX2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TREX2 Gene

mRNA differential expression in normal tissues according to GTEx for TREX2 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x9.7), Skin - Sun Exposed (Lower leg) (x8.8), and Artery - Aorta (x4.6).

Protein differential expression in normal tissues from HIPED for TREX2 Gene

This gene is overexpressed in Monocytes (58.2) and Plasma (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TREX2 Gene



Protein tissue co-expression partners for TREX2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TREX2

SOURCE GeneReport for Unigene cluster for TREX2 Gene:

Hs.644635

mRNA Expression by UniProt/SwissProt for TREX2 Gene:

Q9BQ50-TREX2_HUMAN
Tissue specificity: Detected in heart, breast, prostate, skeletal muscle, testis, uterus, bone marrow, colon, small intestine, stomach and thymus.
genes like me logo Genes that share expression patterns with TREX2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TREX2 Gene

Orthologs for TREX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TREX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TREX2 31 30
  • 99.15 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TREX2 31 30
  • 87.01 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Trex2 17 31 30
  • 83.19 (n)
rat
(Rattus norvegicus)
Mammalia Trex2 30
  • 81.5 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 67 (a)
OneToMany
-- 31
  • 66 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TREX2 31
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TREX2 31
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488944 30
  • 56.74 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3165 31
  • 22 (a)
OneToMany
Species where no ortholog for TREX2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TREX2 Gene

ENSEMBL:
Gene Tree for TREX2 (if available)
TreeFam:
Gene Tree for TREX2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TREX2: view image

Paralogs for TREX2 Gene

Paralogs for TREX2 Gene

(1) SIMAP similar genes for TREX2 Gene using alignment to 2 proteins:

  • TREX2_HUMAN
  • Q06S70_HUMAN
genes like me logo Genes that share paralogs with TREX2: view

Variants for TREX2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TREX2 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
716260 Benign: not provided 153,445,200(-) G/A SYNONYMOUS_VARIANT
rs141078733 Benign: Abnormality of neuronal migration 153,445,172(-) G/A NONSENSE
rs35132777 - p.Arg137Cys

Additional dbSNP identifiers (rs#s) for TREX2 Gene

Structural Variations from Database of Genomic Variants (DGV) for TREX2 Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV gain+loss 17666407
esv3577532 CNV gain 25503493

Variation tolerance for TREX2 Gene

Gene Damage Index Score: 1.29; 25.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TREX2 Gene

Human Gene Mutation Database (HGMD)
TREX2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TREX2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TREX2 Gene

Disorders for TREX2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TREX2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
laryngeal benign neoplasm
  • laryngeal tumor
chilblain lupus 1
  • chbl1
aicardi-goutieres syndrome
  • aicardi-goutieres syndrome 1
- elite association - COSMIC cancer census association via MalaCards
Search TREX2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TREX2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TREX2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TREX2 Gene

Publications for TREX2 Gene

  1. Structure and expression of the TREX1 and TREX2 3' --> 5' exonuclease genes. (PMID: 11278605) Mazur DJ … Perrino FW (The Journal of biological chemistry 2001) 3 4 23 54
  2. Excision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases. Characterization of the recombinant proteins. (PMID: 11279105) Mazur DJ … Perrino FW (The Journal of biological chemistry 2001) 3 4 23 54
  3. Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases. (PMID: 10391904) Mazur DJ … Perrino FW (The Journal of biological chemistry 1999) 2 3 4 54
  4. DNA binding induces active site conformational change in the human TREX2 3'-exonuclease. (PMID: 19321497) de Silva U … Hollis T (Nucleic acids research 2009) 3 23 54
  5. TREX1 polymorphisms associated with autoantibodies in patients with systemic lupus erythematosus. (PMID: 18092167) Hur JW … Bae SC (Rheumatology international 2008) 3 41 54

Products for TREX2 Gene

Sources for TREX2 Gene