Aliases for TREML4 Gene

Aliases for TREML4 Gene

  • Triggering Receptor Expressed On Myeloid Cells Like 4 2 3 5
  • TLT4 2 3 4
  • Triggering Receptor Expressed On Myeloid Cells-Like Protein 4 3 4
  • Trem-Like Transcript 4 Protein 3 4
  • TREM Like Transcript 4 2 3
  • TLT-4 3 4
  • Triggering Receptor Expressed On Myeloid Cells-Like 4 2
  • TREML4 5

External Ids for TREML4 Gene

Previous GeneCards Identifiers for TREML4 Gene

  • GC06P041304
  • GC06P041196
  • GC06P040914

Summaries for TREML4 Gene

GeneCards Summary for TREML4 Gene

TREML4 (Triggering Receptor Expressed On Myeloid Cells Like 4) is a Protein Coding gene. Diseases associated with TREML4 include Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is NCR2.

UniProtKB/Swiss-Prot Summary for TREML4 Gene

  • Positively regulates Toll-like receptor TLR7 signaling in macrophages.

Additional gene information for TREML4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TREML4 Gene

Genomics for TREML4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TREML4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J041227 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 679.1 +0.8 814 3 CTCF DPF2 CTBP1 NFE2 ZNF316 TRIM24 MAFG CEBPG MAFK SPI1 TREML4 TREML5P TREML3P RNA5SP207 RF00001-274 TREM1
GH06J041198 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 42.4 -26.9 -26857 6.2 PRDM10 RFX1 LEF1 IKZF1 BACH1 JUND MTA2 ZNF24 MTA1 IKZF2 TREML2 TREML4 TREML3P TREM2 USP49 ADCY10P1 NFYA TREML5P TREML1 ENSG00000218809
GH06J041256 Enhancer 1.1 Ensembl ENCODE CraniofacialAtlas 26.9 +28.2 28170 4.1 ZNF629 ZNF692 PRDM1 ZIC2 ZNF561 ZBTB44 ZNF10 ZXDB RUNX3 ESR1 TREML4 TREML3P TREM1 TSPO2 UNC5CL ADCY10P1 TREML5P ENSG00000278745 ENSG00000218809
GH06J041224 Enhancer 0.3 Ensembl 74 -3.3 -3286 0.8 ZNF512 SPI1 TREML4 LOC105375055 TREML2
GH06J041242 Enhancer 0.6 FANTOM5 Ensembl 38.9 +14.1 14114 0.8 ZNF24 ZFP91 ZNF579 HSALNG0050001 TREML4 TREML2 UNC5CL TREML1 TSPO2 TREM1 NFYA TFEB TREML5P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TREML4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TREML4

Top Transcription factor binding sites by QIAGEN in the TREML4 gene promoter:
  • AP-1
  • AREB6
  • Arnt
  • c-Fos
  • c-Jun
  • FosB
  • Fra-1
  • HNF-4alpha1
  • NCX
  • Pax-4a

Genomic Locations for TREML4 Gene

Genomic Locations for TREML4 Gene
chr6:41,228,287-41,239,386
(GRCh38/hg38)
Size:
11,100 bases
Orientation:
Plus strand
chr6:41,196,062-41,206,620
(GRCh37/hg19)
Size:
10,559 bases
Orientation:
Plus strand

Genomic View for TREML4 Gene

Genes around TREML4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TREML4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TREML4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TREML4 Gene

Proteins for TREML4 Gene

  • Protein details for TREML4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXN2-TRML4_HUMAN
    Recommended name:
    Trem-like transcript 4 protein
    Protein Accession:
    Q6UXN2
    Secondary Accessions:
    • B7ZL92

    Protein attributes for TREML4 Gene

    Size:
    200 amino acids
    Molecular mass:
    21924 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TREML4 Gene

Post-translational modifications for TREML4 Gene

  • Glycosylation at Asn93
  • Modification sites at PhosphoSitePlus

Other Protein References for TREML4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TREML4 Gene

Domains & Families for TREML4 Gene

Gene Families for TREML4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for TREML4 Gene

Suggested Antigen Peptide Sequences for TREML4 Gene

GenScript: Design optimal peptide antigens:
  • Triggering receptor expressed on myeloid cells-like protein 4 (TRML4_HUMAN)
genes like me logo Genes that share domains with TREML4: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TREML4 Gene

Function for TREML4 Gene

Molecular function for TREML4 Gene

UniProtKB/Swiss-Prot Function:
Positively regulates Toll-like receptor TLR7 signaling in macrophages.

