Aliases for TREX2 Gene
External Ids for TREX2 Gene
Previous GeneCards Identifiers for TREX2 Gene
This gene encodes a nuclear protein with 3' to 5' exonuclease activity. The encoded protein participates in double-stranded DNA break repair, and may interact with DNA polymerase delta. [provided by RefSeq, Nov 2012]
GeneCards Summary for TREX2 Gene
TREX2 (Three Prime Repair Exonuclease 2) is a Protein Coding gene. Diseases associated with TREX2 include Laryngeal Benign Neoplasm and Chilblain Lupus 1. Among its related pathways are Chks in Checkpoint Regulation. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and magnesium ion binding. An important paralog of this gene is TREX1.
UniProtKB/Swiss-Prot Summary for TREX2 Gene
Exonuclease with a preference for double-stranded DNA with mismatched 3' termini. May play a role in DNA repair.