Phenotypes From GWAS Catalog for TREML4 Gene

Gene Ontology (GO) - Molecular Function for TREML4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0038023 signaling receptor activity IBA 21873635
genes like me logo Genes that share ontologies with TREML4: view
genes like me logo Genes that share phenotypes with TREML4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TREML4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TREML4 Gene

Localization for TREML4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TREML4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TREML4 gene
Compartment Confidence
plasma membrane 4
extracellular 4
mitochondrion 1
nucleus 1
endosome 1
cytosol 1
lysosome 1
peroxisome 0
endoplasmic reticulum 0

Gene Ontology (GO) - Cellular Components for TREML4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface IBA 21873635
genes like me logo Genes that share ontologies with TREML4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TREML4 Gene

Pathways & Interactions for TREML4 Gene

genes like me logo Genes that share pathways with TREML4: view

Pathways by source for TREML4 Gene

Interacting Proteins for TREML4 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000342570 Q6UXN2-TRML4_HUMAN for TREML4 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TREML4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0034157 positive regulation of toll-like receptor 7 signaling pathway IBA,IMP 25848864
GO:0045087 innate immune response IEA --
GO:0045088 regulation of innate immune response IBA 21873635
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with TREML4: view

No data available for SIGNOR curated interactions for TREML4 Gene

Drugs & Compounds for TREML4 Gene

(1) Drugs for TREML4 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
duloxetine Approved Pharma Antagonist 0
genes like me logo Genes that share compounds with TREML4: view

Transcripts for TREML4 Gene

mRNA/cDNA for TREML4 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TREML4

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TREML4 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2:

Relevant External Links for TREML4 Gene

GeneLoc Exon Structure for
TREML4

Expression for TREML4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TREML4 Gene

mRNA differential expression in normal tissues according to GTEx for TREML4 Gene

This gene is overexpressed in Whole Blood (x40.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TREML4

SOURCE GeneReport for Unigene cluster for TREML4 Gene:

Hs.434181

Evidence on tissue expression from TISSUES for TREML4 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with TREML4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TREML4 Gene

Orthologs for TREML4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TREML4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TREML4 30 31
  • 99.49 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Treml4 30
  • 68.15 (n)
Mouse
(Mus musculus)
Mammalia Treml4 31
  • 38 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 17 (a)
ManyToMany
Species where no ortholog for TREML4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TREML4 Gene

ENSEMBL:
Gene Tree for TREML4 (if available)
TreeFam:
Gene Tree for TREML4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TREML4: view image

Paralogs for TREML4 Gene

Paralogs for TREML4 Gene

(1) SIMAP similar genes for TREML4 Gene using alignment to 2 proteins:

  • TRML4_HUMAN
  • H7C4X5_HUMAN

Pseudogenes.org Pseudogenes for TREML4 Gene

genes like me logo Genes that share paralogs with TREML4: view

Variants for TREML4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TREML4 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs7769759 - p.Thr168Ile
rs9369265 - p.Trp73Arg
rs9471515 - p.Thr146Lys

Additional dbSNP identifiers (rs#s) for TREML4 Gene

Structural Variations from Database of Genomic Variants (DGV) for TREML4 Gene

Variant ID Type Subtype PubMed ID
nsv602970 CNV gain 21841781
nsv823679 CNV loss 20364138

Variation tolerance for TREML4 Gene

Residual Variation Intolerance Score: 78.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.87; 48.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TREML4 Gene

Human Gene Mutation Database (HGMD)
TREML4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TREML4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TREML4 Gene

Disorders for TREML4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TREML4 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TREML4

genes like me logo Genes that share disorders with TREML4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TREML4 Gene

Publications for TREML4 Gene

  1. The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity. (PMID: 25848864) Ramirez-Ortiz ZG … Means TK (Nature immunology 2015) 3 4
  2. Integrative DNA, RNA, and protein evidence connects TREML4 to coronary artery calcification. (PMID: 24975946) Sen SK … Biesecker LG (American journal of human genetics 2014) 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
  4. The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44. (PMID: 12645956) Allcock RJ … Trowsdale J (European journal of immunology 2003) 2 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for TREML4 Gene

Sources for TREML4 Gene